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Original Research

Synthesis, characterization, and mechanistic studies of a gold nanoparticle–amphotericin B covalent conjugate with enhanced antileishmanial efficacy and reduced cytotoxicity

Prakash Kumar1 Department of Biotechnology, National Institute of Pharmaceutical Education and Research (NIPER) – Hajipur, Vaishali, India
,
Pushkar Shivam2 Department of Microbiology, Rajendra Memorial Research Institute of Medical Sciences, Patna, India
,
Saptarshi Mandal3 Department of Chemistry, Indian Institute of Technology Patna, Patna, India
,
Pragya Prasanna1 Department of Biotechnology, National Institute of Pharmaceutical Education and Research (NIPER) – Hajipur, Vaishali, India
,
Saurabh Kumar1 Department of Biotechnology, National Institute of Pharmaceutical Education and Research (NIPER) – Hajipur, Vaishali, India
,
Surendra Rajit Prasad1 Department of Biotechnology, National Institute of Pharmaceutical Education and Research (NIPER) – Hajipur, Vaishali, India
,
Ashish Kumar4 Department of Molecular Biology, Rajendra Memorial Research Institute of Medical Sciences, Patna, India
,
Prolay Das3 Department of Chemistry, Indian Institute of Technology Patna, Patna, India
,
Vahab Ali5 Department of Biochemistry, Rajendra Memorial Research Institute of Medical Sciences, Patna, India
,
Shubhankar Kumar Singh2 Department of Microbiology, Rajendra Memorial Research Institute of Medical Sciences, Patna, India
&
Debabrata Mandal1 Department of Biotechnology, National Institute of Pharmaceutical Education and Research (NIPER) – Hajipur, Vaishali, IndiaCorrespondence[email protected]
 show all
Pages 6073-6101 | Published online: 20 Aug 2019

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References

  • Purkait B, Kumar A, Nandi N, et al. Mechanism of Amphotericin B resistance in clinical isolates of Leishmania donovani. Antimicrob Agents Chemother. 2012;56:21031–41.
  • Kumar R, Pai K, Sundar S. Reactive oxygen intermediates, nitrite and IFN-γ in Indian visceral leishmaniasis. Clin Exp Immunol. 2001; 124(2): 262–265.11422203
  • Singh K, Ali V, Singh KP, et al. Deciphering the interplay between cysteine synthase and thiol cascade proteins in modulating Amphotericin B resistance and survival of Leishmania donovani under oxidative stress. Redox Biol. 2017;12:350–66.28288415

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