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Review

Tumor-targeting delivery of herb-based drugs with cell-penetrating/tumor-targeting peptide-modified nanocarriers

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Pages 1425-1442 | Published online: 09 Mar 2018

References

  • World Health Organization Cancer2018 Available from: http://www.who.int/mediacentre/factsheets/fs297/enAccessed February 13, 2018
  • Pérez-HerreroEFernández-MedardeAAdvanced targeted therapies in cancer: drug nanocarriers, the future of chemotherapyEur J Pharm Biopharm201593527925813885
  • Ghaz-JahanianMAAbbaspour-AghdamFAnarjanNBerenjianAJafarizadeh-MalmiriHApplication of chitosan-based nanocarriers in tumor-targeted drug deliveryMol Biotechnol20155720121825385004
  • TannockIFLeeCMTunggalJKCowanDSEgorinMJLimited penetration of anticancer drugs through tumor tissue: a potential cause of resistance of solid tumors to chemotherapyClin Cancer Res2002887888411895922
  • SutradharKBAminMLNanotechnology in cancer drug delivery and selective targetingISRN Nanotechnology20142014939378
  • GuptaAKaurCDSarafSSarafSTargeting of herbal bioactives through folate receptors: a novel concept to enhance intracellular drug delivery in cancer therapyJ Recept Signal Transduct Res20173731432328095746
  • LundstromKCancer therapy applying viral nanoparticlesKhudyakovYPumpensPViral NanotechnologyBoca RatonTaylor & Francis2015455466
  • BakerJRDendrimer-based nanoparticles for cancer therapyHematology Am Soc Hematol Educ Program200970871920008257
  • JainSHirstDGO’SullivanJMGold nanoparticles as novel agents for cancer therapyBr J Radiol20128510111322010024
  • PandeyHRaniRAgarwaVLiposome and their [sic] applications in cancer therapyBraz Arch Biol Technol201659e16150477
  • BondìMLCraparoEFGiammonaGNanostructured lipid carriers-containing anticancer compounds: preparation, characterization, and cytotoxicity studiesDrug Deliv200714616717364869
  • OerlemansCBultWBosMStormGNijsenJFHenninkWEPolymeric micelles in anticancer therapy: targeting, imaging and triggered releasePharm Res2010272569258920725771
  • ParveenSSahooSKPolymeric nanoparticles for cancer therapyJ Drug Target20081610812318274932
  • GaoHYangZZhangSLigand modified nanoparticles increases [sic] cell uptake, alters endocytosis and elevates glioma distribution and internalizationSci Rep20133253423982586
  • TorchilinVPBensonHTothICell penetrating peptide-modified pharmaceutical nanocarriers for intracellular drug and gene deliveryBiopolymers20089060461018381624
  • ZhangXXEdenHSChenXPeptides in cancer nanomedicine: drug carriers, targeting ligands and protease substratesJ Control Release201215921322056916
  • DissanayakeSDennyWAGamageSSarojiniVRecent developments in anticancer drug delivery using cell penetrating and tumor targeting peptidesJ Control Release2017250627628167286
  • LiuZDelavanBRobertsRTongWLessons learned from two decades of anticancer drugsTrends Pharmacol Sci20173885287228709554
  • PrabhakarUMaedaHJainRKChallenges and key considerations of the enhanced permeability and retention effect for nanomedi-cine drug delivery in oncologyCancer Res2013732412241723423979
  • UlbrichKHoláKSubrVBakandritsosATučekJZbořilRTargeted drug delivery with polymers and magnetic nanoparticlesChem Rev20161165338543127109701
  • ThankiKKushwahVJainSRecent advances in tumor targeting approachesDevarajanPVJainSTargeted Drug Delivery: Concepts and DesignHeidelbergSpringer201541112
  • YuXTraseIRenMDuvalKGuoXChenZDesign of nanoparticle-based carriers for targeted drug deliveryJ Nanomater20162016108725027398083
  • XuXHoWZhangXBertrandNFarokhzadOCancer nanomedicine: from targeted delivery to combination therapyTrends Mol Med20152122323225656384
  • FangJNakamuraHMaedaHThe EPR effect: unique features of tumor blood vessels for drug delivery, factors involved, and limitations and augmentation of the effectAdv Drug Deliv Rev20116313615120441782
  • BahramiBHojjat-FarsangiMMohammadiHNanoparticles and targeted drug delivery in cancer therapyImmunol Lett2017190648328760499
  • KunjachanSRychlikBStormGKiesslingFLammersTMultidrug resistance: physiological principles and nanomedical solutionsAdv Drug Deliv Rev2013651852186524120954
  • YildizIShuklaSSteinmetzNFApplications of viral nanoparticles in medicineCurr Opin Biotechnol20112290190821592772
  • GuptaCPrakashDGuptaSCancer treatment with nano-diamondsFront Biosci (Schol Ed)20179627027814575
  • YaoVJD’AngeloSButlerKSLigand-targeted theranostic nanomedicines against cancerJ Control Release201624026728626772878
  • de OliveiraROde Santa MariaLCBarrattGNanomedicine and its applications to the treatment of prostate cancerAnn Pharm Fr20147230331625220226
  • BabaeiMEshghiHAbnousKRahimizadehMRamezaniMPromising gene delivery system based on polyethylenimine-modified silica nanoparticlesCancer Gene Ther20172415616428128214
  • PetrosRADeSimoneJMStrategies in the design of nanoparticles for therapeutic applicationsNat Rev Drug Discov2010961562720616808
  • YameenBChoiWVilosCSwamiAShiJFarokhzadOCInsight into nanoparticle cellular uptake and intracellular targetingJ Control Release201419048549924984011
  • ZhongYMengFDengCZhongZLigand-directed active tumor- targeting polymeric nanoparticles for cancer chemotherapyBiomacromolecules2014151955196924798476
  • JaraczSChenJKuznetsovaLVOjimaIRecent advances in tumor-targeting anticancer drug conjugatesBioorg Med Chem2005135043505415955702
  • ThayerAMImproving peptidesChem Eng News2011891320
  • DavidAPeptide ligand-modified nanomedicines for targeting cells at the tumor microenvironmentAdv Drug Deliv Rev201711912014228506743
  • KarraNBenitaSThe ligand nanoparticle conjugation approach for targeted cancer therapyCurr Drug Metab201213224121892918
  • GuidottiGBrambillaLRossiDCell-penetrating peptides: from basic research to clinicsTrends Pharmacol Sci20173840642428209404
  • MeloniBPCraigAJMilechNHopkinsRMWattPMKnuckeyNWThe neuroprotective efficacy of cell-penetrating peptides TAT, pen-etratin, Arg-9, and Pep-1 in glutamic acid, kainic acid, and in vitro ischemia injury models using primary cortical neuronal culturesCell Mol Neurobiol20143417318124213248
  • MaCYinGYouFA specific cell-penetrating peptide induces apoptosis in SKOV3 cells by down-regulation of Bcl-2Biotechnol Lett2013351791179723797900
  • KristensenMBirchDNielsenHMApplications and challenges for use of cell-penetrating peptides as delivery vectors for peptide and protein cargosInt J Mol Sci201617E18526840305
  • HsiehTHA novel cell-penetrating peptide suppresses breast tumorigenesis by inhibiting β-catenin/LEF-1 signalingSci Rep201661915626750754
  • MehtaRYamadaTTaylorBNA cell penetrating peptide derived from azurin inhibits angiogenesis and tumor growth by inhibiting phosphorylation of VEGFR-2, FAK and AktAngiogenesis20111435536921667138
  • KristensenMde GrootAMBerthelsenJFranzykHSijtsANielsenHMConjugation of cell-penetrating peptides to parathyroid hormone affects its structure, potency, and transepithelial permeationBioconjug Chem20152647748825611217
  • SunWFletcherDvan HeeckerenCRDavisPBNon-covalent ligand conjugation to biotinylated DNA nanoparticles using TAT peptide genetically fused to monovalent streptavidinJ Drug Target20122067869022845840
  • CopoloviciDMLangelKEristeELangelUCell-penetrating peptides: design, synthesis, and applicationsASC Nano2014819721994
  • JafariSDizajSMAdibkiaKCell-penetrating peptides and their analogues as novel nanocarriers for drug deliveryBioimpacts2015510311126191505
  • MillettiFCell-penetrating peptides: classes, origin, and current landscapeDrug Discov Today20121785086022465171
  • WangFWangYZhangXZhangWGuoSJinFRecent progress of cell-penetrating peptides as new carriers for intracellular cargo deliveryJ Control Release201417412613624291335
  • RegbergJSrimaneeALangelUApplications of cell-penetrating peptides for tumor targetingPharmaceuticals (Basel)20125991100724280701
  • PalmCJayamanneMKjellanderMHällbrinkMPeptide degradation is a critical determinant for cell-penetrating peptide uptakeBiochim Biophys Acta200717681769177617499577
  • FominayaJBravoJRebolloAStrategies to stabilize cell penetratingTher Deliv201561171119426448473
  • ChorevMGoodmanMRecent developments in retro peptides and proteins: an ongoing topochemical explorationTrends Biotechnol1995134384457546569
  • VaissièreAAldrianGKonateKA retro-inverso cell-penetrating peptide for siRNA deliveryJ Nanobiotechnology2017153428454579
  • HolmTRäägelHAndaloussiSERetro-inversion of certain cell-penetrating peptides causes severe cellular toxicityBiochim Biophys Acta201118081544155121070744
  • HornMReichartFNatividad-TietzSDiazDNeundorfITuning the properties of a novel short cell-penetrating peptide by intramolecular cyclization with a triazole bridgeChem Commun (Cab)20165222612264
  • Lättig-TünnemannGPrinzMHoffmannDBackbone rigidity and static presentation of guanidinium groups increases cellular uptake of arginine-rich cell-penetrating peptidesNat Commun2011245321878907
  • FriedlerAFriedlerDLuedtkeNWTorYLoyterAGilonCDevelopment of a functional backbone cyclic mimetic of the HIV-1 Tat arginine-rich motifJ Biol Chem2000275237832378910764789
  • ReissmannSCell penetration: scope and limitations by the application of cell-penetrating peptidesJ Pept Sci20142076078425112216
  • DietzGPBahrMDelivery of bioactive molecules into the cell: the Trojan horse approachMol Cell Neurosci2004278513115485768
  • DurzyńskaJPrzysieckaLNawrotRViral and other cell-penetrating peptides as vectors of therapeutic agents in medicineJ Pharmacol Exp Ther2015354324225922342
  • VerdurmenWPBrockRBiological responses towards cationic peptides and drug carriersTrends Pharmacol Sci20113211612421167610
  • El-AndaloussiSJärverPJohanssonHJCargo-dependent cytotoxicity and delivery efficacy of cell-penetrating peptides: a comparative studyBiochem J200740728529217627607
  • UusnaJLangelKLangelUToxicity, Immunogenicity, uptake, and kineticsLangelUCell-Penetrating Peptides: Methods and Protocols2nd edHeidelbergSpringer2015133148
  • SuhorutsenkoJOskolkovNArukuuskPCell-penetrating peptides, PepFects, show no evidence of toxicity and immunogenicity in vitro and in vivoBioconjug Chem2011222255226221978260
  • KilkKMahlapuuRSoometsULangelUAnalysis of in vitro toxicity of five cell-penetrating peptides by metabolic profilingToxicology2009265879519799958
  • AguileraTATimmersMMOlsonESJiangTTsienRYSystemic in vivo distribution of activatable cell penetrating peptides is superior to that of cell penetrating peptidesIntegr Biol (Camb)2009137138120023744
  • MoschosSAJonesSWPerryMMLung delivery studies using siRNA conjugated to TAT48–60 and penetratin reveal peptide induced reduction in gene expression and induction of innate immunityBioconjug Chem2007181450145917711319
  • CarterELauCYToshDWardSGMrsnyRJCell penetrating peptides fail to induce an innate immune response in epithelial cells in vitro: implications for continued therapeutic useEur J Pharm Biopharm201385121923958314
  • CardozoAKBuchillierVMathieuMCell-permeable peptides induce dose- and length-dependent cytotoxic effectsBiochim Biophys Acta200717682222223417626783
  • YenHJHsuSHTsaiCLCytotoxicity and immunological response of gold and silver nanoparticles of different sizesSmall200951553156119326357
  • HeXLiJAnSJiangCpH-sensitive drug-delivery systems for tumor targetingTher Deliv201341499151024304248
  • OlsonEIn vivo characterization of activatable cell penetrating peptides for targeting protease activity in cancerIntegr Biol (Camb)2009138239320023745
  • MacEwanSRChilkotiAHarnessing the power of cell-penetrating peptides: activatable carriers for targeting systemic delivery of cancer therapeutics and imaging agentsWiley Interdiscip Rev Nanomed Nanobiotechnol20135314822977001
  • KurrikofKGestinMLangelURecent in vivo advances in cell-penetrating peptide-assisted drug deliveryExpert Opin Drug Deliv20151337338726634750
  • JinEZhangBSunXAcid-active cell-penetrating peptides for in vivo tumor-targeted drug deliveryJ Am Chem Soc201313593394023253016
  • ChengHZhuJYXuXDActivable cell-penetrating peptide conjugated prodrug for tumor targeted drug deliveryACS Appl Mater Interfaces20157160611606926161578
  • RegbergJVasconcelosLMadaniFLangelUHällbrinkMpH-responsive PepFect cell-penetrating peptidesInt J Pharm2016501323826821060
  • ZhaoBXZhaoYHuangYThe efficiency of tumor-specific pH-responsive peptide-modified polymeric micelles containing pacli-taxelBiomaterials2012332508252022197569
  • ZhangQTangJFuLA pH-responsive α-helical cell penetrating peptide-mediated liposomal delivery systemBiomaterials2013347980799323891517
  • YaoJMaYZhangWDesign of new acid-activated cell-penetrating peptides for tumor drug deliveryPeerJ20175e342928603674
  • LeeDNohIYooJRejinoldNSKimYCpH-controllable cell-penetrating polypeptide that exhibits cancer targetingActa Biomater20175718719628528116
  • HeHSunLYeJEnzyme-triggered, cell penetrating peptide-mediated delivery of anti-tumor agentsJ Control Release2016240677626514292
  • van DuijnhovenSMRobillardMSNicolayKGrüllHTumor targeting of MMP-2/9 activatable cell-penetrating imaging probes is caused by tumor-independent activationJ Nucl Med20115227928621233187
  • ShiNQGaoWXiangBQiXREnhancing cellular uptake of activable cell-penetrating peptide-doxorubicin conjugate by enzymatic cleavageInt J Nanomedicine201271613162122619516
  • GaoHZhangSCaoSYangZPangZJiangXAngiopep-2 and activatable cell-penetrating peptide dual-functionalized nanoparticles for systemic glioma-targeting deliveryMol Pharm2014112755276324983928
  • XiaHGuGHuQActivatable cell penetrating peptide-conjugated nanoparticles with enhanced permeability for site-specific targeting delivery of anticancer drugBioconjug Chem20132441943023350619
  • ZhuLWangTPercheFTaigindATorchilinVPEnhanced anticancer activity of nanopreparation containing an MMP2-sensitive PEG-drug conjugate and cell-penetrating moietyProc Natl Acad Sci U S A2013110170471705224062440
  • YooJRejinoldNSLeeDJonSKimYCProtease-activatable cell-penetrating peptide possessing ROS-triggered phase transition for enhanced cancer therapyJ Control Release20172648910128842316
  • WhitneyMCrispJLOlsonESParallel in vivo and in vitro selection using phage display identifies protease-dependent tumor-targeting peptidesJ Biol Chem2010285225322254120460372
  • LiJLiuFShaoQEnzyme-responsive cell-penetrating peptide conjugated mesoporous silica quantum dot nanocarriers for controlled release of nucleus-targeted drug molecules and real-time intracellular fluorescence imaging of tumor cellsAdv Healthc Mater201431230123924550203
  • BraunGBSugaharaKNYuOMUrokinase-controlled tumor penetrating peptideJ Control Release201623218819527106816
  • ZhangDWangaJXuDCell-penetrating peptides as noninvasive transmembrane vectors for the development of novel multifunctional drug-delivery systemsJ Control Release201622913013926993425
  • ShamayYAdarLAshkenasyGDavidALight induced drug delivery into cancer cellsBiomaterials2011321377138621074848
  • LinWXieXYangYEnhanced small interfering RNA delivery into cells by exploiting the additive effect between photo-sensitive peptides and targeting ligandsJ Pharm Pharmacol2015671215123125880614
  • YangYXieXYangYZhangHMeiXPhoto-responsive and NGR-mediated multifunctional nanostructured lipid carrier for tumor-specific therapyJ Pharm Sci20151041328133925630979
  • YangYYangYXieXDual-modified liposomes with a two-photon-sensitive cell penetrating peptide and NGR ligand for siRNA targeting deliveryBiomaterials201548849625701034
  • WalkerLRRyuJSPerkinsEFusion of cell-penetrating peptides to thermally responsive biopolymer improves tumor accumulation of p21 peptide in a mouse model of pancreatic cancerDrug Des Devel Ther2014816491658
  • MitchellKSvensonKBLongmateWMSuppression of integrin α3β1 in breast cancer cells reduces cyclooxygenase-2 gene expression and inhibits tumorigenesis, invasion, and cross-talk to endothelial cellsCancer Res2010706359636720631072
  • LaakkonenPVuorinenKHoming peptides as targeted delivery vehiclesIntegr Biol (Camb)2010232633720657951
  • LiZJChoCPeptides as targeting probes against tumor vasculature for diagnosis and drug deliveryJ Transl Med201210S123046982
  • ArapWPasqualiniRRuoslahtiECancer treatment by targeted drug delivery to tumor vasculature in a mouse modelScience19982793773809430587
  • LuLQiHZhuJVascular-homing peptides for cancer therapyBiomed Pharmacother20179218719528544932
  • ChristianSPilchJAkermanMEPorkkaKLaakkonenPRuoslahtiENucleolin expressed at the cell surface is a marker of endothelial cells in angiogenic blood vesselJ Cell Biol200316387187814638862
  • WangCWangXZhongXThe antitumor activity of tumor-homing peptide-modified thermosensitive liposomes containing doxorubicin on MCF-7/ADR: in vitro and in vivoInt J Nanomedicine2015102229224825834435
  • LiZJWuWKNgSSA novel peptide specifically targeting the vasculature of orthotopic colorectal cancer for imaging detection and drug deliveryJ Control Release201014829230220854857
  • LaakkonenPAkermanMEBiliranHAntitumor activity of a homing peptide that targetsProc Natl Acad Sci U S A20041019381938615197262
  • FogalVZhangLKrajewskiSRuoslahtiEMitochondrial/cell surface protein p32/gC1qR as a molecular target in tumor cells and tumor stromaCancer Res2008687210721818757437
  • SeleciDASeleciMStahlFScheperTTumor homing and penetrating peptide-conjugated niosomes as multi-drug carriers for tumor-targeted drug deliveryRSC Adv201773337833384
  • HeXNaMHKimJSA novel peptide probe for imaging and targeted delivery of liposomal doxorubicin to lung tumorMol Pharm2011843043821222482
  • TeesaluTSugaharaKKotamrajuVRuoslahtiEC-end rule peptides mediate neuropilin-1-dependent cell, vascular, and tissue penetrationProc Natl Acad Sci U S A2009106161571616219805273
  • RuoslahtiETumor penetrating peptides for improved drug deliveryAdv Drug Deliv Rev2017110–111312
  • MyrbergHZhangLMäeMLangelUDesign of a tumor-homing cell-penetrating peptideBioconjug Chem200819707518001077
  • BolhassaniAPotential efficacy of cell-penetrating peptides for nucleic acid and drug delivery in cancerBiochim Biophys Acta2011181623224621840374
  • MäeMMyrbergHEl-AndaloussiSLangelUDesign of a tumor homing cell-penetrating peptide for drug deliveryInt J Pept Res Ther2009151115
  • FanLQDuGXLiPFLiMWSunYZhaoLMImproved breast cancer cell-specific intracellular drug delivery and therapeutic efficacy by coupling decoration with cell penetrating peptide and SP90 peptideBiomed Pharmacother2016841783179127899251
  • GaoHZhangaQYangaYJiangXHeQTumor homing cell penetrating peptide decorated nanoparticles used for enhancing tumor targeting delivery and therapyInt J Pharm201547824025025448586
  • LimKJSungBHShinJRA cancer specific cell-penetrating peptide, BR2, for the efficient delivery of an scFv into cancer cellsPLoS One20138e6608423776609
  • ShengYYouYChenYDual-targeting hybrid peptide-conjugated doxorubicin for drug resistance reversal in breast cancerInt J Pharm201651211327521706
  • LelleMFreidelCKaloyanovaSOvercoming drug resistance by cell-penetrating peptide-mediated delivery of a doxorubicin dimer with high DNA-binding affinityEur J Med Chem201713033634528273560
  • FengCRuiMShenHTumor-specific delivery of doxorubicin through conjugation of pH-responsive peptide for overcoming drug resistance in cancerInt J Pharm201752832233328606508
  • CraggGMNewmanDJPlants as a source of anti-cancer agentsJ Ethnopharmacol2005100727916009521
  • SoloweyELichtensteinMSallonSPaavilainenHSoloweyELorberboum-GalskiHEvaluating medicinal plants for anticancer activityScientificWorldJournal2014201472140225478599
  • AhmadRAhmadNNaqviAAShehzadAAl-GhamdiMSRole of traditional Islamic and Arabic plants in cancer therapyJ Tradit Complement Med2017719520428417090
  • ShahUShahRAcharyaSAcharyaNNovel anticancer agents from plant sourcesChin J Nat Med2013111623
  • KhazirJMirBAPilcherLRileyDLRole of plants in anticancer drug discoveryPhytochem Lett20147173181
  • OkounevaTHillBTWilsonLJordanMAThe effects of vinflunine, vinorelbine, and vinblastine on centromere dynamicsMol Cancer Ther2003242743612748304
  • SimoensCLardonFPauwelsBComparative study of the radiosensitising and cell cycle effects of vinflunine and vinorelbine, in-vitroBMC Cancer200886518312675
  • ThapaRKKhanGMParajuli-BaralKThapaPHerbal medicine incorporated nanoparticles: advancements in herbal treatmentAsian J Biomed Pharm Sci20133714
  • WallMEWaniMCCookCEPlant antitumor agents – I: the isolation and structure of camptothecin, a novel alkaloidal leukemia and tumor inhibitor from Camptotheca acuminataJ Am Chem Soc19668838883890
  • PrakashOKumarAKumarPAnticancer potential of plants and natural productsAm J Pharmacol Sci20131104115
  • SaeidniaSAbdollahiMPerspective study on anticancer drugs from natural originInt J Pharmacol20141090108
  • DhillonNAggarwalBBNewmanRAPhase II trial of curcumin in patients with advanced pancreatic cancerClin Cancer Res2008144491449918628464
  • TeitenMHGaaschtFDicatoMDiederichMAnticancer bioactivity of compounds from medicinal plants used in European medieval traditionsBiochem Pharmacol2013861239124723973807
  • TanWLuJHuangMAnti-cancer natural products isolated from Chinese medicinal herbsChin Med201162721777476
  • BishayeeASethiGBioactive natural products in cancer prevention and therapy: progress and promiseSemin Cancer Biol201640–4113
  • HerstPMDavisJENeesonPBerridgeMVRitchieDSThe anticancer drug, phenoxodiol, kills primary myeloid and lymphoid leukemic blasts and rapidly proliferating T cellsHaematologica20099492893419535345
  • SaeidniaSAbdollahiMPerspective study on anticancer drugs from natural originInt J Pharmacol20141090108
  • AodahAPavlikAKarlageKMyrdalPBPreformulation studies on piperlonguminePLoS One201611e015170726982320
  • SaklaniAKuttySKPlant-derived compounds in clinical trialsDrug Discov Today20081316117118275914
  • WaniWTarawadiKKaul-GhanekarRNanocarriers for delivery of herbal based drugs in breast cancer: an overviewJ Nano Res2015342940
  • AnandPKunnumakkaraANewmanRAggarwalBBBioavailability of curcumin: problems and promisesMol Pharm2007480781817999464
  • KangarlouSRamezanpourSBalalaieSMohammadiSRHaririanICurcumin-loaded nanoliposomes linked to homing peptides for integrin targeting and neuropilin-1-mediated internalizationPharm Biol20175527728527937055
  • SimionVStanDConstantinescuCAConjugation of curcumin-loaded lipid nanoemulsions with cell-penetrating peptides increases their cellular uptake and enhances the anti-inflammatory effects in endothelial cellsJ Pharm Pharmacol20166819520726748549
  • DasKNimushakaviSChaudhuriADasPKAn integrin-targeting RGDK-tagged nanocarrier: anticancer efficacy of loaded curcuminChemMedChem20178738750
  • LiZWuXLiJAntitumor activity of celastrol nanoparticles in a xenograft retinoblastoma tumor modelInt J Nanomedicine2012723892398 doi:10.2147/IJN.S2994522661892
  • ShawPCLeeKMWongKBRecent advances in trichosanthin, a ribosome-inactivating protein with multiple pharmacological propertiesToxicon20054568368915804517
  • LuYZLiPFLiYZEnhanced anti-tumor activity of trichosanthin after combination with a human-derived cell-penetrating peptide, and a possible mechanism of activityFitoterapia201611218319027050721
  • ChenJLiSShenQFolic acid and cell-penetrating peptide conjugated PLGA–PEG bifunctional nanoparticles for vincristine sulfate deliveryEur J Pharm Sci20124743044322796217
  • AminAGali-MuhtasibHOckerMSchneider-StockROverview of major classes of plant-derived anticancer drugsInt J Biomed Sci2009511123675107
  • BernabeuECagelMLagomarsinoEMorettonMChiappettaDAPaclitaxel: what has been done and the challenges remain aheadInt J Pharm201752647449528501439
  • FuHShiKHuGTumor-targeted paclitaxel delivery and enhanced penetration using TAT-decorated liposomes comprising redox-responsive poly(ethylene glycol)J Pharm Sci20151041160117325449709
  • Simón-GraciaLHuntHScodellerPiRGD peptide conjugation potentiates intraperitoneal tumor delivery of paclitaxel with polymersomesBiomaterials201610424725727472162
  • DuanZChenCQinJCell-penetrating peptide conjugates to enhance the antitumor effect of paclitaxel on drug-resistant lung cancerDrug Deliv20172475276428468542
  • GaneshTImproved biochemical strategies for targeted delivery of taxoidsBioorg Med Chem20071535373545
  • YoonHYKwakSSJangMHDocetaxel-loaded RIPL peptide (IPLVVPLRRRRRRRRC)-conjugated liposomes: drug release, cytotoxicity, and antitumor efficacyInt J Pharm201752322923728341149
  • ZhangJMWangLChanHFCo-delivery of paclitaxel and tetrandrine via iRGD peptide conjugated lipid-polymer hybrid nanoparticles overcome multidrug resistance in cancer cellsSci Rep201774605728470171
  • ShahinMAhmedSKaurKLavasanifarADecoration of polymeric micelles with cancer-specific peptide ligands for active targeting of paclitaxelBiomaterials2011325123513321501865
  • HuQGaoXGuGGlioma therapy using tumor homing and penetrating peptide-functionalized PEG–PLA nanoparticles loaded with paclitaxelBiomaterials2013345640565023639530
  • KulhariHPoojaDShrivastavaSNaiduVGPeptide conjugated polymeric nanoparticles as a carrier for targeted delivery of docetaxelColloids Surf B Biointerfaces201411716617324632389
  • AlloattiDGianniniGVesciLCamptothecins in tumor homing via an RGD sequence mimeticBioorg Med Chem Lett2012226509651222959246
  • YangZLuoXZhangXLiuJJiangQTargeted delivery of 10-hydroxycamptothecin to human breast cancers by cyclic RGD-modified lipid-polymer hybrid nanoparticlesBiomed Mater2013802501223507576