A versatile endosome acidity-induced sheddable gene delivery system: increased tumor targeting and enhanced transfection efficiency

References

• Kanasty R, Dorkin JR, Vegas A, Anderson D. Delivery materials for siRNA therapeutics. Nat Mater. 2013;12:967. doi:10.1038/nmat376524150415
   PubMed Web of Science ®Google Scholar
• Akinc A, Zumbuehl A, Goldberg M, et al. A combinatorial library of lipid-like materials for delivery of RNAi therapeutics. Nat Biotechnol. 2008;26:561. doi:10.1038/nbt140218438401
   PubMed Web of Science ®Google Scholar
• Jiepin Y, Qiang Z, Hong C, Yiyun C. Surface-engineered dendrimers in gene delivery. Chem Rev. 2015;115(11):5274–5300. doi:10.1021/cr500542t25944558
   PubMedGoogle Scholar
• Zhou D, Cutlar L, Gao Y, et al. The transition from linear to highly branched poly(β-amino ester)s: branching matters for gene delivery. Sci Adv. 2016;2(6):e1600102–e1600102. doi:10.1126/sciadv.160037527386572
   PubMed Web of Science ®Google Scholar
• Jordan JG, Robert L, Daniel G. A combinatorial polymer library approach yields insight into nonviral gene delivery. Acc Chem Res. 2008;41(6):749–759. doi:10.1021/ar700233618507402
   PubMedGoogle Scholar
• Chen C, Zheng P, Cao Z, et al. PEGylated hyperbranched polyphosphoester based nanocarriers for redox-responsive delivery of doxorubicin. Biomater Sci. 2016;4(3):412–417. doi:10.1039/c5bm00440c26626655
   PubMedGoogle Scholar
• Islam MA, Reesor EKG, Xu Y, Zope HR, Zetter BR, Shi J. Biomaterials for mRNA delivery. Biomater Sci. 2015;3(12):1519–1533. doi:10.1039/c5bm00198f26280625
   PubMed Web of Science ®Google Scholar
• Lv H, Zhang S, Wang B, Cui S, Yan J. Toxicity of cationic lipids and cationic polymers in gene delivery. J Control Release. 2006;114(1):100–109. doi:10.1016/j.jconrel.2006.04.01416831482
   PubMed Web of Science ®Google Scholar
• Luo D, Saltzman WM. Synthetic DNA delivery systems. Nat Biotechnol. 2000;18:33. doi:10.1038/7950110625387
   PubMed Web of Science ®Google Scholar
• Zhang J, Wang C, Lu M, et al. Intracellular distribution and internalization pathways of guanidinylated bioresponsive poly(amido amine)s in gene delivery. Asian J Pharm Sci. 2018;13(4):360–372. doi:10.1016/j.ajps.2018.02.008
   PubMed Web of Science ®Google Scholar
• Wang M, Liu H, Li L, Cheng Y. A fluorinated dendrimer achieves excellent gene transfection efficacy at extremely low nitrogen to phosphorus ratios. Nat Commun. 2014;5:3053. doi:10.1038/ncomms597224407172
   PubMed Web of Science ®Google Scholar
• Pierrat P, Wang R, Kereselidze D, et al. Efficient in vitro and in vivo pulmonary delivery of nucleic acid by carbon dot-based nanocarriers. Biomaterials. 2015;51:290–302. doi:10.1016/j.biomaterials.2015.02.01725771019
   PubMed Web of Science ®Google Scholar
• Zhou J, Liu J, Cheng CJ, et al. Biodegradable poly(amine-co-ester) terpolymers for targeted gene delivery. Nat Mater. 2011;11:82. doi:10.1038/nmat318722138789
   PubMedGoogle Scholar
• Nam J-P, Nah J-W. Target gene delivery from targeting ligand conjugated chitosan–PEI copolymer for cancer therapy. Carbohydr Polym. 2016;135:153–161. doi:10.1016/j.carbpol.2015.08.05326453863
   PubMed Web of Science ®Google Scholar
• Nia AH, Amini A, Taghavi S, Eshghi H, Abnous K, Ramezani M. A facile Friedel–Crafts acylation for the synthesis of polyethylenimine-grafted multi-walled carbon nanotubes as efficient gene delivery vectors. Int J Pharm. 2016;502(1):125–137. doi:10.1016/j.ijpharm.2016.02.03426906459
   PubMedGoogle Scholar
• Zhang X, Tang W, Yang Z, et al. PEGylated poly(amine-co-ester) micelles as biodegradable non-viral gene vectors with enhanced stability, reduced toxicity and higher in vivo transfection efficacy. J Mater Chem B. 2014;2(25):4034–4044. doi:10.1039/c4tb00439f
   PubMed Web of Science ®Google Scholar
• Qiao Y, Huang Y, Qiu C, et al. The use of PEGylated poly [2-(N,N-dimethylamino) ethyl methacrylate] as a mucosal DNA delivery vector and the activation of innate immunity and improvement of HIV-1-specific immune responses. Biomaterials. 2010;31(1):115–123. doi:10.1016/j.biomaterials.2009.09.03219781770
   PubMed Web of Science ®Google Scholar
• Huang R-Q, Qu Y-H, Ke W-L, Zhu J-H, Liu Y, Jiang C. Efficient gene delivery targeted to the brain using a transferrin-conjugated polyethyleneglycol-modified polyamidoamine dendrimer. Faseb J. 2007;21(4):1117–1125. doi:10.1096/fj.06-7380com17218540
   PubMed Web of Science ®Google Scholar
• Hatakeyama H, Akita H, Harashima H. A multifunctional envelope type nano device (MEND) for gene delivery to tumours based on the EPR effect: a strategy for overcoming the PEG dilemma. Adv Drug Deliv Rev. 2011;63(3):152–160. doi:10.1016/j.addr.2010.09.00120840859
   PubMed Web of Science ®Google Scholar
• Gu J, Wang X, Jiang X, et al. Self-assembled carboxymethyl poly (l-histidine) coated poly (β-amino ester)/DNA complexes for gene transfection. Biomaterials. 2012;33(2):644–658. doi:10.1016/j.biomaterials.2011.09.07622030282
   PubMedGoogle Scholar
• Hashida M, Mahato RI, Kawabata K, Miyao T, Nishikawa M, Takakura Y. Pharmacokinetics and targeted delivery of proteins and genes. J Control Release. 1996;41(1):91–97. doi:10.1016/0168-3659(96)01360-0
   Web of Science ®Google Scholar
• Jevprasesphant R, Penny J, Jalal R, Attwood D, McKeown NB, D’Emanuele A. The influence of surface modification on the cytotoxicity of PAMAM dendrimers. Int J Pharm. 2003;252(1):263–266.12550802
   PubMedGoogle Scholar
• He C, Yin L, Tang C, Yin C. Size-dependent absorption mechanism of polymeric nanoparticles for oral delivery of protein drugs. Biomaterials. 2012;33(33):8569–8578. doi:10.1016/j.biomaterials.2012.07.06322906606
   PubMed Web of Science ®Google Scholar
• Elechalawar CK, Sridharan K, Pal A, et al. Cationic folate-mediated liposomal delivery of bis-arylidene oxindole induces efficient melanoma tumor regression. Biomater Sci. 2017;5(9):1898–1909. doi:10.1039/c7bm00405b28715002
   PubMed Web of Science ®Google Scholar
• Wu B, Yu P, Cui C, et al. Folate-containing reduction-sensitive lipid–polymer hybrid nanoparticles for targeted delivery of doxorubicin. Biomater Sci. 2015;3(4):655–664. doi:10.1039/c4bm00462k26222425
   PubMed Web of Science ®Google Scholar
• Soniat M, Chook YM. Nuclear localization signals for four distinct Karyopherin-beta nuclear import systems. Biochem J. 2015;468:353–362. doi:10.1042/BJ2015036826173234
   PubMed Web of Science ®Google Scholar
• Leung HM, Chan MS, Liu LS, et al. Dual-function, cationic, peptide-coated nanodiamond systems: facilitating nuclear-targeting delivery for enhanced gene therapy applications. ACS Sustainable Chem Eng. 2018;6(8):9671–9681. doi:10.1021/acssuschemeng.8b00446
   Web of Science ®Google Scholar
• Hao X, Li Q, Ali H, et al. POSS-cored and peptide functionalized ternary gene delivery systems with enhanced endosomal escape ability for efficient intracellular delivery of plasmid DNA. J Mater Chem B. 2018;6(25):4251–4263. doi:10.1039/C8TB00786A
   PubMed Web of Science ®Google Scholar
• Alvisi G, Poon IKH, Jans DA, et al. Tumor-specific nuclear targeting: promises for anti-cancer therapy? Drug Resist Updates. 2006;9(1):40–50. doi:10.1016/j.drup.2006.02.003
   PubMed Web of Science ®Google Scholar
• Vogelstein B, Lane D, Levine AJ. Surfing the p53 network. Nature. 2000;408(6810):307–310. doi:10.1038/3504267511099028
   PubMed Web of Science ®Google Scholar
• Levine AJ, Hu W, Feng Z. The P53 pathway: what questions remain to be explored? Cell Death Differ. 2006;13(6):1027. doi:10.1038/sj.cdd.440191016557269
   PubMed Web of Science ®Google Scholar
• Aliaga C, Bravo-Moraga F, Gonzalez-Nilo D, et al. Location of TEMPO derivatives in micelles: subtle effect of the probe orientation. Food Chem. 2016;192:395–401. doi:10.1016/j.foodchem.2015.07.03626304365
   PubMed Web of Science ®Google Scholar
• Cheng F, Guan X, Cao H, et al. Characteristic of core materials in polymeric micelles effect on their micellar properties studied by experimental and dpd simulation methods. Int J Pharm. 2015;492(1):152–160. doi:10.1016/j.ijpharm.2015.07.03126196277
   PubMedGoogle Scholar
• Moraes C, Anjos J, Maruno M, Alonso A, Rocha-Filho P. Development of lamellar gel phase emulsion containing baru oil (Dipteryx alata Vog.) as a prospective delivery system for cutaneous application. Asian J Pharm Sci. 2018;13(2):183–190. doi:10.1016/j.ajps.2017.09.003
   PubMed Web of Science ®Google Scholar
• Rutnakornpituk M, Ngamdee P, Phinyocheep P. Synthesis, characterization and properties of chitosan modified with poly(ethylene glycol)–polydimethylsiloxane amphiphilic block copolymers. Polymer. 2005;46(23):9742–9752. doi:10.1016/j.polymer.2005.08.051
   Web of Science ®Google Scholar
• Wang H, Zhao P, Liang X, et al. Folate-PEG coated cationic modified chitosan–cholesterol liposomes for tumor-targeted drug delivery. Biomaterials. 2010;31(14):4129–4138. doi:10.1016/j.biomaterials.2010.01.08920163853
   PubMedGoogle Scholar
• Liang X, Ren X, Liu Z, et al. An efficient nonviral gene-delivery vector based on hyperbranched cationic glycogen derivatives. Int J Nanomed. 2014. 2014;9:(1):419–435.
   PubMedGoogle Scholar
• Han L, Zhou X. Synthesis and characterization of liposomes nano-composite-particles with hydrophobic magnetite as a MRI probe. Appl Surf Sci. 2016;376:252–260. doi:10.1016/j.apsusc.2016.03.164
   Web of Science ®Google Scholar
• Hu Y, Zhao N, Yu B, Liu F, Xu F-J. Versatile types of polysaccharide-based supramolecular polycation/pDNA nanoplexes for gene delivery. Nanoscale. 2014;6(13):7560–7569. doi:10.1039/c4nr01590h24890703
   PubMedGoogle Scholar
• Luo K, Li C, Li L, She W, Wang G, Gu Z. Arginine functionalized peptide dendrimers as potential gene delivery vehicles. Biomaterials. 2012;33(19):4917–4927. doi:10.1016/j.biomaterials.2012.03.03022484048
   PubMed Web of Science ®Google Scholar
• Dash PR, Read ML, Barrett LB, Wolfert MA, Seymour LW. Factors affecting blood clearance and in vivo distribution of polyelectrolyte complexes for gene delivery. Gene Ther. 1999;6:643. doi:10.1038/sj.gt.330084310476224
   PubMed Web of Science ®Google Scholar
• Plank C, Mechtler K, Szoka F, Wagner E. Activation of the complement system by synthetic DNA complexes: a potential barrier for intravenous gene delivery. Hum Gene Ther. 1996;7(12):1437–1446. doi:10.1089/hum.1996.7.12-14378844203
   PubMed Web of Science ®Google Scholar
• Kibria G, Hatakeyama H, Sato Y, Harashima H. Anti-tumor effect via passive anti-angiogenesis of PEGylated liposomes encapsulating doxorubicin in drug resistant tumors. Int J Pharm. 2016;509(1):178–187. doi:10.1016/j.ijpharm.2016.05.04727234700
   PubMedGoogle Scholar
• Yin H, Kanasty RL, Eltoukhy AA, Vegas AJ, Dorkin JR, Anderson DG. Non-viral vectors for gene-based therapy. Nat Rev Genet. 2014;15:541. doi:10.1038/nrg376325022906
   PubMed Web of Science ®Google Scholar
• Remoli ME, Giacomini E, Lutfalla G, et al. Selective expression of Type I IFN genes in human dendritic cells infected with mycobacterium tuberculosis. J Immunol. 2002;169:366–374. doi:10.4049/jimmunol.169.1.36612077266
   PubMed Web of Science ®Google Scholar
• Vignali DAA, Kuchroo VK. IL-12 family cytokines: immunological playmakers. Nat Immunol. 2012;13:722. doi:10.1038/ni.236622814351
   PubMed Web of Science ®Google Scholar
• Sabharanjak S, Mayor S. Folate receptor endocytosis and trafficking. Adv Drug Deliv Rev. 2004;56(8):1099–1109. doi:10.1016/j.addr.2004.01.01015094209
   PubMed Web of Science ®Google Scholar
• Varkouhi AK, Scholte M, Storm G, Haisma HJ. Endosomal escape pathways for delivery of biologicals. J Control Release. 2011;151(3):220–228. doi:10.1016/j.jconrel.2010.11.00421078351
   PubMed Web of Science ®Google Scholar
• Sun Y, Xian L, Xing H, et al. Factors influencing the nuclear targeting ability of nuclear localization signals. J Drug Target. 2016;24(10):927–933. doi:10.1080/1061186X.2016.118427327126810
   PubMed Web of Science ®Google Scholar