Hypoxia-activated prodrugs and redox-responsive nanocarriers

References

• WilsonWRHayMPTargeting hypoxia in cancer therapyNat Rev Cancer201111639341021606941
   PubMed Web of Science ®Google Scholar
• SemenzaGLTargeting HIF-1 for cancer therapyNat Rev Cancer200331072173213130303
   PubMed Web of Science ®Google Scholar
• PenteaMButuMSamfiraICristinaRTButnariuMExtraction and analytical study of salvinorin from leaves of Salvia divinorumDig J Nanomater Bios2015101291297
   Web of Science ®Google Scholar
• PutnokySCauniiAButnariuMStudy on the stability and antioxidant effect of the Allium ursinum watery extractChem Cent J2013712123369571
   PubMedGoogle Scholar
• ChenYHuLDesign of anticancer prodrugs for reductive activationMed Res Rev2009291296418688784
   PubMed Web of Science ®Google Scholar
• ButnariuMDetection of the polyphenolic components in Ribes nigrum LAnn Agric Environ Med2014211111424742033
   PubMed Web of Science ®Google Scholar
• ButnariuMCauniiAPutnokySReverse phase chromatographic behaviour of major components in Capsicum Annuum extractChem Cent J20126114623206805
   PubMedGoogle Scholar
• RodinoSButuMNegoescuCCauniiACristinaRTButnariuMSpectrophotometric method for quantitative determination of nystatin antifungal agent in pharmaceutical formulationsDig J Nanomaterials Bios20149312151222
   Web of Science ®Google Scholar
• BarbatCRodinoSPetrachePButuMButnariuMMicroencapsulation of the allelochemical compounds and study of their release from different productsDig J Nanomater Bios201383945953
   Web of Science ®Google Scholar
• ButuALRodinoSGoleaDLiposomal nanodelivery system for proteasome inhibitor anticancer drug bortezomibFarmacia2015632224229
   Web of Science ®Google Scholar
• MengFHenninkWEZhongZReduction-sensitive polymers and bioconjugates for biomedical applicationsBiomaterials200930122180219819200596
   PubMed Web of Science ®Google Scholar
• ButnariuMGrozeaIAntioxidant (Antiradical) CompoundsJ Bioequiv Availab2012461719
   Google Scholar
• NegreaPCauniiASaracIButnariuMThe study of infrared spectrum of chitin and chitosan extract as potential sources of biomassDig J Nanomater Bios201510411291138
   Web of Science ®Google Scholar
• DennyWAHypoxia-activated prodrugs in cancer therapy: progress to the clinicFuture Oncol20106341942820222798
   PubMed Web of Science ®Google Scholar
• SiegelDYanCRossDNAD(P)H:quinone oxidoreductase 1 (NQO1) in the sensitivity and resistance to antitumor quinonesBiochem Pharmacol20128381033104022209713
   PubMed Web of Science ®Google Scholar
• XuSYaoHPeiLDesign, synthesis, and biological evaluation of NAD(P)H: Quinone oxidoreductase (NQO1)-targeted oridonin prodrugs possessing indolequinone moiety for hypoxia-selective activationEur J Med Chem201713231032128395199
   PubMed Web of Science ®Google Scholar
• InmanMMoodyCJSynthesis of Indolequinones from Bromo-quinones and Enamines Mediated by Cu(OAc)2⋅H2OJ Org Chem201075176023602620690687
   PubMed Web of Science ®Google Scholar
• HallBSMeredithELWilkinsonSRTargeting the substrate preference of a type I nitroreductase to develop antitrypanosomal quinone-based prodrugsAntimicrob Agents Chemother201256115821583022948871
   PubMed Web of Science ®Google Scholar
• LajinessJPRobertsonWMDunwiddieIDesign, synthesis, and evaluation of duocarmycin O-amino phenol prodrugs subject to tunable reductive activationJ Med Chem201053217731773820942408
   PubMed Web of Science ®Google Scholar
• SharmaKIyerASenguptaKChakrapaniHINDQ/NO, a bioreductively activated nitric oxide prodrugOrg Lett201315112636263923659457
   PubMed Web of Science ®Google Scholar
• HuangBDesaiATangSThomasTPBakerJRThe synthesis of a c(RGDyK) targeted SN38 prodrug with an indolequinone structure for bioreductive drug releaseOrg Lett20101271384138720192275
   PubMed Web of Science ®Google Scholar
• KumarRKimE-JHanJHypoxia-directed and activated theranostic agent: Imaging and treatment of solid tumorBiomaterials201610411912827449948
   PubMed Web of Science ®Google Scholar
• ZhuRBaumannRPPenkethPGShyamKSartorelliACHypoxia-Selective O6-Alkylguanine-DNA Alkyltransferase Inhibitors: Design, Synthesis, and Evaluation of 6-(Benzyloxy)-2-(aryldiazenyl)-9 H-purines as Prodrugs of O6-BenzylguanineJ Med Chem20135631355135923311288
   PubMed Web of Science ®Google Scholar
• ZhuRLiuM-CLuoM-Z4-Nitrobenzyloxycarbonyl Derivatives of O6-Benzylguanine as Hypoxia-Activated Prodrug Inhibitors of O6-Alkylguanine-DNA Alkyltransferase (AGT), Which Produces Resistance to Agents Targeting the O-6 Position of DNA GuanineJ Med Chem201154217720772821955333
   PubMed Web of Science ®Google Scholar
• ZhuRSeowHABaumannRPDesign of a hypoxia-activated prodrug inhibitor of O6-alkylguanine-DNA alkyltransferaseBioorg Med Chem Lett201222196242624722932317
   PubMed Web of Science ®Google Scholar
• Cazares-KörnerCPiresIMSwallowIDCH-01 is a hypoxia-activated prodrug that sensitizes cells to hypoxia/reoxygenation through inhibition of Chk1 and Aurora AACS Chem Biol2013871451145923597309
   PubMed Web of Science ®Google Scholar
• WolfeALDuncanKKParelkarNKBrownDVielhauerGABogerDLEfficacious cyclic N-acyl O-amino phenol duocarmycin prodrugsJ Med Chem201356104104411523627265
   PubMed Web of Science ®Google Scholar
• HeapyAMPattersonAVSmaillJBSynthesis and cytotoxicity of pyranonaphthoquinone natural product analogues under bioreductive conditionsBioorg Med Chem201321247971798024436995
   PubMed Web of Science ®Google Scholar
• MendozaMFHollabaughNMHettiarachchiSUMccarleyRLHuman NAD(P)H:quinone oxidoreductase type I (hNQO1) activation of quinone propionic acid trigger groupsBiochemistry201251408014802622989153
   PubMed Web of Science ®Google Scholar
• BaeJNaelMAJiangLQuinone propionic acid-based redox-triggered polymer nanoparticles for drug delivery: Computational analysis and in vitro evaluationJ Appl Polym Sci20141311340461
   Web of Science ®Google Scholar
• ChoHBaeJGarripelliVKAndersonJMJunHWJoSRedox-sensitive polymeric nanoparticles for drug deliveryChem Commun2012484860436045
   PubMed Web of Science ®Google Scholar
• ÇelikAYetişGAn unusually cold active nitroreductase for prodrug activationsBioorg Med Chem201220113540355022546205
   PubMed Web of Science ®Google Scholar
• BenitoJShiYSzymanskaBPronounced hypoxia in models of murine and human leukemia: high efficacy of hypoxia-activated prodrug PR-104PLoS One201168e2310821853076
   PubMed Web of Science ®Google Scholar
• Karnthaler-BenbakkaCGrozaDKoblmüllerBTargeting a targeted drug: an approach toward hypoxia-activatable tyrosine kinase inhibitor prodrugsChemMedChem201611212410242127706901
   PubMed Web of Science ®Google Scholar
• MengFEvansJWBhupathiDMolecular and cellular pharmacology of the hypoxia-activated prodrug TH-302Mol Cancer Ther201211374075122147748
   PubMed Web of Science ®Google Scholar
• LiuQSunJDWangJTH-302, a hypoxia-activated prodrug with broad in vivo preclinical combination therapy efficacy: optimization of dosing regimens and schedulesCancer Chemother Pharmacol20126961487149822382881
   PubMed Web of Science ®Google Scholar
• HuJvan ValckenborghEXuDSynergistic induction of apoptosis in multiple myeloma cells by bortezomib and hypoxia-activated prodrug TH-302, in vivo and in vitroMol Cancer Ther20131291763177323832122
   PubMed Web of Science ®Google Scholar
• WangJFoehrenbacherASuJThe 2-nitroimidazole EF5 is a biomarker for oxidoreductases that activate the bioreductive prodrug CEN-209 under hypoxiaClin Cancer Res20121861684169522167409
   PubMed Web of Science ®Google Scholar
• HunterFWWangJPatelRHomologous recombination repair-dependent cytotoxicity of the benzotriazine di-N-oxide CEN-209: comparison with other hypoxia-activated prodrugsBiochem Pharmacol201283557458522182429
   PubMed Web of Science ®Google Scholar
• DragovichPSBroccatelliFChenJDesign, synthesis, and biological evaluation of pyrrolobenzodiazepine-containing hypoxia-activated prodrugsBioorg Med Chem Lett201727235300530429079474
   PubMed Web of Science ®Google Scholar
• YamazakiHLaiYCTatenoMHypoxia-activated prodrug TH-302 decreased survival rate of canine lymphoma cells under hypoxic conditionPLoS One2017125e017730528489881
   PubMed Web of Science ®Google Scholar
• TakakusagiYKishimotoSNazSRadiotherapy Synergizes with the Hypoxia-Activated Prodrug Evofosfamide: In Vitro and In Vivo StudiesAntioxid Redox Signal201828213114028741367
   PubMed Web of Science ®Google Scholar
• WojtkowiakJWCornnellHCMatsumotoSPyruvate sensitizes pancreatic tumors to hypoxia-activated prodrug TH-302Cancer Metab201531225635223
   PubMedGoogle Scholar
• LohseIRasowskiJCaoPTargeting hypoxic microenvironment of pancreatic xenografts with the hypoxia-activated prodrug TH-302Oncotarget2016723335713358027248663
   PubMedGoogle Scholar
• HajjCRussellJHartCPA Combination of Radiation and the Hypoxia-Activated Prodrug Evofosfamide (TH-302) is Efficacious against a Human Orthotopic Pancreatic Tumor ModelTransl Oncol201710576076528778024
   PubMed Web of Science ®Google Scholar
• LiapisVLabrinidisAZinonosIHypoxia-activated pro-drug TH-302 exhibits potent tumor suppressive activity and cooperates with chemotherapy against osteosarcomaCancer Lett2015357116016925444931
   PubMed Web of Science ®Google Scholar
• BaumannRPPenkethPGIshiguroKShyamKZhuYLSartorelliACReductive activation of the prodrug 1,2-bis(methylsulfonyl)-1-(2-chloroethyl)-2-[[1-(4-nitrophenyl)ethoxy]carbonyl]hydrazine (KS119) selectively occurs in oxygen-deficient cells and overcomes O6-alkylguanine-DNA alkyltransferase mediated KS119 tumor cell resistanceBiochem Pharmacol201079111553156120005211
   PubMed Web of Science ®Google Scholar
• LindquistKECranJDKordicKSelective radiosensitization of hypoxic cells using BCCA621C: a novel hypoxia activated prodrug targeting DNA-dependent protein kinaseTumor Microenvironment and Therapy201314655
   Google Scholar
• FuJLiuLHuangZHybrid Molecule from O2-(2,4-Dinitrophe-nyl)diazeniumdiolate and Oleanolic Acid: A Glutathione S-Transferase π-Activated Nitric Oxide Prodrug with Selective Anti-Human Hepa-tocellular Carcinoma Activity and Improved StabilityJ Med Chem201356114641465523617697
   PubMed Web of Science ®Google Scholar
• ChengWYuanYQiuNPengPShengRHuYIdentification of novel 4-anilinoquinazoline derivatives as potent EGFR inhibitors both under normoxia and hypoxiaBioorg Med Chem201422246796680525468044
   PubMed Web of Science ®Google Scholar
• StevensonRJDennyWATercelMPruijnFBAshoorzadehANitro seco analogues of the duocarmycins containing sulfonate leaving groups as hypoxia-activated prodrugs for cancer therapyJ Med Chem20125562780280222339090
   PubMed Web of Science ®Google Scholar
• JohnsonKMParsonsZDBarnesCLGatesKSToward hypoxia-selective DNA-alkylating agents built by grafting nitrogen mustards onto the bioreductively activated, hypoxia-selective DNA-oxidizing agent 3-amino-1,2,4-benzotriazine 1,4-dioxide (tirapazamine)J Org Chem201479167520753125029663
   PubMed Web of Science ®Google Scholar
• HicksKOSiimBGJaiswalJKPharmacokinetic/pharmaco-dynamic modeling identifies SN30000 and SN29751 as tirapazamine analogues with improved tissue penetration and hypoxic cell killing in tumorsClin Cancer Res201016204946495720732963
   PubMed Web of Science ®Google Scholar
• ShenXRajapakseAGallazziFIsotopic labeling experiments that elucidate the mechanism of DNA strand cleavage by the hypoxia-selective antitumor agent 1,2,4-benzotriazine 1,4-di-N-oxideChem Res Toxicol201427111111824328261
   PubMed Web of Science ®Google Scholar
• WilliamsKJAlbertellaMRFitzpatrickBIn vivo activation of the hypoxia-targeted cytotoxin AQ4N in human tumor xenograftsMol Cancer Ther20098123266327519996276
   PubMed Web of Science ®Google Scholar
• NesbittHWorthingtonJErringtonRJThe unidirectional hypoxia-activated prodrug OCT1002 inhibits growth and vascular development in castrate-resistant prostate tumorsProstate201777151539154728944496
   PubMed Web of Science ®Google Scholar
• NesbittHByrneNMWilliamsSNTargeting Hypoxic Prostate Tumors Using the Novel Hypoxia-Activated Prodrug OCT1002 Inhibits Expression of Genes Associated with Malignant ProgressionClin Cancer Res20172371797180827697998
   PubMed Web of Science ®Google Scholar
• FengLChengLDongZTheranostic Liposomes with Hypoxia-Activated Prodrug to Effectively Destruct Hypoxic Tumors Post-Photodynamic TherapyACS Nano201711192793728027442
   PubMed Web of Science ®Google Scholar
• ShenSWuYLiKVersatile hyaluronic acid modified AQ4N-Cu(II)-gossypol infinite coordination polymer nanoparticles: Multiple tumor targeting, highly efficient synergistic chemotherapy, and real-time self-monitoringBiomaterials201815419721229128847
   PubMed Web of Science ®Google Scholar
• LavaggiMLCabreraMCelanoLThomsonLCerecettoHGonzálezMBiotransformation of Phenazine 5,10-Dioxides under Hypoxic Conditions as an Example of Activation of Anticancer Prod-rug: An Interdisciplinary Experiment for Biochemistry or Organic ChemistryJ Chem Educ2013901013881391
   Web of Science ®Google Scholar
• ChowdhuryGSarkarUPullenSDNA strand cleavage by the phenazine di-N-oxide natural product myxin under both aerobic and anaerobic conditionsChem Res Toxicol201225119720622084973
   PubMed Web of Science ®Google Scholar
• LavaggiMLCabreraMPintosCNovel Phenazine 5,10-Dioxides Release ⋅OH in Simulated Hypoxia and Induce Reduction of Tumour Volume In VivoISRN Pharmacol201120116111
   Google Scholar
• GondaMNievesMNunesEPhenazine N,N′-dioxide scaffold as selective hypoxic cytotoxin pharmacophore. Structural modifications looking for further DNA topoisomerase II-inhibition activityMedChemComm201343595607
   Web of Science ®Google Scholar
• LavaggiMLNievesMCabreraMStructural modifications on the phenazine N,N′-dioxide-scaffold looking for new selective hypoxic cytotoxinsEur J Med Chem201045115362536920846761
   PubMed Web of Science ®Google Scholar
• YadavPMarshallAJReynissonJDennyWAHayMPAndersonRFFragmentation of the quinoxaline N-oxide bond to the ˙OH radical upon one-electron bioreductionChem Commun201450891372913731
   PubMed Web of Science ®Google Scholar
• HeffernMCYamamotoNHolbrookRJEckermannALMeadeTJCobalt derivatives as promising therapeutic agentsCurr Opin Chem Biol201317218919623270779
   PubMed Web of Science ®Google Scholar
• GrafNLippardSJRedox activation of metal-based prodrugs as a strategy for drug deliveryAdv Drug Deliv Rev20126411993100422289471
   PubMed Web of Science ®Google Scholar
• YamamotoNRenfrewAKKimBJBryceNSHambleyTWDual targeting of hypoxic and acidic tumor environments with a cobalt(III) chaperone complexJ Med Chem20125524110131102123199008
   PubMed Web of Science ®Google Scholar
• KimBJHambleyTWBryceNSVisualising the hypoxia selectivity of cobalt(III) prodrugsChem Sci201121121352142
   Web of Science ®Google Scholar
• Karnthaler-BenbakkaCGrozaDKryeziuKTumor-targeting of EGFR inhibitors by hypoxia-mediated activationAngew Chem Int Edit201453471293012935
   PubMed Web of Science ®Google Scholar
• ChangJY-CLuG-LStevensonRJCross-Bridged Cyclen or Cyclam Co(III) Complexes Containing Cytotoxic Ligands as Hypoxia-Activated ProdrugsInorg Chem201352137688769823773210
   PubMed Web of Science ®Google Scholar
• BustamanteFLSMirandaFSCastroFAVResendeJALCPereiraMDLanznasterMA study on the properties and reactivity of naphthoquinone–cobalt(III) prototypes for bioreductive prodrugsJ Inorg Biochem2014132374424326134
   PubMed Web of Science ®Google Scholar
• G-LLStevensonRJChangJY-CTercel M. N-alkylated cyclen cobalt (III) complexes of 1-(chloromethyl)-3-(5,6,7-trimethoxyindol-2-ylcarbonyl)-2,3-dihydro-1H-pyrrolo [3,2-f] quinolin-5-ol DNA alkylating agent as hypoxia-activated prodrugsBioorg Med Chem201119164861486721775153
   PubMed Web of Science ®Google Scholar
• LinQBaoCYangYHighly Discriminating Photorelease of Anticancer Drugs Based on Hypoxia Activatable Phototrigger Conjugated Chitosan NanoparticlesAdv Mater201325141981198623401259
   PubMed Web of Science ®Google Scholar
• ThambiTDeepaganVGYoonHYHypoxia-responsive polymeric nanoparticles for tumor-targeted drug deliveryBiomaterials20143551735174324290696
   PubMed Web of Science ®Google Scholar
• PercheFBiswasSWangTZhuLTorchilinVHypoxia-Targeted siRNA DeliveryAngew Chem20141261334303434
   Google Scholar
• NakahataMTakashimaYYamaguchiHHaradaARedox-responsive self-healing materials formed from host–guest polymersNat Commun20112151122027591
   PubMedGoogle Scholar
• StaffRHGalleiMMazurowskiMPatchy Nanocapsules of Poly(vinylferrocene)-Based Block Copolymers for Redox-Responsive ReleaseACS Nano20126109042904923020219
   PubMed Web of Science ®Google Scholar
• HanLZhangX-YWangY-LRedox-responsive theranostic nanoplatforms based on inorganic nanomaterialsJ Control Release2017259405228288893
   PubMed Web of Science ®Google Scholar
• YangHYLiYLeeDSMultifunctional and Stimuli-Responsive Magnetic Nanoparticle-Based Delivery Systems for Biomedical ApplicationsAdvanced Therapeutics2018121800011
   Google Scholar
• StephenZRKievitFMVeisehORedox-Responsive Magnetic Nanoparticle for Targeted Convection-Enhanced Delivery of O6-Benzylguanine to Brain TumorsACS Nano2014810103831039525247850
   PubMed Web of Science ®Google Scholar
• NehateCAji AlexMRKumarAKoulVCombinatorial delivery of superparamagnetic iron oxide nanoparticles (γFe2 O3) and doxorubicin using folate conjugated redox sensitive multiblock polymeric nanocarriers for enhancing the chemotherapeutic efficacy in cancer cellsMater Sci Eng C Mater Biol Appl2017751128114328415398
   PubMed Web of Science ®Google Scholar
• LiuJChenQZhuWNanoscale-Coordination-Polymer-Shelled Manganese Dioxide Composite Nanoparticles. A Multistage Redox/pH/H2O2-Responsive Cancer Theranostic NanoplatformAdv Funct Mater201727101605926
   Web of Science ®Google Scholar
• ZhaoSYuQPanJRedox-responsive mesoporous selenium delivery of doxorubicin targets MCF-7 cells and synergistically enhances its anti-tumor activityActa Biomater20175429430628267598
   PubMed Web of Science ®Google Scholar
• ZhaiSHuXHuYWuBXingDVisible light-induced crosslinking and physiological stabilization of diselenide-rich nanoparticles for redox-responsive drug release and combination chemotherapyBiomaterials2017121415428068593
   PubMed Web of Science ®Google Scholar
• BehrooziFAbdkhodaieMJAbandansariHSEngineering Folate-Targeting Diselenide-containing Triblock Copolymer as a Redox-Responsive Shell-sheddable Micelle for Antitumor Therapy In VivoActa Biomater2018
   PubMed Web of Science ®Google Scholar
• ChengRFengFMengFDengCFeijenJZhongZGlutathione-responsive nano-vehicles as a promising platform for targeted intracellular drug and gene deliveryJ Control Release2011152121221295087
   PubMed Web of Science ®Google Scholar
• LeeMHYangZLimCWDisulfide-cleavage-triggered chemosensors and their biological applicationsChem Rev201311375071510923577659
   PubMed Web of Science ®Google Scholar
• WeiHZhuoR-XZhangX-ZDesign and development of polymeric micelles with cleavable links for intracellular drug deliveryProg Polym Sci2013383–4503535
   Web of Science ®Google Scholar
• DispinarTvan CampWde CockLJde GeestBGdu PrezFERedox-Responsive Degradable PEG Cryogels as Potential Cell Scaffolds in Tissue EngineeringMacromol Biosci201212338339422223302
   PubMed Web of Science ®Google Scholar
• WenHDongCDongHEngineered Redox-Responsive PEG Detachment Mechanism in PEGylated Nano-Graphene Oxide for Intracellular Drug DeliverySmall20128576076922228696
   PubMed Web of Science ®Google Scholar
• XiongHGuoZZhangWZhongHLiuSJiYRedox-responsive biodegradable PEGylated nanographene oxide for efficiently chemophotothermal therapy: a comparative study with non-biodegradable PEGylated nanographene oxideJ Photochem Photobiol B201413819120124976623
   PubMed Web of Science ®Google Scholar
• WuXSunXGuoZIn vivo and in situ tracking cancer chemotherapy by highly photostable NIR fluorescent theranostic prodrugJ Am Chem Soc201413693579358824524232
   PubMed Web of Science ®Google Scholar
• CuiCXueY-NWuMCellular uptake, intracellular trafficking, and antitumor efficacy of doxorubicin-loaded reduction-sensitive micellesBiomaterials201334153858386923452389
   PubMed Web of Science ®Google Scholar
• van der VliesAJHasegawaUHubbellJAReduction-sensitive tioguanine prodrug micellesMol Pharm20129102812281822954101
   PubMed Web of Science ®Google Scholar
• ChangBChenDWangYBioresponsive Controlled Drug Release Based on Mesoporous Silica Nanoparticles Coated with Reductively Sheddable Polymer ShellChem Mater2013254574585
   Web of Science ®Google Scholar
• YangQTanLHeCRedox-responsive micelles self-assembled from dynamic covalent block copolymers for intracellular drug deliveryActa Biomater20151719320025662913
   PubMed Web of Science ®Google Scholar
• ZhangPZhangHHeWZhaoDSongALuanYDisulfide-Linked Amphiphilic Polymer-Docetaxel Conjugates Assembled Redox-Sensitive Micelles for Efficient Antitumor Drug DeliveryBiomacromolecules20161751621163227018501
   PubMed Web of Science ®Google Scholar
• ChenCZhengPCaoZPEGylated hyperbranched polyphosphoester based nanocarriers for redox-responsive delivery of doxorubicinBiomater Sci20164341241726626655
   PubMed Web of Science ®Google Scholar
• TuYPengFWhitePBWilsonDARedox-Sensitive Stomatocyte Nanomotors: Destruction and Drug Release in the Presence of Glu-tathioneAngew Chem Int Edit2017562676207624
   PubMed Web of Science ®Google Scholar
• TangZZhangLWangYLiDZhongZZhouSRedox-responsive star-shaped magnetic micelles with active-targeted and magnetic-guided functions for cancer therapyActa Biomater20164223224627373437
   PubMed Web of Science ®Google Scholar
• ConteCMastrottoFTarescoVEnhanced uptake in 2D- and 3D-lung cancer cell models of redox responsive PEGylated nanoparticles with sensitivity to reducing extra- and intracellular environmentsJ Control Release201827712614129534890
   PubMed Web of Science ®Google Scholar
• ZhangYGuoZCaoZEndogenous albumin-mediated delivery of redox-responsive paclitaxel-loaded micelles for targeted cancer therapyBiomaterials201818324325730179775
   PubMed Web of Science ®Google Scholar
• XiaYWangNQinZPolycarbonate-based core-crosslinked redox-responsive nanoparticles for targeted delivery of anticancer drugJ Mater Chem B201862033483357
   PubMed Web of Science ®Google Scholar
• SunPZhouDGanZNovel reduction-sensitive micelles for triggered intracellular drug releaseJ Control Release201115519610321075151
   PubMed Web of Science ®Google Scholar
• KimJOSahayGKabanovAVBronichTKPolymeric micelles with ionic cores containing biodegradable cross-links for delivery of chemotherapeutic agentsBiomacromolecules201011491992620307096
   PubMed Web of Science ®Google Scholar
• ChenWZouYJiaJFunctional Poly(ε-caprolactone)s via Copolymerization of ε-Caprolactone and Pyridyl Disulfide- Containing Cyclic Carbonate: Controlled Synthesis and Facile Access to Reduction-Sensitive Biodegradable Graft Copolymer MicellesMacromolecules2013463699707
   Web of Science ®Google Scholar
• TangLYWangYCLiYDuJZWangJShell-detachable micelles based on disulfide-linked block copolymer as potential carrier for intracellular drug deliveryBioconjugate Chem200920610951099
   PubMed Web of Science ®Google Scholar
• LiJHuoMWangJRedox-sensitive micelles self-assembled from amphiphilic hyaluronic acid-deoxycholic acid conjugates for targeted intracellular delivery of paclitaxelBiomaterials20123372310232022166223
   PubMed Web of Science ®Google Scholar
• KimHMunSChoiYPhotosensitizer-conjugated polymeric nanoparticles for redox-responsive fluorescence imaging and photodynamic therapyJ Mater Chem B201314429431
   PubMed Web of Science ®Google Scholar
• HanHSChoiKYKoHBioreducible core-crosslinked hyaluronic acid micelle for targeted cancer therapyJ Control Release201520015816625550153
   PubMed Web of Science ®Google Scholar
• HeYChengGXieLNieYHeBGuZPolyethyleneimine/DNA poly-plexes with reduction-sensitive hyaluronic acid derivatives shielding for targeted gene deliveryBiomaterials20133441235124523127334
   PubMed Web of Science ®Google Scholar
• YehP-HSunJ-SWuH-CHwangL-HWangT-WStimuli-responsive HA-PEI nanoparticles encapsulating endostatin plasmid for stem cell gene therapyRSC Adv20133311292212932
   Web of Science ®Google Scholar
• HaoYWangLZhangBManganese dioxide nanosheets-based redox/pH-responsive drug delivery system for cancer theranostic applicationInt J Nanomedicine2016111759177827199556
   PubMed Web of Science ®Google Scholar
• CarvalhoAMTeixeiraRNovoa-CarballalRPiresRAReisRLPashkulevaIRedox-responsive micellar nanoparticles from gly-cosaminoglycans for CD44 targeted drug deliveryBiomacromolecules20181972991299929758159
   PubMed Web of Science ®Google Scholar
• SuYHuYduYRedox-responsive polymer-drug conjugates based on doxorubicin and chitosan oligosaccharide-g-stearic acid for cancer therapyMol Pharm20151241193120225751168
   PubMedGoogle Scholar
• ZhuangYDengHSuYAptamer-Functionalized and Backbone Redox-Responsive Hyperbranched Polymer for Targeted Drug Delivery in Cancer TherapyBiomacromolecules20161762050206227113017
   PubMed Web of Science ®Google Scholar
• SunJLiuYChenYDoxorubicin delivered by a redox-responsive dasatinib-containing polymeric prodrug carrier for combination therapyJ Control Release2017258435528501705
   PubMed Web of Science ®Google Scholar
• YuLChenYLinHduWChenHShiJUltrasmall mesoporous organosilica nanoparticles: Morphology modulations and redox-responsive biodegradability for tumor-specific drug deliveryBiomaterials201816129230529427925
   PubMed Web of Science ®Google Scholar
• WuMMengQChenYLarge pore-sized hollow mesoporous organosilica for redox-responsive gene delivery and synergistic cancer chemotherapyAdv Mater201628101963196926743228
   PubMed Web of Science ®Google Scholar
• ZhangQShenCZhaoNXuF-JRedox-Responsive and Drug-Embedded Silica Nanoparticles with Unique Self-Destruction Features for Efficient Gene/Drug CodeliveryAdv Funct Mater201727101606229
   Web of Science ®Google Scholar
• XiaoDJiaHZMaNZhuoRXZhangXZA redox-responsive mesoporous silica nanoparticle capped with amphiphilic peptides by self-assembly for cancer targeting drug deliveryNanoscale2015722100711007725978679
   PubMed Web of Science ®Google Scholar
• XiaoDHuJJZhuJYWangSBZhuoRXZhangXZA redox-responsive mesoporous silica nanoparticle with a therapeutic peptide shell for tumor targeting synergistic therapyNanoscale2016837167021670927714082
   PubMed Web of Science ®Google Scholar
• TianYGuoRJiaoYRedox stimuli-responsive hollow mesoporous silica nanocarriers for targeted drug delivery in cancer therapyNanoscale Horiz201616480487
   PubMed Web of Science ®Google Scholar
• ZhaoSXuMCaoCYuQZhouYLiuJA Redox-Responsive Strategy Using Mesoporous Silica NPs for Co-delivery of siRNA and DoxorubicinJ Mater Chem B201753369086919
   PubMed Web of Science ®Google Scholar
• GaoLFeiJZhaoJCuiWCuiYLiJpH- and redox-responsive polysaccharide-based microcapsules with autofluorescence for biomedical applicationsChem Eur J201218113185319222344618
   PubMed Web of Science ®Google Scholar
• Remant BahadurKCThapaBXuPpH and redox dual responsive nanoparticle for nuclear targeted drug deliveryMol Pharm2012992719272922876763
   PubMed Web of Science ®Google Scholar
• WuLZouYDengCChengRMengFZhongZIntracellular release of doxorubicin from core-crosslinked polypeptide micelles triggered by both pH and reduction conditionsBiomaterials201334215262527223570719
   PubMed Web of Science ®Google Scholar
• AngCYTanSYTehCRedox and pH Dual Responsive Polymer Based Nanoparticles for In Vivo Drug DeliverySmall20171371602379
   Web of Science ®Google Scholar
• JohnJVUthamanSAugustineRChenHParkI-KKimIpH/redox dual stimuli-responsive sheddable nanodaisies for efficient intracellular tumour-triggered drug deliveryJ Mater Chem B201752550275036
   PubMed Web of Science ®Google Scholar
• Aji AlexMRNehateCVeeranarayananSKumarDSKulshreshthaRKoulVSelf assembled dual responsive micelles stabilized with protein for co-delivery of drug and siRNA in cancer therapyBiomaterials20171339410628433941
   PubMed Web of Science ®Google Scholar
• LinCJKuanCHWangLWIntegrated self-assembling drug delivery system possessing dual responsive and active targeting for orthotopic ovarian cancer theranosticsBiomaterials201690122626974704
   PubMed Web of Science ®Google Scholar
• LiYLiYZhangXSupramolecular PEGylated Dendritic Systems as pH/Redox Dual-Responsive Theranostic Nanoplatforms for Platinum Drug Delivery and NIR ImagingTheranostics2016691293130527375780
   PubMed Web of Science ®Google Scholar
• TeoJYChinWKeXpH and redox dual-responsive biodegradable polymeric micelles with high drug loading for effective anticancer drug deliveryNanomed Nanotechnol Biol Med2017132431442
   PubMed Web of Science ®Google Scholar
• HuWQiuLChengLRedox and pH dual responsive poly(amidoamine) dendrimer-poly(ethylene glycol) conjugates for intracellular delivery of doxorubicinActa Biomater20163624125326995505
   PubMed Web of Science ®Google Scholar
• GuoYNiuBSongQRGD-decorated redox-responsive d-α-tocopherol polyethylene glycol succinate–poly(lactide) nanoparticles for targeted drug deliveryJ Mater Chem B201641323382350
   PubMed Web of Science ®Google Scholar
• ChiYYinXSunKRedox-sensitive and hyaluronic acid func-tionalized liposomes for cytoplasmic drug delivery to osteosarcoma in animal modelsJ Control Release201726111312528666726
   PubMed Web of Science ®Google Scholar
• ZhangSWangDLiYpH- and redox-responsive nanoparticles composed of charge-reversible pullulan-based shells and disulfide-containing poly(β-amino ester) cores for co-delivery of a gene and chemotherapeutic agentNanotechnology2018293232510129761789
   PubMed Web of Science ®Google Scholar
• LuoCSunJLiuDSelf-Assembled Redox Dual-Responsive Prodrug-Nanosystem Formed by Single Thioether-Bridged Paclitaxel-Fatty Acid Conjugate for Cancer ChemotherapyNano Lett20161695401540827490088
   PubMed Web of Science ®Google Scholar
• LiYHuHZhouQα-Amylase- and Redox-Responsive Nanoparticles for Tumor-Targeted Drug DeliveryACS Appl Mater Interfaces2017922192151923028513132
   PubMed Web of Science ®Google Scholar
• JiaXZhangYZouYDual Intratumoral Redox/Enzyme-Responsive NO-Releasing Nanomedicine for the Specific, High-Efficacy, and Low-Toxic Cancer TherapyAdv Mater20183030e170449029889325
   PubMed Web of Science ®Google Scholar
• JiangXLiLLiuJHenninkWEZhuoRFacile fabrication of thermo-responsive and reduction-sensitive polymeric micelles for anticancer drug deliveryMacromol Biosci201212570371122496064
   PubMed Web of Science ®Google Scholar
• HuangXJiangXYangQTriple-stimuli (pH/thermo/reduction) sensitive copolymers for intracellular drug deliveryJ Mater Chem B201311318601868
   PubMed Web of Science ®Google Scholar
• ZhaoCShaoLLuJTriple Redox Responsive Poly(Ethylene Glycol)-Polycaprolactone Polymeric Nanocarriers for Fine-Controlled Drug ReleaseMacromol Biosci20171741600295
   Web of Science ®Google Scholar
• QiuLZhaoYLiBWangZCaoLSunLTriple-stimuli (protease/redox/pH) sensitive porous silica nanocarriers for drug deliverySens Actuators B Chem201724010661074
   Web of Science ®Google Scholar
• AlimoradiHMatikondaSSGambleABGilesGIGreishKHypoxia responsive drug delivery systems in tumor therapyCurr Pharm Des201622192808282026898739
   PubMed Web of Science ®Google Scholar
• ThambiTParkJHLeeDSHypoxia-responsive nanocarriers for cancer imaging and therapy: recent approaches and future perspectivesChem Commun2016525584928500
   PubMed Web of Science ®Google Scholar