Prior anti-CAFs break down the CAFs barrier and improve accumulation of docetaxel micelles in tumor

References

• CrottiSPiccoliMRizzolioFGiordanoANittiDAgostiniMExtracellular Matrix and Colorectal Cancer: How Surrounding Microenvironment Affects Cancer Cell Behavior?J Cell Physiol2017232596797527775168
   PubMed Web of Science ®Google Scholar
• HuiLChenYTumor microenvironment: Sanctuary of the devilCancer Lett2015368171326276713
   PubMed Web of Science ®Google Scholar
• FuxeJKarlssonMCTGF-β-induced epithelial-mesenchymal transition: a link between cancer and inflammationSemin Cancer Biol2012225–645546122627188
   PubMed Web of Science ®Google Scholar
• McMillinDWNegriJMMitsiadesCSThe role of tumour-stromal interactions in modifying drug response: challenges and opportunitiesNat Rev Drug Discov201312321722823449307
   PubMed Web of Science ®Google Scholar
• XouriGChristianSOrigin and function of tumor stroma fibroblastsSemin Cell Dev Bio2010211404619944178
   PubMed Web of Science ®Google Scholar
• MuellerMMFusenigNEFriends or foes – bipolar effects of the tumour stroma in cancerNat Rev Cancer200441183984915516957
   PubMed Web of Science ®Google Scholar
• ZhangHXieCYueJCancer-associated fibroblasts mediated chemoresistance by a FOXO1/TGFβ1 signaling loop in esophageal squamous cell carcinomaMol Carcinog20175631150116327769097
   PubMed Web of Science ®Google Scholar
• SonBLeeSYounHKimEKimWYounBThe role of tumor microenvironment in therapeutic resistanceOncotarget2017833933394527965469
   PubMedGoogle Scholar
• MarusykATabassumDPJaniszewskaMSpatial Proximity to Fibroblasts Impacts Molecular Features and Therapeutic Sensitivity of Breast Cancer Cells Influencing Clinical OutcomesCancer Res201676226495650627671678
   PubMed Web of Science ®Google Scholar
• GaggioliCHooperSHidalgo-CarcedoCFibroblast-led collective invasion of carcinoma cells with differing roles for RhoGTPases in leading and following cellsNat Cell Bio20079121392140018037882
   PubMed Web of Science ®Google Scholar
• Sanz-MorenoVGaggioliCYeoMROCK and JAK1 signaling cooperate to control actomyosin contractility in tumor cells and stromaCancer Cell201120222924521840487
   PubMed Web of Science ®Google Scholar
• PankovaDChenYTerajimaMCancer-Associated Fibroblasts Induce a Collagen Cross-link Switch in Tumor StromaCancer Res201676226495650627671678
   PubMedGoogle Scholar
• SakaiSIwataCTanakaHYIncreased fibrosis and impaired intratumoral accumulation of macromolecules in a murine model of pancreatic cancer co-administered with FGF-2J Control Release201623010911527080571
   PubMed Web of Science ®Google Scholar
• HeldinCHRubinKPietrasKOstmanAHigh interstitial fluid pressure – an obstacle in cancer therapyNat Rev Cancer200441080681315510161
   PubMed Web of Science ®Google Scholar
• SriramanSKAryasomayajulaBTorchilinVPBarriers to drug delivery in solid tumorsTissue Barriers201423e29528e2956525068098
   PubMedGoogle Scholar
• OrimoAGuptaPBSgroiDCStromal fibroblasts present in invasive human breast carcinomas promote tumor growth and angiogenesis through elevated SDF-1/CXCL12 secretionCell2005121333534815882617
   PubMed Web of Science ®Google Scholar
• MongiatMAndreuzziETarticchioGPaulittiAExtracellular matrix: a hard player in angiogenesisInt J Mol Sci2016171118221848
   PubMed Web of Science ®Google Scholar
• MohammadiMChenPEffect of microvascular distribution and its density on interstitial fluid pressure in solid tumors: A computational modelMicrovasc Res2015101263226093178
   PubMed Web of Science ®Google Scholar
• ProvenzanoPPCuevasCChangAEGoelVKvon HoffDDHingoraniSREnzymatic targeting of the stroma ablates physical barriers to treatment of pancreatic ductal adenocarcinomaCancer Cell201221341842922439937
   PubMed Web of Science ®Google Scholar
• GoodmanTTOlivePLPunSHIncreased nanoparticle penetration in collagenase-treated multicellular spheroidsInt J Nanomed200722265274
   PubMed Web of Science ®Google Scholar
• JiTDingYZhaoYPeptide assembly integration of fibroblast-targeting and cell-penetration features for enhanced antitumor drug deliveryAdv Mater201527111865187325651789
   PubMed Web of Science ®Google Scholar
• AzumaHBannoKYoshimuraTPharmacological properties of N-(3′,4′-dimethoxycinnamoyl) anthranilic acid (N-5’), a new anti-atopic agentBr J Pharmacol197658448348863304
   PubMed Web of Science ®Google Scholar
• IsajiMMiyataHAjisawaYTranilast: A New Application in the Cardiovascular Field as an antiproliferative drugCardiovasc Drug Rev1998163288299
   Google Scholar
• SaitoHFushidaSHaradaSImportance of human peritoneal mesothelial cells in the progression, fibrosis, and control of gastric cancer: inhibition of growth and fibrosis by tranilastGastric Cancer201821111328948368
   PubMed Web of Science ®Google Scholar
• OhshioYHanaokaJKontaniKTeramotoKTranilast inhibits the function of cancer-associated fibroblasts responsible for the induction of immune suppressor cell typesScand J Immunol201480640841625224016
   PubMed Web of Science ®Google Scholar
• ChakrabartiRSubramaniamVAbdallaSJothySPrud’hommeGJTranilast inhibits the growth and metastasis of mammary carcinomaAnticancer Drugs200920533434519322072
   PubMed Web of Science ®Google Scholar
• IshiiGOchiaiANeriSPhenotypic and functional heterogeneity of cancer-associated fibroblast within the tumor microenvironmentAdv Drug Deliv Rev20169918619626278673
   PubMed Web of Science ®Google Scholar
• WangATLiangDSLiuYJQiXRRoles of ligand and TPGS of micelles in regulating internalization, penetration and accumulation against sensitive or resistant tumor and therapy for multidrug resistant tumorsBiomaterials20155316017225890716
   PubMed Web of Science ®Google Scholar
• TongS-WXiangBDongD-WQiX-REnhanced antitumor efficacy and decreased toxicity by self-associated docetaxel in phospholipid-based micellesInt J Pharm20124341–241341922698861
   PubMed Web of Science ®Google Scholar
• SunLLiuY-JYangZ-ZQiX-RTumor specific delivery with redox-triggered mesoporous silica nanoparticles inducing neovascularization suppression and vascular normalizationRSC Adv20155685556655578
   Web of Science ®Google Scholar
• GaoKSunJLiuKLiuXHeZPreparation and characterization of a submicron lipid emulsion of docetaxel: submicron lipid emulsion of docetaxelDrug Dev Ind Pharm200834111227123718720137
   PubMed Web of Science ®Google Scholar
• KuppensIEBoschTMvan MaanenMJOral bioavailability of docetaxel in combination with OC144-093 (ONT-093)Cancer Chemother Pharmacol2005551727815316750
   PubMed Web of Science ®Google Scholar
• Ebrahim AttiaABOngZYHedrickJLMixed micelles self-assembled from block copolymers for drug deliveryCurr Opin Colloid Interface Sci2011163182194
   Web of Science ®Google Scholar
• HuCMZhangLTherapeutic nanoparticles to combat cancer drug resistanceCurr Drug Metab200910883684120214578
   PubMed Web of Science ®Google Scholar
• MouQMaYZhuXYanDA small molecule nanodrug consisting of amphiphilic targeting ligand-chemotherapy drug conjugate for targeted cancer therapyJ Control Release2016230344427040815
   PubMed Web of Science ®Google Scholar
• CortesJEPazdurRDocetaxelJ Clin Oncol19951310264326557595719
   PubMed Web of Science ®Google Scholar
• SubramaniamVChakrabartiRPrud’hommeGJJothySTranilast inhibits cell proliferation and migration and promotes apoptosis in murine breast cancerAnticancer Drugs201021435136120145538
   PubMed Web of Science ®Google Scholar
• ChakrabartiRSubramaniamVAbdallaSJothySPrud’hommeGJTranilast inhibits the growth and metastasis of mammary carcinomaAnticancer Drugs200920533434519322072
   PubMed Web of Science ®Google Scholar
• LiYJinMShaoSSmall-sized polymeric micelles incorporating docetaxel suppress distant metastases in the clinically-relevant 4T1 mouse breast cancer modelBMC Cancer20141432924885518
   PubMed Web of Science ®Google Scholar
• SubramaniamVChakrabartiRPrud’hommeGJJothySTranilast inhibits cell proliferation and migration and promotes apoptosis in murine breast cancerAnticancer Drugs201021435136120145538
   PubMed Web of Science ®Google Scholar
• ZhangJMiaoLGuoSSynergistic anti-tumor effects of combined gemcitabine and cisplatin nanoparticles in a stroma-rich bladder carcinoma modelJ Control Release20141821909624637468
   PubMed Web of Science ®Google Scholar
• KaushikSPickupMWWeaverVMFrom transformation to metastasis: deconstructing the extracellular matrix in breast cancerCancer Metastasis Rev201635465566727914000
   PubMed Web of Science ®Google Scholar
• PulaskiBATermanDSKhanSMullerEOstrand-RosenbergSCoop-erativity of Staphylococcal aureus enterotoxin B superantigen, major histocompatibility complex class II, and CD80 for immunotherapy of advanced spontaneous metastases in a clinically relevant postoperative mouse breast cancer modelCancer Res200060102710271510825145
   PubMed Web of Science ®Google Scholar
• WeaverVMPetersenOWWangFReversion of the malignant phenotype of human breast cells in three-dimensional culture and in vivo by integrin blocking antibodiesJ Cell Biol199713712312459105051
   PubMed Web of Science ®Google Scholar
• CukiermanECell migration analyses within fibroblast-derived 3-D matricesMethods Mol Biol2005294799315576907
   PubMedGoogle Scholar
• GaoWXiangBMengTTLiuFQiXRChemotherapeutic drug delivery to cancer cells using a combination of folate targeting and tumor microenvironment-sensitive polypeptidesBiomaterials201334164137414923453200
   PubMed Web of Science ®Google Scholar
• SckellASafabakhshNDellianMJainRKPrimary tumor size-dependent inhibition of angiogenesis at a secondary site: an intravital microscopic study in miceCancer Res19985824586658699865747
   PubMed Web of Science ®Google Scholar
• ThurstonGMcLeanJWRizenMCationic liposomes target angiogenic endothelial cells in tumors and chronic inflammation in miceJ Clin Invest19981017140114139525983
   PubMed Web of Science ®Google Scholar
• DebbagePLGriebelJRiedMGneitingTDevriesAHutzlerPLectin intravital perfusion studies in tumor-bearing mice: micrometer-resolution, wide-area mapping of microvascular labeling, distinguishing efficiently and inefficiently perfused microregions in the tumorJ Histochem Cytochem19984656276399562571
   PubMed Web of Science ®Google Scholar
• DvorakHFTumor stroma, tumor blood vessels, and antiangiogenesis therapyCancer J201521423724326222073
   PubMed Web of Science ®Google Scholar
• BaxterLTJainRKTransport of fluid and macromolecules in tumors. I. Role of interstitial pressure and convectionMicrovasc Res1989371771042646512
   PubMed Web of Science ®Google Scholar
• PulaskiBAClementsVKPipelingMROstrand-RosenbergSImmunotherapy with vaccines combining MHC class II/CD80+ tumor cells with interleukin-12 reduces established metastatic disease and stimulates immune effectors and monokine induced by interferon γCancer Immunol Immunother2000491344510782864
   PubMed Web of Science ®Google Scholar
• HeppnerGHMillerFRShekharPMNontransgenic models of breast cancerBreast Cancer Res20002533133411250725
   PubMed Web of Science ®Google Scholar
• ZhangCWinnardPTJrDasariSLabel-free Raman spectroscopy provides early determination and precise localization of breast cancer-colonized bone alterationsChem Sci20189374375329629144
   PubMed Web of Science ®Google Scholar
• MajidiniaMYousefiBBreast tumor stroma: A driving force in the development of resistance to therapiesChem Biol Drug Des201789330931828042683
   PubMed Web of Science ®Google Scholar
• RyanMCOrrDJAHorganKFibroblast stimulation of breast cancer cell growth in a serum-free systemBr J Cancer1993676126812738512812
   PubMed Web of Science ®Google Scholar
• BuschSAcarAMagnussonYGregerssonPRydénLLandbergGTGF-beta receptor type-2 expression in cancer-associated fibroblasts regulates breast cancer cell growth and survival and is a prognostic marker in pre-menopausal breast cancerOncogene2015341273824336330
   PubMed Web of Science ®Google Scholar
• SarinHPhysiologic upper limits of pore size of different blood capillary types and another perspective on the dual pore theory of microvascular permeabilityJ Angiogenes Res201021143320701757
   PubMedGoogle Scholar
• CabralHMatsumotoYMizunoKAccumulation of sub-100 nm polymeric micelles in poorly permeable tumours depends on sizeNat Nanotechnol201161281582322020122
   PubMed Web of Science ®Google Scholar
• ChauhanVPStylianopoulosTMartinJDNormalization of tumour blood vessels improves the delivery of nanomedicines in a size-dependent mannerNat Nanotechnol20127638338822484912
   PubMed Web of Science ®Google Scholar
• LielegOBaumgärtelRMBauschARSelective filtering of particles by the extracellular matrix: an electrostatic bandpassBiophys J20099761569157719751661
   PubMed Web of Science ®Google Scholar
• JainRKTongRTMunnLLEffect of vascular normalization by antiangiogenic therapy on interstitial hypertension, peritumor edema, and lymphatic metastasis: insights from a mathematical modelCancer Res20076762729273517363594
   PubMed Web of Science ®Google Scholar
• SwartzMAFleuryMEInterstitial flow and its effects in soft tissuesAnnu Rev Biomed Eng20079122925617459001
   PubMedGoogle Scholar
• ParaisoKHSmalleyKSFibroblast-mediated drug resistance in cancerBiochem Pharmacol20138581033104123376122
   PubMed Web of Science ®Google Scholar
• ProvenzanoPPHingoraniSRHyaluronan, fluid pressure and stromal resistance in pancreas cancerBr J Cancer201310811823299539
   PubMed Web of Science ®Google Scholar
• LiuJLiaoSDiop-FrimpongBTGF-β blockade improves the distribution and efficacy of therapeutics in breast carcinoma by normalizing the tumor stromaProc Natl Acad Sci U S A201210941166181662322996328
   PubMed Web of Science ®Google Scholar
• HanahanDFolkmanJPatterns and Emerging Mechanisms of the Angiogenic Switch during TumorigenesisCell19968633533648756718
   PubMed Web of Science ®Google Scholar
• JainRKNormalization of tumor vasculature: an emerging concept in antiangiogenic therapyScience20053075706586215637262
   PubMed Web of Science ®Google Scholar
• CavacoARezaeiMNilandSEbleJACollateral Damage Intended-Cancer-Associated Fibroblasts and Vasculature Are Potential Targets in Cancer TherapyInt J Mol Sci2017181123552398
   PubMed Web of Science ®Google Scholar
• Johansson-PercivalAHeBLiZJDe novo induction of intratumoral lymphoid structures and vessel normalization enhances immunotherapy in resistant tumorsNat Immunol201718111207121728892469
   PubMed Web of Science ®Google Scholar
• TaurinSNehoffHvan AswegenTGreishKTumor vasculature, EPR effect, and anticancer nanomedicine: connecting the dots In: Bae, Han Y, Mrsny, Randall J, Park Kinam, editors Cancer Targeted Drug DeliveryNew YorkSpringer2013207239
   Google Scholar
• MaedaHToward a full understanding of the EPR effect in primary and metastatic tumors as well as issues related to its heterogeneityAdv Drug Deliv Rev2015913625579058
   PubMed Web of Science ®Google Scholar
• XieFCaiWLiuYVaccarin attenuates the human EA.hy926 endothelial cell oxidative stress injury through inhibition of Notch signalingInt J Mol Med201535113514225352009
   PubMed Web of Science ®Google Scholar
• LiSDangYYOi Lam CheGVEGFR tyrosine kinase inhibitor II (VRI) induced vascular insufficiency in zebrafish as a model for studying vascular toxicity and vascular preservationToxicol Appl Pharmacol2014280340842025234792
   PubMed Web of Science ®Google Scholar
• DurrantDCorwinFSimoniDcis-3,4′,5-Trimethoxy-3′-aminostilbene disrupts tumor vascular perfusion without damaging normal organ perfusionCancer Chemother Pharmacol200963219120018365199
   PubMed Web of Science ®Google Scholar
• SuzawaHKikuchiSAraiNKodaAThe mechanism involved in the inhibitory action of tranilast on collagen biosynthesis of keloid fibroblastsJpn J Pharmacol199260291961282576
   PubMedGoogle Scholar
• KojimaYAcarAEatonENAutocrine TGF-beta and stromal cell-derived factor-1 (SDF-1) signaling drives the evolution of tumor-promoting mammary stromal myofibroblastsProc Natl Acad Sci U S A201010746200092001421041659
   PubMed Web of Science ®Google Scholar