Targeting cell cycle protein in gastric cancer with CDC20siRNA and anticancer drugs (doxorubicin and quercetin) co-loaded cationic PEGylated nanoniosomes

References

• Sitarz R, Skierucha M, Mielko J, Offerhaus GJA, Maciejewski R, Polkowski WP. Gastric cancer: epidemiology, prevention, classification, and treatment. Cancer Manag Res. 2018;10:239–48. doi:10.2147/CMAR.S149619
   Google Scholar
• Ramasamy T, Ruttala HB, Gupta B, et al. Smart chemistry-based nanosized drug delivery systems for systemic applications: a comprehensive review. J Control Release. 2017;258:226–253. doi:10.1016/j.jconrel.2017.04.04328472638
   PubMed Web of Science ®Google Scholar
• Clavreul A, Pourbaghi-Masouleh M, Roger E, Menei P. Nanocarriers and nonviral methods for delivering antiangiogenic factors for glioblastoma therapy: the story so far. Int J Nanomedicine. 2019;14:2497–513. doi:10.2147/IJN.S194858
   Google Scholar
• Wang L, Zhang J, Wan L, Zhou X, Wang Z, Wei W. Targeting Cdc20 as a novel cancer therapeutic strategy. Pharmacol Ther. 2015;151:141–151. doi:10.1016/j.pharmthera.2015.04.00225850036
   PubMed Web of Science ®Google Scholar
• Wu W-J, Hu K-S, Wang D-S, et al. CDC20 overexpression predicts a poor prognosis for patients with colorectal cancer. J Transl Med. 2013;11(1):142. doi:10.1186/1479-5876-11-14223758705
   PubMedGoogle Scholar
• Chang DZ, Ma Y, Ji B, et al. Increased CDC20 expression is associated with pancreatic ductal adenocarcinoma differentiation and progression. J Hematol Oncol. 2012;5:15. doi:10.1186/1756-8722-5-1522475564
   PubMed Web of Science ®Google Scholar
• Kato T, Daigo Y, Aragaki M, Ishikawa K, Sato M, Kaji M. Overexpression of CDC20 predicts poor prognosis in primary non-small cell lung cancer patients. J Surg Oncol. 2012;106(4):423–430. doi:10.1002/jso.2310922488197
   PubMed Web of Science ®Google Scholar
• Ding ZY, Wu HR, Zhang JM, Huang GR, Ji DD. Expression characteristics of CDC20 in gastric cancer and its correlation with poor prognosis. Int J Clin Exp Pathol. 2014;7(2):722–727.24551295
   PubMed Web of Science ®Google Scholar
• Wang G, Zhang J, Liu L, Sharma S, Dong Q. Quercetin potentiates doxorubicin mediated antitumor effects against liver cancer through p53/Bcl-xl. PLoS One. 2012;7(12):e51764. doi:10.1371/journal.pone.005176423240061
   PubMed Web of Science ®Google Scholar
• Hemati M, Haghiralsadat F, Yazdian F, Jafari F, Moradi A, Malekpour-Dehkordi Z. Development and characterization of a novel cationic PEGylated niosome-encapsulated forms of doxorubicin, quercetin and siRNA for the treatment of cancer by using combination therapy. Artif Cell Nanomed Biotechnol. 2019;47(1):1295–1311. doi:10.1080/21691401.2018.1489271
   PubMed Web of Science ®Google Scholar
• Ag Seleci D, Seleci M, Walter J-G, Stahl F, Scheper T. Niosomes as Nanoparticular Drug Carriers: fundamentals and Recent Applications. J Nanomater. 2016;2016:13. doi:10.1155/2016/7372306
   Web of Science ®Google Scholar
• De Silva L, Fu J-Y, Htar TT, et al. Characterization, optimization, and in vitro evaluation of Technetium-99m-labeled niosomes. Int J Nanomedicine. 2019;14:1101–1117. doi:10.2147/IJN.S18491230863048
   PubMedGoogle Scholar
• Ojeda E, Puras G, Agirre M, et al. The role of helper lipids in the intracellular disposition and transfection efficiency of niosome formulations for gene delivery to retinal pigment epithelial cells. Int J Pharm. 2016;503(1–2):115–126. doi:10.1016/j.ijpharm.2016.02.04326956159
   PubMedGoogle Scholar
• Zhi D, Zhang S, Wang B, Zhao Y, Yang B, Yu S. Transfection efficiency of cationic lipids with different hydrophobic domains in gene delivery. Bioconjug Chem. 2010;21(4):563–577. doi:10.1021/bc900393r20121120
   PubMed Web of Science ®Google Scholar
• Ojeda E, Puras G, Agirre M, et al. Niosomes based on synthetic cationic lipids for gene delivery: the influence of polar head-groups on the transfection efficiency in HEK-293, ARPE-19 and MSC-D1 cells. Org Biomol Chem. 2015;13(4):1068–1081. doi:10.1039/c4ob02087a25412820
   PubMedGoogle Scholar
• Ertekin ZC, Bayindir ZS, Yuksel N. Stability studies on piroxicam encapsulated niosomes. Curr Drug Deliv. 2015;12(2):192–199.25056419
   PubMed Web of Science ®Google Scholar
• Chen J, Cheng D, Li J, et al. Influence of lipid composition on the phase transition temperature of liposomes composed of both DPPC and HSPC. Drug Dev Ind Pharm. 2013;39(2):197–204. doi:10.3109/03639045.2012.66891222443684
   PubMed Web of Science ®Google Scholar
• Majumder P, Bhunia S, Bhattacharyya J, Chaudhuri A. Inhibiting tumor growth by targeting liposomally encapsulated CDC20siRNA to tumor vasculature: therapeutic RNA interference. J Control Release. 2014;180:100–108. doi:10.1016/j.jconrel.2014.02.01224556418
   PubMed Web of Science ®Google Scholar
• Musacchio A, Salmon ED. The spindle-assembly checkpoint in space and time. Nat Rev Mol Cell Biol. 2007;8:379. doi:10.1038/nrm216317426725
   PubMed Web of Science ®Google Scholar
• Li K, Mao Y, Lu L, et al. Silencing of CDC20 suppresses metastatic castration-resistant prostate cancer growth and enhances chemosensitivity to docetaxel. Int J Oncol. 2016;49(4):1679–1685. doi:10.3892/ijo.2016.367127633058
   PubMedGoogle Scholar
• Choi J-W, Kim Y, Lee J-H, Kim Y-S. High expression of spindle assembly checkpoint proteins CDC20 and MAD2 is associated with poor prognosis in urothelial bladder cancer. Virchows Archiv. 2013;463(5):681–687. doi:10.1007/s00428-013-1473-623995871
   PubMed Web of Science ®Google Scholar
• Ramasamy T, Kim JH, Choi JY, et al. pH sensitive polyelectrolyte complex micelles for highly effective combination chemotherapy. J Mate Chem B. 2014;2(37):6324–6333. doi:10.1039/C4TB00867G
   PubMed Web of Science ®Google Scholar
• Deng G, Chen C, Zhang J, et al. Se@SiO2 nanocomposites attenuate doxorubicin-induced cardiotoxicity through combatting oxidative damage. Artif Cell Nanomed Biotechnol. 2018;46(supp2):112–121. doi:10.1080/21691401.2018.1452250
   Web of Science ®Google Scholar
• Ramasamy T, Ruttala H, Chitrapriya N, et al. Engineering of Cell Microenvironment-responsive Polypeptide Nanovehicle Co-encapsulating a Synergistic Combination of Small Molecules for Effective Chemotherapy in Solid Tumors. Acta Biomater 2017;48:131–143. doi: 10.1016/j.actbio.2016.10.034
   Google Scholar
• Bhunia S, Radha V, Chaudhuri A. CDC20siRNA and paclitaxel co-loaded nanometric liposomes of a nipecotic acid-derived cationic amphiphile inhibit xenografted neuroblastoma. Nanoscale. 2017;9(3):1201–1212. doi:10.1039/c6nr07532k28045167
   PubMed Web of Science ®Google Scholar
• Vergoni B, Cornejo PJ, Gilleron J, et al. dna damage and the activation of the p53 pathway mediate alterations in metabolic and secretory functions of adipocytes. Diabetes. 2016;65(10):3062–3074. doi:10.2337/db16-001427388216
   PubMed Web of Science ®Google Scholar
• Kidokoro T, Tanikawa C, Furukawa Y, Katagiri T, Nakamura Y, Matsuda K. CDC20, a potential cancer therapeutic target, is negatively regulated by p53. Oncogene. 2008;27(11):1562–1571. doi:10.1038/sj.onc.121079917873905
   PubMed Web of Science ®Google Scholar