Factors Affecting Hospitalization Length and in-Hospital Death Due to COVID-19 Infection in Saudi Arabia: A Single-Center Retrospective Analysis

References

• Zhou F, Yu T, Du R, et al. Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study. Lancet. 2020;395(10229):1054–1062. doi:10.1016/S0140-6736(20)30566-3
   PubMed Web of Science ®Google Scholar
• Hoffmann M, Kleine-Weber H, Schroeder S, et al. SARS-CoV-2 cell entry depends on ACE2 and TMPRSS2 and is blocked by a clinically proven protease inhibitor. cell. 2020;181(2):271–280. e8. doi:10.1016/j.cell.2020.02.052
   PubMed Web of Science ®Google Scholar
• Van Doremalen N, Bushmaker T, Morris DH, et al. Aerosol and surface stability of SARS-CoV-2 as compared with SARS-CoV-1. N Engl J Med. 2020;382(16):1564–1567. doi:10.1056/NEJMc2004973
   PubMed Web of Science ®Google Scholar
• Wang D, Hu B, Hu C. Clinical characteristics of 138 hospitalized patients with 2019 novel coronavirus-infected pneumonia in Wuhan, China. JAMA. 2020;323(11):1061–1069. doi:10.1001/jama.2020.1585
   PubMed Web of Science ®Google Scholar
• Chen N, Zhou M, Dong X, et al. Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study. Lancet. 2020;395(10223):507–513. doi:10.1016/S0140-6736(20)30211-7
   PubMed Web of Science ®Google Scholar
• Chen H, Xie Z, Zhu Y, et al. Chinese medicine for COVID-19: a protocol for systematic review and meta-analysis. Medicine. 2020;99:25.
   Google Scholar
• Assiri RA, Bepari A, Patel W, et al. Exploration of sex and age-based associations in clinical characteristics, predictors of severity, and duration of stay among COVID-19 Patients at the University Hospital of Saudi Arabia. Healthcare. 2023;11:5.
   Web of Science ®Google Scholar
• Rodriguez-Morales AJ, Cardona-Ospina JA, Gutiérrez-Ocampo E, et al. Clinical, laboratory and imaging features of COVID-19: a systematic review and meta-analysis. Travel Med Infect Dis. 2020;34:101623. doi:10.1016/j.tmaid.2020.101623
   PubMed Web of Science ®Google Scholar
• Cascella M, Rajnik M, Aleem A, et al. Features, evaluation and treatment coronavirus (COVID-19). In: StatPearls. Treasure Island (FL): StatPearls Publishing; 2020.
   Google Scholar
• Jiang F, Deng L, Zhang L, et al. Review of the clinical characteristics of coronavirus disease 2019 (COVID-19). J Gen Intern Med. 2020;35:1545–1549. doi:10.1007/s11606-020-05762-w
   PubMed Web of Science ®Google Scholar
• Aljuaid M, Alotair H, Alnajjar F, et al. Risk factors associated with in-hospital mortality patients with COVID-19 in Saudi Arabia. PLoS One. 2022;17(6):e0270062. doi:10.1371/journal.pone.0270062
   PubMed Web of Science ®Google Scholar
• Al-Otaiby M, Almutairi KM, Vinluan JM, et al. Demographic characteristics, comorbidities, and length of stay of COVID-19 patients admitted into intensive care units in Saudi Arabia: a nationwide retrospective study. Front Med. 2022;9:893954. doi:10.3389/fmed.2022.893954
   Web of Science ®Google Scholar
• Rosenbaum L. Facing Covid-19 in Italy - ethics, logistics, and therapeutics on the epidemic’s front line. N Engl J Med. 2020;382(20):1873–1875. doi:10.1056/NEJMp2005492
   PubMed Web of Science ®Google Scholar
• World Health Organization. Clinical Management of COVID-19: Interim Guidance, 27 May 2020. World Health Organization; 2020.
   Google Scholar
• Froes F. And now for something completely different: from 2019-nCoV and COVID-19 to 2020-nMan. Pulmonology. 2020;26(2):114. doi:10.1016/j.pulmoe.2020.02.010
   PubMed Web of Science ®Google Scholar
• Adhikari SP, Meng S, Wu Y-J, et al. Epidemiology, causes, clinical manifestation and diagnosis, prevention and control of coronavirus disease (COVID-19) during the early outbreak period: a scoping review. Infect Dis Poverty. 2020;9(1):29. doi:10.1186/s40249-020-00646-x
   PubMed Web of Science ®Google Scholar
• Barry M, Al Amri M, Memish ZA. COVID-19 in the shadows of MERS-CoV in the Kingdom of Saudi Arabia. J Epidemiol Glob Health. 2020;10(1):1. doi:10.2991/jegh.k.200218.003
   PubMed Web of Science ®Google Scholar
• Zhao W, Zha X, Wang N, et al. Clinical characteristics and durations of hospitalized patients with COVID-19 in Beijing: a retrospective cohort study. Cardiovasc Innovat Appl. 2021;6(1):33–44. doi:10.15212/CVIA.2021.0019
   Web of Science ®Google Scholar
• Feng Y, Ling Y, Bai T, et al. COVID-19 with different severities: a multicenter study of clinical features. Am J Respir Crit Care Med. 2020;201(11):1380–1388. doi:10.1164/rccm.202002-0445OC
   PubMed Web of Science ®Google Scholar
• Liu K, Chen Y, Lin R, et al. Clinical features of COVID-19 in elderly patients: a comparison with young and middle-aged patients. J Infect. 2020;80(6):e14–e18. doi:10.1016/j.jinf.2020.03.005
   PubMed Web of Science ®Google Scholar
• Onder G, Rezza G, Brusaferro S. Case-fatality rate and characteristics of patients dying in relation to COVID-19 in Italy. JAMA. 2020;323(18):1775–1776. doi:10.1001/jama.2020.4683
   PubMed Web of Science ®Google Scholar
• Porcheddu R, Serra C, Kelvin D, et al. Similarity in Case Fatality Rates (CFR) of COVID-19/SARS-COV-2 in Italy and China. J Infect Dev Ctries. 2020;14(2):125–128. doi:10.3855/jidc.12600
   PubMed Web of Science ®Google Scholar
• Li LQ, Huang T, Wang Y-Q, et al. COVID-19 patients’ clinical characteristics, discharge rate, and fatality rate of meta-analysis. J Med Virol. 2020;92(6):577–583. doi:10.1002/jmv.25757
   PubMed Web of Science ®Google Scholar
• Xia W, Shao J, Guo Y, et al. Clinical and CT features in pediatric patients with COVID‐19 infection: different points from adults. Pediatr Pulmonol. 2020;55(5):1169–1174. doi:10.1002/ppul.24718
   PubMed Web of Science ®Google Scholar
• Yehia BR, Winegar A, Fogel R, et al. Association of race with mortality among patients hospitalized with coronavirus disease 2019 (COVID-19) at 92 US hospitals. JAMA network open. 2020;3(8):e2018039–e2018039. doi:10.1001/jamanetworkopen.2020.18039
   PubMed Web of Science ®Google Scholar
• Xie J, Zu Y, Alkhatib A, et al. Metabolic syndrome and COVID-19 mortality among adult black patients in New Orleans. Diabetes Care. 2021;44(1):188–193. doi:10.2337/dc20-1714
   Web of Science ®Google Scholar
• Conti P, Younes A. Coronavirus COV-19/SARS-CoV-2 affects women less than men: clinical response to viral infection. J Biol Regul Homeost Agents. 2020;34(2):339–343. doi:10.23812/Editorial-Conti-3
   PubMed Web of Science ®Google Scholar
• Alqahtani AM, AlMalki ZS, Alalweet RM, et al. Assessing the severity of illness in patients with coronavirus disease in Saudi Arabia: a retrospective descriptive cross-sectional study. Front Public Health. 2020;8:593256. doi:10.3389/fpubh.2020.593256
   PubMed Web of Science ®Google Scholar
• Shaikh FS, Aldhafferi N, Buker A, et al. Comorbidities and risk factors for severe outcomes in COVID-19 patients in Saudi Arabia: a retrospective cohort study. J Multidiscip Healthc. 2021;14:2169–2183. doi:10.2147/JMDH.S317884
   PubMed Web of Science ®Google Scholar
• Al Dossary R, Alnimr A, Aljindan R, et al. Predictors of illness severity in COVID-19 cases in Saudi Arabia. Infect Drug Resist. 2021;Volume 14:4097–4105. doi:10.2147/IDR.S333300
   Web of Science ®Google Scholar
• Al Mutair A, Elhazmi A, Alhumaid S, et al. Examining the clinical prognosis of critically ill patients with COVID-19 admitted to intensive care units: a nationwide Saudi study. Medicina. 2021;57(9):878. doi:10.3390/medicina57090878
   PubMedGoogle Scholar
• Alahmari AK, Almalki ZS, Albassam AA, et al. Factors associated with length of hospital stay among COVID-19 patients in Saudi Arabia: a retrospective study during the first pandemic wave. Healthcare. 2022;7:1201. doi:10.3390/healthcare10071201
   Google Scholar
• Alwafi H, Naser AY, Qanash S, et al. Predictors of length of hospital stay, mortality, and outcomes among hospitalised COVID-19 patients in Saudi Arabia: a cross-sectional study. J Multidiscip Healthc. 2021;Volume 14:839–852. doi:10.2147/JMDH.S304788
   Web of Science ®Google Scholar
• Li C, Chen Q, Wang J, et al. Clinical characteristics of chronic liver disease with coronavirus disease 2019 (COVID-19): a cohort study in Wuhan, China. Aging. 2020;12(16):15938. doi:10.18632/aging.103632
   PubMedGoogle Scholar
• Alghamdi S. Clinical characteristics and treatment outcomes of severe (ICU) COVID-19 patients in Saudi Arabia: a single centre study. Saudi Pharm J. 2021;29(10):1096–1101. doi:10.1016/j.jsps.2021.08.008
   PubMed Web of Science ®Google Scholar
• Rees EM, Nightingale ES, Jafari Y, et al. COVID-19 length of hospital stay: a systematic review and data synthesis. BMC Med. 2020;18:1–22. doi:10.1186/s12916-020-01726-3
   PubMed Web of Science ®Google Scholar
• Wu Z, McGoogan JM. Characteristics of and important lessons from the coronavirus disease 2019 (COVID-19) outbreak in China: summary of a report of 72 314 cases from the Chinese Center for Disease Control and Prevention. JAMA. 2020;323(13):1239–1242. doi:10.1001/jama.2020.2648
   PubMed Web of Science ®Google Scholar
• Chen S, Zhang Z, Yang J, et al. Fangcang shelter hospitals: a novel concept for responding to public health emergencies. Lancet. 2020;395(10232):1305–1314. doi:10.1016/S0140-6736(20)30744-3
   PubMed Web of Science ®Google Scholar
• Wang Z, Liu Y, Wei L, et al. What are the risk factors of hospital length of stay in the novel coronavirus pneumonia (COVID-19) patients? A survival analysis in southwest China. PLoS One. 2022;17(1):e0261216. doi:10.1371/journal.pone.0261216
   PubMed Web of Science ®Google Scholar
• Guo A, Lu J, Tan H, et al. Risk factors on admission associated with hospital length of stay in patients with COVID-19: a retrospective cohort study. Sci Rep. 2021;11(1):7310. doi:10.1038/s41598-021-86853-4
   PubMed Web of Science ®Google Scholar
• Khatal SJ, Sule SS, Ajinkya Jayaji Pandhare AJ, et al. Predictors of length of hospital stay in patients with COVID-19: a retrospective study. J Clin Diagn Res. 2023;17:1.
   Web of Science ®Google Scholar
• Thiruvengadam G, Lakshmi M, Ramanujam R. A study of factors affecting the length of hospital stay of COVID-19 patients by Cox-proportional hazard model in a South Indian tertiary care hospital. J Prim Care Community Health. 2021;12:21501327211000231. doi:10.1177/21501327211000231
   Web of Science ®Google Scholar
• Alqassieh RS, Bsisu IK, Al-Sabbagh MQ, et al. Clinical characteristics and predictors of the duration o f hospital stay in COVID-19 patients in Jordan [version 1; peer. F1000Research. 2020;9:1439. doi:10.12688/f1000research.27419.1
   Google Scholar
• Yang L, Xie X, Tu Z, et al. The signal pathways and treatment of cytokine storm in COVID-19. Signal Transduct Target Ther. 2021;6(1):255. doi:10.1038/s41392-021-00679-0
   PubMed Web of Science ®Google Scholar
• Han Y, Zhang H, Mu S, et al. Lactate dehydrogenase, an independent risk factor of severe COVID-19 patients: a retrospective and observational study. Aging. 2020;12(12):11245–11258. doi:10.18632/aging.103372
   PubMedGoogle Scholar
• Ferrari D, Motta A, Strollo M, et al. Routine blood tests as a potential diagnostic tool for COVID-19. Clin Chem Lab Med. 2020;58(7):1095–1099. doi:10.1515/cclm-2020-0398
   PubMed Web of Science ®Google Scholar
• Eastin C, Eastin T. Clinical characteristics of coronavirus disease 2019 in China. J Emerg Med. 2020;58(4):711–712. doi:10.1016/j.jemermed.2020.04.004
   Google Scholar
• Akdogan D, Guzel M, Tosun D, et al. Diagnostic and early prognostic value of serum CRP and LDH levels in patients with possible COVID-19 at the first admission. J Infect Dev Ctries. 2021;15(6):766–772. doi:10.3855/jidc.14072
   PubMed Web of Science ®Google Scholar
• Huang C, Wang Y, Li X, et al. Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. Lancet. 2020;395(10223):497–506. doi:10.1016/S0140-6736(20)30183-5
   PubMed Web of Science ®Google Scholar
• Myers LC, Parodi SM, Escobar GJ, et al. Characteristics of hospitalized adults with COVID-19 in an integrated health care system in California. JAMA. 2020;323(21):2195–2198. doi:10.1001/jama.2020.7202
   PubMed Web of Science ®Google Scholar
• Richardson S, Hirsch JS, Narasimhan M, et al. Presenting characteristics, comorbidities, and outcomes among 5700 patients hospitalized with COVID-19 in the New York City Area. JAMA. 2020;323(20):2052–2059. doi:10.1001/jama.2020.6775
   PubMed Web of Science ®Google Scholar
• Barry M, AlMohaya A, AlHijji A, et al. Clinical characteristics and outcome of hospitalized COVID-19 Patients in a MERS-CoV Endemic Area. J Epidemiol Glob Health. 2020;10(3):214–221. doi:10.2991/jegh.k.200806.002
   PubMed Web of Science ®Google Scholar
• Grasselli G, Zangrillo A, Zanella A, et al. Baseline characteristics and outcomes of 1591 patients infected with SARS-CoV-2 admitted to icus of the Lombardy region, Italy. JAMA. 2020;323(16):1574–1581. doi:10.1001/jama.2020.5394
   PubMed Web of Science ®Google Scholar
• Ejaz H, Alsrhani A, Zafar A, et al. COVID-19 and comorbidities: deleterious impact on infected patients. J Infect Public Health. 2020;13(12):1833–1839. doi:10.1016/j.jiph.2020.07.014
   PubMed Web of Science ®Google Scholar
• Yang J, Zheng YA, Gou X, et al. Prevalence of comorbidities and its effects in patients infected with SARS-CoV-2: a systematic review and meta-analysis. Int J Infect Dis. 2020;94:91–95. doi:10.1016/j.ijid.2020.03.017
   PubMed Web of Science ®Google Scholar
• Guan WJ, Liang W-H, Zhao Y, et al. Comorbidity and its impact on 1590 patients with COVID-19 in China: a nationwide analysis. Eur Respir J. 2020;55(5):2000547. doi:10.1183/13993003.00547-2020
   PubMed Web of Science ®Google Scholar
• Mehta P, McAuley DF, Brown M, et al. COVID-19: consider cytokine storm syndromes and immunosuppression. Lancet. 2020;395(10229):1033–1034. doi:10.1016/S0140-6736(20)30628-0
   PubMed Web of Science ®Google Scholar
• Pan F, Yang L, Li Y, et al. Factors associated with death outcome in patients with severe coronavirus disease-19 (COVID-19): a case-control study. Int J Med Sci. 2020;17(9):1281–1292. doi:10.7150/ijms.46614
   PubMed Web of Science ®Google Scholar
• Yan Y, Yang Y, Wang F, et al. Clinical characteristics and outcomes of patients with severe covid-19 with diabetes. BMJ Open Diabetes Res Care. 2020;8(1):e001343. doi:10.1136/bmjdrc-2020-001343
   PubMed Web of Science ®Google Scholar
• Deng SQ, Peng HJ. Characteristics of and public health responses to the coronavirus disease 2019 outbreak in China. J Clin Med. 2020;9(2):575. doi:10.3390/jcm9020575
   PubMed Web of Science ®Google Scholar
• Al Mutair A, Al Mutairi A, Alhumaid S, et al. Examining and investigating the impact of demographic characteristics and chronic diseases on mortality of COVID-19: retrospective study. PLoS One. 2021;16(9):e0257131. doi:10.1371/journal.pone.0257131
   PubMed Web of Science ®Google Scholar
• Alswaidi FM, Assiri AM, Alhaqbani HH, et al. Characteristics and outcome of COVID-19 cases in Saudi Arabia: review of six-months of data (March-August 2020). Saudi Pharm J. 2021;29(7):682–691. doi:10.1016/j.jsps.2021.04.030
   PubMed Web of Science ®Google Scholar
• Ibrahim ME, AL-Aklobi OS, Abomughaid MM, et al. Epidemiological, clinical, and laboratory findings for patients of different age groups with confirmed coronavirus disease 2019 (COVID-19) in a hospital in Saudi Arabia. PLoS One. 2021;16(4):e0250955. doi:10.1371/journal.pone.0250955
   PubMed Web of Science ®Google Scholar
• Guo Y-R, Cao Q-D, Hong Z-S, et al. The origin, transmission and clinical therapies on coronavirus disease 2019 (COVID-19) outbreak–an update on the status. Mil Med Res. 2020;7:1–10. doi:10.1186/s40779-020-00240-0
   PubMed Web of Science ®Google Scholar
• Zhu B, Feng X, Jiang C, et al. Correlation between white blood cell count at admission and mortality in COVID-19 patients: a retrospective study. BMC Infect Dis. 2021;21:1–5. doi:10.1186/s12879-021-06277-3
   PubMed Web of Science ®Google Scholar
• Tsui PT, Kwok ML, Yuen H, et al. Severe acute respiratory syndrome: clinical outcome and prognostic correlates. Emerg Infect Dis. 2003;9(9):1064. doi:10.3201/eid0909.030362
   PubMed Web of Science ®Google Scholar
• Pouw N, van de Maat J, Veerman K, et al. Clinical characteristics and outcomes of 952 hospitalized COVID-19 patients in The Netherlands: a retrospective cohort study. PLoS One. 2021;16(3):e0248713. doi:10.1371/journal.pone.0248713
   PubMed Web of Science ®Google Scholar
• Yang C, Qiu X, Zeng Y-K, et al. Coronavirus disease 2019: a clinical review. Eur Rev Med Pharmacol Sci. 2020;24(8):4585–4596. doi:10.26355/eurrev_202004_21045
   PubMed Web of Science ®Google Scholar
• Lakhani JD, Kapadia S, Choradiya R, et al. COVID-19 and Multiorgan Dysfunction Syndrome. IntechOpen; 2021.
   Google Scholar