Seizure Remission and Its Predictors Among Epileptic Patients on Follow-Up at Public Hospitals in Eastern Ethiopia: A Retrospective Cohort Study

References

• De Boer HM, Mula M, Sander JW. The global burden and stigma of epilepsy. Epilepsy Behav. 2008;12(4):540–546. doi:10.1016/j.yebeh.2007.12.019
   PubMed Web of Science ®Google Scholar
• Fisher RS, Boas WVE, Blume W, et al. Epileptic seizures and epilepsy: definitions proposed by the International League Against Epilepsy (ILAE) and the International Bureau for Epilepsy (IBE). Epilepsia. 2005;46(4):470–472. doi:10.1111/j.0013-9580.2005.66104.x
   PubMed Web of Science ®Google Scholar
• Fisher RS, Cross JH, French JA, et al. Operational classification of seizure types by the International League Against Epilepsy: position paper of the ILAE Commission for Classification and Terminology. Epilepsia. 2017;58(4):522–530. doi:10.1111/epi.13670
   PubMed Web of Science ®Google Scholar
• Devinsky O, Vezzani A, O’Brien TJ, et al. Epilepsy. Nat Rev Dis Primers. 2018;4:18024. doi:10.1038/nrdp.2018.24
   PubMed Web of Science ®Google Scholar
• Fisher RS, Acevedo C, Arzimanoglou A, et al. ILAE official report: a practical clinical definition of epilepsy. Epilepsia. 2014;55(4):475–482. doi:10.1111/epi.12550
   PubMed Web of Science ®Google Scholar
• Epilepsy implementation task force. Provincial guidelines for the management of epilepsy in adults and children. Version 1.0. Critical Care Services Ontario; 2015.
   Google Scholar
• Neligan A, Hauser WA, Sander JW. The epidemiology of the epilepsies. Handb Clin Neurol. 2012;107:113–133.
   PubMedGoogle Scholar
• World Health Organization. Epilepsy: A Public Health Imperative. Geneva, Switzerland: World Health Organization; 2019:171.
   Google Scholar
• Fodjo JNS, Mandro M, Wonya’rossi D, et al. Economic burden of epilepsy in rural Ituri, Democratic Republic of Congo. EClinicalMedicine. 2019;9:60–66. doi:10.1016/j.eclinm.2019.03.010
   PubMedGoogle Scholar
• Tekle‐Haimanot R, Forsgren L, Ekstedt J. Incidence of epilepsy in rural central Ethiopia. Epilepsia. 1997;38(5):541–546. doi:10.1111/j.1528-1157.1997.tb01138.x
   PubMed Web of Science ®Google Scholar
• Worku D. Review article: epilepsy in Ethiopia. Am Acad Neurol. 2013;80(7):10–1212.
   Google Scholar
• DiPiro JT, Wells BG, Schwinghammer TL, DiPiro CV. Pharmacotherapy Handbook. 9th ed. McGraw-hill; 2015.
   Google Scholar
• Kerr M, Scheepers M, Arvio M, et al. Consensus guidelines into the management of epilepsy in adults with an intellectual disability. J Intell Disabil Res. 2009;53(8):687–694. doi:10.1111/j.1365-2788.2009.01182.x
   PubMedGoogle Scholar
• Kwan P, Arzimanoglou A, Berg AT, et al. Definition of Drug Resistant Epilepsy: Consensus Proposal by the Ad Hoc Task Force of the ILAE Commission on Therapeutic Strategies. Wiley Online Library; 2010.
   Google Scholar
• Glauser T, Ben‐Menachem E, Bourgeois B, et al. ILAE treatment guidelines: evidence‐based analysis of antiepileptic drug efficacy and effectiveness as initial monotherapy for epileptic seizures and syndromes. Epilepsia. 2006;47(7):1094–1120. doi:10.1111/j.1528-1167.2006.00585.x
   PubMed Web of Science ®Google Scholar
• Food Medicine Health Administration and Control Authority. Ethiopian Standard Treatment Guidelines for General Hospitals. 3rd ed. Food Medicine Health Administration and Control Authority; 2014.
   Google Scholar
• World Health Organization. Anti-Epileptic Medicines for Medication Resistant Convulsive Epilepsy. Swiztherland, Geneva: World Health Organization; 2015.
   Google Scholar
• Neligan A, Bell GS, Johnson AL, Goodridge DM, Shorvon SD, Sander JW. The long-term risk of premature mortality in people with epilepsy. Brain. 2011;134(2):388–395. doi:10.1093/brain/awq378
   PubMedGoogle Scholar
• Bruno E, Nimaga K, Foba I, et al. Results of an action-research on epilepsy in rural Mali. PLoS One. 2012;7(8):e44469. doi:10.1371/journal.pone.0044469
   PubMed Web of Science ®Google Scholar
• Sperling MR. The consequences of uncontrolled epilepsy. CNS Spectr. 2004;9(2):98–109. doi:10.1017/S1092852900008464
   PubMed Web of Science ®Google Scholar
• Golyala A, Kwan P. Drug development for refractory epilepsy: the past 25 years and beyond. Seizure. 2017;44:147–156. doi:10.1016/j.seizure.2016.11.022
   PubMed Web of Science ®Google Scholar
• Laxer KD, Trinka E, Hirsch LJ, et al. The consequences of refractory epilepsy and its treatment. Epilepsy Behav. 2014;37:59–70. doi:10.1016/j.yebeh.2014.05.031
   PubMed Web of Science ®Google Scholar
• Abiy H, Shiferaw Z, Tafere Y. Clinical outcome and its associated factors among children with meningitis admitted in Debre Markos Comprehensive Specialized Hospital, Northwest Ethiopia, 2019. Int J Nurs Care Res. 2023;1(1):1–6.
   Google Scholar
• Beyene A, Ayalew AF, Mulat G, Simachew Kassa A, Birhan T, Russo E. The treatment outcomes of epilepsy and its root causes in children attending at the University of Gondar teaching hospital: a retrospective cohort study, 2018. PLoS One. 2020;15(3):e0230187. doi:10.1371/journal.pone.0230187
   PubMed Web of Science ®Google Scholar
• Zewudie A, Mamo Y, Feyissa D, Yimam M, Mekonen G, Abdela A. Epilepsy treatment outcome and its predictors among ambulatory patients with epilepsy at Mizan-Tepi University Teaching Hospital, southwest Ethiopia. Neurol Res Int. 2020;2020:1–8. doi:10.1155/2020/8109858
   Web of Science ®Google Scholar
• Bekele F, Gezimu W. Treatment outcome and associated factors among epileptic patients at ambulatory clinic of Mettu Karl Comprehensive Specialized Hospital: a cross-sectional study. SAGE Open Med. 2022;10:20503121221125149. doi:10.1177/20503121221125149
   Web of Science ®Google Scholar
• Krumholz A, Wiebe S, Gronseth GS, et al. Evidence-based guideline: management of an unprovoked first seizure in adults: report of the guideline development subcommittee of the American Academy of Neurology and the American Epilepsy Society: evidence-based guideline. Epilepsy Curr. 2015;15(3):144–152. doi:10.5698/1535-7597-15.3.144
   PubMed Web of Science ®Google Scholar
• Radhakrishnan K. Challenges in the management of epilepsy in resource-poor countries. Nat Rev Neurol. 2009;5(6):323–330. doi:10.1038/nrneurol.2009.53
   PubMed Web of Science ®Google Scholar
• Desjarlais RR. World Mental Health: Problems and Priorities in Low-Income Countries. USA: Oxford University Press; 1995.
   Google Scholar
• Panahi S, Aram Z, Jafari S, Ma J, Sprott JC. Modeling of epilepsy based on chaotic artificial neural network. Chaos Solitons Fractals. 2017;105:150–156. doi:10.1016/j.chaos.2017.10.028
   Web of Science ®Google Scholar
• Chen Z, Brodie MJ, Liew D, Kwan P. Treatment outcomes in patients with newly diagnosed epilepsy treated with established and new antiepileptic drugs: a 30-year longitudinal cohort study. JAMA Neurol. 2018;75(3):279–286. doi:10.1001/jamaneurol.2017.3949
   PubMed Web of Science ®Google Scholar
• Ethiopia CSA. Population Projection of Ethiopia for All Regions at Wereda Level from 2014–2017. Addis Ababa: Agency CS; 2013.
   Google Scholar
• Gidey K, Chelkeba L, Gemechu TD, Daba FB. Treatment response and predictors in patients with newly diagnosed epilepsy in Ethiopia: a retrospective cohort study. Sci Rep. 2019;9(1):1–7. doi:10.1038/s41598-019-52574-y
   PubMedGoogle Scholar
• Ashmawi A, Hosny H, Abdelalim A, Bianchi E, Beghi E. The long-term prognosis of newly diagnosed epilepsy in Egypt: a retrospective cohort study from an epilepsy center in Greater Cairo. Seizure. 2016;41:86–95. doi:10.1016/j.seizure.2016.07.016
   PubMed Web of Science ®Google Scholar
• Brodie MJ, Barry SJE, Bamagous GA, Norrie JD, Kwan P. Patterns of treatment response in newly diagnosed epilepsy. Neurology. 2012;78(20):1548–1554. doi:10.1212/WNL.0b013e3182563b19
   PubMed Web of Science ®Google Scholar
• Thompson K, Kulkarni J, Sergejew AA. Reliability and validity of a new Medication Adherence Rating Scale (Mars) for the psychoses. Schizophr Res. 2000;42(3):241–247. doi:10.1016/S0920-9964(99)00130-9
   PubMed Web of Science ®Google Scholar
• Zhang Y, Yu N, Su L, Di Q. A prospective cohort study of prognosis for newly diagnosed epilepsy in east China. BMC Neurol. 2013;13(1):1–8. doi:10.1186/1471-2377-13-116
   PubMedGoogle Scholar
• Shen C, Du Y, Lu R, et al. Factors predictive of late remission in a cohort of Chinese patients with newly diagnosed epilepsy. Seizure. 2016;37:20–24. doi:10.1016/j.seizure.2016.02.007
   PubMed Web of Science ®Google Scholar
• Yazie TS, Kefale B, Molla M, Biagini G. Treatment outcome of epileptic patients receiving antiepileptic drugs in Ethiopia: a systematic review and meta-analysis. Behav Neurol. 2021;2021:1–11. doi:10.1155/2021/5586041
   Web of Science ®Google Scholar
• Niriayo YL, Mamo A, Kassa TD, et al. Treatment outcome and associated factors among patients with epilepsy. Sci Rep. 2018;8(1):1–9. doi:10.1038/s41598-018-35906-2
   PubMedGoogle Scholar
• Tigistu M, Azale T, Kebebe H, Yihunie T. Frequency of seizure attack and associated factors among patients with epilepsy at University of Gondar Referral Hospital: a cross-sectional study, Gondar, North West Ethiopia, 2017. BMC Res Notes. 2018;11(1):1–6. doi:10.1186/s13104-018-3761-3
   PubMedGoogle Scholar
• Del Felice A, Beghi E, Boero G, et al. Early versus late remission in a cohort of patients with newly diagnosed epilepsy. Epilepsia. 2010;51(1):37–42. doi:10.1111/j.1528-1167.2009.02141.x
   PubMed Web of Science ®Google Scholar
• Ndoye NF, Sow AD, Diop AG, et al. Prevalence of epilepsy its treatment gap and knowledge, attitude and practice of its population in sub-urban Senegal an ILAE/IBE/WHO study. Seizure. 2005;14(2):106–111. doi:10.1016/j.seizure.2004.11.003
   PubMed Web of Science ®Google Scholar
• Birru EM, Shafi M, Geta M. Drug therapy of epileptic seizures among adult epileptic outpatients of University of Gondar Referral and Teaching Hospital, Gondar, North West Ethiopia. Neuropsychiatr Dis Treat. 2016;12:3213–3219. doi:10.2147/NDT.S119030
   PubMedGoogle Scholar
• Gurshaw M, Agalu A, Chanie T. Anti-epileptic drug utilization and treatment outcome among epileptic patients on follow-up in a resource poor setting. J Young Pharm. 2014;6(3):47. doi:10.5530/jyp.2014.3.8
   Google Scholar
• Rogawski MA, Johnson MR. Intrinsic severity as a determinant of antiepileptic drug refractoriness. Epilepsy Curr. 2008;8(5):127–130. doi:10.1111/j.1535-7511.2008.00272.x
   PubMedGoogle Scholar
• Gilad R, Lampl Y, Gabbay U, Eshel Y, Sarova-Pinhas I. Early treatment of a single generalized tonic-clonic seizure to prevent recurrence. Arch Neurol. 1996;53(11):1149–1152. doi:10.1001/archneur.1996.00550110089017
   PubMedGoogle Scholar
• Gabr WM, Shams MEE. Adherence to medication among outpatient adolescents with epilepsy. Saudi Pharm J. 2015;23(1):33–40. doi:10.1016/j.jsps.2014.05.003
   PubMed Web of Science ®Google Scholar
• Hovinga CA, Asato MR, Manjunath R, et al. Association of non-adherence to antiepileptic drugs and seizures, quality of life, and productivity: survey of patients with epilepsy and physicians. Epilepsy Behav. 2008;13(2):316–322. doi:10.1016/j.yebeh.2008.03.009
   PubMed Web of Science ®Google Scholar
• Nasir BB, Yifru YM, Engidawork E, Gebrewold MA, Woldu MA, Berha AB. Antiepileptic drug treatment outcomes and seizure-related injuries among adult patients with epilepsy in a tertiary care hospital in Ethiopia. Patient Relat Outcome Meas. 2020;11:119–127. doi:10.2147/PROM.S243867
   PubMed Web of Science ®Google Scholar
• Nevitt S, Sudell M, Weston J, Tudur Smith C, Marson AG. Antiepileptic drug monotherapy for epilepsy: a network meta-analysis of individual participant data. Cochrane Database Syst Rev. 2017. doi:10.1002/14651858.CD011412.pub2
   Google Scholar