References
- VaupelPKelleherDKHöckelMOxygen status of malignant tumors: pathogenesis of hypoxia and significance for tumor therapySemin Oncol2001282 Suppl 82935
- VaupelPSchlengerKKnoopCHöckelMOxygenation of human tumors: evaluation of tissue oxygen distribution in breast cancers by computerized O2 tension measurementsCancer Res19915112331633222040005
- HockelMSchlengerKAralBAssociation between tumor hypoxia and malignant progression in advanced cancer of the uterine cervixCancer Res19965619450945158813149
- SemenzaGLTargeting HIF-1 for cancer therapyNat Rev Cancer200331072173213130303
- MinchintonAITannockIFDrug penetration in solid tumoursNat Rev Cancer20066858359216862189
- ReySSchitoLKoritzinskyMWoutersBGMolecular targeting of hypoxia in radiotherapyAdv Drug Deliv Rev2017109456227771366
- YaoYZhangMLiuTPerfluorocarbon-encapsulated PLGA-PEG emulsions as enhancement agents for highly efficient reoxygenation to cell and organismACS Appl Mater Interfaces2015733183691837826222132
- BrownJMWilsonWRExploiting tumour hypoxia in cancer treatmentNat Rev Cancer20044643744715170446
- CarmelietPJainRKMolecular mechanisms and clinical applications of angiogenesisNature2011473734729830721593862
- HorsmanMRMortensenLSPetersenJBBuskMOvergaardJImaging hypoxia to improve radiotherapy outcomeNat Rev Clin Oncol201291267468723149893
- WilsonWRHayMPTargeting hypoxia in cancer therapyNat Rev Cancer201111639341021606941
- TeicherBARoseCMOxygen-carrying perfluorochemical emulsion as an adjuvant to radiation therapy in miceCancer Res19844410428542886467189
- TeicherBARoseCMPerfluorochemical emulsions can increase tumor radiosensitivityScience198422346399349366695191
- HartzlerGORutherfordBDMcconahayDRJohnsonWLGiorgiLV“High-risk” percutaneous transluminal coronary angioplastyAm J Cardiol1988611433G37G
- TeicherBAHoldenSAAraGDupuisNPGoffDRestoration of tumor oxygenation after cytotoxic therapy by a perflubron emulsion/carbogen breathingCancer J Sci Am19951143489166453
- FeldmanLAFabreMSGrassoCPerfluorocarbon emulsions radiosensitise brain tumors in carbogen breathing mice with orthotopic GL261 gliomasPLoS ONE2017129e018425028873460
- WoutersBGBrownJMCells at intermediate oxygen levels can be more important than the “hypoxic fraction” in determining tumor response to fractionated radiotherapyRadiat Res199714755415509146699
- LeeHYKimHWLeeJHOhSHControlling oxygen release from hollow microparticles for prolonged cell survival under hypoxic environmentBiomaterials20155358359125890754
- ChengYChengHJiangCPerfluorocarbon nanoparticles enhance reactive oxygen levels and tumour growth inhibition in photodynamic therapyNat Commun20156878526525216
- SongGLiangCYiXPerfluorocarbon-loaded hollow Bi2Se3 nanoparticles for timely supply of oxygen under near-infrared light to enhance the radiotherapy of cancerAdv Mater201628142716272326848553
- SongGJiCLiangCTaOx decorated perfluorocarbon nanodroplets as oxygen reservoirs to overcome tumor hypoxia and enhance cancer radiotherapyBiomaterials201711225726327768978
- PorterTKricsfeldDCheathamSLiSEffect of blood and microbubble oxygen and nitrogen content on perfluorocarbon-filled dextrose albumin microbubble size and efficacy: in vitro and in vivo studiesJ Am Soc Echocardiogr19981154214259619612
- SwansonEJMohanVKheirJBordenMAPhospholipid-stabilized microbubble foam for injectable oxygen deliveryLangmuir20102620157261572920873807
- CavalliRBisazzaARolfoAUltrasound-mediated oxygen delivery from chitosan nanobubblesInt J Pharm20093781–221521719501639
- EisenbreyJRAlbalaLKramerMRDevelopment of an ultrasound sensitive oxygen carrier for oxygen delivery to hypoxic tissueInt J Pharm2015478136136725448552
- KwanJJKayaMBordenMADaytonPATheranostic oxygen delivery using ultrasound and microbubblesTheranostics20122121174118423382774
- SongXFengLLiangCYangKLiuZUltrasound triggered tumor oxygenation with oxygen-shuttle nanoperfluorocarbon to overcome hypoxia-associated resistance in cancer therapiesNano Lett201616106145615327622835
- WangPLiXYaoCOrthogonal near-infrared upconversion co-regulated site-specific O2 delivery and photodynamic therapy for hypoxia tumor by using red blood cell microcarriersBiomaterials20171259010028235648
- IshidaTMasudaKIchikawaTAccelerated clearance of a second injection of PEGylated liposomes in miceInt J Pharm20032551–216717412672612
- GaoMLiangCSongXErythrocyte-membrane-enveloped perfluorocarbon as nanoscale artificial red blood cells to relieve tumor hypoxia and enhance cancer radiotherapyAdv Mater201729351701429
- RenHLiuJLiYOxygen self-enriched nanoparticles functionalized with erythrocyte membranes for long circulation and enhanced phototherapyActa Biomater20175926928228663143
- KuangYBalakrishnanKGandhiVPengXHydrogen peroxide inducible DNA cross-linking agents: targeted anticancer prodrugsJ Am Chem Soc201113348192781928122035519
- AbbasiAZGordijoCRAminiMAHybrid manganese dioxide nanoparticles potentiate radiation therapy by modulating tumor hypoxiaCancer Res201676226643665627758881
- ChoMHChoiEKimSGohSChoiYRedox-responsive manganese dioxide nanoparticles for enhanced MR imaging and radiotherapy of lung cancerFront Chem2017510929255705
- HuangFXiaFA smart photodynamic therapy strategy: depletion of glutathione in cancer cellsSci Bull2017625312313
- TianLChenQYiXAlbumin-templated manganese dioxide nanoparticles for enhanced radioisotope therapySmall201713251700640
- FanWBuWShenBIntelligent MnO2 nanosheets anchored with upconversion nanoprobes for concurrent pH-/H2O2-responsive UCL imaging and oxygen-elevated synergetic therapyAdv Mater2015272841554161
- YangGZhangRLiangCManganese dioxide coated WS2@ Fe3O4/sSiO2 nanocomposites for pH-responsive MR imaging and oxygen-elevated synergetic therapySmall2018142
- YiXChenLZhongXCore–shell Au@MnO2 nanoparticles for enhanced radiotherapy via improving the tumor oxygenationNano Res201691132673278
- LiuJChenQZhuWNanoscale-coordination-polymer-shelled manganese dioxide composite nanoparticles: a multistage redox/pH/H2O2-responsive cancer theranostic nanoplatformAdv Funct Mater201727101605926
- AdamsGEHypoxic cell sensitizers for radiotherapyInt J Radiat Oncol Biol Phys197841–2135141632141
- CuiLTseKZahediPHypoxia and cellular localization influence the radiosensitizing effect of gold nanoparticles (AuNPs) in breast cancer cellsRadiat Res2014182547548825361396
- YenHJHsuSHTsaiCLCytotoxicity and immunological response of gold and silver nanoparticles of different sizesSmall20095131553156119326357
- BartneckMKeulHASinghSRapid uptake of gold nanorods by primary human blood phagocytes and immunomodulatory effects of surface chemistryACS Nano2010463073308620507158
- TaylorUKleinSPetersenSNonendosomal cellular uptake of ligand-free, positively charged gold nanoparticlesCytometry A201077543944620104575
- ArvizoRRBhattacharyyaSKudgusRAIntrinsic therapeutic applications of noble metal nanoparticles: past, present and futureChem Soc Rev20124172943297022388295
- JainSCoulterJAButterworthKTGold nanoparticle cellular uptake, toxicity and radiosensitisation in hypoxic conditionsRadiother Oncol2014110234234724444528
- van HauteDLiuATBerlinJMCoating metal nanoparticle surfaces with small organic molecules can reduce nonspecific cell uptakeACS Nano201812111712729261281
- ShenJKimHCMuCMultifunctional gold nanorods for siRNA gene silencing and photothermal therapyAdv Healthc Mater20143101629163724692076
- MaNLiuPHeNAction of gold nanospikes-based nanoradiosensitizers: cellular internalization, radiotherapy, and autophagyACS Appl Mater Interfaces2017937315263154228816044
- LiangGJinXZhangSXingDRGD peptide-modified fluorescent gold nanoclusters as highly efficient tumor-targeted radiotherapy sensitizersBiomaterials20171449510428834765
- BhattaraiSRDerryPJAzizKGold nanotriangles: scale up and X-ray radiosensitization effects in miceNanoscale20179165085509328134383
- DouYGuoYLiXSize-tuning ionization to optimize gold nanoparticles for simultaneous enhanced CT imaging and radiotherapyACS Nano20161022536254826815933
- MaNWuFGZhangXShape-dependent radiosensitization effect of gold nanostructures in cancer radiotherapy: comparison of gold nanoparticles, nanospikes, and nanorodsACS Appl Mater Interfaces2017915130371304828338323
- SauerRBeckerHHohenbergerWPreoperative versus postoperative chemoradiotherapy for rectal cancerN Engl J Med2004351171731174015496622
- Sebag-MontefioreDStephensRJSteeleRPreoperative radiotherapy versus selective postoperative chemoradiotherapy in patients with rectal cancer (MRC CR07 and NCIC-CTG C016): a multicentre, randomised trialLancet2009373966681182019269519
- BossetJFColletteLCalaisGChemotherapy with preoperative radiotherapy in rectal cancerN Engl J Med2006355111114112316971718
- GibsonJDKhanalBPZubarevERPaclitaxel-functionalized gold nanoparticlesJ Am Chem Soc200712937116531166117718495
- ZhengYSancheLGold nanoparticles enhance DNA damage induced by anti-cancer drugs and radiationRadiat Res2009172111411919580513
- CuiLHerSDunneMSignificant radiation enhancement effects by gold nanoparticles in combination with cisplatin in triple negative breast cancer cells and tumor xenograftsRadiat Res2017187214716028085639
- DavidiESDreifussTMotieiMCisplatin-conjugated gold nanoparticles as a theranostic agent for head and neck cancerHead Neck2018401707829130566
- Vallet-RegíMBalasFArcosDMesoporous materials for drug deliveryAngew Chem Int Ed Engl200746407548755817854012
- FanWShenBBuWRattle-structured multifunctional nanotheranostics for synergetic chemo-/radiotherapy and simultaneous magnetic/luminescent dual-mode imagingJ Am Chem Soc2013135176494650323574400
- FanWShenBBuWDesign of an intelligent sub-50 nm nuclear-targeting nanotheranostic system for imaging guided intranuclear radiosensitizationChem Sci2015631747175328694946
- LiuYLiuYBuWRadiation-/hypoxia-induced solid tumor metastasis and regrowth inhibited by hypoxia-specific upconversion nanoradiosensitizerBiomaterials2015491825725549
- SongGChaoYChenYAll-in-one theranostic nanoplatform based on hollow TaOx for chelator-free labeling imaging, drug delivery, and synergistically enhanced radiotherapyAdv Funct Mater2016264582438254
- ChenYSongGDongZDrug-loaded mesoporous tantalum oxide nanoparticles for enhanced synergetic chemoradiotherapy with reduced systemic toxicitySmall20171381602869
- WickiAWitzigmannDBalasubramanianVHuwylerJNanomedicine in cancer therapy: challenges, opportunities, and clinical applicationsJ Control Rel2015200138157
- AllenTMCullisPRLiposomal drug delivery systems: from concept to clinical applicationsAdv Drug Deliv Rev2013651364823036225
- ZhuYLiaoLApplications of nanoparticles for anticancer drug delivery: a reviewJ Nanosci Nanotechnol20151574753477326373036
- MasoodRHusainSRRahmanAGillPPotentiation of cytotoxicity of Kaposi’s sarcoma related to immunodeficiency syndrome (AIDS) by liposome-encapsulated doxorubicinAIDS Res Hum Retroviruses1993987417468217343
- LiuHXieYZhangYDevelopment of a hypoxia-triggered and hypoxic radiosensitized liposome as a doxorubicin carrier to promote synergetic chemo-/radio-therapy for gliomaBiomaterials201712113014328088075
- LiuHMZhangYFXieYDHypoxia-responsive ionizable liposome delivery siRNA for glioma therapyInt J Nanomedicine2017121065108328223799
- ZhangRSongXLiangCCatalase-loaded cisplatin-prodrug-constructed liposomes to overcome tumor hypoxia for enhanced chemo-radiotherapy of cancerBiomaterials2017138132128550753
- SchitoLSemenzaGLHypoxia-inducible factors: master regulators of cancer progressionTrends Cancer201621275877028741521
- ReySSchitoLWoutersBGEliasofSKerbelRSTargeting hypoxia-inducible factors for antiangiogenic cancer therapyTrends Cancer20173752954128718406
- DewhirstMWCaoYMoellerBCycling hypoxia and free radicals regulate angiogenesis and radiotherapy responseNat Rev Cancer20088642543718500244
- MoellerBJCaoYLiCYDewhirstMWRadiation activates HIF-1 to regulate vascular radiosensitivity in tumors: role of reoxygenation, free radicals, and stress granulesCancer Cell20045542944115144951
- VossMHHussainAVogelzangNA randomized phase II trial of CRLX101 in combination with bevacizumab versus standard of care in patients with advanced renal cell carcinomaAnn Oncol201728112754276028950297
- MaedaHToward a full understanding of the EPR effect in primary and metastatic tumors as well as issues related to its heterogeneityAdv Drug Deliv Rev2015913625579058
- ClarkAJWileyDTZuckermanJECRLX101 nanoparticles localize in human tumors and not in adjacent, nonneoplastic tissue after intravenous dosingProc Natl Acad Sci USA2016113143850385427001839
- ChenYXuGZhengYNanoformulation of D-α-tocopheryl polyethylene glycol 1000 succinate-b-poly(ε-caprolactone-ran-glycolide) diblock copolymer for siRNA targeting HIF-1α for nasopharyngeal carcinoma therapyInt J Nanomed20151013751386
- ZhaoXLiFLiYCo-delivery of HIF1α siRNA and gemcitabine via biocompatible lipid-polymer hybrid nanoparticles for effective treatment of pancreatic cancerBiomaterials201546132525678112
- LiuJNBuWShiJChemical design and synthesis of functionalized probes for imaging and treating tumor hypoxiaChem Rev201711796160622428426202
- SongGChengLChaoYYangKLiuZEmerging nanotechnology and advanced materials for cancer radiation therapyAdv Mater201729321700996
- DouYLiXYangWPB@Au core-satellite multifunctional nanotheranostics for magnetic resonance and computed tomography imaging in vivo and synergetic photothermal and radiosensitive therapyACS Appl Mater Interfaces2017921263127228029033
- XiaoQZhengXBuWA core/satellite multifunctional nanotheranostic for in vivo imaging and tumor eradication by radiation/photothermal synergistic therapyJ Am Chem Soc201313535130411304823924214
- YiXYangKLiangCImaging-guided combined photothermal and radiotherapy to treat subcutaneous and metastatic tumors using iodine-131-doped copper sulfide nanoparticlesAdv Funct Mater2015252946894699
- ZouLWangHHeBCurrent approaches of photothermal therapy in treating cancer metastasis with nanotherapeuticsTheranostics20166676277227162548
- MaNXuHAnLRadiation-sensitive diselenide block co-polymer micellar aggregates: toward the combination of radiotherapy and chemotherapyLangmuir201127105874587821488607
- CookTWangZAlberSNitric oxide and ionizing radiation synergistically promote apoptosis and growth inhibition of cancer by activating p53Cancer Res200464218015802115520210
- KimJYungBCKimWJChenXCombination of nitric oxide and drug delivery systems: tools for overcoming drug resistance in chemotherapyJ Control Rel2017263SI223230
- FanWBuWZhangZX-ray radiation-controlled NO-release for on-demand depth-independent hypoxic radiosensitizationAngew Chem Int Ed Engl20155447140261403026228648
- LiuFLouJHristovDX-ray responsive nanoparticles with triggered release of nitrite, a precursor of reactive nitrogen species, for enhanced cancer radiosensitizationNanoscale2017938146271463428936509
- GuoZZhuSYongYSynthesis of BSA-coated BiOI@Bi2 S3 semiconductor heterojunction nanoparticles and their applications for radio/photodynamic/photothermal synergistic therapy of tumorAdv Mater201729441704136
- DuJGuZssYanLPoly(vinylpyrollidone)- and selenocysteine-modified Bi2Se3 nanoparticles enhance radiotherapy efficacy in tumors and promote radioprotection in normal tissuesAdv Mater201729341701268