Lactobionic Acid Conjugated Quercetin Loaded Organically Modified Silica Nanoparticles Mitigates Cyclophosphamide Induced Hepatocytotoxicity

References

• Rehman MU, Tahir M, Ali F, et al. Cyclophosphamide-induced nephrotoxicity, genotoxicity, and damage in kidney genomic DNA of Swiss albino mice: the protective effect of Ellagic acid. Mol Cell Biochem. 2012;365:119–127. doi:10.1007/s11010-012-1250-x22286819
   PubMed Web of Science ®Google Scholar
• Haubitz M. Acute and long-term toxicity of cyclophosphamide. Transplantationsmedizin. 2007;19:26–31.
   Google Scholar
• Zarei M, Shivanandappa T. Amelioration of cyclophosphamide-induced hepatotoxicity by the root extract of decalepis hamiltonii in mice. Food Chem Toxicol. 2013;57:179–184. doi:10.1016/j.fct.2013.03.02823542512
   PubMed Web of Science ®Google Scholar
• Mohammad MK, Avila D, Zhang J, et al. Acrolein cytotoxicity in hepatocytes involves endoplasmic reticulum stress, mitochondrial dysfunction and oxidative stress. Toxicol Appl Pharmacol. 2012;265:73–82. doi:10.1016/j.taap.2012.09.02123026831
   PubMed Web of Science ®Google Scholar
• Adams JD, Klaidman LK. Acrolein-induced oxygen radical formation. Free Radic Biol Med. 1993;15:187–193. doi:10.1016/0891-5849(93)90058-38397144
   PubMed Web of Science ®Google Scholar
• Kim YW, Ki SH, Lee JR, et al. Liquiritigenin, an aglycone of liquiritin in Glycyrrhizae radix, prevents acute liver injuries in rats induced by acetaminophen with or without buthionine sulfoximine. Chem Biol Interact. 2006;161:125–138. doi:10.1016/j.cbi.2006.03.00816647697
   PubMed Web of Science ®Google Scholar
• Wagoner J, Negash A, Kane OJ, et al. Multiple effects of silymarin on the hepatitis C virus lifecycle. Hepatology. 2010;51:1912–1921. doi:10.1002/hep.2358720512985
   PubMed Web of Science ®Google Scholar
• Manna P, Sinha M, Sil PC. Protection of arsenic-induced hepatic disorder by arjunolic acid. Basic Clin Pharmacol Toxicol. 2007;101:333–338. doi:10.1111/pto.2007.101.issue-517910617
   PubMed Web of Science ®Google Scholar
• Zhao X, Cong X, Zheng L, Xu L, Yin L, Peng J. Dioscin, a natural steroid saponin, shows remarkable protective effect against acetaminophen-induced liver damage in vitro and in vivo. Toxicol Lett. 2012;214:69–80. doi:10.1016/j.toxlet.2012.08.00522939915
   PubMed Web of Science ®Google Scholar
• Erlund I. Review of the flavonoids quercetin, hesperetin, and naringenin. Dietary sources, bioactivities, bioavailability, and epidemiology. Nutr Res. 2004;24:851–874. doi:10.1016/j.nutres.2004.07.005
   Web of Science ®Google Scholar
• Erden Inal M, Kahraman A. The protective effect of flavonol quercetin against ultraviolet a induced oxidative stress in rats. Toxicology. 2000;154:21–29. doi:10.1016/S0300-483X(00)00268-711118667
   PubMedGoogle Scholar
• Igura K, Ohta T, Kuroda Y, Kaji K. Resveratrol and quercetin inhibit angiogenesis in vitro. Cancer Lett. 2001;171:11–16. doi:10.1016/S0304-3835(01)00443-811485823
   PubMed Web of Science ®Google Scholar
• Yang K, Lamprecht SA, Liu Y, et al. Chemoprevention studies of the flavonoids quercetin and rutin in normal and azoxymethane-treated mouse colon. Carcinogenesis. 2000;21:1655–1660. doi:10.1093/carcin/21.9.165510964096
   PubMed Web of Science ®Google Scholar
• Sorata Y, Takahama U, Kimura M. Protective effect of quercetin and rutin on photosensitized lysis of human erythrocytes in the presence of hematoporphyrin. Biochim Biophys Acta Gen Subj. 1984;799:313–317. doi:10.1016/0304-4165(84)90276-9
   PubMed Web of Science ®Google Scholar
• Bona S, Filippin LI, Di Naso FC, et al. Effect of antioxidant treatment on fibrogenesis in rats with carbon tetrachloride-induced cirrhosis. ISRN Gastroenterol. 2012;2012:1–7. doi:10.5402/2012/762920
   Google Scholar
• Chen X, Yin OQP, Zuo Z, Chow MSS. Pharmacokinetics and modeling of quercetin and metabolites. Pharm Res. 2005;22:892–901. doi:10.1007/s11095-005-4584-115948033
   PubMed Web of Science ®Google Scholar
• Harwood M, Danielewska B, Borzelleca JF, Flamm GW, Williams GM, Lines TC. A critical review of the data related to the safety of quercetin and lack of evidence of in vivo toxicity, including lack of genotoxic/carcinogenic properties. Food Chem Toxicol. 2007;45:2179–2205. doi:10.1016/j.fct.2007.05.01517698276
   PubMed Web of Science ®Google Scholar
• Justino GC, Santos MR, Canário S, Borges C, Florêncio MH, Mira L. Plasma quercetin metabolites: structure-antioxidant activity relationships. Arch Biochem Biophys. 2004;432:109–121. doi:10.1016/j.abb.2004.09.00715519302
   PubMed Web of Science ®Google Scholar
• Kumar R, Roy I, Ohulchanskyy TY, et al. Covalently dye-linked, surface-controlled, and bioconjugated organically modified silica nanoparticles as targeted probes for optical imaging. ACS Nano. 2008;2:449–456. doi:10.1021/nn700370b19206569
   PubMed Web of Science ®Google Scholar
• Liu H, Wang H, Xu Y, et al. Lactobionic acid-modified dendrimer-entrapped gold nanoparticles for targeted computed tomography imaging of human hepatocellular carcinoma. ACS Appl Mater Interfaces. 2014;6:6944–6953. doi:10.1021/am500761x24712914
   PubMed Web of Science ®Google Scholar
• Maitra A, Dinda AK, Prashant CK, Naqvi S, Unnithan J, Samim M. Curcumin loaded organically modified silica (ORMOSIL) nanoparticle; a novel agent for cancer therapy. Int J Nanotechnol. 2012;9:862–871. doi:10.1504/IJNT.2012.049451
   Web of Science ®Google Scholar
• Chen G, Li D, Li J, et al. Targeted doxorubicin delivery to hepatocarcinoma cells by lactobionic acid-modified laponite nanodisks. New J Chem. 2015;39:2847–2855. doi:10.1039/C4NJ01916D
   Web of Science ®Google Scholar
• Lowry OH, Rosebrough NJ, Farr AL, Randall RJ. Protein measurement with the Folin phenol reagent. J Biol Chem. 1951;193:265–275.14907713
   PubMed Web of Science ®Google Scholar
• Dwivedi DK, Jena GB. Glibenclamide protects against thioacetamide-induced hepatic damage in Wistar rat: investigation on NLRP3, MMP-2, and stellate cell activation. Naunyn Schmiedebergs Arch Pharmacol. 2018;391:1257–1274. doi:10.1007/s00210-018-1540-230066023
   PubMedGoogle Scholar
• Ohkawa H, Ohishi N, Yagi K. Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Anal Biochem. 1979;95:351–358. doi:10.1016/0003-2697(79)90738-336810
   PubMed Web of Science ®Google Scholar
• Kakkar P, Das B, Viswanathan PN. A modified spectrophotometric assay of superoxide dismutase. Indian J Biochem Biophys. 1984;21:130–132.6490072
   PubMed Web of Science ®Google Scholar
• Sinha AK. Colorimetric assay of catalase. Anal Biochem. 1972;47:389–394. doi:10.1016/0003-2697(72)90132-74556490
   PubMed Web of Science ®Google Scholar
• Hissin PJ, Hilf R. A fluorometric method for determination of oxidized and reduced glutathione in tissues. Anal Biochem. 1976;74:214–226. doi:10.1016/0003-2697(76)90326-2962076
   PubMed Web of Science ®Google Scholar
• Habig WH, Michael J, Pabst WBJ. The first enzymetic step in mercapturic acid formation. J Biol Chem. 1974;249:7130–7140.4436300
   PubMed Web of Science ®Google Scholar
• Sherif IO. The effect of natural antioxidants in cyclophosphamide-induced hepatotoxicity: role of Nrf2/HO-1 pathway. Int Immunopharmacol. 2018;61:29–36. doi:10.1016/j.intimp.2018.05.00729800788
   PubMed Web of Science ®Google Scholar
• Olayinka ET, Ore A, Ola OS, Adeyemo OA. Protective effect of quercetin on melphalan-induced oxidative stress and impaired renal and hepatic functions in rat. Chemother Res Pract. 2014;2014:1–8. doi:10.1155/2014/936526
   Google Scholar
• Verma SK, Rastogi S, Arora I, Javed K, Akhtar M, Samim M. Nanoparticle based delivery of quercetin for the treatment of carbon tetrachloride mediated liver cirrhosis in rats. J Biomed Nanotechnol. 2016;12:274–285. doi:10.1166/jbn.2016.215327305761
   PubMedGoogle Scholar
• Ashkani S, Bagheri F, Azarpira N, et al. Protective effects of quercetin on thioacetamide-induced acute liver damage and its related biochemical and pathological alterations. Egypt J Intern Med. 2017;28:123.
   Google Scholar
• Chen X. Protective effects of quercetin on liver injury induced by ethanol. Pharmacogn Mag. 2010;6:135. doi:10.4103/0973-1296.6290020668581
   PubMed Web of Science ®Google Scholar
• Lakshmi T, Sri Renukadevi B, Senthilkumar S, et al. Seed and bark extracts of Acacia catechu protects liver from acetaminophen induced hepatotoxicity by modulating oxidative stress, antioxidant enzymes and liver function enzymes in Wistar rat model. Biomed Pharmacother. 2018;108:838–844. doi:10.1016/j.biopha.2018.08.07730372895
   PubMed Web of Science ®Google Scholar
• Zhai X, Zhang Z, Liu W, et al. Protective effect of ALDH2 against cyclophosphamide-induced acute hepatotoxicity via attenuating oxidative stress and reactive aldehydes. Biochem Biophys Res Commun. 2018;499:93–98. doi:10.1016/j.bbrc.2018.03.04129524404
   PubMedGoogle Scholar
• Sreelatha S, Padma PR, Umadevi M. Protective effects of Coriandrum sativum extracts on carbon tetrachloride-induced hepatotoxicity in rats. Food Chem Toxicol. 2009;47:702–708. doi:10.1016/j.fct.2008.12.02219146910
   PubMed Web of Science ®Google Scholar
• Kabirifar R, Ghoreshi ZA, Safari F, Karimollah A, Moradi A, Eskandari-nasab E. Quercetin protects liver injury induced by bile duct ligation via attenuation of Rac1 and NADPH oxidase1 expression in rats. Hepatobiliary Pancreat Dis Int. 2017;16:88–95. doi:10.1016/S1499-3872(16)60164-928119263
   PubMedGoogle Scholar
• Ezhilarasan D. Oxidative stress is bane in chronic liver diseases: clinical and experimental perspective. Arab J Gastroenterol. 2018;19:56–64. doi:10.1016/j.ajg.2018.03.00229853428
   PubMed Web of Science ®Google Scholar
• Raghu R, Karthikeyan S. Zidovudine and isoniazid induced liver toxicity and oxidative stress: evaluation of mitigating properties of silibinin. Environ Toxicol Pharmacol. 2016;46:217–224. doi:10.1016/j.etap.2016.07.01427497728
   PubMed Web of Science ®Google Scholar
• Gutteridge JMC. Lipid peroxidation and antioxidants as biomarkers of tissue damage. Clin Chem. 1995;41:1819.7497639
   PubMed Web of Science ®Google Scholar
• Basu A, Bhattacharjee A, Samanta A, Bhattacharya S. Prevention of cyclophosphamide-induced hepatotoxicity and genotoxicity: effect of an l-cysteine based oxovanadium(IV) complex on oxidative stress and DNA damage. Environ Toxicol Pharmacol. 2015;40:747–757. doi:10.1016/j.etap.2015.08.03526432771
   PubMed Web of Science ®Google Scholar
• Tzankova V, Aluani D, Kondeva-Burdina M, et al. Hepatoprotective and antioxidant activity of quercetin loaded chitosan/alginate particles in vitro and in vivo in a model of paracetamol-induced toxicity. Biomed Pharmacother. 2017;92:569–579. doi:10.1016/j.biopha.2017.05.00828577496
   PubMed Web of Science ®Google Scholar
• Oyagbemi AA, Omobowale OT, Asenuga ER, Akinleye AS, Ogunsanwo RO, Saba AB. Cyclophosphamide-induced hepatotoxicity in wistar rats: the modulatory role of gallic acid as a hepatoprotective and chemopreventive phytochemical. Int J Prev Med. 2016;61:29–36.
   Google Scholar
• Singh C, Prakash C, Tiwari KN, Mishra SK, Kumar V. Premna integrifolia ameliorates cyclophosphamide-induced hepatotoxicity by modulation of oxidative stress and apoptosis. Biomed Pharmacother. 2018;107:634–643. doi:10.1016/j.biopha.2018.08.03930118879
   PubMed Web of Science ®Google Scholar
• Lin SY, Wang YY, Chen WY, Chuang YH, Pan PH, Chen CJ. Beneficial effect of quercetin on cholestatic liver injury. J Nutr Biochem. 2014;25:1183–1195. doi:10.1016/j.jnutbio.2014.06.00325108658
   PubMedGoogle Scholar
• Droge W. Free radicals in the physiological control of cell function. Physiol Rev. 2002;82:47–95. doi:10.1152/physrev.00018.200111773609
   PubMed Web of Science ®Google Scholar
• Chakraborty P, Roy SS, Basu A, Bhattacharya S. Sensitization of cancer cells to cyclophosphamide therapy by an organoselenium compound through ROS-mediated apoptosis. Biomed Pharmacother. 2016;84:1992–1999. doi:10.1016/j.biopha.2016.11.00627856111
   PubMedGoogle Scholar
• HA D, van Ommen B, van Bladeren PJ. Involvement of human glutathione s-transferase isoenzymes in the conjugation of cyclophosphamide metabolites with glutathione. Cancer Res. 1994;54:6215–6220.7954469
   PubMed Web of Science ®Google Scholar
• Tuorkey MJ. Therapeutic potential of nigella sativa oil against cyclophosphamide-induced DNA damage and hepatotoxicity. Nutr Cancer. 2017;69:498–504. doi:10.1080/01635581.2017.128540828287318
   PubMed Web of Science ®Google Scholar
• Mahmoud AM. Hesperidin protects against cyclophosphamide-induced hepatotoxicity by upregulation of PPARγ and abrogation of oxidative stress and inflammation. Can J Physiol Pharmacol. 2014;92:717–724. doi:10.1139/cjpp-2014-020425079140
   PubMed Web of Science ®Google Scholar