The Kynurenine/Tryptophan Ratio as a Promising Metabolomic Biomarker for Diagnosing the Spectrum of Tuberculosis Infection and Disease

References

• Bujak R, Struck-Lewicka W, Markuszewski MJ, Kaliszan R. Metabolomics for laboratory diagnostics. J Pharm Biomed Anal. 2015;113:108–120. doi:10.1016/j.jpba.2014.12.017
   PubMed Web of Science ®Google Scholar
• Hanna LE, Babu H, Sperk M, et al. Plasma metabolic signature and abnormalities in hiv-infected individuals on long-term successful antiretroviral therapy. Metabolites. 2019;9(10):1–16.
   Web of Science ®Google Scholar
• Tounta V, Liu Y, Cheyne A, Larrouy-Maumus G. Metabolomics in infectious diseases and drug discovery. Mol Omi. 2021;17(3):376–393. doi:10.1039/D1MO00017A
   PubMed Web of Science ®Google Scholar
• Gowda GAN, Zhang S, Gu H, Asiago V, Shanaiah N, Raftery D. Metabolomics-based methods for early disease diagnostics: a review. Expert Rev Mol Diagn. 2008;8(5):617. doi:10.1586/14737159.8.5.617
   PubMed Web of Science ®Google Scholar
• Crook AA, Powers R. Quantitative NMR-based biomedical metabolomics: current status and applications. Molecules. 2020;25(21):5128. doi:10.3390/molecules25215128
   PubMed Web of Science ®Google Scholar
• Baidoo EEK, Teixeira Benites V. Mass spectrometry-based microbial metabolomics: techniques, analysis, and applications. Methods Mol Biol. 2019;1859:11–69.
   PubMedGoogle Scholar
• Odom JD, Sutton VR. Metabolomics in clinical practice: improving diagnosis and informing management. Clin Chem. 2021;67(12):1606–1617. doi:10.1093/clinchem/hvab184
   PubMed Web of Science ®Google Scholar
• Isa F, Collins S, Lee MH, et al. Mass spectrometric identification of urinary biomarkers of pulmonary tuberculosis. EBioMedicine. 2018;31:157. doi:10.1016/j.ebiom.2018.04.014
   PubMed Web of Science ®Google Scholar
• van Laarhoven A, Dian S, Aguirre-Gamboa R, et al. Cerebral tryptophan metabolism and outcome of tuberculous meningitis: an observational cohort study. Lancet Infect Dis. 2018;18(5):526–535. doi:10.1016/S1473-3099(18)30053-7
   PubMed Web of Science ®Google Scholar
• Cui L, Lu H, Lee YH. Challenges and emergent solutions for LC-MS/MS based untargeted metabolomics in diseases. Mass Spectrom Rev. 2018;37(6):772–792. doi:10.1002/mas.21562
   PubMed Web of Science ®Google Scholar
• Liebenberg C, Luies L, Williams AA. Metabolomics as a tool to investigate HIV/TB co-infection. Front Mol Biosci. 2021;8(October):1–19. doi:10.3389/fmolb.2021.692823
   Google Scholar
• Floc’h N L, Otten W, Merlot E. Tryptophan metabolism, from nutrition to potential therapeutic applications. Amino Acids. 2011;41(5):1195–1205. doi:10.1007/s00726-010-0752-7
   PubMed Web of Science ®Google Scholar
• Moriska M, Lubis G, Herman RB, Moriska M, Lubis G, Herman RB. Hubungan antara Kadar Total Triptofan Plasma dan Indeks Massa Tubuh dengan Gejala Depresi dan Skor [Association between Total Plasma Tryptophan Levels and Body Mass Index with Depression Symptoms and Scores]. Sari Pediatri.2016;17(5):373–378.
   Google Scholar
• Shi W, Wu J, Tan Q, et al. Plasma indoleamine 2,3-dioxygenase activity as a potential biomarker for early diagnosis of multidrug-resistant tuberculosis in tuberculosis patients. Infect Drug Resist. 2019;12:1265–1276. doi:10.2147/IDR.S202369
   PubMed Web of Science ®Google Scholar
• Adu-Gyamfi CG, Savulescu D, George JA, Suchard MS. Indoleamine 2, 3-dioxygenase- mediated tryptophan catabolism: a leading star or supporting act in the tuberculosis and HIV Pas-de-Deux? Front Cell Infect Microbiol. 2019;9(October):1–12. doi:10.3389/fcimb.2019.00372
   PubMedGoogle Scholar
• Suchard MS, Adu-Gyamfi CG, Cumming BM, Savulescu DM. Evolutionary views of tuberculosis: indoleamine 2,3-dioxygenase catalyzed nicotinamide synthesis reflects shifts in macrophage metabolism: indoleamine 2,3-dioxygenase reflects altered macrophage metabolism during tuberculosis pathogenesis. BioEssays. 2020;42(5):1–10. doi:10.1002/bies.201900220
   Web of Science ®Google Scholar
• Bo L, Guojun T, Li G. An expanded neuroimmunomodulation axis: sCD83-indoleamine 2,3-dioxygenase-kynurenine pathway and updates of kynurenine pathway in neurologic diseases. Front Immunol. 2018;9(JUN). doi:10.3389/fimmu.2018.01363
   PubMedGoogle Scholar
• Mondanelli G, Iacono A, Carvalho A, et al. Amino acid metabolism as drug target in autoimmune diseases. Autoimmun Rev. 2019;18(4):334–348. doi:10.1016/j.autrev.2019.02.004
   PubMed Web of Science ®Google Scholar
• Krupa A, Kowalska I. The kynurenine pathway—new linkage between innate and adaptive immunity in autoimmune endocrinopathies. Int J Mol Sci. 2021;22(18):9879. doi:10.3390/ijms22189879
   PubMed Web of Science ®Google Scholar
• Badawy AAB. Tryptophan availability for kynurenine pathway metabolism across the life span: control mechanisms and focus on aging, exercise, diet and nutritional supplements. Neuropharmacology. 2017;112(Pt B):248–263. doi:10.1016/j.neuropharm.2015.11.015
   PubMedGoogle Scholar
• Strasser B, Gostner JM, Fuchs D. Mood, food, and cognition: role of tryptophan and serotonin. Curr Opin Clin Nutr Metab Care. 2016;19(1):55–61. doi:10.1097/MCO.0000000000000237
   PubMed Web of Science ®Google Scholar
• Marszalek-Grabska M, Walczak K, Gawel K, et al. Kynurenine emerges from the shadows – current knowledge on its fate and function. Pharmacol Ther. 2021;225:107845. doi:10.1016/j.pharmthera.2021.107845
   PubMed Web of Science ®Google Scholar
• Collins JM, Siddiqa A, Jones DP, et al. Tryptophan catabolism reflects disease activity in human tuberculosis. JCI Insight. 2020;5(10):1.
   Web of Science ®Google Scholar
• Yeung AWS, Terentis AC, King NJC, Thomas SR. Role of indoleamine 2,3-dioxygenase in health and disease. Clin Sci. 2015;129(7):601–672.
   PubMed Web of Science ®Google Scholar
• Seishima M, Yamamoto Y, Sakurai M, et al. Serum profiles of tryptophan-kynurenine pathway metabolites in psoriasis. Explor Immunol. 2021;1:258–268.
   Google Scholar
• Munn DH, Mellor AL. Indoleamine 2,3 dioxygenase and metabolic control of immune responses. Trends Immunol. 2013;34(3):137–143. doi:10.1016/j.it.2012.10.001
   PubMed Web of Science ®Google Scholar
• Olsson O, Skogmar S, Tesfaye F, Mulleta D, Jansson M, Björkman P. Kynurenine/tryptophan ratio for detection of active tuberculosis in adults with HIV prior to antiretroviral therapy. AIDS. 2022;36(9):1245–1253. doi:10.1097/QAD.0000000000003235
   PubMed Web of Science ®Google Scholar
• Adu-Gyamfi CG, Snyman T, Makhathini L, et al. Diagnostic accuracy of plasma kynurenine/tryptophan ratio, measured by enzyme-linked immunosorbent assay, for pulmonary tuberculosis. Int J Infect Dis. 2020;99:441–448. doi:10.1016/j.ijid.2020.08.028
   PubMed Web of Science ®Google Scholar
• Blumenthal A, Nagalingam G, Huch JH, et al. M. tuberculosis induces potent activation of IDO-1, but this is not essential for the immunological control of infection. PLoS One. 2012;7(5):e37314. doi:10.1371/journal.pone.0037314
   PubMed Web of Science ®Google Scholar
• Shaun Lott J. The tryptophan biosynthetic pathway is essential for Mycobacterium tuberculosis to cause disease. Biochem Soc Trans. 2020;48(5):2029–2037. doi:10.1042/BST20200194
   PubMed Web of Science ®Google Scholar
• Adu-Gyamfi C, Savulescu D, Mikhathani L, et al. Plasma kynurenine-to-tryptophan ratio, a highly sensitive blood-based diagnostic tool for tuberculosis in pregnant women living with Human Immunodeficiency Virus (HIV). Clin Infect Dis. 2021;73(6):1027–1036. doi:10.1093/cid/ciab232
   PubMed Web of Science ®Google Scholar
• Schnittman SR, Byakwaga H, Boum Y, et al. Changes in immune activation during pregnancy and the postpartum period in treated HIV infection. Open Forum Infect Dis. 2021;8(6):1–9. doi:10.1093/ofid/ofab245
   Web of Science ®Google Scholar
• Bantug GR, Galluzzi L, Kroemer G, Hess C. The spectrum of T cell metabolism in health and disease. Nat Rev Immunol. 2018;18(1):19–34. doi:10.1038/nri.2017.99
   PubMed Web of Science ®Google Scholar
• Byakwaga H, Hunt PW, Laker-Oketta M, et al. The kynurenine pathway of tryptophan catabolism and AIDS-associated kaposi sarcoma in Africa. J Acquir Immune Defic Syndr. 2015;70(3):296–303. doi:10.1097/QAI.0000000000000747
   PubMed Web of Science ®Google Scholar
• Abrahem R, Chiang E, Haquang J, Nham A, Ting YS, Venketaraman V. The role of dendritic cells in TB and HIV infection. J Clin Med. 2020;9(8):1–15. doi:10.3390/jcm9082661
   Web of Science ®Google Scholar
• Drain PK, Bajema KL, Dowdy D, et al. Incipient and subclinical tuberculosis: a clinical review of early stages and progression of infection. Clin Microbiol Rev. 2018;31(4). doi:10.1128/CMR.00021-18
   PubMed Web of Science ®Google Scholar
• Haas MK, Belknap RW. Diagnostic tests for latent tuberculosis infection. Clin Chest Med. 2019;40(4):829–837. doi:10.1016/j.ccm.2019.07.007
   PubMed Web of Science ®Google Scholar
• Adu-Gyamfi CG, Snyman T, Hoffmann CJ, et al. Plasma indoleamine 2, 3-dioxygenase, a biomarker for tuberculosis in human immunodeficiency virus-infected patients. Clin Infect Dis. 2017;65(8):1356–1363. doi:10.1093/cid/cix550
   PubMed Web of Science ®Google Scholar
• Suzuki Y, Suda T, Asada K, et al. Serum indoleamine 2,3-dioxygenase activity predicts prognosis of pulmonary tuberculosis. Clin Vaccine Immunol. 2012;19(3):436–442. doi:10.1128/CVI.05402-11
   PubMed Web of Science ®Google Scholar
• Wang X, Mehra S, Kaushal D, Veazey RS, Xu H. Abnormal tryptophan metabolism in HIV and Mycobacterium tuberculosis Infection. Front Microbiol. 2021;12(June):1–9.
   Google Scholar