Optimization of nanoemulsion containing gemcitabine and evaluation of its cytotoxicity towards human fetal lung fibroblast (MRC5) and human lung carcinoma (A549) cells

References

• Dela Cruz CS, Tanoue LT, Matthay RA. Lung Cancer: Epidemiology, Etiology, and Prevention. Clin Chest Med. 2011;32(4):605–644. doi:10.1016/j.ccm.2011.09.00122054876
   PubMed Web of Science ®Google Scholar
• Soni N, Soni N, Pandey H, Maheshwari R, Kesharwani P. Augmented delivery of gemcitabine in lung cancer cells exploring mannose anchored solid lipid nanoparticles. J Colloid Interface Sci. 2016;481:107–116. doi:10.1016/j.jcis.2016.07.02027459173
   PubMed Web of Science ®Google Scholar
• Asmawi AA, Salim N, Ngan CL, et al. Excipient selection and aerodynamic characterisation of nebulised lipid-based nanoemulsion loaded with docetaxel for lung cancer treatment. Drug Deliv Transl Res. 2018;9(2):543–554. doi:10.1007/s13346-018-0526-4
   Web of Science ®Google Scholar
• Arbain NH, Salim N, Masoumi HRF, Wong TW, Basri M, Abdul Rahman MB. In vitro evaluation of the inhalable quercetin loaded nanoemulsion for pulmonary delivery. Drug Deliv Transl Res. 2018;67:497–507.
   Google Scholar
• Morabito A, Gebbia V, Di M, et al. Randomized phase III trial of gemcitabine and cisplatin vs. gemcitabine alone in patients with advanced non-small cell lung cancer and a performance status of 2: the CAPPA-2 study. Lung Cancer. 2013;81:77–83. doi:10.1016/j.lungcan.2013.04.00823643177
   PubMedGoogle Scholar
• Hessmann E, Patzak MS, Klein L, et al. Fibroblast drug scavenging increases intratumoral gemcitabine accumulation in murine pancreas cancer. Gut. 2016;67(3):497–507. doi:10.1136/gutjnl-2016-311954
   Web of Science ®Google Scholar
• Liang T, Zhou Z, Cao Y, Ma M, Wang X, Jing K. Gemcitabine-based polymer-drug conjugate for enhanced anticancer effect in colon cancer. Int J Pharm. 2016;513(1–2):564–571. doi:10.1016/j.ijpharm.2016.09.01827613255
   PubMedGoogle Scholar
• Bornmann C, Graeser R, Esser N, et al. A new liposomal formulation of Gemcitabine is active in an orthotopic mouse model of pancreatic cancer accessible to bioluminescence imaging. Cancer Chemother Pharmacol. 2008;61(3):395–405. doi:10.1007/s00280-007-0482-z17554540
   PubMedGoogle Scholar
• Alvarellos ML, Lamba J, Sangkuhl K, et al. PharmGKB summary. Pharmacogenet Genomics. 2014;24(11):564–574. doi:10.1097/FPC.000000000000008625162786
   PubMedGoogle Scholar
• Abu-Fayyad A, Nazzal S. Gemcitabine-vitamin E conjugates: synthesis, characterisation, entrapment into nanoemulsions, and in-vitro deamination and antitumor activity. Int J Pharm. 2017;528:463–470. doi:10.1016/j.ijpharm.2017.06.03128627455
   PubMedGoogle Scholar
• Anderson BH, Lund B, Bach F, Thatcher N, Walling J, Hansen HH. Single-agent activity of weekly gemcitabine in advanced non-small-cell lung cancer: a Phase II Study. Am Soc Clin Oncol. 1994;12(9):821–1826. doi:10.1200/JCO.1994.12.9.1821
   Web of Science ®Google Scholar
• Ruiz Van Haperen VWT, Veerman G, Vermorken JB, Pinedo HM, Peters GJ. Regulation of phosphorylation of Deoxycytidine and 2′,2′-difluorodeoxycytidine (Gemcitabine); effects of Cytidine 5′-Triphosphate and Uridine 5′-Triphosphate in relation to Chemosensitivity for 2′,2′-Difluorodeoxycytidine. Biochem Pharmacol. 1996;51:911–918. doi:10.1016/0006-2952(95)02402-68651941
   PubMed Web of Science ®Google Scholar
• Akhter S, Ahmad J, Rizwanullah M, Rahman M, Zaki Ahmad M, Rizvi MMA. Nanotechnology-based inhalation treatments for lung cancer: state of the art. Nanotechnol Sci Appl. 2015;8:55–56. doi:10.2147/NSA.S4905226640374
   PubMedGoogle Scholar
• Sung JC, Pulliam BL, Edwards DA. Nanoparticles for drug delivery to the lungs. Trends Biotechnol. 2007;25:563–570. doi:10.1016/j.tibtech.2007.09.00517997181
   PubMed Web of Science ®Google Scholar
• Onischuk AA, Tolstikova TG, Baklanov AM, Khvostov MV. Generation, inhalation delivery and anti-hypertensive effect of nisoldipine nano aerosol. J Aerosol Sci. 2014;78:41–54. doi:10.1016/j.jaerosci.2014.08.004
   Web of Science ®Google Scholar
• Garbuzenko OB, Mainelis G, Taratula O, Minko T. Inhalation treatment of lung cancer: the influence of composition, size and shape of nanocarriers on their lung accumulation and retention. Cancer Biol Med. 2014;11(1):44.24738038
   PubMedGoogle Scholar
• Tadros TF. Emulsion Formation, Stability, and Rheology (T. F. Tadros, Ed.) 1st ed. Wiley-VCH Verlag Gmbh & Co. KGaA;2013.
   Google Scholar
• Jaiswal M, Dudhe R, Sharma PK. Nanoemulsion: an advanced mode of drug delivery system. 3 Biotech. 2015;5(2):123–127. doi:10.1007/s13205-014-0214-0
   PubMedGoogle Scholar
• Salim N, Ahmad N, Musa SH, Hashim R, Tadros TF, Basri M. Nanoemulsion as a topical delivery system of antipsoriatic drugs. RSC Adv. 2016;6:6234–6250.
   Web of Science ®Google Scholar
• Khan I, Bahuguna A, Kumar P, Bajpai VK, Kang SC. In vitro and in vivo antitumor potential of carvacrol nanoemulsion against human lung adenocarcinoma A549 cells via mitochondrial-mediated apoptosis. Sci Rep. 2018;8(1):712–714.29335465
   PubMedGoogle Scholar
• Choudhury H, Gorain B, Karmakar S, et al. Improvement of cellular uptake, in vitro antitumor activity and sustained release profile with increased bioavailability from a nanoemulsion platform. Int J Pharm. 2014;460(1–2):131–143. doi:10.1016/j.ijpharm.2013.10.05524239580
   PubMedGoogle Scholar
• Solans C, Izquierdo P, Nolla J, Azemar N, Garcia-celma MJ. Nanoemulsions. Curr Opin Colloid Interface Sci. 2005;10(3–4):102–110. doi:10.1016/j.cocis.2005.06.004
   Web of Science ®Google Scholar
• Amani A, York P, Chrystyn H, Clark BJ. Evaluation of a nanoemulsion-based formulation for respiratory delivery of budesonide by nebulizers. Am Pharm Sci Pharm Sci Tech. 2010;11(3):1147–1151.
   Google Scholar
• Nasr M, Nawaz S, Elhissi A. Amphotericin B lipid nanoemulsion aerosols for targeting peripheral respiratory airways via nebulization. Int J Pharm. 2012;436:611–616. doi:10.1016/j.ijpharm.2012.07.02822842623
   PubMed Web of Science ®Google Scholar
• Sulaiman CIS, Basri M, Masoumi HRF, Chee WJ, Ashari SE, Ismail M. Effects of temperature, time, and solvent ratio on the extraction of phenolic compounds and the anti-radical activity of Clinacanthus nutans Lindau leaves by response surface methodology. Chem Cent J. 2017;11:1–11. doi:10.1186/s13065-017-0351-828101128
   PubMedGoogle Scholar
• Ribeiro RC, Barreto SM, Ostrosky EA, Da Rocho-Filho PA, Verissimo LM, Ferrari M. Production and characterisation of cosmetic nanoemulsions containing Opuntia ficusindica (L.) mill extract as moisturizing agent. Molecules. 2015;20(2):2492–2509.25648593
   PubMedGoogle Scholar
• Kim SY, Naskar D, Kundu SC, et al. Formulation of biologically-inspired silk-based drug carriers for pulmonary delivery targeted for lung cancer. Sci Rep. 2015;5(1):11878. doi:10.1038/srep1187826234773
   PubMedGoogle Scholar
• Wyszogrodzka G, Dorożyński P, Gil B, et al. Iron-based metal-organic frameworks as a theranostic carrier for local tuberculosis therapy. Pharm Res. 2018;35(7):144. doi:10.1007/s11095-018-2425-229777389
   PubMedGoogle Scholar
• Hwang TL, Fang CL, Chen CH, Fang JY. Permeation enhancer containing water-in-oil nanoemulsions as carriers for intravesical cisplatin delivery. Pharm Res. 2009;26(10):2314–2323. doi:10.1007/s11095-008-9767-019653070
   PubMed Web of Science ®Google Scholar
• Prajapati HN, Dalrymple DM, Serajuddin ATM, et al. Formulation and physiochemical study of a-tocopherol based oil in water nanoemulsion stabilised with non-toxic, biodegradable surfactant: sodium stearoyl lactate. Ultrason Sonochem. 2016;29(1):285–305. doi:10.1016/j.ultsonch.2015.09.007
   Google Scholar
• Frasch-Melnik S, Spyropoulos F, Norton IT. W1/O/W2double emulsions stabilised by fat crystals: formulation, stability and salt release. J Colloid Interface Sci. 2010;350(1):178–185. doi:10.1016/j.jcis.2010.06.03920621305
   PubMedGoogle Scholar
• Matos M, Gutierres G, Coca J, Pazos C. Preparation of water-in-oil-water (W/O/W) double emulsions containing trans-resveratrol. Colloids Surf A. 2014;442:69–79. doi:10.1016/j.colsurfa.2013.05.065
   Web of Science ®Google Scholar
• Sood S, Jain K, Gowthamarajan K. Optimization of curcumin nanoemulsion for intranasal delivery using the design of experiment and its toxicity assessment. Colloids Surf B. 2014;113:330–337. doi:10.1016/j.colsurfb.2013.09.018
   PubMed Web of Science ®Google Scholar
• Azhar SSNA, Ashari SE, Salim N. Development of a kojic monooleate-enriched oil-in-water nanoemulsion as a potential carrier for hyperpigmentation treatment. Int J Nanomedicine. 2018;13:6465–6479. doi:10.2147/IJN.S17762730410332
   PubMed Web of Science ®Google Scholar
• Musa SH, Basri M, Masoumi HRF, Karjiban RA, Malek EA, Basri H. Formulation optimisation of palm kernel oil esters nanoemulsion-loaded with chloramphenicol suitable for meningitis treatment. Colloids Surf B. 2013;112:1139. doi:10.1016/j.colsurfb.2013.07.043
   Web of Science ®Google Scholar
• Musa SH, Basri M, Masoumi HRF, Shamsudin N, Salim N. Enhancement of physicochemical properties of nanocolloidal carrier loaded with cyclosporine for tropical treatment of psoriasis: in vitro diffusion and in vivo hydrating action. Int J Nanomed. 2017;12:2427–2441. doi:10.2147/IJN.S125302
   PubMed Web of Science ®Google Scholar
• Artiga-artigas M, Lanjari-pérez Y, Martín-belloso O. Curcumin-loaded nanoemulsions stability as affected by the nature and concentration of surfactant. Food Chem. 2018;266:466–474. doi:10.1016/j.foodchem.2018.06.04330381213
   PubMed Web of Science ®Google Scholar
• Chang HB, Chen BH. Inhibition of lung cancer cells A549 and H460 by curcuminoid extracts and nanoemulsions prepared from Curcuma longa Linnaeus. Int J Nanomedicine. 2015;10:5059–5080.26345201
   PubMed Web of Science ®Google Scholar
• Mini E, Nobili S, Caciagli B, Landini I, Mazzei T. Cellular pharmacology of gemcitabine. Ann Oncol. 2006;17:7–12. doi:10.1093/annonc/mdj941
   PubMed Web of Science ®Google Scholar
• Jia Y, Xie J. Promising molecular mechanisms responsible for gemcitabine resistance in cancer. Genes Dis. 2015;2(4):299–306. doi:10.1016/j.gendis.2015.07.00330258872
   PubMedGoogle Scholar
• Toschi L, Cappuzzo F. Gemcitabine for the treatment of advanced nonsmall cell lung cancer. Onco Targets Ther. 2009;2:209–217.20616908
   PubMed Web of Science ®Google Scholar
• Lee W.H, Loo C.Y, Young P.M, Traini D, Mason R.S, Rohanizadeh R. Recent advances in curcumin nanoformulation for cancer therapy. Expert Opinion Drug Delivery. 2014;11:1183–1201.
   PubMed Web of Science ®Google Scholar