Direct modulation of myelin-autoreactive CD4⁺ and CD8⁺ T cells in EAE mice by a tolerogenic nanoparticle co-carrying myelin peptide-loaded major histocompatibility complexes, CD47 and multiple regulatory molecules

References

• TurjemanKBavliYKizelszteinPNano-drugs based on nano sterically stabilized liposomes for the treatment of inflammatory neurodegenerative diseasesPLoS One2015107e013044226147975
   PubMed Web of Science ®Google Scholar
• ReichardtHMGoldRLuhderFGlucocorticoids in multiple sclerosis and experimental autoimmune encephalomyelitisExpert Rev Neurother20066111657167017144780
   PubMedGoogle Scholar
• VosoughiRFreedmanMSTherapy of MSClin Neurol Neurosurg2010112536538520362388
   PubMed Web of Science ®Google Scholar
• de RosboNKKayeJFEisensteinMThe myelin-associated oligodendrocytic basic protein region MOBP15-36 encompasses the immunodominant major encephalitogenic epitope(s) for SJL/J mice and predicted epitope(s) for multiple sclerosis-associated HLA-DRB1*1501J Immunol200417321426143515240739
   PubMed Web of Science ®Google Scholar
• Jadidi-NiaraghFMirshafieyAThe deviated balance between regulatory T cell and Th17 in autoimmunityImmunopharmacol Immunotoxicol201234572773922316060
   PubMed Web of Science ®Google Scholar
• TamRYFuehrmannTMitrousisNShoichetMSRegenerative therapies for central nervous system diseases: a biomaterials approachNeuropsychopharmacology201439116918824002187
   PubMed Web of Science ®Google Scholar
• TanerTHacksteinHWangZMorelliAEThomsonAWRapamycin-treated, alloantigen-pulsed host dendritic cells induce ag-specific T cell regulation and prolong graft survivalAm J Transplant20055222823615643982
   PubMed Web of Science ®Google Scholar
• HarrisonLCVaccination against self to prevent autoimmune disease: the type 1 diabetes modelImmunol Cell Biol200886213914518180798
   PubMed Web of Science ®Google Scholar
• LutterottiAYousefSSputtekAAntigen-specific tolerance by autologous myelin peptide-coupled cells: a phase 1 trial in multiple sclerosisSci Transl Med20135188188ra175
   Web of Science ®Google Scholar
• Van BrusselILeeWPRomboutsMTolerogenic dendritic cell vaccines to treat autoimmune diseases: can the unattainable dream turn into reality?Autoimmun Rev201413213815024120737
   PubMed Web of Science ®Google Scholar
• MansillaMJSelles-MorenoCFabregas-PuigSBeneficial effect of tolerogenic dendritic cells pulsed with MOG autoantigen in experimental autoimmune encephalomyelitisCNS Neurosci Ther201521322223025403984
   PubMed Web of Science ®Google Scholar
• ZhangLGuoYXiaCQInfusion of Sulfosuccinimidyl-4-[N-maleim-idomethyl]cyclohexane-1-carboxylate-conjugated MOG35-55-coupled spleen cells effectively prevents and reverses experimental autoimmune encephalomyelitis in miceJ Immunol Res2015201512968226258148
   PubMed Web of Science ®Google Scholar
• KleistCMohrEGaikwadSAutoantigen-specific immunosuppression with tolerogenic peripheral blood cells prevents relapses in a mouse model of relapsing-remitting multiple sclerosisJ Transl Med20161419927131971
   PubMedGoogle Scholar
• MartIn-FontechaASebastianiSHopkenUERegulation of dendritic cell migration to the draining lymph node: impact on T lymphocyte traffic and primingJ Exp Med2003198461562112925677
   PubMed Web of Science ®Google Scholar
• TackenPJde VriesIJTorensmaRFigdorCGDendritic-cell immunotherapy: from ex vivo loading to in vivo targetingNat Rev Immunol200771079080217853902
   PubMed Web of Science ®Google Scholar
• ZhouHFanZDengJHyaluronidase embedded in nanocarrier PEG shell for enhanced tumor penetration and highly efficient antitumor efficacyNano Lett20161653268327727057591
   PubMed Web of Science ®Google Scholar
• Thao leQByeonHJLeeCPharmaceutical potential of tacrolimus-loaded albumin nanoparticles having targetability to rheumatoid arthritis tissuesInt J Pharm20164971–226827626657273
   PubMed Web of Science ®Google Scholar
• ThondawadaMWadhwaniADAn effective treatment approach of DPP-IV inhibitor encapsulated polymeric nanoparticles conjugated with anti-CD-4 mAb for type 1 diabetesDrug Dev Ind Pharm2018110
   Web of Science ®Google Scholar
• GettsDRMartinAJMcCarthyDPMicroparticles bearing encephalitogenic peptides induce T-cell tolerance and ameliorate experimental autoimmune encephalomyelitisNat Biotechnol201230121217122423159881
   PubMed Web of Science ®Google Scholar
• YesteANadeauMBurnsEJWeinerHLQuintanaFJNanoparticle-mediated codelivery of myelin antigen and a tolerogenic small molecule suppresses experimental autoimmune encephalomyelitisProc Natl Acad Sci U S A201210928112701127522745170
   PubMed Web of Science ®Google Scholar
• HunterZMcCarthyDPYapWTA biodegradable nanoparticle platform for the induction of antigen-specific immune tolerance for treatment of autoimmune diseaseACS Nano2014832148216024559284
   PubMed Web of Science ®Google Scholar
• CappellanoGWoldetsadikADOrilieriESubcutaneous inverse vaccination with PLGA particles loaded with a MOG peptide and IL-10 decreases the severity of experimental autoimmune encephalomyelitisVaccine201432435681568925149432
   PubMed Web of Science ®Google Scholar
• MaldonadoRALaMotheRAFerrariJDPolymeric synthetic nanoparticles for the induction of antigen-specific immunological toleranceProc Natl Acad Sci U S A20151122E156E16525548186
   PubMed Web of Science ®Google Scholar
• ChoJJStewartJMDrashanskyTTAn antigen-specific semitherapeutic treatment with local delivery of tolerogenic factors through a dual-sized microparticle system blocks experimental autoimmune encephalomyelitisBiomaterials2017143799228772190
   PubMed Web of Science ®Google Scholar
• LuJMWangXMarin-MullerCCurrent advances in research and clinical applications of PLGA-based nanotechnologyExpert Rev Mol Diagn20099432534119435455
   PubMed Web of Science ®Google Scholar
• DanhierFAnsorenaESilvaJMCocoRLe BretonAPreatVPLGA-based nanoparticles: an overview of biomedical applicationsJ Control Release2012161250552222353619
   PubMed Web of Science ®Google Scholar
• KapoorDNBhatiaAKaurRSharmaRKaurGDhawanSPLGA: a unique polymer for drug deliveryTher Deliv201561415825565440
   PubMed Web of Science ®Google Scholar
• IqbalMZafarNFessiHElaissariADouble emulsion solvent evaporation techniques used for drug encapsulationInt J Pharm2015496217319026522982
   PubMed Web of Science ®Google Scholar
• HofstetterHHShiveCLForsthuberTGPertussis toxin modulates the immune response to neuroantigens injected in incomplete Freund’s adjuvant: induction of Th1 cells and experimental autoimmune encephalomyelitis in the presence of high frequencies of Th2 cellsJ Immunol2002169111712512077236
   PubMed Web of Science ®Google Scholar
• FissoloNCostaCNurtdinovRNTreatment with MOG-DNA vaccines induces CD4+CD25+FoxP3+ regulatory T cells and up-regulates genes with neuroprotective functions in experimental autoimmune encephalomyelitisJ Neuroinflammation2012913922727044
   PubMed Web of Science ®Google Scholar
• WenJRibeiroRTanakaMZhangYActivation of CB2 receptor is required for the therapeutic effect of ABHD6 inhibition in experimental autoimmune encephalomyelitisNeuropharmacology20159919620926189763
   PubMed Web of Science ®Google Scholar
• PinoPACardonaAEIsolation of brain and spinal cord mononuclear cells using percoll gradientsJ Vis Exp201148 pii 2348
   PubMed Web of Science ®Google Scholar
• GettsDRSheaLDMillerSDKingNJCHarnessing nanoparticles for immune modulation: (Trends in Immunology 36, 419–427; July 2016)Trends Immunol2016371071527614797
   PubMed Web of Science ®Google Scholar
• TsaiRKRodriguezPLDischerDESelf inhibition of phagocytosis: the affinity of “marker of self” CD47 for SIRPalpha dictates potency of inhibition but only at low expression levelsBlood Cells Mol Dis2010451677420299253
   PubMed Web of Science ®Google Scholar
• MassarelliEPapadimitrakopoulouVWelshJTangCTsaoASImmunotherapy in lung cancerTransl Lung Cancer Res201431536325806281
   PubMedGoogle Scholar
• BettelliEPaganyMWeinerHLLiningtonCSobelRAKuchrooVKMyelin oligodendrocyte glycoprotein-specific T cell receptor transgenic mice develop spontaneous autoimmune optic neuritisJ Exp Med200319791073108112732654
   PubMed Web of Science ®Google Scholar
• WeinerHLMultiple sclerosis is an inflammatory T-cell-mediated autoimmune diseaseArch Neurol200461101613161515477521
   PubMedGoogle Scholar
• BielekovaBSungMHKadomNSimonRMcFarlandHMartinRExpansion and functional relevance of high-avidity myelin-specific CD4+ T cells in multiple sclerosisJ Immunol200417263893390415004197
   PubMed Web of Science ®Google Scholar
• HusebyESLiggittDBrabbTSchnabelBOhlenCGovermanJA pathogenic role for myelin-specific CD8(+) T cells in a model for multiple sclerosisJ Exp Med2001194566967611535634
   PubMed Web of Science ®Google Scholar
• FischerHJvan den BrandtJLingnerTModulation of CNS autoimmune responses by CD8(+) T cells coincides with their oligoclonal expansionJ Neuroimmunol2016290263226711565
   PubMed Web of Science ®Google Scholar
• GlennJDSmithMDCalabresiPAWhartenbyKAMesenchymal stem cells differentially modulate effector CD8+ T cell subsets and exacerbate experimental autoimmune encephalomyelitisStem Cells201432102744275524911892
   PubMed Web of Science ®Google Scholar
• SalamaADChitnisTImitolaJCritical role of the programmed death-1 (PD-1) pathway in regulation of experimental autoimmune encephalomyelitisJ Exp Med20031981717812847138
   PubMed Web of Science ®Google Scholar
• CarterLLLeachMWAzoiteiMLPD-1/PD-L1, but not PD-1/PD-L2, interactions regulate the severity of experimental autoimmune encephalomyelitisJ Neuroimmunol20071821–212413417182110
   PubMed Web of Science ®Google Scholar
• ZamaniMRAslaniSSalmaninejadAJavanMRRezaeiNPD-1/PD-L and autoimmunity: a growing relationshipCell Immunol2016310274127660198
   PubMed Web of Science ®Google Scholar
• FantiniMCBeckerCMonteleoneGPalloneFGallePRNeurathMFCutting edge: TGF-beta induces a regulatory phenotype in CD4+CD25-T cells through Foxp3 induction and downregulation of Smad7J Immunol200417295149515315100250
   PubMed Web of Science ®Google Scholar
• MarieJCLiggittDRudenskyAYCellular mechanisms of fatal early-onset autoimmunity in mice with the T cell-specific targeting of transforming growth factor-beta receptorImmunity200625344145416973387
   PubMed Web of Science ®Google Scholar
• MirshafieyAMohsenzadeganMTGF-beta as a promising option in the treatment of multiple sclerosisNeuropharmacology2009566–792993619285095
   PubMed Web of Science ®Google Scholar
• HowellMDWintersSTOleeTPowellHCCarloDJBrostoffSWVaccination against experimental allergic encephalomyelitis with T cell receptor peptidesScience198924649306686702814489
   PubMed Web of Science ®Google Scholar
• ChenYKuchrooVKInobeJHaflerDAWeinerHLRegulatory T cell clones induced by oral tolerance: suppression of autoimmune encephalomyelitisScience19942655176123712407520605
   PubMed Web of Science ®Google Scholar
• GrouxHO’GarraABiglerMA CD4+ T-cell subset inhibits antigen-specific T-cell responses and prevents colitisNature199738966527377429338786
   PubMed Web of Science ®Google Scholar
• StromnesIMGovermanJMActive induction of experimental allergic encephalomyelitisNat Protoc2006141810181917487163
   PubMed Web of Science ®Google Scholar
• CuYSaltzmanWMDrug delivery: stealth particles give mucus the slipNat Mater2009811113
   PubMed Web of Science ®Google Scholar
• MitragotriSLahannJPhysical approaches to biomaterial designNat Mater200981152319096389
   PubMed Web of Science ®Google Scholar
• BhaskarSTianFStoegerTMultifunctional nanocarriers for diagnostics, drug delivery and targeted treatment across blood-brain barrier: perspectives on tracking and neuroimagingPart Fibre Toxicol20107320199661
   PubMed Web of Science ®Google Scholar
• HwangSRKimKNano-enabled delivery systems across the blood-brain barrierArch Pharm Res2014371243024170511
   PubMed Web of Science ®Google Scholar
• KohaneDSMicroparticles and nanoparticles for drug deliveryBiotechnol Bioeng200796220320917191251
   PubMed Web of Science ®Google Scholar
• ChenKHLundyDJTohEKNanoparticle distribution during systemic inflammation is size-dependent and organ-specificNanoscale2015738158631587226359216
   PubMed Web of Science ®Google Scholar
• BrunsHBessellCVarelaJCCD47 Enhances in vivo functionality of artificial antigen-presenting cellsClin Cancer Res20152192075208325593301
   PubMed Web of Science ®Google Scholar