Design, modeling, expression, and chemoselective PEGylation of a new nanosize cysteine analog of erythropoietin

References

• ElliottSPhamEMacdougallICErythropoietins: a common mechanism of actionExp Hematol200836121573158418922615
   PubMed Web of Science ®Google Scholar
• LongDLDohertyDHEisenbergSPDesign of homogeneous, monopegylated erythropoietin analogs with preserved in vitro bioactivityExp Hematol200634669770416728273
   PubMed Web of Science ®Google Scholar
• JelkmannWControl of erythropoietin gene expression and its use in medicineMethods Enzymol200743517919717998055
   PubMed Web of Science ®Google Scholar
• WurmFMProduction of recombinant protein therapeutics in cultivated mammalian cellsNat Biotechnol200422111393139815529164
   PubMed Web of Science ®Google Scholar
• TestaUErythropoietic stimulating agentsExpert Opin Emerg Drugs201015111913820158404
   PubMed Web of Science ®Google Scholar
• WangY-JChenJHaoS-JEfficient preparation and PEGylation of recombinant human non-glycosylated erythropoietin expressed as inclusion body in E. coliInt J Pharm201038615616419932158
   PubMed Web of Science ®Google Scholar
• ElliottSGiffinJSuggsSSecretion of glycosylated human erythropoietin from yeast directed by the [alpha]-factor leader regionGene19897911671802673934
   PubMed Web of Science ®Google Scholar
• PasutGVeroneseFMPEGylation for improving the effectiveness of therapeutic biomoleculesDrugs Today200945968769519956810
   PubMed Web of Science ®Google Scholar
• TillmannHCKuhnBKränzlinBEfficacy and immunogenicity of novel erythropoietic agents and conventional rhEPO in rats with renal insufficiencyKidney Int2006691606716374424
   PubMed Web of Science ®Google Scholar
• JevševarSKunsteljMPorekarVGPEGylation of therapeutic proteinsBiotechnol J20105111312820069580
   PubMed Web of Science ®Google Scholar
• FeeCJVan AlstineJAPEG-proteins: reaction engineering and separation issuesChem Eng Sci2006613924939
   Web of Science ®Google Scholar
• AgoramBDoshiSGeggCInvestigation of the effects of altered receptor binding activity on the clearance of erythropoiesis-stimulating proteins: nonerythropoietin receptor-mediated pathways may play a major roleJ Pharm Sci20099862198221118837016
   PubMed Web of Science ®Google Scholar
• MacdougallICEckardtKUNovel strategies for stimulating erythropoiesis and potential new treatments for anaemiaLancet2006368953994795316962885
   PubMed Web of Science ®Google Scholar
• Gaberc-PorekarVZoreIPodobnikBMenartVObstacles and pitfalls in the PEGylation of therapeutic proteinsCurr Opin Drug Discov Devel2008112242250
   PubMedGoogle Scholar
• ChiuKAgoubiLLLeeIEffects of polymer molecular weight on the size, activity, and stability of PEG-functionalized trypsinBiomacromolecules201011123688369220979350
   PubMed Web of Science ®Google Scholar
• MaldineyTRichardCSeguinJEffect of core diameter, surface coating, and PEG chain length on the biodistribution of persistent luminescence nanoparticles in miceACS Nano201133
   Google Scholar
• SaliABlundellTLComparative protein modelling by satisfaction of spatial restraintsJ Mol Biol199323437798158254673
   PubMed Web of Science ®Google Scholar
• EramianDDevosDMeloFA composite score for predicting errors in protein structure modelsProtein Science2006151653166616751606
   PubMed Web of Science ®Google Scholar
• LindahlEHessBvan der SpoelDGROMACS 3.0: a package for molecular simulation and trajectory analysisJ Mol Model200178306317
   Web of Science ®Google Scholar
• GansJDShallowayDQmol: a program for molecular visualization on windows-based PCsJ Mol Graph Model200119655757960911552684
   PubMed Web of Science ®Google Scholar
• DelphineCBDavidMRJanHJVery fast prediction and rationalization of pKa values for protein-ligand complexesProteins200873376578318498103
   PubMed Web of Science ®Google Scholar
• FraczkiewiczRBraunWExact and efficient analytical calculation of the accessible surface areas and their gradients for macromoleculesJ Comp Chem199819319333
   Web of Science ®Google Scholar
• MeyerTSLambertsBLUse of Coomassie brilliant blue R250 for the electrophoresis of microgram quantities of parotid saliva proteins on acrylamide-gel stripsBiochim Biophys Acta196510711441454159310
   PubMed Web of Science ®Google Scholar
• AmanlouMSiadatSDAlaviAGd3+-DTPA-DG: novel nanoszied dual anticancer and molecular imaging agentInt J Nanomedicine2011674776321589643
   PubMed Web of Science ®Google Scholar
• RobertsMJBentleyMDHarrisJMChemistry for peptide and protein PEGylationAdv Drug Deliv Rev200254445947612052709
   PubMed Web of Science ®Google Scholar
• DesjarlaisJRZalevskyJMethods for rational PEGylation of proteinsUnited States Patent and Trademark Office Pre-Grant Publication2007
   Google Scholar
• IbragimovaGTWadeRCImportance of explicit salt ions for protein stability in molecular dynamics simulationBiophys J1998746290629119635744
   PubMed Web of Science ®Google Scholar
• BoisselJPLeeWRPresnellSRErythropoietin structure-function relationships. Mutant proteins that test a model of tertiary structureJ Biol Chem19932682115983159938340419
   PubMed Web of Science ®Google Scholar
• WenDBoisselJPShowersMErythropoietin structure-function relationships. Identification of functionally important domainsJ Biol Chem19942693622839228468077236
   PubMed Web of Science ®Google Scholar
• WangYSYoungsterSGraceMStructural and biologic characterization of PEGylated recombinant interferon alpha-2b and its therapeutic implicationsAdv Drug Deliv Rev200254454757012052714
   PubMed Web of Science ®Google Scholar
• HuaizhiDMinZYuZChunhuaYSynthesis and purification of mono-PEGylated insulinChem Biol Drug Des200769213213817381727
   PubMed Web of Science ®Google Scholar
• SyedRSReidSWLiCEfficiency of signalling through cytokine receptors depends critically on receptor orientationNature199839567015115169774108
   PubMed Web of Science ®Google Scholar
• RecenyMAScobleHAKimYStructural characterization of natural human urinary and recombinant DNA-derived erythropoietinJ Biol Chem19872623517156171633680293
   PubMed Web of Science ®Google Scholar
• WangYJHaoSJLiuYDPEGylation markedly enhances the in vivo potency of recombinant human non-glycosylated erythropoietin: A comparison with glycosylated erythropoietinJ Control Release201014530631320427020
   PubMed Web of Science ®Google Scholar
• FilpulaDZhaoHReleasable PEGylation of proteins with customized linkersAdv Drug Deliv Rev2008601294917884239
   PubMed Web of Science ®Google Scholar
• ClarkROlsonKFuhGLong-acting growth hormones produced by conjugation with polyethylene glycolJ Biol Chem19962713621969219778703002
   PubMed Web of Science ®Google Scholar
• BasuAYangKWangMStructure-function engineering of interfferon-β-1b for improving stability, solubility, potency, immunogenicity, and pharmacokinetic properties by site-selective mono-PEGylationBioconjug Chem200617361863016704199
   PubMed Web of Science ®Google Scholar
• BailonPPalleroniASchafferCARational design of a potent, long-lasting form of interferon: a 40 kDa branched polyethylene glycol-conjugated interferon α-2a for the treatment of hepatitis CBioconjug Chem200112219520211312680
   PubMed Web of Science ®Google Scholar
• BakerDPLinEYLinKN-terminally PEGylated human interferon-β-1a with improved pharmacokinetic properties and in vivo efficacy in a melanoma angiogenesis modelBioconjug Chem200617117918816417267
   PubMed Web of Science ®Google Scholar
• TsutsumiYKihiraTTsunodaSIPolyethylene glycol modification of interleukin-6 enhances its thrombopoietic activityJ Control Release1995333447450
   Web of Science ®Google Scholar
• MacdougallICCERA (continuous erythropoietin receptor activator): a new erythropoiesis-stimulating agent for the treatment of anemiaCurr Hematol Rep20054643644016232379
   PubMedGoogle Scholar
• PoolC Inventor. Formation of novel erythropoietin conjugates using transglutaminase;2006
   Google Scholar
• TakeuchiMTakasakiSShimadaMKobataARole of sugar chains in the in vitro biologic activity of human erythropoietin produced in recombinant Chinese hamster ovary cellsJ Biol Chem19902652112127121302373681
   PubMed Web of Science ®Google Scholar
• EisukeTGoseiKMasatsuguUThe role of carbohydrate in recombinant human erythropoietinEur J Biochem199018824054112156701
   PubMedGoogle Scholar
• WenDBoisselJPTracyTEErythropoietin structure-function relationships: high degree of sequence homology among mammalsBlood1993825150715168364201
   PubMed Web of Science ®Google Scholar