References
- StrawBEMacLachlanNJCorbettWTCarterPBScheyHMComparison of tissue reactions produced by Haemophilus pleuropneumoniae vaccines made with six different adjuvants in swineCan J Comp Med19854921491514016580
- BomfordRAluminium salts: perspectives in their use as adjuvantsGregoriadisGAllisonACPosteGImmunological Adjuvants and VaccinesNATO ASI Series (Series A: Life Sciences)179Boston, MASpringer19893541
- GotoNKatoHMaeyamaJEtoKYoshiharaSStudies on the toxicities of aluminium hydroxide and calcium phosphate as immunological adjuvants for vaccinesVaccine19931199149188212836
- MirzaAKingATroakesCExleyCAluminium in brain tissue in familial Alzheimer’s diseaseJ Trace Elem Med Biol201740303628159219
- FreundJCasalsJHosmerEPSensitization and antibody formation after injection of tubercle bacilli and paraffin oilExp Biol Med1937373509513
- Stuart-HarrisCHAdjuvant influenza vaccinesBull World Health Organ1969413615621
- JohnsonAGEnhancement of Antibody Response to Protein Antigens by A Lipopolysaccharide (Endotoxin) Derived from Salmonella TyphosaCollege ParkUniversity of Maryland1955
- WeinerGJLiuHMWooldridgeJEDahleCEKriegAMImmunostimulatory oligodeoxynucleotides containing the CpG motif are effective as immune adjuvants in tumor antigen immunizationProc Natl Acad Sci U S A1997942010833108379380720
- O’HaganDTTsaiTFBritoLAEmulsion based vaccine adjuvantsHum Vaccin Immunother20139816981700
- MoserCAmackerMZurbriggenRInfluenza virosomes as a vaccine adjuvant and carrier systemExpert Rev Vaccines201110443744621506642
- MoserCMetcalfeICViretJFVirosomal adjuvanted antigen delivery systemsExpert Rev Vaccines20032218919612899570
- TakahashiHTakeshitaTMoreinBPutneySGermainRNBerzofskyJAInduction of CD8+ cytotoxic T cells by immunization with purified HIV-1 envelope protein in ISCOMsNature199034462698738752184369
- HeZWlazloAPKowalczykDWViral recombinant vaccines to the E6 and E7 antigens of HPV-16Virology2000270114616110772987
- PolakosNKDraneDCoxJCharacterization of hepatitis C virus core-specific immune responses primed in rhesus macaques by a nonclassical ISCOM vaccineJ Immunol200116653589359811207320
- LaytonRCPetrovskyNGigliottiAPDelta inulin polysaccharide adjuvant enhances the ability of split-virion H5N1 vaccine to protect against lethal challenge in ferretsVaccine201129376242625121736913
- MataEIgartuaMPatarroyoMEPedrazJLHernándezRMEnhancing immunogenicity to PLGA microparticulate systems by incorporation of alginate and RGD-modified alginateEur J Pharm Sci2011441–2324021699977
- VerheulRJSlütterBBalSMBouwstraJAJiskootWHenninkWECovalently stabilized trimethyl chitosan-hyaluronic acid nanoparticles for nasal and intradermal vaccinationJ Control Release20111561465221784113
- SilvaDGCooperPDPetrovskyNInulin-derived adjuvants efficiently promote both Th1 and Th2 immune responsesImmunol Cell Biol200482661161615550119
- TizardIRCarpenterRHMcAnalleyBHKempMCThe biological activities of mannans and related complex carbohydratesMol Biother1989162902962692629
- MataESalvadorAIgartuaMHernándezRMPedrazJLMalaria vaccine adjuvants: latest update and challenges in preclinical and clinical researchBiomed Res Int2013201324119
- GordonDKelleyPHeinzelSCooperPPetrovskyNImmunogenicity and safety of Advax™, a novel polysaccharide adjuvant based on delta inulin, when formulated with hepatitis B surface antigen: a randomized controlled Phase 1 studyVaccine201432486469647725267153
- ItoMBanAIshiharaMAnti-ulcer effects of chitin and chitosan, healthy foods, in ratsJpn J Pharmacol200082321822510887952
- DaiTTanakaMHuangYYHamblinMRChitosan preparations for wounds and burns: antimicrobial and wound-healing effectsExpert Rev Anti Infect Ther20119785787921810057
- XiaYFanQHaoDWuJMaGSuZChitosan-based mucosal adjuvants: Sunrise on the oceanVaccine201533445997601026271831
- SinhaVRSinglaAKWadhawanSChitosan microspheres as a potential carrier for drugsInt J Pharm20042741–213315072779
- LiXMinMDuNChitin, chitosan, and glycated chitosan regulate immune responses: the novel adjuvants for cancer vaccineClin Dev Immunol2013201338702323533454
- WedmoreIMcManusJGPusateriAEHolcombJBA special report on the chitosan-based hemostatic dressing: experience in current combat operationsJ Trauma200660365565816531872
- de BrittoDde MouraMRAouadaFAMattosoLHCAssisOBGN,N,N-trimethyl chitosan nanoparticles as a vitamin carrier systemFood Hydrocoll2012272487493
- ChangHLiXTengYComparison of adjuvant efficacy of chitosan and aluminum hydroxide for intraperitoneally administered inactivated influenza H5N1 vaccineDNA Cell Biol201029956356820380570
- HunsawongTSunintaboonPWaritSImmunogenic properties of a BCG adjuvanted chitosan nanoparticle-based dengue vaccine in human dendritic cellsPLoS Negl Trop Dis201599e000395826394138
- NohKHParkYMKimHSGM-CSF-loaded chitosan hydrogel as an immunoadjuvant enhances antigen-specific immune responses with reduced toxicityBMC Immunol2014154825323934
- AbdelAllahNHAbdeltawabNFBoseilaAAAminMAChitosan and sodium alginate combinations are alternative, efficient, and safe natural adjuvant systems for hepatitis B vaccine in mouse modelEvid Based Complement Alternat Med201620161765968427493674
- YuWHuTConjugation with an Inulin-Chitosan Adjuvant Markedly Improves the Immunogenicity of Mycobacterium tuberculosis CFP10-TB10.4 Fusion ProteinMol Pharm201613113626363527723352
- SmithAPerelmanMHinchcliffeMChitosan: a promising safe and immune-enhancing adjuvant for intranasal vaccinesHum Vaccin Immunother201410379780724346613
- GhendonYMarkushinSAkopovaIKoptiaevaIKrivtsovGChitosan as an adjuvant for poliovaccineJ Med Virol201183584785221412793
- SuiZChenQFangFZhengMChenZCross-protection against influenza virus infection by intranasal administration of M1-based vaccine with chitosan as an adjuvantVaccine201028487690769820870054
- SuiZChenQWuRCross-protection against influenza virus infection by intranasal administration of M2-based vaccine with chitosan as an adjuvantArch Virol2010155453554420195654
- ZhengMQuDWangHIntranasal administration of chitosan against Influenza A (H7N9) virus infection in a mouse modelSci Rep201662872927353250
- GongYTaoLWangFChitosan as an adjuvant for a Helicobacter pylori therapeutic vaccineMol Med Rep20151234123413226095723
- GordonSTeichmannEYoungKFinnieKRadesTHookSIn vitro and in vivo investigation of thermosensitive chitosan hydrogels containing silica nanoparticles for vaccine deliveryEur J Pharm Sci201041236036820633644
- GordonSSaupeAMcBurneyWRadesTHookSComparison of chitosan nanoparticles and chitosan hydrogels for vaccine deliveryJ Pharm Pharmacol200860121591160019000363
- GordonSYoungKWilsonRChitosan hydrogels containing liposomes and cubosomes as particulate sustained release vaccine delivery systemsJ Liposome Res201222319320422188610
- HightonAJKojarunchittTGirardinAHookSKempRAChitosan hydrogel vaccine generates protective CD8 T cell memory against mouse melanomaImmunol Cell Biol201593763464025708538
- WenZSXuYLZouXTXuZRChitosan nanoparticles act as an adjuvant to promote both Th1 and Th2 immune responses induced by ovalbumin in miceMar Drugs2011961038105521747747
- SnymanDHammanJHKotzeAFEvaluation of the mucoadhesive properties of N-trimethyl chitosan chlorideDrug Dev Ind Pharm2003291616912602493
- KotzéAFLuessenHLde LeeuwBJde BoerBGVerhoefJCJungingerHEN-trimethyl chitosan chloride as a potential absorption enhancer across mucosal surfaces: in vitro evaluation in intestinal epithelial cells (Caco-2)Pharm Res1997149119712029327448
- MaoZMaLJiangYYanMGaoCShenJN,N,N-Trimethylchitosan chloride as a gene vector: synthesis and applicationMacromol Biosci20077685586317549777
- ThanouMMKotzéAFScharringhausenTEffect of degree of quaternization of N-trimethyl chitosan chloride for enhanced transport of hydrophilic compounds across intestinal caco-2 cell monolayersJ Control Release2000641–3152510640642
- HammanJHSchultzCMKotzéAFN-trimethyl chitosan chloride: optimum degree of quaternization for drug absorption enhancement across epithelial cellsDrug Dev Ind Pharm200329216117212648013
- SievalABThanouMKotzéAFVerhoefJCBrusseeJJungingerHEPreparation and NMR characterization of highly substitutedN-trimethyl chitosan chlorideCarbohydr Polym1998362–3157165
- DomardARinaudoMTerrassinCNew method for the quaternization of chitosanInt J Biol Macromol198682105107
- KimCHChoiJWChunHJChoiKSSynthesis of chitosan derivatives with quaternary ammonium salt and their antibacterial activityPolym Bull1997384387393
- De BrittoDAssisOBGA novel method for obtaining a quaternary salt of chitosanCarbohydr Polym2007692305310
- ÖvRHolappaJJónsdóttirSSteinssonHMássonMN-selective ‘one pot’ synthesis of highly N-substituted trimethyl chitosan (TMC)Carbohydr Polym2008743740744
- VerheulRJAmidiMvan der WalSvan RietEJiskootWHenninkWESynthesis, characterization and in vitro biological properties of O-methyl free N,N,N-trimethylated chitosanBiomaterials200829273642364918556059
- KulkarniADPatelHMSuranaSJVanjariYHBelgamwarVSPardeshiCVN,N,N-Trimethyl chitosan: An advanced polymer with myriad of opportunities in nanomedicineCarbohydr Polym201715787590227988003
- BoonyoWJungingerHEWaranuchNPolnokAPitaksuteepongTChitosan and trimethyl chitosan chloride (TMC) as adjuvants for inducing immune responses to ovalbumin in mice following nasal administrationJ Control Release2007121316817517644205
- HagenaarsNMastrobattistaEVerheulRJPhysicochemical and immunological characterization of N,N,N-trimethyl chitosan-coated whole inactivated influenza virus vaccine for intranasal administrationPharm Res20092661353136419224344
- VerheulRJHagenaarsNvan EsTA step-by-step approach to study the influence of N-acetylation on the adjuvanticity of N,N,N-trimethyl chitosan (TMC) in an intranasal nanoparticulate influenza virus vaccineEur J Pharm Sci201245446747422009112
- KeanTThanouMBiodegradation, biodistribution and toxicity of chitosanAdv Drug Deliv Rev201062131119800377
- SchipperNGVårumKMArturssonPChitosans as absorption enhancers for poorly absorbable drugs. 1: Influence of molecular weight and degree of acetylation on drug transport across human intestinal epithelial (Caco-2) cellsPharm Res19961311168616928956335
- NishimuraKNishimuraSSeoHNishiNTokuraSAzumaIMacrophage activation with multi-porous beads prepared from partially deacetylated chitinJ Biomed Mater Res1986209135913723491076
- BoonthaSJungingerHEWaranuchNPolnokAPitaksuteepongTChitosan and trimethyl chitosan particles as oral vaccine delivery systems: comparison of the potential to initiate immune responsesJMMM20112114347
- HagenaarsNVerheulRJMoorenIRelationship between structure and adjuvanticity of N,N,N-trimethyl chitosan (TMC) structural variants in a nasal influenza vaccineJ Control Release2009140212613319712713
- SlütterBSoemaPCDingZVerheulRHenninkWJiskootWConjugation of ovalbumin to trimethyl chitosan improves immunogenicity of the antigenJ Control Release2010143220721420074597
- BalSMSlütterBJiskootWBouwstraJASmall is beautiful: N-trimethyl chitosan-ovalbumin conjugates for microneedle-based transcutaneous immunisationVaccine201129234025403221443959
- MohananDSlütterBHenriksen-LaceyMAdministration routes affect the quality of immune responses: a cross-sectional evaluation of particulate antigen-delivery systemsJ Control Release2010147334234920727926
- LiuQZhengXZhangCAntigen-conjugated N-trimethylam-inoethylmethacrylate chitosan nanoparticles induce strong immune responses after nasal administrationPharm Res2015321223624970313
- SlütterBBalSKeijzerCNasal vaccination with N-trimethyl chitosan and PLGA based nanoparticles: nanoparticle characteristics determine quality and strength of the antibody response in mice against the encapsulated antigenVaccine201028386282629120638455
- HagenaarsNManiaMde JongPRole of trimethylated chitosan (TMC) in nasal residence time, local distribution and toxicity of an intranasal influenza vaccineJ Control Release20101441172420100528
- ZarifpourMHadizadehFImanMTafaghodiMPreparation and characterization of trimethyl chitosan nanospheres encapsulated with tetanus toxoid for nasal immunization studiesPharm Sci2013184193198
- ChadharVParasharAKPatelMKumarRDevelopment and characterization of tetanus toxoid loaded trimethylchitosan chloride nanoparticles for nasal immunizationCurrent Research in Pharmaceutical Sciences20124197202
- SayınBSomavarapuSLiXWMono-N-carboxymethyl chitosan (MCC) and N-trimethyl chitosan (TMC) nanoparticles for non-invasive vaccine deliveryInt J Pharm20083631–213914818662762
- SayınBSomavarapuSLiXWSesardicDŞenelSAlparOHTMC-MCC (N-trimethyl chitosan-mono-N-carboxymethyl chitosan) nanocomplexes for mucosal delivery of vaccinesEur J Pharm Sci200938436236919733658
- BaudnerBCMorandiMGiulianiMMModulation of immune response to group C meningococcal conjugate vaccine given intranasally to mice together with the LTK63 mucosal adjuvant and the trimethyl chitosan delivery systemJ Infect Dis2004189582883214976599
- FarhadianADounighiNMAvadiMEnteric trimethyl chitosan nanoparticles containing hepatitis B surface antigen for oral deliveryHum Vaccin Immunother201511122811281826158754
- AbkarMFasihi-RamandiMKooshkiHSahebghadam LotfiALotfiASOral immunization of mice with Omp31-loaded N-trimethyl chitosan nanoparticles induces high protection against Brucella melitensis infectionInt J Nanomedicine2017128769877829263667
- AbkarMLotfiASAmaniJSurvey of Omp19 immunogenicity against Brucella abortus and Brucella melitensis: influence of nanoparticulation versus traditional immunizationVet Res Commun201539421722826395469
- SlütterBPlapiedLFievezVMechanistic study of the adjuvant effect of biodegradable nanoparticles in mucosal vaccinationJ Control Release2009138211312119445980
- BalSMDingZKerstenGFJiskootWBouwstraJAMicroneedle-based transcutaneous immunisation in mice with N-trimethyl chitosan adjuvanted diphtheria toxoid formulationsPharm Res20102791837184720559701
- van der MaadenKSekerdagESchipperPKerstenGJiskootWBouwstraJLayer-by-layer assembly of inactivated poliovirus and N-trimethyl chitosan on pH-sensitive microneedles for dermal vaccinationLangmuir201531318654866026145437
- SchipperPvan der MaadenKGroeneveldVDiphtheria toxoid and N-trimethyl chitosan layer-by-layer coated pH-sensitive microneedles induce potent immune responses upon dermal vaccination in miceJ Control Release2017262283628710002
- PoecheimJBarnier-QuerCCollinNBorchardGAg85A DNA vaccine delivery by nanoparticles: influence of the formulation characteristics on immune responsesVaccines (Basel)201643E3227626449
- BalSMSlütterBVerheulRBouwstraJAJiskootWAdjuvanted, antigen loaded N-trimethyl chitosan nanoparticles for nasal and intra-dermal vaccination: adjuvant- and site-dependent immunogenicity in miceEur J Pharm Sci201245447548122009113
- SlütterBJiskootWDual role of CpG as immune modulator and physical crosslinker in ovalbumin loaded N-trimethyl chitosan (TMC) nanoparticles for nasal vaccinationJ Control Release2010148111712120600405
- BentoDStaatsHFGonçalvesTBorgesODevelopment of a novel adjuvanted nasal vaccine: C48/80 associated with chitosan nanoparticles as a path to enhance mucosal immunityEur J Pharm Biopharm20159314916425818119
- BoonthaSJungingerHEWaranuchNPolnokAPitaksuteepongTFormation of particles prepared using chitosan and their trimethyl chitosan derivatives for oral vaccine delivery: effect of molecular weight and degree of quaternizationSongklanakarin J Sci Technol2010324363371
- LiXYLiXKongXYPreparation of N-trimethyl chitosan-protein nanoparticles intended for vaccine deliveryJ Nanosci Nanotechnol20101084850485821125819
- BalSMSlütterBvan RietEEfficient induction of immune responses through intradermal vaccination with N-trimethyl chitosan containing antigen formulationsJ Control Release2010142337438319932723
- XuJXuBShouDXiaXHuYPreparation and evaluation of vancomycin-loaded N-trimethyl chitosan nanoparticlesPolymers20157918501870
- SongRFLiXJChengXLPaclitaxel-loaded trimethyl chitosan-based polymeric nanoparticle for the effective treatment of gastroenteric tumorsOncol Rep20143241481148825051142
- AmidiMRomeijnSGBorchardGJungingerHEHenninkWEJiskootWPreparation and characterization of protein-loaded N-trimethyl chitosan nanoparticles as nasal delivery systemJ Control Release20061111–210711616380189
- MalikAGuptaMManiRGogoiHBhatnagarRTrimethyl chitosan nanoparticles encapsulated protective antigen protects the mice against anthraxFront Immunol2018956229616046
- BoonyoWJungingerHEWaranuchNPolnokAPitaksuteepongTPreparation and characterization of particles from chitosan with different molecular weights and their trimethyl chitosan derivatives for nasal immunizationJMMM20171825965
- SubbiahRRamalingamPRamasundaramSN,N,N-Trimethyl chitosan nanoparticles for controlled intranasal delivery of HBV surface antigenCarbohydr Polym20128941289129724750944
- TafaghodiMKerstenGJiskootWOriginal Research Nano-adjuvanted polio vaccine: Preparation and characterization of chitosan and trim-ethylchitosan (TMC) nanoparticles loaded with inactivated polio virus and coated with sodium alginateNanomed J201414220228
- DabaghianMEbrahimiSMNikbakhat BorojeniGUse of N-trim-ethyl chitosan for intranasal delivery of DNA encoding M2e-HSP70c in miceIran J Vet Med201372123128
- AmirnasrMFallah TaftiTSankianMRezaeiATafaghodiMImmunization against HTLV-I with chitosan and tri-methylchitosan nanoparticles loaded with recombinant env23 and env13 antigens of envelope protein gp46Microb Pathog201697384427235335
- KarimiSMSankianMKhademiFTafaghodiMChitosan (CHT) and trimethylchitosan (TMC) nanoparticles as adjuvant/delivery system for parenteral and nasal immunization against Mycobacterium tuberculosis (MTb) ESAT-6 antigenNanomed J201634223229
- PoecheimJAdjuvanted Trimethyl Chitosan based Nanoparticle Formulations to Improve Immunogenicity of DNA VaccinesGenevaUniversity of Geneva2015
- ZhaoKSunYChenGBiological evaluation of N-2-hy-droxypropyl trimethyl ammonium chloride chitosan as a carrier for the delivery of live Newcastle disease vaccineCarbohydr Polym2016149283927261727
- ZhaoKLiSLiWQuaternized chitosan nanoparticles loaded with the combined attenuated live vaccine against Newcastle disease and infectious bronchitis elicit immune response in chicken after intranasal administrationDrug Deliv20172411574158629029568
- TafaghodiMSalujaVKerstenGFHepatitis B surface antigen nanoparticles coated with chitosan and trimethyl chitosan: Impact of formulation on physicochemical and immunological characteristicsVaccine201230365341534822749834
- MarasiniNGhaffarKAGiddamAKHighly immunogenic trimethyl chitosan-based delivery system for intranasal lipopeptide vaccines against group A streptococcusCurr Drug Deliv201714570170827440071
- KaravasiliCBouropoulosNSygellouLAmanatiadouEPVizirianakisISFatourosDGPLGA/DPPC/trimethylchitosan spray-dried microparticles for the nasal delivery of ropinirole hydrochloride: in vitro, ex vivo and cytocompatibility assessmentMater Sci Eng C Mater Biol Appl2016591053106226652464
- KeijzerCSlütterBvan der ZeeRJiskootWvan EdenWBroereFPLGA, PLGA-TMC and TMC-TPP nanoparticles differentially modulate the outcome of nasal vaccination by inducing tolerance or enhancing humoral immunityPLoS One2011611e2668422073184
- NantachitNSunintaboonPUbolSResponses of primary human nasal epithelial cells to EDIII-DENV stimulation: the first step to intranasal dengue vaccinationVirol J201613114227538960
- IshiiKJAkiraSToll or toll-free adjuvant path toward the optimal vaccine developmentJ Clin Immunol200727436337117370119
- SchijnsVEImmunological concepts of vaccine adjuvant activityCurr Opin Immunol200012445646310899018
- CarrollECJinLMoriAThe vaccine adjuvant chitosan promotes cellular immunity via DNA sensor cGAS-STING-dependent induction of type I interferonsImmunity201644359760826944200
- RiteauNSherAChitosan: an adjuvant with an unanticipated STINGImmunity201644352252426982361
- BellichBD’AgostinoISemeraroSGaminiACesàroA“The Good, the Bad and the Ugly” of ChitosansMar Drugs2016145E9927196916
- SantanderSPAokiMHernandezJFGalactomannan from Caesalpinia spinosa induces phenotypic and functional maturation of human dendritic cellsInt Immunopharmacol201111665266021255695
- OnishiNKawamotoSUedaKDietary pulverized konjac glucomannan prevents the development of allergic rhinitis-like symptoms and IgE response in miceBiosci Biotechnol Biochem200771102551255617928709
- IshiiMKojimaNMucosal adjuvant activity of oligomannose-coated liposomes for nasal immunizationGlycoconj J201027111512319816665
- McCarthyREArnoldLWBabcockGFDextran sulphate: an adjuvant for cell-mediated immune responsesImmunology1977326963974328389
- SuzukiMTakatsukiFMaedaYYHamuroJChiharaGLentinan: rationale for development and therapeutic potentialClin Immunother199422121133
- MirzaZSotoERDikengilFLevitzSMOstroffGRBeta-glucan particles as vaccine adjuvant carriersMethods Mol Biol2017162514315728584989
- AinaiAIchinoheTTamuraSZymosan enhances the mucosal adjuvant activity of poly(I:C) in a nasal influenza vaccineJ Med Virol201082347648420087927
- LeelayuwapanHKangwanrangsanNChawengkirttikulRSynthesis and immunological studies of the lipomannan backbone glycans found on the surface of Mycobacterium tuberculosisJ Org Chem201782147190719928682637
- SareiFDounighiNMZolfagharianHKhakiPBidhendiSMAlginate nanoparticles as a promising adjuvant and vaccine delivery systemIndian J Pharm Sci201375444244924302799
- AbrahamERobinsonAOral immunization with bacterial poly-saccharide and adjuvant enhances antigen-specific pulmonary secretory antibody response and resistance to pneumoniaVaccine19919107577641759494
- ChenFZhangZRYuanFQinXWangMHuangYIn vitro and in vivo study of N-trimethyl chitosan nanoparticles for oral protein deliveryInt J Pharm20083491–222623317825506