References
- BodeCZhaoGSteinhagenFKinjoTKlinmanDMCpG DNA as vaccine adjuvantExpert Rev Vaccines201110449951121506647
- FonsecaDEKlineJNUse of CpG oligonucleotides in treatment of asthma and allergic diseaseAdv Drug Delivery Rev2009613256262
- HanagataNCpG oligodeoxynucleotide nanomedicines for the prophylaxis or treatment of cancers, infectious diseases, and allergiesInt J Nanomedicine20171251553128144136
- ShirotaHKlinmanDMRecent progress concerning CpG DNA and its use as a vaccine adjuvantExpert Rev Vaccines201413229931224308579
- Brazolot MillanCLWeeratnaRKriegAMSiegristCADavisHLCpG DNA can induce strong Th1 humoral and cell-mediated immune responses against hepatitis B surface antigen in young miceProc Natl Acad Sci U S A1998952615553155589861007
- ChuRSTargoniOSKriegAMLehmannPVHardingCVCpG oligodeoxynucleotides act as adjuvants that switch on T helper (Th1) immunityJ Exp Med199718610162316319362523
- GürselMVerthelyiDGürselIIshiiKJKlinmanDMDifferential and competitive activation of human immune cells by distinct classes of CpG oligodeoxynucleotidesJ Leukoc Biol200271581382011994506
- HemmiHTakeuchiOKawaiTA Toll-like receptor recognizes bacterial DNANature2000408681374074511130078
- HornungVRothenfusserSBritschSQuantitative expression of toll-like receptor 1–10 mRNA in cellular subsets of human peripheral blood mononuclear cells and sensitivity to CpG oligodeoxynucleotidesJ Immunol200216894531453711970999
- TakeshitaFLeiferCAGurselICutting edge: role of toll-like receptor 9 in CpG DNA-induced activation of human cellsJ Immunol200116773555355811564765
- BauerMRedeckeVEllwartJWBacterial CpG DNA triggers activation and maturation of human CD11c−, CD123+ dendritic cellsJ Immunol200116685000500711290780
- KadowakiNHoSAntonenkoSSubsets of human dendritic cell precursors express different Toll-like receptors and respond to different microbial antigensJ Exp Med2001194686386911561001
- KrugATowarowskiABritschSToll-like receptor expression reveals CpG DNA as a unique microbial stimulus for plasmacytoid dendritic cells which synergizes with CD40 ligand to induce high amounts of IL-12Eur J Immunol200131103026303711592079
- KriegAMCpG motifs in bacterial DNA and their immune effectsAnnu Rev Immunol20022070976011861616
- KrugARothenfusserSHornungVIdentification of CpG oligodeoxynucleotide sequences with high induction of IFN-alpha/beta in plasmacytoid dendritic cellsEur J Immunol20013172154216311449369
- VerthelyiDIshiiKJGruselMTakeshitaFKlinmanDMHuman peripheral blood cells differentially recognize and respond to two distinct CpG motifsJ Immunol200116642372237711160295
- HartmannGWeeratnaRDBallasZKDelineation of a CpG phosphorothioate oligodeoxynucleotide for activating primate immune responses in vitro and in vivoJ Immunol200016431617162410640783
- HartmannGKriegAMMechanism and function of a newly identified CpG DNA motif in human primary B cellsJ Immunol2000164294495310623843
- HartmannGBattianyJPoeckHRational design of new CpG oligonucleotides that combine B cell activation with high IFN-α induction in plasmacytoid dendritic cellsEur J Immunol20033361633164112778481
- MarshallJDFearonKAbbateCIdentification of a novel CpG DNA class and motif that optimally stimulate B cell and plasmacytoid dendritic cell functionsJ Leukoc Biol200373678179212773511
- SamulowitzUWeberMWeeratnaRA novel class of immunestimulatory CpG oligodeoxynucleotides unifies high potency in type I interferon induction with preferred structural propertiesOligonucleotides20102029310120384481
- AhonenCLDoxseeCLMcGurranSMCombined TLR and CD40 triggering induces potent CD8+ T cell expansion with variable dependence on type I IFNJ Exp Med2004199677578415007094
- ChoHJHayashiTDattaSKIFN-alpha beta promote priming of antigen-specific CD8+ and CD4+ T lymphocytes by immunostimulatory DNA-based vaccinesJ Immunol2002168104907491311994440
- NierkensSden BrokMHGarciaZImmune adjuvant efficacy of CpG oligonucleotide in cancer treatment is founded specifically upon TLR9 function in plasmacytoid dendritic cellsCancer Res201171206428643721788345
- KerkmannMCostaLTRichterCSpontaneous formation of nucleic acid-based nanoparticles is responsible for high interferon-alpha induction by CpG-A in plasmacytoid dendritic cellsJ Biol Chem200528098086809315591070
- KleinDCLatzEEspevikTStokkeBTHigher order structure of short immunostimulatory oligonucleotides studied by atomic force microscopyUltramicroscopy2010110668969320202756
- PuigMGrajkowskiABoczowskaMAusinCBeaucageLVerthelyiDUse of thermolytic protective groups to prevent G-tetrad formation in CpG ODN type D: structural studies and immunomodulatory activity in primatesNucleic Acids Res200634226488649517130156
- AinalemMLCampbellRANylanderTInteractions between DNA and poly(amido amine) dendrimers on silica surfaceLangmuir201026118625863520429604
- GungorBYagciFCTincerGCpG ODN nanorings induce IFNα from plasmacytoid dendritic cells and demonstrate potent vaccine adjuvant activitySci Transl Med20146235235ra61
- HurtadoPPehCALL-37 promotes rapid sensing of CpG oligodeoxynucleotides by B lymphocytes and plasmacytoid dendritic cellsJ Immunol201018431425143520042575
- KerkmannMLochmannDWeyemannJImmunostimulatory properties of CpG-oligonucleotides are enhanced by the use of protamine nanoparticlesOligonucleotides200616431332217155907
- KobiyamaKAoshiTNaritaHNonagonistic Dectin-1 ligand transforms CpG into a multitask nanoparticulate TLR9 agonistProc Natl Acad Sci U S A201411183086309124516163
- AgrawalSZhaoQJiangZToxicologic effects of an oligodeoxynucleotide phosphorothioate and its analogs following intravenous administration in ratsAntisense Nucleic Acid Drug Dev1997765755849450915
- BjersingJLErikssonKTarkowskiACollinsLVThe arthritogenic and immunostimulatory properties of phosphorothioate oligodeoxynucleotides rely on synergy between the activities of the nuclease-resistant backbone and CpG motifsInflammation2004281395115072229
- BrownDAKangSHGryaznovSMEffect of phosphorothioate modification of oligodeoxynucleotides on specific protein bindingJ Biol Chem19942694326801268057929417
- HeikenwalderMPolymenidouMJuntTLymphoid follicle destruction and immunosuppression after repeated CpG oligodeoxy-nucleotide administrationNat Med200410218719214745443
- HenrySPNovotnyWLeedsJAulettaCKornbrustDJInhibition of coagulation by a phosphorothioate oligonucleotideAntisense Nucleic Acid Drug Dev1997755035109361909
- LevinAAA review of the issues in the pharmacokinetics and toxicology of phosphorothioate antisense oligonucleotidesBiochim Biophys Acta199914891698410806998
- SheehanJPLanHCPhosphorothioate oligonucleotides inhibit the intrinsic tenase complexBlood1998925161716259716589
- ShawDRRustagiPKKandimallaERManningANJiangZAgrawalSEffects of synthetic oligonucleotides on human complement and coagulationBiochem Pharmacol1997538112311329175717
- UnterholznerLThe interferon response to intracellular DNA: why so many receptors?Immunobiology2013218111312132123962476
- MengWYamazakiTNishidaYHanagataNNuclease-resistant immunostimulatory phosphodiester CpG oligodeoxynucleotides as human Toll-like receptor 9 agonistBMC Biotechnol2011118821943407
- BertranOdel ValleLJRevilla-LópezGMineralization of DNA into nanoparticles of hydroxyapatiteDalton Trans201443131732724105025
- HartmannGWeinerGJKriegAMCpG DNA: a potential signal for growth, activation and maturation of human dendritic cellsProc Natl Acad Sci U S A199996169305931010430938
- NapolitaniGRinaldiABertoniFSallustoFLanzavecchiaASelected Toll-like receptor agonist combinations in synergistically trigger a T helper type I-polarizing program in dendritic cellsNat Immunol20056876977615995707
- RomanMMartin-OrozcoEGoodmanJSImmunostimulatory DNA sequences function as T helper-1 promoting adjuvantsNat Med1997388498549256274
- HirshVPaz-AresLBoyerMRandomized phase III trial of paclitaxel/carboplatin with or without PF-3512676 (Toll-like receptor 9 agonist) as first-line treatment for advanced non-small-cell lung cancerJ Clin Oncol201129192667267421632509
- ManegoldCvan ZandwijkNSzczesnaAA phase III randomized study of gemcitabine and cisplatin with or without PF-3512676 (TLR9 agonist) as first-line treatment of advanced non-small-cell lung cancerAnn Oncol2012231727721464154
- SchmidtMAntonKNordhausCJunghansCWittiBWormMCytokine and Ig-production by CpG-containing sequences with phosphodiester backbone and dumbbell-shapeAllergy2006611566316364157
- SchmidtMHagnerNMarcoAKonig-MeredizSASchroffMWittigBDesign and structural requirements of the potent and safe TLR-9 agonistic immunomodulator MGN1703Nucleic Acid Ther201525313014025826686
- WeihrauchMRRichlyHvon Bergwelt-BaildonMSPhase I clinical study of the toll-like receptor 9 agonist MGN1703 in patients with metastatic solid tumorsEur J Cancer201551214615625480557
- UmSHLeeJBParkNKwonSYUmbachCCLuoDEnzyme-catalysed assembly of DNA hydrogelNat Mater200651079780116998469
- KooJEShinSWUmSHLeeJYX-shaped DNA potentiates therapeutic efficacy in colitis-associated colon cancer through dual activation of TLR9 and inflammasomesMol Cancer20151410425971982
- MohriKNishikawaMTakahashiNDesign and development of nanosized DNA assemblies in polypod-like structures as efficient vehicles for immunostimulatory CpG motifs to immune cellsACS Nano2012675931594022721419
- NishikawaMOgawaKUmekiYInjectable, self-gelling, biodegradable, and immunomodulatory DNA hydrogel for antigen deliveryJ Control Release2014180253224530618
- YamamotoSElectrostatic interaction chromatography process for protein separations: impact of engineering analysis of biorecognition mechanism on process optimizationChem Eng Technol2005281113871393
- IshikawaHBarberGNSTING is an endoplasmic reticulum adaptor that facilitates innate immune signalingNature2008455721367467818724357
- IshikawaHMaZBarberGNSTING regulates intracellular DNA-mediated, type-I interferon-dependent innate immunityNature2009461726578879219776740
- SunWLiYChenLERIS, an endoplasmic reticulum IFN stimulator, activates innate immune signaling through dimerizationProc Natl Acad Sci U S A2009106218653865819433799
- ZhongBYangYLiSThe adaptor protein MITA links virus-sensing receptors to IRF3 transcription factor activationImmunity200829453855018818105
- JoshiVBAdamcakova-DoddAJingXDevelopment of a poly (lactic-co-glycolic acid) particle vaccine to protect against house dust mite induced allergyAAPS J201416597598524981892