References
- WHOGlobal Surveillance, Prevention and Control of Chronic Respiratory Diseases: A Comprehensive ApproachGenevaWorld Health Organization2007
- van den BergeMten HackenNHCohenJDoumaWRPostmaDSSmall airway disease in asthma and COPD: clinical implicationsChest2011139241242321285055
- VestboJHurdSSAgustiAGGlobal strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease: GOLD executive summaryAm J Respir Crit Care Med2013187434736522878278
- FainSBPanthSREvansMDEarly emphysematous changes in asymptomatic smokers: detection with 3He MR imagingRadiology2006239387588316714465
- ShakerSBStavngaardTHestadMBachKSTonnesenPDirksenAThe extent of emphysema in patients with COPDClin Respir J200931152120298367
- BennettWDSmaldoneGCUse of aerosols to estimate mean air-space size in chronic obstructive pulmonary diseaseJ Appl Physiol (1985)1988644155415603378990
- GebhartJHeyderJStahlhofenWUse of aerosols to estimate pulmonary air-space dimensionsJ Appl Physiol Respir Environ Exerc Physiol19815124654767263453
- BlanchardJDAerosol bolus dispersion and aerosol-derived airway morphometry: assessment of lung pathology and response to therapy, Part 1J Aerosol Med19969218320510163350
- BlanchardJDAerosol bolus dispersion and aerosol-derived airway morphometry: assessment of lung pathology and response to therapy, Part 2J Aerosol Med199694453476
- PalmesEDUse of aerosols to measure pulmonary dimensionsJ Air Pollut Control Assoc196818106715683224
- PalmesEDMeasurement of pulmonary air spaces using aerosolsArch Intern Med1973131176794682064
- BrodayDMGeorgopoulosPGrowth and deposition of hygroscopic particulate matter in the human lungsAerosol Sci Technol2001341144159
- HeyderJAssessment of airway geometry with inert aerosolsJ Aerosol Med1989228997
- RosenthalFSAerosol recovery following breathholding derived from the distribution of chordlengths in pulmonary tissueJ Aerosol Sci1989202267277
- BrandPBeinertTFruhmannGHillebrechtAHeyderJAerosol derived airway morphometry at different levels of lung inflationJ Aerosol Med199363165176
- BlanchardJDHeyderJO’DonnellCRBrainJDAerosol-derived lung morphometry: comparisons with a lung model and lung function indexesJ Appl Physiol (1985)1991714121612241757343
- ZemanKLBennettWDMeasuring alveolar dimensions at total lung capacity by aerosol-derived airway morphometryJ Aerosol Med19958213514710155351
- BrandPRiegerCBeinertTHeyderJAerosol derived airway morphometry in healthy subjectsEur Respir J1995810163916468586115
- HankinsonJLPalmesEDLappNLPulmonary air space size in coal minersAm Rev Respir Dis19791193391397443618
- BennettWDSmaldoneGCHuman variation in the peripheral air-space deposition of inhaled particlesJ Appl Physiol (1985)1987624160316103597231
- NikiforovAILippmannMPalmesEDValidation of an in vivo aerosol probe technique by measurements of deposition and mor-phometry in excised human lungsAnn Occup Hyg198832inhaled particles VI3339
- SpektorDMHuntPRRosenthalFLippmannMInfluence of airway and airspace sizes on particle deposition in excised donkey lungsExp Lung Res198593–43633874076059
- RahmelASchwalenACalziaEHuberASchulzHMeyerMAerosol-derived airway dimensions of dog lungs: comparison of bolus and single-breath techniquesMohrUBatesDVFabelHUtellMJAdvances in Controlled Clinical Inhalation Studies Ilsi MonographsSpringer-Verlag, Berlin1993377386
- BrandPSelzerTTuchTSchulzAHeyderJAccuracy and resolution power of aerosol-derived airway morphometry in a simple lung modelExp Lung Res19942031852057925138
- ZemanKLBennettWDGrowth of the small airways and alveoli from childhood to the adult lung measured by aerosol-derived airway morphometryJ Appl Physiol (1985)2006100396597116357074
- BeinertTBrandPBehrJVogelmeierCHeyderJPeripheral airspace dimensions in patients with COPDChest1995108499810037555176
- BrandPKohlhäuflNMeyerTSelzerTHeyderJHäussingerKAerosol-derived airway morphometry and aerosol bolus dispersion in patients with lung fibrosis and lung emphysemaChest1999116254354810453886
- KohlhäuflMBrandPRockCNoninvasive diagnosis of emphysema. Aerosol morphometry and aerosol bolus dispersion in comparison to HRCTAm J Respir Crit Care Med1999160391391810471618
- LehnigkBSchleissMBrandPHeyderJMagnussenHJörresRAAerosol-derived airway morphometry (ADAM) in patients with lung emphysema diagnosed by computed tomography – reproducibility, diagnostic information and modellingEur J Med Res2007122748317369121
- ShakerSBMaltbaekNBrandPHaeussermannSDirksenAQuantitative computed tomography and aerosol morphometry in COPD and alpha1-antitrypsin deficiencyEur Respir J2005251233015640319
- BrandPLetzelSBuchtaMCan aerosol-derived airway mor-phometry detect early, asymptomatical lung emphysema?J Aerosol Med200316214315112823908
- LehnigkBSchleissMBluhmePAerosol-derived effective air space diameter (EAD) in different types of emphysema as characterized by computer tomography compared to healthy subjectsJ Aerosol Med19958126
- LehnigkBSchleissMBluhmePAerosol derived airway morphometry in emphysema and fibrosisAm J Respir Crit Care Med1995151118
- AndersonPJGannLPTennalKHillerFCAirway caliber and function in restrictive lung diseaseAm Rev Respir Dis19931474A451
- MeyerMRahmelAOAerosol-derived airway dimensions of dog lungs in histamine-induced bronchoconstrictionJ Aerosol Sci1993245671681
- RahmelAMeyerMAirway dimensions during histamine-induced airway constriction in dogsAnn Occup Hyg199438inhaled particles VII181187
- Schiller-ScotlandCFGebhartJLintlHSiekmeierRKronenbergerHHuman airway diameters derived from aerosol inhalation studies: reactions of non-smokers and smokers to bronchodilatorsJ Aerosol Sci198920813051308
- RosenthalFSAerosol deposition and dispersion characterize lung injury in a canine model of emphysemaJ Appl Physiol (1985)1995784158515957615474
- SchulzHSchulzABrandPAerosol bolus dispersion and effective airway diameters in mildly asthmatic childrenEur Respir J1995845665737664855
- BrodayDDeposition of ultrafine particles at carinal ridges of the upper bronchial airwaysAerosol Sci Technol200438109911000
- LandahlHDOn the removal of air-borne droplets by the human respiratory tract: I. The lungBull Math Biophys19501214356
- AndersonPJWilsonJDHillerFCRespiratory tract deposition of ultrafine particles in subjects with obstructive or restrictive lung diseaseChest1990975111511202331906
- BrownJSZemanKLBennettWDUltrafine particle deposition and clearance in the healthy and obstructed lungAm J Respir Crit Care Med200216691240124712403694
- LöndahlJSwietlickiERisslerJExperimental determination of the respiratory tract deposition of diesel combustion particles in patients with chronic obstructive pulmonary diseasePart Fibre Toxicol201293022839109
- MöllerWFeltenKSommererKDeposition, retention, and translocation of ultrafine particles from the central airways and lung peripheryAm J Respir Crit Care Med2008177442643217932382
- MualaADiesel Exhaust and Wood Smoke Exposure: Mechanisms, inflammation and interventionUmeå: Public Health and Clinical MedicineUmeå University2014
- International Commission on Radiological ProtectionHuman Respiratory Tract Model for Radiological Protection: A Report of a Task Group of the International Commission on Radiological ProtectionOxford, NYPergamon1994
- FazioFWollmerPLavenderJPBarrMMClinical ventilation imaging with In-113m aerosol: a comparison with Kr-81mJ Nucl Med19822343063147069494
- FlemingJConwayJMajoralCControlled, parametric, indi-vidualized, 2-D and 3-D imaging measurements of aerosol deposition in the respiratory tract of asthmatic human subjects for model validationJ Aerosol Med Pulm Drug Deliv201528643245125859710
- HäussermannSAcerbiDBrandPLung deposition of formot-erol HFA (Atimos/Forair) in healthy volunteers, asthmatic and COPD patientsJ Aerosol Med200720333134117894539
- RamannaLTashkinDPTaplinGVRadioaerosol lung imaging in chronic obstructive pulmonary disease: comparison with pulmonary function tests and roentgenographyChest1975685634640
- SweeneyTDSkornikWABrainJDHatchVGodleskiJJChronic bronchitis alters the pattern of aerosol deposition in the lungAm J Respir Crit Care Med19951512 Pt 14824887842210
- TaplinGVTashkinDPChopraSKEarly detection of chronic obstructive pulmonary disease using radionuclide lung-imaging proceduresChest1977715567575856554
- MaceyDJMarshallRAbsolute quantitation of radiotracer uptake in the lungs using a gamma cameraJ Nucl Med19822387317346213741
- KleinstreuerCZhangZAirflow and particle transport in the human respiratory systemAnnu Rev Fluid Mech201042301334
- RostamiAAComputational modeling of aerosol deposition in respiratory tract: a reviewInhal Toxicol200921426229019235608
- MartonenTCommentary ‘Effects of asymmetric branch flow rates on aerosol deposition in bifurcating airways’, by Z. Zhang, C. Kleinstreuer and C. S. KimJ Med Eng Technol200125312412711530827
- XiJLongestPWMartonenTBEffects of the laryngeal jet on nano- and microparticle transport and deposition in an approximate model of the upper tracheobronchial airwaysJ Appl Physiol (1985)200810461761177718388247
- FarkasABalásházyISimulation of the effect of local obstructions and blockage on airflow and aerosol deposition in central human airwaysJ Aerosol Sci2007388865884
- XiJLongestPWEffects of oral airway geometry characteristics on the diffusional deposition of inhaled nanoparticlesJ Biomech Eng2008130101100818298184
- ZhangZKleinstreuerCKimCSAirflow and nanoparticle deposition in a 16-generation tracheobronchial airway modelAnn Biomed Eng200836122095211018850271
- ZhangZKleinstreuerCDonohueJFKimCSComparison of micro-and nano-size particle depositions in a human upper airway modelJ Aerosol Sci2005362211233
- ZhangZKleinstreuerCKimCSComparison of analytical and CFD models with regard to micron particle deposition in a human 16-generation tracheobronchial airway modelJ Aerosol Sci20094011628
- SturmRTheoretical models for the simulation of particle deposition and tracheobronchial clearance in lungs of patients with chronic bronchitisAnn Transl Med201311325332949
- SturmRHofmannWStochastic simulation of alveolar particle deposition in lungs affected by different types of emphysemaJ Aerosol Med200417435737215684735
- BennettWDZemanKLKimCMascarellaJEnhanced deposition of fine particles in COPD patients spontaneously breathing at restInhal Toxicol199791114
- KimCSKangTCComparative measurement of lung deposition of inhaled fine particles in normal subjects and patients with obstructive airway diseaseAm J Respir Crit Care Med199715538999059117024
- KimCSLewarsGASacknerMAMeasurement of total lung aerosol deposition as an index of lung abnormalityJ Appl Physiol (1985)1988644152715363378987
- LoveRGMuirDCAerosol deposition and airway obstructionAm Rev Respir Dis19761145891897984581
- Schiller-ScotlandCFGebhartJHochrainerDSiekmeierRDeposition of inspired aerosol particles within the respiratory tract of patients with obstructive lung diseaseToxicol Lett1996881–32552618920746
- HindsWCAerosol Technology: Properties, Behavior, and Measurement of Airborne Particles2nd edJohn Wiley & Sons, Inc1999
- LongestPWXiJXComputational investigation of particle inertia effects on submicron aerosol deposition in the respiratory tractJ Aerosol Sci2007381111130
- MacintyreNCrapoROViegiGStandardisation of the single-breath determination of carbon monoxide uptake in the lungEur Respir J200526472073516204605
- GrgicBMartinARFinlayWHThe effect of unsteady flow rate increase on in vitro mouth-throat deposition of inhaled bolusesJ Aerosol Sci2006371012221233
- SmaldoneGCPhysiological and pathological considerations for aerosol deposition: expiration and models of depositionJ Aerosol Med200013438739111262445
- BennettWDSmaldoneGCInspiratory vs expiratory aerosol deposition in excised dog lungsJ Aerosol Sci19871814957
- PriceOTAsgharianBMillerFJCasseeFRde Winter-SorkinaRMultiple Path Particle Dosimetry model (MPPD v1.0): a model for human and rat airway particle dosimetryRIVM rapport 6500100302002
- HeyderJCharting human thoracic airways by aerosolsClin Phys Physiol Meas19834129376831840
- PalmesEDAltshulerBNelsonNDeposition of aerosols in the human respiratory tract during breath holdingDaviesCNBritish Occupational Hygiene SocietyInhaled Particles and Vapours2nd edNew York, NYSymposium Publications Division, Pergamon Press1967339347
- RosenthalFSA model for determining alveolar and small airway dimensions from aerosol recovery dataJ Appl Physiol (1985)19855825825913980361
- HeyderJGravitational deposition of aerosol particles within a system of randomly oriented tubesJ Aerosol Sci197562133137
- GebhartJHeyderJRemoval of aerosol particles from stationary air within porous mediaJ Aerosol Sci1985162175187
- GoldbergISSmithRBSettling and diffusion of aerosol particles in small airways during breath holdingAnn Biomed Eng198195–65575756753666
- YuCPLiuCSTaulbeeDBSimultaneous diffusion and sedimentation of aerosols in a horizontal cylinderJ Aerosol Sci197785309316
- TsudaAHenryFSButlerJPParticle transport and deposition: basic physics of particle kineticsCompr Physiol2013341437147124265235
- HofemeierPSznitmanJRevisiting pulmonary acinar particle transport: convection, sedimentation, diffusion, and their interplayJ Appl Physiol (1985)2015118111375138525882387
- FishlerRHofemeierPEtzionYDubowskiYSznitmanJParticle dynamics and deposition in true-scale pulmonary acinar modelsSci Rep201551407126358580
- SznitmanJRespiratory microflows in the pulmonary acinusJ Biomech201346228429823178038
- JohannessenASkorgeTDBottaiMMortality by level of emphysema and airway wall thicknessAm J Respir Crit Care Med2013187660260823328525
- StratelisGMölstadSJakobssonPZetterströmOThe impact of repeated spirometry and smoking cessation advice on smokers with mild COPDScand J Prim Health Care200624313313916923621
- EfferthTVerdorferIMiyachiHGenomic imbalances in drug-resistant T-cell acute lymphoblastic CEM leukemia cell linesBlood Cells Mol Dis200229111312482398
- de LangeEEMuglerJP3rdBrookemanJRLung air spaces: MR imaging evaluation with hyperpolarized 3He gasRadiology1999210385185710207491
- SalernoMAltesTAMuglerJP3rdNakatsuMHatabuHde LangeEEHyperpolarized noble gas MR imaging of the lung: potential clinical applicationsEur J Radiol2001401334411673006
- MuglerJP3rdAltesTAHyperpolarized 129Xe MRI of the human lungJ Magn Reson Imaging201337231333123355432
- KimCSJaquesPARespiratory dose of inhaled ultrafine particles in healthy adultsPhilos Trans A Math Phys Eng Sci2000358177526932705
- LandahlHDTracewellTNLassenWHOn the retention of airborne particulates in the human lung: IIAMA Arch Ind Hyg Occup Med19513435936614818443
- StoegerTReinhardCTakenakaSInstillation of six different ultrafine carbon particles indicates a surface area threshold dose for acute lung inflammation in miceEnviron Health Perspect2006114332833316507453
- JakobssonJKFHedlundJKumlinJWollmerPLöndahlJA new method for measuring lung deposition efficiency of airborne nanopar-ticles in a single breathScientific Reports201663614727819335
- LöndahlJMöllerWPagelsJHKreylingWGSwietlickiESchmidOMeasurement techniques for respiratory tract deposition of airborne nanoparticles: a critical reviewJ Aerosol Med Pulm Drug Deliv201427422925424151837