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Original Research

Oral absorption and lymphatic transport of baicalein following drug–phospholipid complex incorporation in self-microemulsifying drug delivery systems

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Pages 7291-7306 | Published online: 06 Sep 2019

References

  • Swartz MA. The physiology of the lymphatic system. Adv Drug Deliv Rev. 2001;50(1):3–20.11489331
  • Porter C, Pouton CJ, Charman W, Charman WN. Enhancing intestinal drug solubilisation using lipid-based delivery systems. Adv Drug Deliv Rev. 2008;60(6):673–691. doi:10.1016/j.addr.2007.10.01418155801
  • O’Driscoll CM. Lipid-based formulations for intestinal lymphatic delivery. Eur J Hosp Pharm. 2002;15(5):405–415.
  • Caliph SM, Charman WN, Porter CJH. Effect of short-, medium-, and long-chain fatty acid-based vehicles on the absolute oral bioavailability and intestinal lymphatic transport of halofantrine and assessment of mass balance in lymph-cannulated and non-cannulated rats. J Pharm Sci. 2000;89(8):1073–1084. doi:10.1002/1520-6017(200008)89:8<1073::aid-jps12>3.0.co;2-v10906731
  • Pouton CW. Formulation of self-emulsifying drug delivery systems. Adv Drug Deliv Rev. 1997;25(1):47–58. doi:10.1016/S0169-409X(96)00490-5
  • Aboulfotouh K, Allam AA, El-Badry M, El-Sayed AM. Role of self-emulsifying drug delivery systems in optimizing the oral delivery of hydrophilic macromolecules and reducing interindividual variability. Colloids Surf B Biointerfaces. 2018;167(2018):82–92. doi:10.1016/j.colsurfb.2018.03.03429627681
  • Gursoy RN, Benita S. Self-emulsifying drug delivery systems (SEDDS) for improved oral delivery of lipophilic drugs. Biomed Pharmacother. 2004;58(3):173–182. doi:10.1016/j.biopha.2004.02.00115082340
  • René H, Porter CJH, Edwards GA, Anette M, Kristensen HG, Charman WN. Examination of oral absorption and lymphatic transport of halofantrine in a triple-cannulated canine model after administration in self-microemulsifying drug delivery systems (SMEDDS) containing structured triglycerides. Eur J Hosp Pharm. 2003;20(1):91–97.
  • Minghui S, Xuezhen Z, Kewen X, et al. Intestinal absorption and intestinal lymphatic transport of sirolimus from self-microemulsifying drug delivery systems assessed using the single-pass intestinal perfusion (SPIP) technique and a chylomicron flow blocking approach: linear correlation with or. Saudi Pharm J. 2011;43(3):132–140. doi:10.1016/j.ejps.2011.04.011
  • Zhao L, Zhang L, Meng L, Wang J, Zhai G. Design and evaluation of a self-microemulsifying drug delivery system for apigenin. Drug Dev Ind Pharm. 2013;39(5):662–669. doi:10.3109/03639045.2012.68737822607130
  • Borhade V, Nair H, Hegde D. Design and evaluation of Self-Microemulsifying Drug Delivery System (SMEDDS) of tacrolimus. AAPS PharmSciTech. 2008;9(1):13–21. doi:10.1208/s12249-007-9014-818446456
  • Mandawgade SD, Sharma S, Pathak S, Patravale VB. Development of SMEDDS using natural lipophile: application to β-artemether delivery. Int J Pharm. 2008;362(1):179–183. doi:10.1016/j.ijpharm.2008.06.02118652886
  • Zhang L, Zhang L, Zhang M, et al. Self-emulsifying drug delivery system and the applications in herbal drugs. Drug Deliv. 2013;22(4):475–486. doi:10.3109/10717544.2013.86165924321014
  • Wu X, Xu J, Huang X, Wen C. Self-microemulsifying drug delivery system improves curcumin dissolution and bioavailability. Drug Dev Ind Pharm. 2011;37(1):15. doi:10.3109/03639045.2010.48956020738181
  • Qiao J, Ji D, Sun S, et al. Oral bioavailability and lymphatic transport of pueraria flavone-loaded self-emulsifying drug-delivery systems containing sodium taurocholate in rats. Pharmaceutics. 2018;10(3):147. doi:10.3390/pharmaceutics10030147
  • Kimura Y, Okuda H, Arichi S. Effects of baicalein on leukotriene C4 biosynthesis in human lymphocytes. Phytother Res. 1987;1(1):48–49. doi:10.1002/(ISSN)1099-1573
  • Yin J, Xiang C, Wang P, Yin Y, Hou Y. Biocompatible nanoemulsions based on hemp oil and less surfactants for oral delivery of baicalein with enhanced bioavailability. Int J Nanomedicine. 2017;12:2923–2931. doi:10.2147/IJN.S13116728435268
  • Pi J, Wang S, Wen L, et al. A nano-cocrystal strategy to improve the dissolution rate and oral bioavailability of baicalein. Asian J Pharm Sci. 2019;14(2):154-164. S1818087617309492-.
  • Yan Z, Lei S, Yaping H, et al. Baicalein selectively induces apoptosis in activated lymphocytes and ameliorates concanavalin a-induced hepatitis in mice. PLoS One. 2013;8(7):e69592. doi:10.1371/journal.pone.006959223894507
  • Lam HT, Le-Vinh B, Phan TNQ, Bernkop-Schnürch A. Self-emulsifying drug delivery systems and cationic surfactants: do they potentiate each other in cytotoxicity? J Pharm Pharmacol. 2019;71(2):156–166. doi:10.1111/jphp.1302130251762
  • Zhou H, Wan J, Wu L, et al. A new strategy for enhancing the oral bioavailability of drugs with poor water-solubility and low liposolubility based on phospholipid complex and supersaturated SEDDS. PLoS One. 2013;8(12):e84530. doi:10.1371/journal.pone.008453024391965
  • Wu H, Long X, Yuan F, et al. Combined use of phospholipid complexes and self-emulsifying microemulsions for improving the oral absorption of a BCS class IV compound, baicalin. Acta Pharm Sin B. 2014;4(3):217–226. doi:10.1016/j.apsb.2014.03.00226579386
  • Zhou Y, Dong W, Ye J, et al. A novel matrix dispersion based on phospholipid complex for improving oral bioavailability of baicalein: preparation, in vitro and in vivo evaluations. Drug Deliv. 2017;24(1):720–728. doi:10.1080/10717544.2017.131196828436702
  • Khoo S-M, Humberstone AJ, Porter CJH, Edwards GA, Charman WN. Formulation design and bioavailability assessment of lipidic self-emulsifying formulations of halofantrine. Int J Pharm. 1998;167(1):155–164. doi:10.1016/S0378-5173(98)00054-4
  • Kadu PJ, Kushare SS, Thacker DD, Gattani SG. Enhancement of oral bioavailability of atorvastatin calcium by self-emulsifying drug delivery systems (SEDDS). Pharm Dev Technol. 2011;16(1):65–74. doi:10.3109/1083745090349933320088679
  • Singh B, Khurana L, Bandyopadhyay S, Kapil R, Katare OO. Development of optimized self-nano-emulsifying drug delivery systems (SNEDDS) of carvedilol with enhanced bioavailability potential. Drug Deliv. 2011;18(8):599–612. doi:10.3109/10717544.2011.60468622008038
  • Avachat AM, Patel VG. Self nanoemulsifying drug delivery system of stabilized ellagic acid–phospholipid complex with improved dissolution and permeability. Saudi Pharm J. 2015;23(3):276–289. doi:10.1016/j.jsps.2014.11.00126106276
  • Zhang P, Liu Y, Feng N, Xu J. Preparation and evaluation of self-microemulsifying drug delivery system of oridonin. Int J Pharm. 2008;355(1):269–276. doi:10.1016/j.ijpharm.2007.12.02618242895
  • Elnaggar YSR, El-Massik MA, Abdallah OY. Self-nanoemulsifying drug delivery systems of tamoxifen citrate: design and optimization. Int J Pharm. 2009;380(1):133–141. doi:10.1016/j.ijpharm.2009.07.01519635537
  • Shen H, Zhong M. Preparation and evaluation of self-microemulsifying drug delivery systems (SMEDDS) containing atorvastatin. J Pharm Pharmacol. 2010;58(9):1183–1191. doi:10.1211/jpp.58.9.0004
  • Marianecci C, Paolino D, Celia C, Fresta M, Carafa M, Alhaique F. Non-ionic surfactant vesicles in pulmonary glucocorticoid delivery: characterization and interaction with human lung fibroblasts. J Control Release. 2010;147(1):127–135. doi:10.1016/j.jconrel.2010.06.02220603167
  • Celia C, Trapasso E, Cosco D, Paolino D, Fresta M. Turbiscan lab expert analysis of the stability of ethosomes and ultradeformable liposomes containing a bilayer fluidizing agent. Colloids Surf B Biointerfaces. 2009;72(1):155–160. doi:10.1016/j.colsurfb.2009.03.00719376689
  • Kang BK, Lee Jschon SK, Jeong SY, et al. Development of self-microemulsifying drug delivery systems (SMEDDS) for oral bioavailability enhancement of simvastatin in beagle dogs. Int J Pharm. 2004;274(1):65–73. doi:10.1016/j.ijpharm.2003.12.02815072783
  • Wenli L, Rui T, Wenjing H, et al. Preparation and evaluation of self-microemulsifying drug delivery system of baicalein. Fitoterapia. 2012;83(8):1532–1539. doi:10.1016/j.fitote.2012.08.02122982454
  • Zupančič O, Partenhauser A, Lam HT, Rohrer J, Bernkop-Schnürch A. Development and in vitro characterisation of an oral self-emulsifying delivery system for daptomycin. Eur J Hosp Pharm. 2016;81:129–136. doi:10.1016/j.ejps.2015.10.005
  • Zangenberg NH, Müllertz A, Kristensen HG, Hovgaard L. A dynamic in vitro lipolysis model. I. Controlling the rate of lipolysis by continuous addition of calcium. Eur J Hosp Pharm. 2001;14(2):115–122.
  • Dahan A, Hoffman A. Rationalizing the selection of oral lipid based drug delivery systems by an in vitro dynamic lipolysis model for improved oral bioavailability of poorly water soluble drugs. J Controlled Release. 2008;129(1):1–10. doi:10.1016/j.jconrel.2008.03.021
  • Christensen JØ, Schultz K, Mollgaard B, Kristensen HG, Mullertza A. Solubilisation of poorly water-soluble drugs during in vitro lipolysis of medium- and long-chain triacylglycerols. Eur J Hosp Pharm. 2004;23(3):287–296. doi:10.1016/j.ejps.2004.08.003
  • Zhang J, Lv H, Jiang K, Gao Y. Enhanced bioavailability after oral and pulmonary administration of baicalein nanocrystal. Int J Pharm. 2011;420(1):180–188. doi:10.1016/j.ijpharm.2011.08.02321878378
  • He X, Pei L, Tong HHY, Ying Z. Comparison of spray freeze drying and the solvent evaporation method for preparing solid dispersions of baicalein with pluronic F68 to improve dissolution and oral bioavailability. AAPS PharmSciTech. 2011;12(1):104–113. doi:10.1208/s12249-010-9560-321181514
  • Zhang Y, Luo R, Chen Y, Ke X, Hu D, Han M. Application of carrier and plasticizer to improve the dissolution and bioavailability of poorly water-soluble baicalein by hot melt extrusion. AAPS PharmSciTech. 2014;15(3):560–568. doi:10.1208/s12249-013-0071-x24570374
  • Fan Z, Wu J, Fang X, Sha X. A new function of vitamin E-TPGS in the intestinal lymphatic transport of lipophilic drugs: enhancing the secretion of chylomicrons. Int J Pharm. 2013;445(1–2):141–147. doi:10.1016/j.ijpharm.2013.01.07023396256
  • Lind ML, Jette J, René H, Anette M. Intestinal lymphatic transport of halofantrine in rats assessed using a chylomicron flow blocking approach: the influence of polysorbate 60 and 80. Saudi Pharm J. 2008;35(3):211–218. doi:10.1016/j.ejps.2008.07.003
  • Vivek M, Rashmi J, Komal P, Manish N, Amita J. Solid lipid nanoparticles (SLN) of efavirenz as lymph targeting drug delivery system: elucidation of mechanism of uptake using chylomicron flow blocking approach. Int J Pharm. 2015;495(1):439–446. doi:10.1016/j.ijpharm.2015.09.01426367780
  • Dahan A, Hoffman A. Use of a dynamic in vitro lipolysis model to rationalize oral formulation development for poor water soluble drugs: correlation with in vivo data and the relationship to intra-enterocyte processes in rats. Pharm Res. 2006;23(9):2165–2174. doi:10.1007/s11095-006-9054-x16902814
  • Chen M, Wu Q, Jiang J, et al. Preparation, characterization and in vivo evaluation of a formulation of dantrolene sodium with hydroxypropyl-β-cyclodextrin. J Pharm Biomed Anal. 2017;135:153–159. doi:10.1016/j.jpba.2016.12.02228027523
  • Ju L, Wenlan W, Qiuwei L, Shan C. Long-circulating nanoliposomes (LCNs) sustained delivery of baicalein (BAI) with desired oral bioavailability in vivo. Drug Deliv. 2013;20(8):319–323. doi:10.3109/10717544.2013.83442024028326
  • Huang Y, Zhang B, Gao Y, Zhang J, Shi L. Baicalein–nicotinamide cocrystal with enhanced solubility, dissolution, and oral bioavailability. J Pharm Sci. 2014;103(8):2330–2337. doi:10.1002/jps.2404824903146
  • Feng J, Xu W, Tao X, et al. Simultaneous determination of baicalin, baicalein, wogonin, berberine, palmatine and jatrorrhizine in rat plasma by liquid chromatography–tandem mass spectrometry and application in pharmacokinetic studies after oral administration of traditional Chinese. J Pharm Biomed Anal. 2010;53(3):591–598. doi:10.1016/j.jpba.2010.04.00220430560
  • Jun-Xiao Y, Wang W, Li-Hui Q, Chun-Yu L, Qi C, Yong-Hong L. An LC-MS/MS method for the simultaneous determination of chlorogenic acid, forsythiaside A and baicalin in rat plasma and its application to pharmacokinetic study of shuang-huang-lian in rats. J Pharm Biomed Anal. 2010;52(4):625–630. doi:10.1016/j.jpba.2010.01.03520153596
  • Ali H, Nazzal M, Zaghloul AAA, Nazzal S. Comparison between lipolysis and compendial dissolution as alternative techniques for the in vitro characterization of α-tocopherol self-emulsified drug delivery systems (SEDDS). Int J Pharm. 2008;352(1):104–114. doi:10.1016/j.ijpharm.2007.10.02318065173
  • Dahan A, Hoffman A. Evaluation of a chylomicron flow blocking approach to investigate the intestinal lymphatic transport of lipophilic drugs. Eur J Pharm Sci. 2005;24(4):381–388. doi:10.1016/j.ejps.2004.12.00615734305
  • Pouton CW. Lipid formulations for oral administration of drugs: non-emulsifying, self-emulsifying and ‘Self-microemulsifying’ drug delivery systems. Eur J Hosp Pharm. 2000;11(2,supplement):S93–S98. doi:10.1016/S0928-0987(00)00167-6