Predictors and Clinical Significance of Myocardial Injury in Elderly Patients Under the COVID-19 Pandemic

References

• Zhou F, Yu T, Du R, et al. Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study. Lancet. 2020;395(10229):1054–1062. doi:10.1016/S0140-6736(20)30566-3
   PubMed Web of Science ®Google Scholar
• Moccia F, Gerbino A, Lionetti V, et al. COVID-19-associated cardiovascular morbidity in older adults: a position paper from the Italian Society of Cardiovascular Researches. Geroscience. 2020;42(4):1021–1049. doi:10.1007/s11357-020-00198-w
   PubMed Web of Science ®Google Scholar
• Smith DJ, Hakim AJ, Leung GM, et al. COVID-19 mortality and vaccine coverage - Hong Kong Special Administrative Region. MMWR Morb Mortal Wkly Rep. 2022;71(15):545–548. doi:10.15585/mmwr.mm7115e1
   PubMed Web of Science ®Google Scholar
• Lindner D, Fitzek A, Brauninger H, et al. Association of cardiac infection with SARS-CoV-2 in confirmed COVID-19 autopsy cases. JAMA Cardiol. 2020;5(11):1281–1285. doi:10.1001/jamacardio.2020.3551
   PubMed Web of Science ®Google Scholar
• Schurink B, Roos E, Radonic T, et al. Viral presence and immunopathology in patients with lethal COVID-19: a prospective autopsy cohort study. Lancet Microbe. 2020;1(7):e290–e299. doi:10.1016/S2666-5247(20)30144-0
   PubMedGoogle Scholar
• Nuzzi V, Merlo M, Specchia C, et al. The prognostic value of serial troponin measurements in patients admitted for COVID-19. ESC Heart Fail. 2021;8(5):3504–3511. doi:10.1002/ehf2.13462
   PubMed Web of Science ®Google Scholar
• Poterucha TJ, Elias P, Jain SS, et al. Admission cardiac diagnostic testing with electrocardiography and troponin measurement prognosticates increased 30-day mortality in COVID-19. J Am Heart Assoc. 2021;10(1):e018476. doi:10.1161/JAHA.120.018476
   PubMed Web of Science ®Google Scholar
• Arnau-Barres I, Pascual-Dapena A, Lopez-Montesinos I, et al. Prevalence and prognostic value of myocardial injury in the initial presentation of SARS-CoV-2 infection among older adults. J Clin Med. 2021;10(16):3738. doi:10.3390/jcm10163738
   PubMed Web of Science ®Google Scholar
• Maloberti A, Biolcati M, Giannattasio C. Troponin elevation in COVID-19 patients: an important stratification biomarker with still some open questions. Int J Cardiol. 2021;341:107–109. doi:10.1016/j.ijcard.2021.07.049
   PubMed Web of Science ®Google Scholar
• Cheng R, Leedy D. COVID-19 and acute myocardial injury: the heart of the matter or an innocent bystander? Heart. 2020;106(15):1122–1124. doi:10.1136/heartjnl-2020-317025
   PubMed Web of Science ®Google Scholar
• Sandoval Y, Januzzi JJ, Jaffe AS. Cardiac troponin for assessment of myocardial injury in COVID-19. J Am Coll Cardiol. 2020;76(10):1244–1258. doi:10.1016/j.jacc.2020.06.068
   PubMed Web of Science ®Google Scholar
• Imazio M, Klingel K, Kindermann I, et al. COVID-19 pandemic and troponin: indirect myocardial injury, myocardial inflammation or myocarditis? Heart. 2020;106(15):1127–1131. doi:10.1136/heartjnl-2020-317186
   PubMed Web of Science ®Google Scholar
• Obas V, Vasan RS. The aging heart. Clin Sci. 2018;132(13):1367–1382. doi:10.1042/CS20171156
   PubMed Web of Science ®Google Scholar
• Zhang X, Zhang W, Chen S. Shanghai’s life-saving efforts against the current omicron wave of the COVID-19 pandemic. Lancet. 2022;399:2011–2012. doi:10.1016/S0140-6736(22)00838-8
   PubMed Web of Science ®Google Scholar
• Thygesen K, Alpert JS, Jaffe AS, et al. Fourth universal definition of myocardial infarction. J Am Coll Cardiol. 2018;72(18):2231–2264. doi:10.1016/j.jacc.2018.08.1038
   PubMed Web of Science ®Google Scholar
• Chinese National Health Commission. Guideline on prevention and control of COVID‐19. Available from: http://www.nhc.gov.cn/yzygj/s7653p/202008/0a7bdf12bd4b46e5bd28ca7f9a7f5e5a/files/a449a3e2e2c94d9a856d5faea2ff0f94.pdf.2022. Accessed June 10, 2022.
   Google Scholar
• Shanghai Municipal Health Commission. Home page; 2022. Available from: https://wsjkw.sh.gov.cn/yqtb/index.html. Accessed June 10, 2022.
   Google Scholar
• Shanghai Municipal Health Commission. Shanghai Municipal Administrator of Traditional Chinese Medicine. [Homepage on the internet] Pandemic notification. Available from: https://wsjkw.sh.gov.cn/xwfb/20220514/5680eabd2c7741118cddb443e3e671ce.html. Accessed June 10, 2022.
   Google Scholar
• Doyen D, Dupland P, Morand L, et al. Characteristics of cardiac injury in critically ill patients with Coronavirus Disease 2019. Chest. 2021;159(5):1974–1985. doi:10.1016/j.chest.2020.10.056
   PubMed Web of Science ®Google Scholar
• De Michieli L, Ola O, Knott JD, et al. High-sensitivity cardiac troponin T for the detection of myocardial injury and risk stratification in COVID-19. Clin Chem. 2021;67(8):1080–1089. doi:10.1093/clinchem/hvab062
   PubMed Web of Science ®Google Scholar
• Roh JD, Kitchen RR, Guseh JS, et al. Plasma proteomics of COVID-19-associated cardiovascular complications: implications for pathophysiology and therapeutics. JACC Basic Transl Sci. 2022;7:425–441. doi:10.1016/j.jacbts.2022.01.013
   PubMedGoogle Scholar
• Lippi G, Lavie CJ, Sanchis-Gomar F. Cardiac troponin I in patients with coronavirus disease 2019 (COVID-19): evidence from a meta-analysis. Prog Cardiovasc Dis. 2020;63(3):390–391. doi:10.1016/j.pcad.2020.03.001
   PubMed Web of Science ®Google Scholar
• Nishihira K, Yoshioka G, Kuriyama N, et al. Impact of frailty on outcomes in elderly patients with acute myocardial infarction who undergo percutaneous coronary intervention. Eur Heart J Qual Care Clin Outcomes. 2021;7(2):189–197. doi:10.1093/ehjqcco/qcaa018
   PubMed Web of Science ®Google Scholar
• Montone RA, Iannaccone G, Meucci MC, Gurgoglione F, Niccoli G. Myocardial and microvascular injury due to Coronavirus Disease 2019. Eur Cardiol. 2020;15:e52. doi:10.15420/ecr.2020.22
   PubMed Web of Science ®Google Scholar
• Maloberti A, Giannattasio C, Rebora P, et al. Incident atrial fibrillation and In-hospital mortality in SARS-CoV-2 patients incident atrial fibrillation and In-hospital mortality in SARS-CoV-2 patients. Biomedicines. 2022;10(8):1940. doi:10.3390/biomedicines10081940
   PubMed Web of Science ®Google Scholar
• Monneret D, Gellerstedt M, Bonnefont-Rousselot D. Determination of age- and sex-specific 99th percentiles for high-sensitive troponin T from patients: an analytical imprecision- and partitioning-based approach. Clin Chem Lab Med. 2018;56(5):818–829. doi:10.1515/cclm-2017-0256
   PubMed Web of Science ®Google Scholar
• Gore MO, Seliger SL, Defilippi CR, et al. Age- and sex-dependent upper reference limits for the high-sensitivity cardiac troponin T assay. J Am Coll Cardiol. 2014;63(14):1441–1448. doi:10.1016/j.jacc.2013.12.032
   PubMed Web of Science ®Google Scholar
• Chapman AR, Bularga A, Mills NL. High-sensitivity cardiac troponin can be an ally in the fight against COVID-19. Circulation. 2020;141(22):1733–1735. doi:10.1161/CIRCULATIONAHA.120.047008
   PubMed Web of Science ®Google Scholar
• Vu VH, Nguyen TC, Pham QDD, Pham DN, Le LB, Le KM. Prevalence and impact of myocardial injury among patients hospitalized with COVID-19. Front Cardiovasc Med. 2023;10:1202332. doi:10.3389/fcvm.2023.1202332
   PubMedGoogle Scholar
• Rinaldi R, Basile M, Salzillo C, et al.; Of The Gemelli Against Covid Group. Myocardial injury portends a higher risk of mortality and long-term cardiovascular sequelae after hospital discharge in COVID-19 survivors. J Clin Med. 2022;11(19):5964. doi:10.3390/jcm11195964
   PubMed Web of Science ®Google Scholar
• Wang F, Nie J, Wang H, et al. Characteristics of peripheral lymphocyte subset alteration in COVID-19 pneumonia. J Infect Dis. 2020;221(11):1762–1769. doi:10.1093/infdis/jiaa150
   PubMed Web of Science ®Google Scholar
• Li X, Liu C, Mao Z, et al. Predictive values of neutrophil-to-lymphocyte ratio on disease severity and mortality in COVID-19 patients: a systematic review and meta-analysis. Critical Care. 2020;24(1):647. doi:10.1186/s13054-020-03374-8
   PubMed Web of Science ®Google Scholar
• Violi F, Cangemi R, Romiti GF, et al. Is albumin predictor of mortality in COVID-19? Antioxid Redox Signal. 2021;35(2):139–142. doi:10.1089/ars.2020.8142
   PubMed Web of Science ®Google Scholar
• Arques S. Human serum albumin in cardiovascular diseases. Eur J Intern Med. 2018;52:8–12. doi:10.1016/j.ejim.2018.04.014
   PubMed Web of Science ®Google Scholar
• Arroyo V, García-Martinez R, Salvatella X. Human serum albumin, systemic inflammation, and cirrhosis. J Hepatol. 2014;61(2):396–407. doi:10.1016/j.jhep.2014.04.012
   PubMed Web of Science ®Google Scholar
• Lam FW, Cruz MA, Leung HC, Parikh KS, Smith CW, Rumbaut RE. Histone induced platelet aggregation is inhibited by normal albumin. Thromb Res. 2013;132(1):69–76. doi:10.1016/j.thromres.2013.04.018
   PubMed Web of Science ®Google Scholar
• Arques S, Ambrosi P. Human serum albumin in the clinical syndrome of heart failure. J Card Fail. 2011;17(6):451–458. doi:10.1016/j.cardfail.2011.02.010
   PubMed Web of Science ®Google Scholar
• Eckart A, Struja T, Kutz A, et al. Relationship of nutritional status, inflammation, and serum albumin levels during acute illness: a prospective study. Am J Med. 2020;133(6):713–722. doi:10.1016/j.amjmed.2019.10.031
   PubMed Web of Science ®Google Scholar
• Caraceni P, Domenicali M, Tovoli A, et al. Clinical indications for the albumin use: still a controversial issue. Eur J Intern Med. 2013;24(8):721–728. doi:10.1016/j.ejim.2013.05.015
   PubMed Web of Science ®Google Scholar
• Fan E, Stewart TE. Albumin in critical care: SAFE, but worth its salt? Crit Care. 2004;8(5):297–299. doi:10.1186/cc2943
   PubMed Web of Science ®Google Scholar