Effect of 2nd and 3rd generation PAMAM dendrimers on proliferation, differentiation, and pro-inflammatory cytokines in human keratinocytes and fibroblasts

References

• Medina C, Santos-Martinez MJ, Radomski A, Corrigan OI, Radomski MW. Nanoparticles: pharmacological and toxicological significance. Br J Pharmacol. 2007;150(5):552−558.17245366
   PubMed Web of Science ®Google Scholar
• Hsu HJ, Bugno J, Lee SR, Hong S. Dendrimer-based nanocarriers: a versatile platform for drug delivery. Wiley Interdiscip Rev Nanomed Nanobiotechnol. 2017;9(1). doi:10.1002/wnan.1409
   PubMed Web of Science ®Google Scholar
• Da Silva Santos S, Igne Ferreira E, Giarolla J. Dendrimer prodrugs. Molecules. 2016;21(6):686. doi:10.3390/molecules21060686
   PubMed Web of Science ®Google Scholar
• Pisal DS, Yellepeddi VK, Kumar A, et al. Permeability of surface-modified polyamidoamine (PAMAM) dendrimers across Caco-2 cell monolayers. Int J Pharm. 2008;350(1–2):113−121. doi:10.1016/j.ijpharm.2007.08.03317913410
   PubMedGoogle Scholar
• Malik N, Evagorou EG, Duncan R. Dendrimer-platinate: a novel approach to cancer chemotherapy. Anticancer Drugs. 1999;10(8):767−776. doi:10.1097/00001813-199909000-0001010573209
   PubMedGoogle Scholar
• Gurdag S, Khandare J, Stapels S, Matherly LH, Kannan RM. Activity of dendrimer-methotrexate conjugates on methotrexate-sensitive and -resistant cell lines. Bioconjug Chem. 2006;17(2):275−283. doi:10.1021/bc050185516536456
   PubMed Web of Science ®Google Scholar
• Ke W, Zhao Y, Huang R, Jiang C, Pei Y. Enhanced oral bioavailability of doxorubicin in a dendrimer drug delivery system. J Pharm Sci. 2008;97(6):2208−2216. doi:10.1002/jps.2115517879294
   PubMed Web of Science ®Google Scholar
• Kurtoglu YE, Mishra MK, Kannan S, Kannan RM. Drug release characteristics of PAMAM dendrimer-drug conjugates with different linkers. Int J Pharm. 2010;384(1−2):189−194. doi:10.1016/j.ijpharm.2009.10.01719825406
   PubMedGoogle Scholar
• Li J, Liang H, Liu J, Wang Z. Poly (amidoamine) (PAMAM) dendrimer mediated delivery of drug and pDNA/siRNA for cancer therapy. Int J Pharm. 2018;546(1−2):215−225. doi:10.1016/j.ijpharm.2018.05.04529787895
   PubMed Web of Science ®Google Scholar
• Salimi M, Sarkar S, Fathi S, et al. Biodistribution, pharmacokinetics, and toxicity of dendrimer-coated iron oxide nanoparticles in BALB/c mice. Int J Nanomedicine. 2018;13:1483−1493. doi:10.2147/IJN.S15729329559777
   PubMed Web of Science ®Google Scholar
• Winnicka K, Bielawski K, Bielawska A. Synthesis and cytotoxic activity of G3 PAMAM-NH(2) dendrimer-modified digoxin and proscillaridin A conjugates in breast cancer cells. Pharmacol Rep. 2010;62(2):414−423. doi:10.1016/S1734-1140(10)70283-820508299
   PubMedGoogle Scholar
• Bielawski K, Bielawska A, Muszyńska A, Popławska B, Czarnomysy R. Cytotoxic activity of G3 PAMAM-NH₂ dendrimer-chlorambucil conjugate in human breast cancer cells. Environ Toxicol Pharmacol. 2011;32(3):364−372. doi:10.1016/j.etap.2011.08.00222004955
   PubMed Web of Science ®Google Scholar
• Paszko E, Ehrhardt C, Senge MO, Kelleher DP, Reynolds JV. Nanodrug applications in photodynamic therapy. Photodiagnosis Photodyn Ther. 2011;8(1):14−29. doi:10.1016/j.pdpdt.2010.12.00121333931
   PubMedGoogle Scholar
• Ficker M, Theeuwen MJM, Janaszewska A, et al. Complexes of indomethacin with 4-carbomethoxy-pyrrolidone PAMAM dendrimers show improved anti-inflammatory properties and temperature-dependent binding and release profile. Mol Pharm. 2018. doi:10.1021/acs.molpharmaceut.8b00567
   Google Scholar
• Fox LJ, Richardson RM, Briscoe WH. PAMAM dendrimer - cell membrane interactions. Adv Colloid Interface Sci. 2018;257:1−18. doi:10.1016/j.cis.2018.06.00530008347
   PubMed Web of Science ®Google Scholar
• Wróblewska M, Winnicka K. The effect of cationic polyamidoamine dendrimers on physicochemical characteristics of hydrogels with erythromycin. Int J Mol Sci. 2015;16(9):20277−20289. doi:10.3390/ijms16092027726343637
   PubMed Web of Science ®Google Scholar
• Winnicka K, Wróblewska M, Sosnowska K, Car H, Kasacka I. Evaluation of cationic polyamidoamine dendrimers’ dermal toxicity in the rat skin model. Drug Des Devel Ther. 2015;9:1367−1377. doi:10.2147/DDDT.S78336
   PubMed Web of Science ®Google Scholar
• Maji S, Agarwal T, Maiti TK. PAMAM (generation 4) incorporated gelatin 3D matrix as an improved dermal substitute for skin tissue engineering. Colloids Surf B Biointerfaces. 2017;155:128−134. doi:10.1016/j.colsurfb.2017.04.00328419941
   PubMed Web of Science ®Google Scholar
• Cheng Y, Man N, Xu T, et al. Transdermal delivery of nonsteroidal anti-inflammatory drugs mediated by polyamidoamine (PAMAM) dendrimers. J Pharm Sci. 2007;96(3):595−602.17094130
   PubMed Web of Science ®Google Scholar
• Chauhan AS, Sridevi S, Chalasani KB, et al. Dendrimer-mediated transdermal delivery: enhanced bioavailability of indomethacin. J Control Release. 2003;90(3):335−343. doi:10.1016/S0168-3659(03)00200-112880700
   PubMed Web of Science ®Google Scholar
• Barrientos S, Stojadinovic O, Golinko MS, Brem H, Tomic-Canic M. Growth factors and cytokines in wound healing. Wound Repair Regen. 2008;16(5):585−601. doi:10.1111/j.1524-475X.2008.00410.x19128254
   PubMed Web of Science ®Google Scholar
• Shaw TJ, Martin P. Wound repair at a glance. J Cell Sci. 2009;122(18):3209−3213. doi:10.1242/jcs.03118719726630
   PubMed Web of Science ®Google Scholar
• Ferreira LE, Muniz BV, Burga-Sánchez J, et al. The effect of two drug delivery systems in ropivacaine cytotoxicity and cytokine release by human keratinocytes and fibroblasts. J Pharm Pharmacol. 2017;69(2):161−171. doi:10.1111/jphp.1268028033682
   PubMedGoogle Scholar
• Peterkofsky B, Chojkier M, Bateman J. Immunochemistry of the extracellular matrix In: H Furthmayr, editor. Determination of collagen synthesis in tissue and cell culture system. Vol 2 CRC Press; 2018:19–47.
   Google Scholar
• Czarnomysy R, Surażyński A, Muszyńska A, Gornowicz A, Bielawska A, Bielawski K. A novel series of pyrazole-platinum(II) complexes as potential anti-cancer agents that induce cell cycle arrest and apoptosis in breast cancer cells. J Enzyme Inhib Med Chem. 2018;33(1):1006–1023. doi:10.1080/14756366.2018.147168729862867
   PubMed Web of Science ®Google Scholar
• Zaręba I, Celinska-Janowicz K, Surażynski A, Miltyk W, Pałka J. Proline oxidase silencing induces proline-dependent pro-survival pathways in MCF-7 cells. Oncotarget. 2018;9(17):13748–13757. doi:10.18632/oncotarget.2446629568391
   PubMedGoogle Scholar
• Cheng Y, Zhao L, Li Y, Xu T. Design of biocompatible dendrimers for cancer diagnosis and therapy: current status and future perspectives. Chem Soc Rev. 2011;40(5):2673–2703. doi:10.1039/c0cs00097c21286593
   PubMed Web of Science ®Google Scholar
• Yang K, Weng L, Cheng Y, et al. Host-guest chemistry of dendrimer-drug complexes. 6. Fully acetylated dendrimers as biocompatible drug vehicles using dexamethasone 21-phosphate as a model drug. J Phys Chem B. 2011;115(10):2185–2195. doi:10.1021/jp111044k21338144
   PubMedGoogle Scholar
• Duncan R, Izzo L. Dendrimer biocompatibility and toxicity. Adv Drug Deliv Rev. 2005;57(15):2215–2237. doi:10.1016/j.addr.2005.09.01916297497
   PubMed Web of Science ®Google Scholar
• Shao N, Su Y, Hu J, Zhang J, Zhang H, Cheng Y. Comparison of generation 3 polyamidoamine dendrimer and generation 4 polypropylenimine dendrimer on drug loading, complex structure, release behavior, and cytotoxicity. Int J Nanomedicine. 2011;6:3361–3372. doi:10.2147/IJN.S2702822267921
   PubMed Web of Science ®Google Scholar
• Dave K, Krishna Venuganti VV. Dendritic polymers for dermal drug delivery. Ther Deliv. 2017;8(12):1077–1096. doi:10.4155/tde-2017-009129125060
   PubMed Web of Science ®Google Scholar
• Shetty PK, Manikkath J, Tupally K, et al. Skin delivery of EGCG and silibinin: potential of peptide dendrimers for enhanced skin permeation and deposition. AAPS PharmSciTech. 2017;18(6):2346–2357. doi:10.1208/s12249-015-0403-028124212
   PubMed Web of Science ®Google Scholar
• Schultz GS, Davidson JM, Kirsner RS, Bornstein P, Herman IM. Dynamic reciprocity in the wound microenvironment. Wound Repair Regen. 2011;19(2):134–148. doi:10.1111/j.1524-475X.2010.00647.x21362080
   PubMed Web of Science ®Google Scholar
• Werner S, Krieg T, Smola H. Keratinocyte-fibroblast interactions in wound healing. J Invest Dermatol. 2007;127(5):998–1008. doi:10.1038/sj.jid.570064717435785
   PubMed Web of Science ®Google Scholar
• Shirakata Y. Regulation of epidermal keratinocytes by growth factors. J Dermatol Sci. 2010;59(2):73–80. doi:10.1016/j.jdermsci.2010.05.00220570492
   PubMedGoogle Scholar
• Donejko M, Przylipiak A, Rysiak E, et al. Hyaluronic acid abrogates ethanol-dependent inhibition of collagen biosynthesis in cultured human fibroblasts. Drug Des Devel Ther. 2015;9:6225–6233.
   PubMed Web of Science ®Google Scholar
• Juranova J, Frankova J, Ulrichova J. The role of keratinocytes in inflammation. J Appl Biomed. 2017;15:169−179. doi:10.1016/j.jab.2017.05.003
   Web of Science ®Google Scholar
• Landen NX, Li D, Stahle M. Transition from inflammation to proliferation: a critical step during wound healing. Cell Mol Life Sci. 2016;73(20):3861−3885. doi:10.1007/s00018-016-2268-027180275
   PubMed Web of Science ®Google Scholar
• Monteiller C, Tran L, MacNee W, et al. The pro-inflammatory effects of low-toxicity low-solubility particles, nanoparticles and fine particles, on epithelial cells in vitro: the role of surface area. Occup Environ Med. 2007;64(9):609−615. doi:10.1136/oem.2005.02480217409182
   PubMed Web of Science ®Google Scholar
• Stylianou E, Saklatvala J. Interleukin-1. Int J Biochem Cell Biol. 1998;30(10):1075−1079. doi:10.1016/S1357-2725(98)00081-89785472
   PubMedGoogle Scholar
• Cahill CM, Rogers JT. Interleukin (IL) 1beta induction of IL-6 is mediated by a novel phosphatidylinositol 3-kinase-dependent AKT/IkappaB kinase alpha pathway targeting activator protein-1. J Biol Chem. 2008;283(38):25900−25912. doi:10.1074/jbc.M70769220018515365
   PubMed Web of Science ®Google Scholar
• Liechty KW, Crombleholme TM, Cass DL, Martin B, Adzick NS. Diminished interleukin-8 (IL-8) production in the fetal wound healing response. J Surg Res. 1998;77(1):80−84. doi:10.1006/jsre.1998.53459698538
   PubMed Web of Science ®Google Scholar
• Zhang Y, Wang L, Zhang M, Jin M, Bai C, Wang X. Potential mechanism of interleukin-8 production from lung cancer cells: an involvement of EGF-EGFR-PI3K-Akt-Erk pathway. J Cell Physiol. 2012;227(1):35−43. doi:10.1002/jcp.2272221412767
   PubMed Web of Science ®Google Scholar
• Zhang J, Zhang D, Yan T, et al. BNIP3 promotes the motility and migration of keratinocyte under hypoxia. Exp Dermatol. 2017;26(5):416−422. doi:10.1111/exd.1324827783443
   PubMedGoogle Scholar
• Naha PC, Davoren M, Lyng FM, Byrne HJ. Reactive oxygen species (ROS) induced cytokine production and cytotoxicity of PAMAM dendrimers in J774A.1 cells. Toxicol Appl Pharmacol. 2010;246(1–2):91−99. doi:10.1016/j.taap.2010.04.01420420846
   PubMed Web of Science ®Google Scholar
• Pai CL, Shieh MJ, Lou PJ, Huang FH, Wang TW, Lai PS. Characterization of the uptake and intracellular trafficking of G4 polyamidoamine dendrimers. Aust J Chem. 2011;64(3):302−308. doi:10.1071/CH10358
   Web of Science ®Google Scholar
• Nyitrai G, Héja L, Jablonkai I, Pál I, Visy J, Kardos J. Polyamidoamine dendrimer impairs mitochondrial oxidation in brain tissue. J Nanobiotechnology. 2013;11:9. doi:10.1186/1477-3155-11-923556550
   PubMed Web of Science ®Google Scholar
• Smith PE, Brender JR, Dürr UH, et al. Solid-state NMR reveals the hydrophobic-core location of poly(amidoamine) dendrimers in biomembranes. J Am Chem Soc. 2010;132(23):8087−8097. doi:10.1021/ja101524z20481633
   PubMed Web of Science ®Google Scholar
• Smith DJ, Ng H, Kluck RM, Nagley P. The mitochondrial gateway to cell death. IUBMB Life. 2008;60(6):383−389. doi:10.1002/iub.4418425780
   PubMedGoogle Scholar
• Lee JH, Cha KE, Kim MS, et al. Nanosized polyamidoamine (PAMAM) dendrimer-induced apoptosis mediated by mitochondrial dysfunction. Toxicol Lett. 2009;190(2):202−207. doi:10.1016/j.toxlet.2009.07.01819643170
   PubMed Web of Science ®Google Scholar
• Lee H, Larson RG. Multiscale modeling of dendrimers and their interactions with bilayers and polyelectrolytes. Molecules. 2009;14(1):423−438. doi:10.3390/molecules1403108119158654
   PubMedGoogle Scholar
• Kroemer G, Galluzzi L, Brenner C. Mitochondrial membrane permeabilization in cell death. Physiol Rev. 2007;87(1):99−163. doi:10.1152/physrev.00013.200617237344
   PubMed Web of Science ®Google Scholar
• Czarnomysy R, Bielawska A, Muszyńska A, Bielawski K. Effects of novel alkyl pyridine platinum complexes on apoptosis in Ishikawa endometrial cancer cells. Med Chem. 2015;11(6):540−550. doi:10.2174/157340641166615020616354725659127
   PubMedGoogle Scholar
• Barman J, Kumar R, Saha G, Tiwari K, Dubey VK. Apoptosis: mediator molecules, interplay with other cell death processes and therapeutic potentials. Curr Pharm Biotechnol. 2018;19(8):644−663. doi:10.2174/138920101966618102211540530129409
   PubMedGoogle Scholar
• Albanesi C, Scarponi C, Giustizieri ML, Girolomoni G. Keratinocytes in inflammatory skin diseases. Curr Drug Targets Inflamm Allergy. 2005;4(3):329−334. doi:10.2174/156801005402203316101542
   PubMedGoogle Scholar
• Albanesi C. Keratinocytes in allergic skin diseases. Curr Opin Allergy Clin Immunol. 2010;10(5):452−456. doi:10.1097/ACI.0b013e32833e08ae20689405
   PubMedGoogle Scholar
• Friedland JC, Lakins JN, Kazanietz MG, Chernoff J, Boettiger D, Weaver VM. alpha6beta4 integrin activates Rac-dependent p21-activated kinase 1 to drive NF-kappaB-dependent resistance to apoptosis in 3D mammary acini. J Cell Sci. 2007;120(20):3700−3712. doi:10.1242/jcs.0348417911169
   PubMedGoogle Scholar
• Albertazzi L, Serresi M, Albanese A, Beltram F. Dendrimer internalization and intracellular trafficking in living cells. Mol Pharm. 2010;7(3):680−688. doi:10.1021/mp900246420394437
   PubMedGoogle Scholar
• Beddoes CM, Case CP, Briscoe WH. Understanding nanoparticle cellular entry: a physicochemical perspective. Adv Colloid Interface Sci. 2015;218:48−68. doi:10.1016/j.cis.2015.01.00725708746
   PubMed Web of Science ®Google Scholar
• Mukherjee SP, Davoren M, Byrne HJ. In vitro mammalian cytotoxicological study of PAMAM dendrimers - towards quantitative structure activity relationships. Toxicol In Vitro. 2010;24(1):169−177. doi:10.1016/j.tiv.2009.09.01419778601
   PubMed Web of Science ®Google Scholar
• Mukherjee SP, Lyng FM, Garcia A, Davoren M, Byrne HJ. Mechanistic studies of in vitro cytotoxicity of poly(amidoamine) dendrimers in mammalian cells. Toxicol Appl Pharmacol. 2010;248(3):259−268. doi:10.1016/j.taap.2010.08.01620736030
   PubMedGoogle Scholar