Dimeric c(RGD) peptide conjugated nanostructured lipid carriers for efficient delivery of Gambogic acid to breast cancer

References

• AlQathama A, Prieto J. Natural products with therapeutic potential in melanoma metastasis. Nat Prod Rep. 2015;32:1170–1182. doi:10.1039/c4np00130c26018751
   PubMed Web of Science ®Google Scholar
• Liang L, Zhang Z. Gambogic acid inhibits malignant melanoma cell proliferation through mitochondrial p66shc/ROS-p53/bax-mediated apoptosis. Cell Physiol Biochem. 2016;38(4):1618–1630. doi:10.1159/00044310227119348
   PubMedGoogle Scholar
• Wang S, Wang L, Chen M, Wang Y. Gambogic acid sensitizes resistant breast cancer cells to doxorubicin through inhibiting P-glycoprotein and suppressing survivin expression. Chem Biol Interact. 2015;235:76–84. doi:10.1016/j.cbi.2015.03.01725824409
   PubMed Web of Science ®Google Scholar
• Lü L, Tang D, Wang L, et al. Gambogic acid inhibits TNF-α-induced invasion of human prostate cancer PC3 cells in vitro through PI3K/Akt and NF-κB signaling pathways. Acta Pharmacol Sin. 2012;33(4):531–541. doi:10.1038/aps.2011.18022426696
   PubMedGoogle Scholar
• Qi Q, Lu N, Li C, et al. Involvement of RECK in gambogic acid induced anti-invasive effect in A549 human lung carcinoma cells. Mol Carcinog. 2015;54(Suppl 1):E13–E25. doi:10.1002/mc.2213824532189
   PubMedGoogle Scholar
• Yang Y, Yang L, You Q, et al. Differential apoptotic induction of gambogic acid, a novel anticancer natural product, on hepatoma cells and normal hepatocytes. Cancer Lett. 2007;256(2):259–266. doi:10.1016/j.canlet.2007.06.01417693016
   PubMedGoogle Scholar
• Youns M, ElKhoely A, Kamel R. The growth inhibitory effect of gambogic acid on pancreatic cancer cells. Naunyn Schmiedebergs Arch Pharmacol. 2018;391(5):551–560. doi:10.1007/s00210-018-1485-529546614
   PubMed Web of Science ®Google Scholar
• Li D, Yang H, Li R, et al. Antitumor activity of gambogic acid on NCI-H1993 xenografts via MET signaling pathway downregulation. Oncol Lett. 2015;10(5):2802–2806. doi:10.3892/ol.2015.371926722245
   PubMedGoogle Scholar
• Wang X, Chen W. Gambogic acid is a novel anti-cancer agent that inhibits cell proliferation, angiogenesis and metastasis. Anticancer Agents Med Chem. 2012;12(8):994–1000.22339063
   PubMed Web of Science ®Google Scholar
• Qi Q, You Q, Gu H, et al. Studies on the toxicity of gambogic acid in rats. J Ethnopharmacol. 2008;117(3):433–438. doi:10.1016/j.jep.2008.02.02718384990
   PubMed Web of Science ®Google Scholar
• Chi Y, Zhan XK, Yu H, et al. An open-labeled, randomized, multicenter phase IIa study of gambogic acid injection for advanced malignant tumors. Chin Med J (Engl). 2013;126(9):1642–1646.23652044
   PubMed Web of Science ®Google Scholar
• Lyu L, Huang LQ, Huang T, Xiang W, Yuan JD, Zhang CH. Cell-penetrating peptide conjugates of gambogic acid enhance the antitumor effect on human bladder cancer EJ cells through ROS-mediated apoptosis. Drug Des Devel Ther. 2018;12:743–756. doi:10.2147/DDDT.S161821
   PubMed Web of Science ®Google Scholar
• Liu L, Qi X, Zhong Z, Zhang E. Nanomedicine-based combination of gambogic acid and retinoic acid chlorochalcone for enhanced anticancer efficacy in osteosarcoma. Biomed Pharmacother. 2016;83:79–84. doi:10.1016/j.biopha.2016.06.00127470553
   PubMed Web of Science ®Google Scholar
• Zhang Y, Yang Z, Tan X, Tang X, Yang Z. Development of a more efficient albumin-based delivery system for gambogic acid with low toxicity for lung cancer therapy. AAPS PharmSciTech. 2016;18(6):1987–1997. doi:10.1208/s12249-016-0670-427933587
   PubMedGoogle Scholar
• Li J, Wang X, Shao Y, Lu X, Chen B. A novel exploration of a combination of gambogic acid with TiO2 nanofibers: the photodynamic effect for HepG2 cell proliferation. Materials. 2014;7(9):6865–6878. doi:10.3390/ma709686528788218
   PubMedGoogle Scholar
• He M, Ro L, Liu J, Chu CC. Folate-decorated arginine-based poly(ester urea urethane) nanoparticles as carriers for gambogic acid and effect on cancer cells. J Biomed Mater Res A. 2017;105(2):475–490. doi:10.1002/jbm.a.3592427706899
   PubMed Web of Science ®Google Scholar
• Chen B, Cailian W, Zhang H. Gambogic acid-loaded magnetic Fe3O4 nanoparticles inhibit Panc-1 pancreatic cancer cell proliferation and migration by inactivating transcription factor ETS1. Int J Nanomedicine. 2012;781. doi:10.2147/IJN22393285
   PubMedGoogle Scholar
• Zhang D, Zou Z, Ren W, et al. Gambogic acid-loaded PEG-PCL nanoparticles act as an effective antitumor agent against gastric cancer. Pharm Dev Technol. 2018;23(1):33–40. doi:10.1080/10837450.2017.129506829069711
   PubMed Web of Science ®Google Scholar
• Doddapaneni R, Patel K, Owaid I, Singh M. Tumor neovasculature-targeted cationic PEGylated liposomes of gambogic acid for the treatment of triple-negative breast cancer. Drug Deliv. 2016;23:1232–1241. doi:10.3109/10717544.2015.112447226701717
   PubMed Web of Science ®Google Scholar
• Wan H, Chen J, Yu X, Zhu X. Titania-coated gold nanorods as an effective carrier for gambogic acid. RSC Adv. 2017;7(78):49518–49525. doi:10.1039/C7RA08560E
   Web of Science ®Google Scholar
• Mandal A, Bisht R, Pal D, et al. Diagnosis and Drug Delivery to the Brain: Novel Strategies. In: Mitra A, Cholkar K, editors.Emerging nanotechnologies for diagnostics, drug delivery and medical devices Amesterdam: Elsevier; 2017;355–374.
   Google Scholar
• Yokoyama M. Polymeric micelles as drug carriers: their lights and shadows. J Drug Target. 2014;22(7):576–583. doi:10.3109/1061186X.2014.93468825012065
   PubMed Web of Science ®Google Scholar
• Pasquarelli N, Porazik C, Bayer H, et al. Contrasting effects of selective MAGL and FAAH inhibition on dopamine depletion and GDNF expression in a chronic MPTP mouse model of Parkinson’s disease. Neurochem Int. 2017;110:14–24. doi:10.1016/j.neuint.2017.08.00328826718
   PubMed Web of Science ®Google Scholar
• Petros RA, DeSimone JM. Strategies in the design of nanoparticles for therapeutic applications. Nat Rev Drug Discov. 2010;9:615–627. doi:10.1038/nrd259120616808
   PubMed Web of Science ®Google Scholar
• Lin C, Zhang X, Chen H, et al. Dual-ligand modified liposomes provide effective local targeted delivery of lung-cancer drug by antibody and tumor lineage-homing cell-penetrating peptide. Drug Deliv. 2018;25(1):256–266. doi:10.1080/10717544.2018.142577729334814
   PubMed Web of Science ®Google Scholar
• Majumder P, Bhunia S, Chaudhuri A. A lipid-based cell penetrating nano-assembly for RNAi-mediated anti-angiogenic cancer therapy. Chem Commun (Camb). 2018;54(12):1489–1492. doi:10.1039/c7cc08517f29359766
   PubMed Web of Science ®Google Scholar
• Zhang Q, Lu L, Zhang L, et al. Dual-functionalized liposomal delivery system for solid tumors based on RGD and a pH-responsive antimicrobial peptide. Sci Rep. 2016;6:19800. doi:10.1038/srep1980026842655
   PubMed Web of Science ®Google Scholar
• White DE, Muller WJ. Multifaceted roles of integrins in breast cancer metastasis. J Mammary Gland Biol Neoplasia. 2007;12(2–3):135–142. doi:10.1007/s10911-007-9045-517602286
   PubMedGoogle Scholar
• Huang R, Li J, Kebebe D, Wu Y, Zhang B, Liu Z. Cell penetrating peptides functionalized gambogic acid-nanostructured lipid carrier for cancer treatment. Drug Deliv. 2018;25:757–765. doi:10.1080/10717544.2018.144647429528244
   PubMed Web of Science ®Google Scholar
• Rashidi LH, Homayoni H, Zou X, Liu L, Chen W. Investigation of the strategies for targeting of the afterglow nanoparticles to tumor cells. Photodiagnosis Photodyn Ther. 2016;13:244–254. doi:10.1016/j.pdpdt.2015.08.00126253653
   PubMedGoogle Scholar
• Salatin S, Yari Khosroushahi A. Overviews on the cellular uptake mechanism of polysaccharide colloidal nanoparticles. J Cell Mol Med. 2017;21(9):1668–1686. doi:10.1111/jcmm.1311028244656
   PubMed Web of Science ®Google Scholar
• Zhang ZH, Wang XP, Ayman WY, Munyendo WL, Lv HX, JP Z. Studies on lactoferrin nanoparticles of gambogic acid for oral delivery. Drug Deliv. 2013;20:86–93. doi:10.3109/10717544.2013.76678123495734
   PubMed Web of Science ®Google Scholar
• DuPre SA, Redelman D, Hunter KW Jr. The mouse mammary carcinoma 4T1: characterization of the cellular landscape of primary tumours and metastatic tumour foci. Int J Exp Pathol. 2007;88(5):351–360. doi:10.1111/j.1365-2613.2007.00539.x17877537
   PubMedGoogle Scholar
• Weidner N. Current pathologic methods for measuring intratumoral microvessel density within breast carcinoma and other solid tumors. Breast Cancer Res Treat. 1995;36:169–180.8534865
   PubMed Web of Science ®Google Scholar
• Danhier F, Le Breton A, Préat V. RGD-based strategies to target alpha(v) beta(3) integrin in cancer therapy and diagnosis. Mol Pharm. 2012;9:2961–2973. doi:10.1021/mp300273322967287
   PubMed Web of Science ®Google Scholar
• Pozzi D, Colapicchioni V, Caracciolo G, et al. Effect of polyethyleneglycol (PEG) chain length on the bio–nano-interactions between PEGylated lipid nanoparticles and biological fluids: from nanostructure to uptake in cancer cells. Nanoscale. 2014;6:2782. doi:10.1039/c3nr05559k24463404
   PubMed Web of Science ®Google Scholar
• Hada T, Sakurai Y, Harashima H. Optimization of a siRNA carrier modified with a pH-sensitive cationic lipid and a Cyclic RGD peptide for efficiently targeting tumor endothelial cells. Pharmaceutics. 2015;7:320–333. doi:10.3390/pharmaceutics703032026389942
   PubMedGoogle Scholar
• Estelrich J, Busquets M, Morán M. Effect of PEGylation on ligand-targeted magnetoliposomes: a missed goal. ACS Omega. 2017;2:6544−6555. doi:10.1021/acsomega.7b0131830023523
   PubMed Web of Science ®Google Scholar
• Bahrami B, Hojjat-Farsangi M, Mohammadi H, et al. Nanoparticles and targeted drug delivery in cancer therapy. Immunol Lett. 2017;190. doi:10.1016/j.imlet.2017.06.004
   PubMed Web of Science ®Google Scholar
• Hynes R. A reevaluation of integrins as regulators of angiogenesis. Nat Med. 2002;8:918–921. doi:10.1038/nm0902-91812205444
   PubMed Web of Science ®Google Scholar
• Wester HJ, Kessler H. Molecular targeting with peptides or peptide- polymer conjugates: just a question of size? J Nucl Med. 2005;46:1552–1560.16157540
   PubMed Web of Science ®Google Scholar
• Yin D, Yang Y, Cai H, Wang F, Peng D, He L. Gambogic acid-loaded electrosprayed particles for site-specific treatment of hepatocellular carcinoma. Mol Pharm. 2014;11(11):4107–4117. doi:10.1021/mp500214a25290462
   PubMedGoogle Scholar
• Dunstan R, Wharton KJ, Quigley C, et al. The use of immunohistochemistry for biomarker assessment - can it compete with other technologies? Toxicol Patho. 2011;139(6):988–1002. doi:10.1177/0192623311419163
   Google Scholar
• De Jong W, Borm P. Drug delivery and nanoparticles: applications and hazards. Int J Nanomedicine. 2008;3:133–149. doi:10.2147/IJN.S59618686775
   PubMed Web of Science ®Google Scholar
• Wolfram J, Zhu M, Yang Y. Safety of nanoparticles in medicine. Curr Drug Targets. 2015;16:1671–1681. doi:10.2174/138945011566614080412480826601723
   PubMed Web of Science ®Google Scholar
• Kim M, Kwon S-H, Choi J, Lee A. A promising biocompatible platform: lipid-based and bio-inspired smart drug delivery systems for cancer therapy. Int J Mol Sci. 2018;19(12):3859. doi:10.3390/ijms19123859
   PubMed Web of Science ®Google Scholar
• Kong B, Seog JH, Graham LM, Lee SB. Experimental considerations on the cytotoxicity of nanoparticles. Nanomedicine. 2011;6(5):929–941. doi:10.2217/nnm.11.7721793681
   PubMed Web of Science ®Google Scholar
• Hong T-K, Tripathy N, Son H-J, et al. A comprehensive in vitro and in vivo study of ZnO nanoparticles toxicit. J Mater Chem B. 2013;1:2985. doi:10.1039/c3tb20251h
   PubMed Web of Science ®Google Scholar
• Sharma P, Brown S, Walter G, et al. Nanoparticles for bioimaging. Adv Colloid Interface Sci. 2006;123:471–485. doi:10.1016/j.cis.2006.05.02616890182
   PubMed Web of Science ®Google Scholar