Self-assembled insulin and nanogels polyelectrolyte complex (Ins/NGs-PEC) for oral insulin delivery: characterization, lyophilization and in-vivo evaluation

References

• Lowman A, Morishita M, Kajita M, Nagai T, Peppas N. Oral delivery of insulin using pH‐responsive complexation gels. J Pharm Sci. 1999;88(9):933–937. doi:10.1021/js980337n10479357
   PubMed Web of Science ®Google Scholar
• Márquez-Beltrán C, Castañeda L, Enciso-Aguilar M, et al. Structure and mechanism formation of polyelectrolyte complex obtained from PSS/PAH system: effect of molar mixing ratio, base–acid conditions, and ionic strength. Colloid Polym Sci. 2013;291(3):683–690. doi:10.1007/s00396-012-2775-y
   Web of Science ®Google Scholar
• Hartig SM, Greene RR, Dikov MM, Prokop A, Davidson JM. Multifunctional nanoparticulate polyelectrolyte complexes. Pharm Res. 2007;24(12):2353–2369. doi:10.1007/s11095-007-9459-117932727
   PubMed Web of Science ®Google Scholar
• Delair T. Colloidal polyelectrolyte complexes of chitosan and dextran sulfate towards versatile nanocarriers of bioactive molecules. Eur J Pharm Biopharm. 2011;78(1):10–18. doi:10.1016/j.ejpb.2010.12.00121138767
   PubMedGoogle Scholar
• Woodley J, Bernkop-Schnürch A. Oral Delivery of Macromolecular Drugs: Barriers, Strategies and Future Trends. Springer 2009.
   Google Scholar
• Schatz C, Lucas J-M, Viton C, Domard A, Pichot C, Delair T. Formation and properties of positively charged colloids based on polyelectrolyte complexes of biopolymers. Langmuir. 2004;20(18):7766–7778. doi:10.1021/la049460m15323530
   PubMedGoogle Scholar
• Ameye D, Voorspoels J, Foreman P, et al. Trypsin inhibition, calcium and zinc ion binding of starch–g-poly (acrylic acid) copolymers and starch/poly (acrylic acid) mixtures for peroral peptide drug delivery. J Controlled Release. 2001;75(3):357–364.
   PubMed Web of Science ®Google Scholar
• Lueßen HL, Verhoef JC, Borchard G, Lehr C-M, de Boer ABG, Junginger HE. Mucoadhesive polymers in peroral peptide drug delivery. II. Carbomer and polycarbophil are potent inhibitors of the intestinal proteolytic enzyme trypsin. Pharm Res. 1995;12(9):1293–1298.8570524
   PubMed Web of Science ®Google Scholar
• Mudassir J, Darwis Y, Yusof SR. Synthesis, characterization and toxicological evaluation of pH-sensitive polyelectrolyte Nanogels. J Polym Res. 2017;24(10):164. doi:10.1007/s10965-017-1321-5
   Web of Science ®Google Scholar
• Tanford C, Epstein J. The Physical Chemistry of Insulin. I. Hydrogen ion titration curve of zinc-free insulin1-3. J Am Chem Soc. 1954;76(8):2163–2169. doi:10.1021/ja01637a035
   Web of Science ®Google Scholar
• Schmitt C, Sanchez C, Thomas F, Hardy J. Complex coacervation between β-lactoglobulin and acacia gum in aqueous medium. Food Hydrocoll. 1999;13(6):483–496. doi:10.1016/S0268-005X(99)00032-6
   Web of Science ®Google Scholar
• Luo Y, Zhang B, Whent M, Yu LL, Wang Q. Preparation and characterization of zein/chitosan complex for encapsulation of α-tocopherol, and its in vitro controlled release study. Colloids Surf B. 2011;85(2):145–152. doi:10.1016/j.colsurfb.2011.02.020
   PubMed Web of Science ®Google Scholar
• Fan Y, Wang Y, Fan Y, Ma J. Preparation of insulin nanoparticles and their encapsulation with biodegradable polyelectrolytes via the layer-by-layer adsorption. Int J Pharm. 2006;324(2):158–167. doi:10.1016/j.ijpharm.2006.05.06216814967
   PubMedGoogle Scholar
• Nam J-P, Choi C, Jang M-K, et al. Insulin-incorporated chitosan nanoparticles based on polyelectrolyte complex formation. Macromol Res. 2010;18(7):630–635. doi:10.1007/s13233-010-0714-7
   Web of Science ®Google Scholar
• Lin Y-H, Chen C-T, Liang H-F, et al. Novel nanoparticles for oral insulin delivery via the paracellular pathway. Nanotechnology. 2007;18(10):105102. doi:10.1088/0957-4484/18/49/495102
   Web of Science ®Google Scholar
• Yoshida K, Hashide R, Ishii T, Takahashi S, Sato K, Anzai J-I. Layer-by-layer films composed of poly (allylamine) and insulin for pH-triggered release of insulin. Colloids Surf B. 2012;91:274–279. doi:10.1016/j.colsurfb.2011.11.017
   PubMed Web of Science ®Google Scholar
• Yoshida K, Sato K, Anzai J-I. Layer-by-layer polyelectrolyte films containing insulin for pH-triggered release. J Mater Chem. 2010;20(8):1546–1552. doi:10.1039/B918226H
   Web of Science ®Google Scholar
• Chen Y, Zheng X, Qian H, Mao Z, Ding D, Jiang X. Hollow core− porous shell structure poly (acrylic acid) nanogels with a superhigh capacity of drug loading. ACS Appl Mater Interfaces. 2010;2(12):3532–3538. doi:10.1021/am100709d21080640
   PubMed Web of Science ®Google Scholar
• Sarmento B, Ribeiro A, Veiga F, Sampaio P, Neufeld R, Ferreira D. Alginate/chitosan nanoparticles are effective for oral insulin delivery. Pharm Res. 2007;24(12):2198–2206. doi:10.1007/s11095-007-9367-417577641
   PubMed Web of Science ®Google Scholar
• Chen L, Remondetto G, Rouabhia M, Subirade M. Kinetics of the breakdown of cross-linked soy protein films for drug delivery. Biomaterials. 2008;29(27):3750–3756. doi:10.1016/j.biomaterials.2008.05.02518547639
   PubMedGoogle Scholar
• Cui F, Qian F, Zhao Z, Yin L, Tang C, Yin C. Preparation, characterization, and oral delivery of insulin loaded carboxylated chitosan grafted poly (methyl methacrylate) nanoparticles. Biomacromolecules. 2009;10(5):1253–1258. doi:10.1021/bm900035u19292439
   PubMed Web of Science ®Google Scholar
• Karnoosh-Yamchi J, Mobasseri M, Akbarzadeh A, et al. Preparation of pH sensitive insulin-loaded Nano hydrogels and evaluation of insulin releasing in different pH conditions. Mol Biol Rep. 2014;41(10):6705–6712. doi:10.1007/s11033-014-3553-324996289
   PubMedGoogle Scholar
• Mauri S, Volk M, Byard S, Berchtold H, Arnolds H. Stabilization of insulin by adsorption on a hydrophobic silane self-assembled monolayer. Langmuir. 2015;31(32):8892–8900. doi:10.1021/acs.langmuir.5b0147726212147
   PubMedGoogle Scholar
• Mukhopadhyay P, Chakraborty S, Bhattacharya S, Mishra R, Kundu P. pH-sensitive chitosan/alginate core-shell nanoparticles for efficient and safe oral insulin delivery. Int J Biol Macromol. 2015;72:640–648. doi:10.1016/j.ijbiomac.2014.08.04025239194
   PubMed Web of Science ®Google Scholar
• Chalasani KB, Russell-Jones GJ, Jain AK, Diwan PV, Jain SK. Effective oral delivery of insulin in animal models using vitamin B12-coated dextran nanoparticles. J Controlled Release. 2007;122(2):141–150. doi:10.1016/j.jconrel.2007.05.019
   PubMed Web of Science ®Google Scholar
• Alibolandi M, Alabdollah F, Sadeghi F, et al. Dextran-b-poly (lactide-co-glycolide) polymersome for oral delivery of insulin: in vitro and in vivo evaluation. J Controlled Release. 2016;227:58–70. doi:10.1016/j.jconrel.2016.02.031
   PubMed Web of Science ®Google Scholar
• Hurkat P, Jain A, Jain A, Shilpi S, Gulbake A, Jain SK. Concanavalin A conjugated biodegradable nanoparticles for oral insulin delivery. J Nanopart Res. 2012;14(11):1219. doi:10.1007/s11051-012-1219-4
   Web of Science ®Google Scholar
• Ibrahim MA, Ismail A, Fetouh MI, Göpferich A. Stability of insulin during the erosion of poly (lactic acid) and poly (lactic-co-glycolic acid) microspheres. J Controlled Release. 2005;106(3):241–252. doi:10.1016/j.jconrel.2005.02.025
   PubMed Web of Science ®Google Scholar
• Péan J-M, Venier-Julienne M-C, Boury F, Menei P, Denizot B, Benoit J-P. NGF release from poly (D, L-lactide-co-glycolide) microspheres. Effect of some formulation parameters on encapsulated NGF stability. J Controlled Release. 1998;56(1):175–187.
   PubMed Web of Science ®Google Scholar
• Shao PG, Bailey LC. Porcine insulin biodegradable polyester microspheres: stability and in vitro release characteristics. Pharm Dev Technol. 2000;5(1):1–9. doi:10.1081/PDT-10010051310669912
   PubMed Web of Science ®Google Scholar
• Shao PG, Bailey LC. Stabilization of pH-induced degradation of porcine insulin in biodegradable polyester microspheres. Pharm Dev Technol. 1999;4(4):633–642. doi:10.1081/PDT-10010140210578518
   PubMed Web of Science ®Google Scholar
• Mukhopadhyay P, Sarkar K, Chakraborty M, Bhattacharya S, Mishra R, Kundu P. Oral insulin delivery by self-assembled chitosan nanoparticles: in vitro and in vivo studies in diabetic animal model. Mater Sci Eng C. 2013;33(1):376–382. doi:10.1016/j.msec.2012.09.001
   PubMed Web of Science ®Google Scholar
• Mudassir J, Darwis Y, Khiang PK. Prerequisite characteristics of nanocarriers favoring oral insulin delivery: nanogels as an opportunity. Int J Polym Mater Polym Biomater. 2015;64(3):155–167. doi:10.1080/00914037.2014.921919
   Web of Science ®Google Scholar