Toxicity of Carbon Nanotubes as Anti-Tumor Drug Carriers

References

• Li H, Shi L, Wei J, et al. Cellular uptake and anticancer activity of salvianolic acid B phospholipid complex loaded nanoparticles in head and neck cancer and precancer cells. Colloids Surf B Biointerfaces. 2016;147:65–72. doi:10.1016/j.colsurfb.2016.07.05327490455
   PubMedGoogle Scholar
• Shanmugam MK, Warrier S, Kumar AP, et al. Potential role of natural compounds as anti-angiogenic agents in cancer. Curr Vasc Pharmacol. 2017;15:503–519. doi:10.2174/157016111566617071309431928707601
   PubMed Web of Science ®Google Scholar
• Yallapu MM, Gupta BK, Jaggi M, et al. Fabrication of curcumin encapsulated PLGA nanoparticles for improved therapeutic effects in metastatic cancer cells. J Colloid Interface Sci. 2010;351:19–29. doi:10.1016/j.jcis.2010.05.02220627257
   PubMed Web of Science ®Google Scholar
• Zamorano JL, Lancellotti P, Rodriguez Munoz D, et al. 2016 ESC position paper on cancer treatments and cardiovascular toxicity developed under the auspices of the ESC committee for practice guidelines: the task force for cancer treatments and cardiovascular toxicity of the European Society of Cardiology (ESC). Eur Heart J. 2016;37:2768–2801. doi:10.1093/eurheartj/ehw21127567406
   PubMed Web of Science ®Google Scholar
• Yitzhak R, Elman NM. Carbon nanotubes in drug delivery: focus on infectious diseases. Expert Opin Drug Del. 2009;6:517–530. doi:10.1517/17425240902865579
   PubMed Web of Science ®Google Scholar
• Eroglu MS, Oner ET, Mutlu EC, et al. Sugar based biopolymers in nanomedicine; new emerging era for cancer imaging and therapy. Curr Top Med Chem. 2016;17:1507–1520. doi:10.2174/1568026616666161222101703
   Web of Science ®Google Scholar
• Jain KK. Role of nanodiagnostics in personalized cancer therapy. Clin Lab Med. 2012;32:15–31. doi:10.1016/j.cll.2011.10.00122340841
   PubMed Web of Science ®Google Scholar
• Nagesetti A, Srinivasan S, McGoron AJ. Polyethylene glycol modified ORMOSIL theranostic nanoparticles for triggered doxorubicin release and deep drug delivery into ovarian cancer spheroids. J Photochem Photobiol B. 2017;174:209–216. doi:10.1016/j.jphotobiol.2017.07.02028800509
   PubMedGoogle Scholar
• Watermann A, Brieger J. Mesoporous silica nanoparticles as drug delivery vehicles in cancer. Nanomaterials (Basel). 2017;7:189.
   PubMedGoogle Scholar
• Jain KK. Advances in the field of nanooncology. BMC Med. 2010;8:83. doi:10.1186/1741-7015-8-8321144040
   PubMed Web of Science ®Google Scholar
• Liu Z, Robinson JT, Tabakman SM, et al. Carbon materials for drug delivery & cancer therapy. Mater Today. 2011;14:316–323. doi:10.1016/S1369-7021(11)70161-4
   Web of Science ®Google Scholar
• Gately RD, In Het Panhuis M. Filling of carbon nanotubes and nanofibres. Beilstein J Nanotechnol. 2015;6:508–516. doi:10.3762/bjnano.6.5325821693
   PubMedGoogle Scholar
• Jin H, Heller DA, Sharma R, et al. Size-dependent cellular uptake and expulsion of single-walled carbon nanotubes: single particle tracking and a generic uptake model for nanoparticles. ACS Nano. 2009;3:149–158. doi:10.1021/nn800532m19206261
   PubMed Web of Science ®Google Scholar
• Lacerda L, Bianco A, Prato M, et al. Carbon nanotubes as nanomedicines: from toxicology to pharmacology. Adv Drug Deliv Rev. 2006;58:1460–1470. doi:10.1016/j.addr.2006.09.01517113677
   PubMed Web of Science ®Google Scholar
• Lamprecht C, Plochberger B, Ruprecht V, et al. A single-molecule approach to explore binding, uptake and transport of cancer cell targeting nanotubes. Nanotechnology. 2014;25:125704. doi:10.1088/0957-4484/25/12/12570424577143
   PubMedGoogle Scholar
• Lamprecht C, Gierlinger N, Heister E, et al. Mapping the intracellular distribution of carbon nanotubes after targeted delivery to carcinoma cells using confocal Raman imaging as a label-free technique. J Phys Condens Matter. 2012;24:164206. doi:10.1088/0953-8984/24/16/16420622466107
   PubMed Web of Science ®Google Scholar
• Iijima S. Helical microtubules of graphitic carbon. Nature. 1991;354:56–58. doi:10.1038/354056a0
   Web of Science ®Google Scholar
• Ezzati Nazhad Dolatabadi J, Omidi Y, Losic D. Carbon nanotubes as an advanced drug and gene delivery nanosystem. Curr Nanosci. 2011;7:297–314. doi:10.2174/157341311795542444
   Web of Science ®Google Scholar
• Liu X, Tao H, Yang K, et al. Optimization of surface chemistry on single-walled carbon nanotubes for in vivo photothermal ablation of tumors. Biomaterials. 2011;32:144–151. doi:10.1016/j.biomaterials.2010.08.09620888630
   PubMed Web of Science ®Google Scholar
• Wang L, Shi J, Jia X, et al. NIR-/pH-responsive drug delivery of functionalized single-walled carbon nanotubes for potential application in cancer chemo-photothermal therapy. Pharm Res. 2013;30:2757–2771. doi:10.1007/s11095-013-1095-323765399
   PubMed Web of Science ®Google Scholar
• Zhang B, Wang H, Shen S, et al. Fibrin-targeting peptide CREKA-conjugated multi-walled carbon nanotubes for self-amplified photothermal therapy of tumor. Biomaterials. 2016;79:46–55. doi:10.1016/j.biomaterials.2015.11.06126695116
   PubMed Web of Science ®Google Scholar
• Marches R, Chakravarty P, Musselman IH, et al. Specific thermal ablation of tumor cells using single-walled carbon nanotubes targeted by covalently-coupled monoclonal antibodies. Int J Cancer. 2009;125:2970–2977. doi:10.1002/(ISSN)1097-021519536775
   PubMedGoogle Scholar
• Jeyamohan P, Hasumura T, Nagaoka Y, et al. Accelerated killing of cancer cells using a multifunctional single-walled carbon nanotube-based system for targeted drug delivery in combination with photothermal therapy. Int J Nanomed. 2013;8:2653–2667.
   PubMed Web of Science ®Google Scholar
• Sobhani Z, Behnam MA, Emami F, et al. Photothermal therapy of melanoma tumor using multiwalled carbon nanotubes. Int J Nanomed. 2017;12:4509–4517. doi:10.2147/IJN
   PubMed Web of Science ®Google Scholar
• Roy E, Patra S, Madhuri R, et al. Carbon dot/TAT peptide co-conjugated bubble nanoliposome for multicolor cell imaging, nuclear-targeted delivery, and chemo/photothermal synergistic therapy. Chem Eng J. 2017;312:144–157. doi:10.1016/j.cej.2016.11.122
   Web of Science ®Google Scholar
• Sheikhpour M, Golbabaie A, Kasaeian A. Carbon nanotubes: a review of novel strategies for cancer diagnosis and treatment. Mater Sci Eng C Mater Biol Appl. 2017;76:1289–1304. doi:10.1016/j.msec.2017.02.13228482496
   PubMedGoogle Scholar
• Chakrabarti M, Kiseleva R, Vertegel A, et al. Carbon nanomaterials for drug delivery and cancer therapy. J Nanosci Nanotechno. 2015;15:5501–5511. doi:10.1166/jnn.2015.10614
   PubMed Web of Science ®Google Scholar
• Caoduro C, Hervouet E, Girard-Thernier C, et al. Carbon nanotubes as gene carriers: focus on internalization pathways related to functionalization and properties. Acta Biomater. 2017;49:36–44. doi:10.1016/j.actbio.2016.11.01327826000
   PubMed Web of Science ®Google Scholar
• Battigelli A, Menard-Moyon C, Da Ros T, et al. Endowing carbon nanotubes with biological and biomedical properties by chemical modifications. Adv Drug Deliv Rev. 2013;65:1899–1920. doi:10.1016/j.addr.2013.07.00623856410
   PubMed Web of Science ®Google Scholar
• Elhissi AM, Ahmed W, Hassan IU, et al. Carbon nanotubes in cancer therapy and drug delivery. J Drug Deliv. 2012;2012:837327. doi:10.1155/2012/83732722028974
   PubMedGoogle Scholar
• Kushwaha SKS, Ghoshal S, Rai AK, et al. Carbon nanotubes as a novel drug delivery system for anticancer therapy: a review. Braz J Pharm Sci. 2013;49:629–643. doi:10.1590/S1984-82502013000400002
   Web of Science ®Google Scholar
• Wan L, Jiao J, Cui Y, et al. Hyaluronic acid modified mesoporous carbon nanoparticles for targeted drug delivery to CD44-overexpressing cancer cells. Nanotechnology. 2016;27:135102. doi:10.1088/0957-4484/27/13/13510226901756
   PubMed Web of Science ®Google Scholar
• Karimi M, Solati N, Ghasemi A, et al. Carbon nanotubes part II: a remarkable carrier for drug and gene delivery. Expert Opin Drug Deliv. 2015;12:1089–1105. doi:10.1517/17425247.2015.100430925613837
   PubMed Web of Science ®Google Scholar
• Augustine S, Singh J, Srivastava M, et al. Recent advances in carbon based nanosystems for cancer theranostics. Biomater Sci. 2017;5:901–952. doi:10.1039/C7BM00008A28401206
   PubMed Web of Science ®Google Scholar
• Chen W, Zheng X, Li S, et al. One-pot synthesis of FePt/CNTs nanocomposites for efficient cellular imaging and cancer therapy. J Nanopart Res. 2015;17:444.
   Web of Science ®Google Scholar
• Saeednia L, Yao L, Cluff K, et al. Sustained releasing of methotrexate from injectable and thermosensitive chitosan-carbon nanotube hybrid hydrogels effectively controls tumor cell growth. ACS Omega. 2019;4:4040–4048. doi:10.1021/acsomega.8b0321230842986
   PubMed Web of Science ®Google Scholar
• Palmer BC, Phelan-Dickenson SJ, DeLouise LA. Multi-walled carbon nanotube oxidation dependent keratinocyte cytotoxicity and skin inflammation. Part Fibre Toxicol. 2019;16:3. doi:10.1186/s12989-018-0285-x30621720
   PubMedGoogle Scholar
• Kasai T, Umeda Y, Ohnishi M, et al. Thirteen-week study of toxicity of fiber-like multi-walled carbon nanotubes with whole-body inhalation exposure in rats. Nanotoxicology. 2015;9:413–422. doi:10.3109/17435390.2014.93390325030099
   PubMed Web of Science ®Google Scholar
• Emerce E, Ghosh M, Oner D, et al. Carbon nanotube- and asbestos-induced DNA and RNA methylation changes in bronchial epithelial cells. Chem Res Toxicol. 2019;32:850–860. doi:10.1021/acs.chemrestox.8b0040630990028
   PubMedGoogle Scholar
• Chernova T, Murphy FA, Galavotti S, et al. Long-fiber carbon nanotubes replicate asbestos-induced mesothelioma with disruption of the tumor suppressor gene Cdkn2a (Ink4a/Arf). Curr Biol. 2017;27:3302–3314 e3306. doi:10.1016/j.cub.2017.09.00729112861
   PubMed Web of Science ®Google Scholar
• Roda E, Coccini T, Barni S, et al. Comparative pulmonary toxicity assessment of pristine and functionalized multi-walled carbon nanotubes intratracheally instilled in rats. Toxicol Lett. 2010;196:S277. doi:10.1016/j.toxlet.2010.03.1137
   Web of Science ®Google Scholar
• Morimoto Y, Hirohashi M, Ogami A, et al. Pulmonary toxicity of well-dispersed multi-wall carbon nanotubes following inhalation and intratracheal instillation. Nanotoxicology. 2012;6:587–599. doi:10.3109/17435390.2011.59491221714591
   PubMed Web of Science ®Google Scholar
• Shen CX, Zhang QF, Li J, et al. Induction of programmed cell death in arabidopsis and rice by single-wall carbon nanotubes. Am J Bot. 2010;97:1602–1609. doi:10.3732/ajb.100007321616795
   PubMed Web of Science ®Google Scholar
• Oberdorster G. Safety assessment for nanotechnology and nanomedicine: concepts of nanotoxicology. J Intern Med. 2010;267:89–105. doi:10.1111/j.1365-2796.2009.02187.x20059646
   PubMed Web of Science ®Google Scholar
• Thurnherr T, Brandenberger C, Fischer K, et al. A comparison of acute and long-term effects of industrial multiwalled carbon nanotubes on human lung and immune cells in vitro. Toxicol Lett. 2011;200:176–186. doi:10.1016/j.toxlet.2010.11.01221112381
   PubMed Web of Science ®Google Scholar
• Osmond-McLeod MJ, Poland CA, Murphy F, et al. Durability and inflammogenic impact of carbon nanotubes compared with asbestos fibres. Part Fibre Toxicol. 2011;8:15.21569450
   PubMed Web of Science ®Google Scholar
• Ursini CL, Maiello R, Ciervo A, et al. Evaluation of uptake, cytotoxicity and inflammatory effects in respiratory cells exposed to pristine and -OH and -COOH functionalized multi-wall carbon nanotubes. J Appl Toxicol. 2016;36:394–403. doi:10.1002/jat.v36.326370214
   PubMed Web of Science ®Google Scholar
• Santos T, Fang X, Chen MT, et al. Sequential administration of carbon nanotubes and near-infrared radiation for the treatment of gliomas. Front Oncol. 2014;4:180. doi:10.3389/fonc.2014.0018025077069
   PubMedGoogle Scholar
• Wang L, Shi J, Zhang H, et al. Synergistic anticancer effect of RNAi and photothermal therapy mediated by functionalized single-walled carbon nanotubes. Biomaterials. 2013;34:262–274. doi:10.1016/j.biomaterials.2012.09.03723046752
   PubMed Web of Science ®Google Scholar
• Jabr-Milane LS, van Vlerken LE, Yadav S, et al. Multi-functional nanocarriers to overcome tumor drug resistance. Cancer Treat Rev. 2008;34:592–602. doi:10.1016/j.ctrv.2008.04.00318538481
   PubMed Web of Science ®Google Scholar
• Meng L, Zhang X, Lu Q, et al. Single walled carbon nanotubes as drug delivery vehicles: targeting doxorubicin to tumors. Biomaterials. 2012;33:1689–1698. doi:10.1016/j.biomaterials.2011.11.00422137127
   PubMed Web of Science ®Google Scholar
• Pacurari M, Yin XJ, Ding M, et al. Oxidative and molecular interactions of multi-wall carbon nanotubes (MWCNT) in normal and malignant human mesothelial cells. Nanotoxicology. 2009;2:155–170. doi:10.1080/17435390802318356
   Web of Science ®Google Scholar
• Hong SY, Tobias G, Al-Jamal KT, et al. Filled and glycosylated carbon nanotubes for in vivo radioemitter localization and imaging. Nat Mater. 2010;9:485–490. doi:10.1038/nmat276620473287
   PubMed Web of Science ®Google Scholar
• Ménard-Moyon, Cécilia, Venturelli E, Fabbro C, et al. The alluring potential of functionalized carbon nanotubes in drug discovery. Expert Opin Drug Dis. 2010;7:691–707. doi:10.1517/17460441.2010.490552
   Google Scholar
• Zhang W, Zhang Z, Zhang Y. The application of carbon nanotubes in target drug delivery systems for cancer therapies. Nanoscale Res Lett. 2011;6:555. doi:10.1186/1556-276X-6-55521995320
   PubMed Web of Science ®Google Scholar
• Lia Z, ALBd B, Soaresc DCF, et al. Functionalized single-walled carbon nanotubes: cellular uptake, biodistribution and applications in drug delivery. Int J Pharm. 2017;524:41–54. doi:10.1016/j.ijpharm.2017.03.01728300630
   PubMedGoogle Scholar
• Kayat J, Gajbhiye V, Tekade RK, et al. Pulmonary toxicity of carbon nanotubes: a systematic report. Nanomedicine. 2011;7:40–49. doi:10.1016/j.nano.2010.06.00820620235
   PubMed Web of Science ®Google Scholar
• Shams H, Holt BD, Mahboobi SH, et al. Actin reorganization through dynamic interactions with single-wall carbon nanotubes. ACS Nano. 2014;8:188–197. doi:10.1021/nn402865e24351114
   PubMedGoogle Scholar
• Al-Jamal KT, Nerl H, Müller KH, et al. Cellular uptake mechanisms of functionalised multi-walled carbon nanotubes by 3D electron tomography imaging. Nanoscale. 2011;3:2627–2635. doi:10.1039/c1nr10080g21603701
   PubMed Web of Science ®Google Scholar
• Kostarelos K, Lacerda L, Pastorin G, et al. Cellular uptake of functionalized carbon nanotubes is independent of functional group and cell type. Nat Nanotechnol. 2007;2:108–113. doi:10.1038/nnano.2006.20918654229
   PubMed Web of Science ®Google Scholar
• Dan E, Walid D, Cécilia MM, et al. Carbon nanotube degradation in macrophages: live nanoscale monitoring and understanding of biological pathway. ACS Nano. 2015;9:10113–10124. doi:10.1021/acsnano.5b0370826331631
   PubMedGoogle Scholar
• Kang B, Chang S, Dai Y, et al. Cell response to carbon nanotubes: size-dependent intracellular uptake mechanism and subcellular fate. Small. 2010;6:2362–2366. doi:10.1002/smll.20100126020878638
   PubMed Web of Science ®Google Scholar
• Kang B, Dai Y, Chang S, et al. Cell response to carbon nanotubes: size-dependent intracellular uptake mechanism and subcellular fate. Small. 2010;6:2362–2366. doi:10.1002/smll.20100126020878638
   PubMed Web of Science ®Google Scholar
• Pantarotto D, Briand J-P, Prato M, et al. Translocation of bioactive peptides across cell membranes by carbon nanotubes. Chem Commun. 2003;10:16–17.
   Google Scholar
• Raffa V, Ciofani G, Vittorio O, et al. Physicochemical properties affecting cellular uptake of carbon nanotubes. Nanomedicine. 2010;5:89–97. doi:10.2217/nnm.09.9520025467
   PubMed Web of Science ®Google Scholar
• Lacerda L, Russier J, Pastorin G, et al. Translocation mechanisms of chemically functionalised carbon nanotubes across plasma membranes. Biomaterials. 2012;33:3334–3343. doi:10.1016/j.biomaterials.2012.01.02422289266
   PubMed Web of Science ®Google Scholar
• Serag MF, Kaji N, Okamoto CGY, et al. Trafficking and subcellular localization of multiwalled carbon nanotubes in plant cells. ACS Nano. 2011;5:493–499. doi:10.1021/nn102344t21141871
   PubMed Web of Science ®Google Scholar
• Caoduro C, Kacem R, Boukari K, et al. Carbon nanotube – protamine hybrid: evaluation of DNA cell penetration. Carbon. 2016;96:742–752. doi:10.1016/j.carbon.2015.09.098
   Web of Science ®Google Scholar
• Yaron PN, Holt BD, Short PA, et al. Single wall carbon nanotubes enter cells by endocytosis and not membrane penetration. J Nanobiotechnol. 2011;9:45. doi:10.1186/1477-3155-9-45
   PubMed Web of Science ®Google Scholar
• HalamodaKenzaoui B, Ceridono M, Urbán P, et al. The agglomeration state of nanoparticles can influence the mechanism of their cellular internalisation. J Nanobiotechnol. 2017;15:48. doi:10.1186/s12951-017-0281-6
   PubMed Web of Science ®Google Scholar
• Mousavi SZ, Nademi Y, Amjad-Iranagh S. et al. Carbon nanotube-encapsulated drug penetration through the cell membrane: an investigation based on steered molecular dynamics simulation. J Membrane Biol;2013 697–704. doi:10.1007/s00232-013-9587-y23979172
   PubMedGoogle Scholar
• Maruyama K, Haniu H, Saito N, et al. Endocytosis of multiwalled carbon nanotubes in bronchial epithelial and mesothelial cells. Biomed Res Int. 2015;2015:793186. doi:10.1155/2015/79318626090445
   PubMedGoogle Scholar
• Kam NWS, Jessop TC, Wender PA, et al. Nanotube molecular transporters? Internalization of carbon nanotube? Protein conjugates into mammalian cells. J Am Chem Soc. 2004;126:6850–6851. doi:10.1021/ja048605915174838
   PubMed Web of Science ®Google Scholar
• Zhang X, Meng L, Wang X, et al. Preparation and cellular uptake of pH-dependent fluorescent single-wall carbon nanotubes. Chemistry. 2010;16:556–561. doi:10.1002/chem.20090116819894228
   PubMed Web of Science ®Google Scholar
• Kotchey GP, Zhao Y, Kagan VE, et al. Peroxidase-mediated biodegradation of carbon nanotubes in vitro and in vivo. Adv Drug Deliv Rev. 2013;65:1921–1932. doi:10.1016/j.addr.2013.07.00723856412
   PubMed Web of Science ®Google Scholar
• Ding Y, Tian R, Yang Z, et al. NADPH oxidase-dependent degradation of single-walled carbon nanotubes in macrophages. J Mater Sci Mater Med. 2017;28:7. doi:10.1007/s10856-016-5817-z27885574
   PubMedGoogle Scholar
• Kagan VE, Konduru NV, Feng W, et al. Carbon nanotubes degraded by neutrophil myeloperoxidase induce less pulmonary inflammation. Nat Nanotechnol. 2010;5:354–359. doi:10.1038/nnano.2010.4420364135
   PubMed Web of Science ®Google Scholar
• Hou J, Wan B, Yang Y, et al. Biodegradation of single-walled carbon nanotubes in macrophages through respiratory burst modulation. Int J Mol Sci. 2016;17:409. doi:10.3390/ijms1703040927011169
   PubMedGoogle Scholar
• Bussy C, Hadad C, Prato M, et al. Intracellular degradation of chemically functionalized carbon nanotubes using a long-term primary microglial culture model. Nanoscale. 2016;8:590–601. doi:10.1039/C5NR06625E26647092
   PubMedGoogle Scholar
• Ding Y, Tian R, Yang Z, et al. Binding of human IgG to single-walled carbon nanotubes accelerated myeloperoxidase-mediated degradation in activated neutrophils. Biophys Chem. 2016;218:36–41.27614147
   PubMed Web of Science ®Google Scholar
• Xanat D, HM M, SF A, et al. Slow biotransformation of carbon nanotubes by horseradish peroxidase. Environ Sci Technol. 2014;48:4826–4834. doi:10.1021/es405327924678632
   PubMedGoogle Scholar
• Allen BL, Kichambare PD, Gou P, et al. Biodegradation of single-walled carbon nanotubes through enzymatic catalysis. Nano Lett. 2008;8:3899–3903. doi:10.1021/nl802315h18954125
   PubMed Web of Science ®Google Scholar
• Liu Y, Zhao YL, Sun BY, et al. Understanding the toxicity of carbon nanotubes. Acc Chem Res. 2013;46:702–713. doi:10.1021/ar300028m22999420
   PubMed Web of Science ®Google Scholar
• Ding Y, Tian R, Yang Z, et al. Effects of serum albumin on the degradation and cytotoxicity of single-walled carbon nanotubes. Biophys Chem. 2017;222:1–6. doi:10.1016/j.bpc.2016.12.00228042968
   PubMedGoogle Scholar
• Lu N, Sui Y, Ding Y, et al. Fibrinogen binding-dependent cytotoxicity and degradation of single-walled carbon nanotubes. J Mater Sci Mater Med. 2018;29:115. doi:10.1007/s10856-018-6123-830019251
   PubMedGoogle Scholar
• Zhang T, Tang M, Yao Y, et al. MWCNT interactions with protein: surface-induced changes in protein adsorption and the impact of protein corona on cellular uptake and cytotoxicity. Int J Nanomedicine. 2019;14:993–1009. doi:10.2147/IJN.S19168930799918
   PubMed Web of Science ®Google Scholar
• Sadr Karimi S, Pante N. Carbon nanotubes as molecular transporters to study a new mechanism for molecular entry into the cell nucleus using actin polymerization force. PLoS One. 2019;14:e0221562. doi:10.1371/journal.pone.022156231437229
   PubMed Web of Science ®Google Scholar
• Shvedova AA, Pietroiusti A, Fadeel B, et al. Mechanisms of carbon nanotube-induced toxicity: focus on oxidative stress. Toxicol Appl Pharmacol. 2012;261:121–133. doi:10.1016/j.taap.2012.03.02322513272
   PubMed Web of Science ®Google Scholar
• Ying L, Yuliang Z, Baoyun S, et al. Understanding the toxicity of carbon nanotubes. Acc Chem Res. 2013;46:702–713. doi:10.1021/ar300028m22999420
   PubMedGoogle Scholar
• Chestkov IV, Jestkova EM, Ershova ES, et al. ROS-induced DNA damage associates with abundance of mitochondrial DNA in white blood cells of the untreated schizophrenic patients. Oxid Med Cell Longev. 2018;2018:8587475. doi:10.1155/2018/858747529682166
   PubMedGoogle Scholar
• Luceri C, Bigagli E, Femia AP, et al. Aging related changes in circulating reactive oxygen species (ROS) and protein carbonyls are indicative of liver oxidative injury. Toxicol Rep. 2018;5:141–145. doi:10.1016/j.toxrep.2017.12.01729854585
   PubMedGoogle Scholar
• Dey U, Ghosh A, Abbas S, et al. Cell damage and mitigation in Swiss albino mice: experiment and modelling. Quantitative Biology 2019;1904:10394.
   Google Scholar
• Dong J, Ma Q. Advances in mechanisms and signaling pathways of carbon nanotube toxicity. Nanotoxicology. 2015;9:658–676. doi:10.3109/17435390.2015.100918725676622
   PubMed Web of Science ®Google Scholar
• Hiraku Y, Guo F, Ma N, et al. Multi-walled carbon nanotube induces nitrative DNA damage in human lung epithelial cells via HMGB1-RAGE interaction and toll-like receptor 9 activation. Part Fibre Toxicol. 2016;13:16. doi:10.1186/s12989-016-0127-727026438
   PubMed Web of Science ®Google Scholar
• de Carvalho Lima EN, Piqueira JRC, Maria DA. Advances in carbon nanotubes for malignant melanoma: a chance for treatment. Mol Diagn Ther. 2018;22:703–715. doi:10.1007/s40291-018-0363-730368765
   PubMedGoogle Scholar
• Chen M, Sun Y, Liang J, et al. Understanding the influence of carbon nanomaterials on microbial communities. Environ Int. 2019;126:690–698. doi:10.1016/j.envint.2019.02.00530875562
   PubMed Web of Science ®Google Scholar
• Huaux F, d’Ursel de Bousies V, Parent MA, et al. Mesothelioma response to carbon nanotubes is associated with an early and selective accumulation of immunosuppressive monocytic cells. Part Fibre Toxicol. 2016;13:46. doi:10.1186/s12989-016-0158-027549627
   PubMed Web of Science ®Google Scholar
• Shvedova AA, Tkach AV, Kisin ER, et al. Carbon nanotubes enhance metastatic growth of lung carcinoma via up-regulation of myeloid-derived suppressor cells. Small. 2013;9:1691–1695. doi:10.1002/smll.20120147022996965
   PubMed Web of Science ®Google Scholar
• Shvedova AA, Kisin ER, Yanamala N, et al. MDSC and TGFbeta are required for facilitation of tumor growth in the lungs of mice exposed to carbon nanotubes. Cancer Res. 2015;75:1615–1623. doi:10.1158/0008-5472.CAN-14-237625744719
   PubMed Web of Science ®Google Scholar
• Dong X, Liu L, Zhu D, et al. Transactivator of transcription (TAT) peptide-chitosan functionalized multiwalled carbon nanotubes as a potential drug delivery vehicle for cancer therapy. Int J Nanomedicine. 2015;10:3829–3840. doi:10.2147/IJN.S8176226082633
   PubMed Web of Science ®Google Scholar
• Liu X, Zhang Y, Li J, et al. Cognitive deficits and decreased locomotor activity induced by single-walled carbon nanotubes and neuroprotective effects of ascorbic acid. Int J Nanomed. 2014;9:823–839.
   PubMed Web of Science ®Google Scholar
• Campagnolo L, Massimiani M, Palmieri G, et al. Biodistribution and toxicity of pegylated single wall carbon nanotubes in pregnant mice. Part Fibre Toxicol. 2013;10:21. doi:10.1186/1743-8977-10-2123742083
   PubMed Web of Science ®Google Scholar
• Simon A, Maletz SX, Hollert H, et al. Effects of multiwalled carbon nanotubes and triclocarban on several eukaryotic cell lines: elucidating cytotoxicity, endocrine disruption, and reactive oxygen species generation. Nanoscale Res Lett. 2014;9:396–410. doi:10.1186/1556-276X-9-39625170332
   PubMed Web of Science ®Google Scholar
• Jiang Y, Zhang H, Wang Y, et al. Modulation of apoptotic pathways of macrophages by surface-functionalized multi-walled carbon nanotubes. PLoS One. 2013;8:e65756. doi:10.1371/journal.pone.006575623755279
   PubMed Web of Science ®Google Scholar
• TSUJI T, USUKURA J. Assessment on a biological toxicity caused by single-walled carbon nanotubes. Nano Biomed. 2012;4:125–132.
   PubMedGoogle Scholar
• Adedara IA, Anao OO, Forcados GE, et al. Low doses of multi-walled carbon nanotubes elicit hepatotoxicity in rats with markers of oxidative stress and induction of pro-inflammatory cytokines. Biochem Biophys Res Commun. 2018;503:3167–3173. doi:10.1016/j.bbrc.2018.08.11230149914
   PubMed Web of Science ®Google Scholar
• Mutlu GM, Budinger GR, Green AA, et al. Biocompatible nanoscale dispersion of single-walled carbon nanotubes minimizes in vivo pulmonary toxicity. Nano Lett. 2010;10:1664–1670. doi:10.1021/nl904248320377197
   PubMed Web of Science ®Google Scholar
• Mostovenko E, Young T, Muldoon PP, et al. Nanoparticle exposure driven circulating bioactive peptidome causes systemic inflammation and vascular dysfunction. Part Fibre Toxicol. 2019;16:20. doi:10.1186/s12989-019-0304-631142334
   PubMedGoogle Scholar
• Liu Z, Cai W, He L, et al. In vivo biodistribution and highly efficient tumour targeting of carbon nanotubes in mice. Nat Nanotechnol. 2007;2:47–52. doi:10.1038/nnano.2006.17018654207
   PubMed Web of Science ®Google Scholar
• Deng X, Yang S, Nie H, et al. A generally adoptable radiotracing method for tracking carbon nanotubes in animals. Nanotechnol. 2008;19:075101. doi:10.1088/0957-4484/19/7/075101
   PubMed Web of Science ®Google Scholar
• Awasthi KK, John PJ, Awasthi A, et al. Multi walled carbon nano tubes induced hepatotoxicity in Swiss albino mice. Micron. 2013;44:359–364. doi:10.1016/j.micron.2012.08.00823000350
   PubMedGoogle Scholar
• Ji Z, Zhang D, Li L, et al. The hepatotoxicity of multi-walled carbon nanotubes in mice. Nanotechnol. 2009;20:445101. doi:10.1088/0957-4484/20/44/445101
   PubMed Web of Science ®Google Scholar
• Patlolla AK, Berry A, Tchounwou PB. Study of hepatotoxicity and oxidative stress in male Swiss-Webster mice exposed to functionalized multi-walled carbon nanotubes. Mol Cell Biochem. 2011;358:189–199. doi:10.1007/s11010-011-0934-y21725842
   PubMed Web of Science ®Google Scholar
• Otsuka K, Yamada K, Taquahashi Y, et al. Long-term polarization of alveolar macrophages to a profibrotic phenotype after inhalation exposure to multi-wall carbon nanotubes. PLoS One. 2018;13:e0205702. doi:10.1371/journal.pone.020570230372450
   PubMedGoogle Scholar
• Jacobsen NR, Møller P, Clausen PA, et al. Biodistribution of carbon nanotubes in animal models. Basic Clin Pharmacol Toxicol. 2016;121(Suppl 3):30. doi:10.1111/bcpt.12705
   Google Scholar
• Puisney C, Baeza-Squiban A, Boland S. Mechanisms of uptake and translocation of nanomaterials in the lung. Adv Exp Med Biol. 2018;1048:21–36.29453530
   PubMed Web of Science ®Google Scholar
• Poulsen SS, Jackson P, Kling K, et al. Multi-walled carbon nanotube physicochemical properties predict pulmonary inflammation and genotoxicity. Nanotoxicology. 2016;10:1263–1275. doi:10.1080/17435390.2016.120235127323647
   PubMed Web of Science ®Google Scholar
• Duke KS, Bonner JC. Mechanisms of carbon nanotube-induced pulmonary fibrosis: a physicochemical characteristic perspective. Wiley Interdiscip Rev Nanomed Nanobiotechnol. 2018;10:e1498. doi:10.1002/wnan.2018.10.issue-328984415
   PubMed Web of Science ®Google Scholar
• Ema M, Gamo M, Honda K. A review of toxicity studies of single-walled carbon nanotubes in laboratory animals. Regul Toxicol Pharmacol. 2016;74:42–63. doi:10.1016/j.yrtph.2015.11.01526619783
   PubMed Web of Science ®Google Scholar
• Francis AP, Devasena T. Toxicity of carbon nanotubes: a review. Toxicol Ind Health. 2018;34:200–210. doi:10.1177/074823371774747229506458
   PubMed Web of Science ®Google Scholar
• Chou CC, Hsiao HY, Hong QS, et al. Single-walled carbon nanotubes can induce pulmonary injury in mouse model. Nano Lett. 2008;8:437–445. doi:10.1021/nl072363418225938
   PubMed Web of Science ®Google Scholar
• Lam CW, James JT, McCluskey R, et al. Pulmonary toxicity of single-wall carbon nanotubes in mice 7 and 90 days after intratracheal instillation. Toxicol Sci. 2004;77:126–134. doi:10.1093/toxsci/kfg24314514958
   PubMed Web of Science ®Google Scholar
• Qin Y, Li S, Zhao G, et al. Long-term intravenous administration of carboxylated single-walled carbon nanotubes induces persistent accumulation in the lungs and pulmonary fibrosis via the nuclear factor-kappa B pathway. Int J Nanomed. 2017;12:263–277. doi:10.2147/IJN.S123839
   PubMed Web of Science ®Google Scholar
• Johnson BB, Santare MH, Novotny JE, et al. Wear behavior of carbon nanotube/high density polyethylene composites. Mech Mater. 2009;41:1108–1115. doi:10.1016/j.mechmat.2009.04.00320161101
   PubMed Web of Science ®Google Scholar
• Erdely A, Hulderman T, Salmen R, et al. Cross-talk between lung and systemic circulation during carbon nanotube respiratory exposure. Potential biomarkers. Nano Lett. 2009;9:36–43. doi:10.1021/nl801828z19049393
   PubMed Web of Science ®Google Scholar
• Ge C, Meng L, Xu L, et al. Acute pulmonary and moderate cardiovascular responses of spontaneously hypertensive rats after exposure to single-wall carbon nanotubes. Nanotoxicol. 2012;6:526–542. doi:10.3109/17435390.2011.587905
   PubMed Web of Science ®Google Scholar
• Chen R, Zhang L, Ge C, et al. Subchronic toxicity and cardiovascular responses in spontaneously hypertensive rats after exposure to multiwalled carbon nanotubes by intratracheal instillation. Chem Res Toxicol. 2015;28:440–450. doi:10.1021/tx500400325580880
   PubMed Web of Science ®Google Scholar
• Suzuki Y, Tada-Oikawa S, Hayashi Y, et al. Single- and double-walled carbon nanotubes enhance atherosclerogenesis by promoting monocyte adhesion to endothelial cells and endothelial progenitor cell dysfunction. Part Fibre Toxicol. 2016;13:54. doi:10.1186/s12989-016-0166-027737702
   PubMedGoogle Scholar
• Guo YY, Zhang J, Zheng YF, et al. Cytotoxic and genotoxic effects of multi-wall carbon nanotubes on human umbilical vein endothelial cells in vitro. Mutat Res. 2011;721:184–191. doi:10.1016/j.mrgentox.2011.01.01421296185
   PubMed Web of Science ®Google Scholar
• Zheng W, McKinney W, Kashon M, et al. The influence of inhaled multi-walled carbon nanotubes on the autonomic nervous system. Part Fibre Toxicol. 2016;13:8. doi:10.1186/s12989-016-0119-726864021
   PubMed Web of Science ®Google Scholar
• Aragon MJ, Topper L, Tyler CR, et al. Serum-borne bioactivity caused by pulmonary multiwalled carbon nanotubes induces neuroinflammation via blood-brain barrier impairment. Proc Natl Acad Sci U S A. 2017;114:E1968–E1976. doi:10.1073/pnas.161607011428223486
   PubMed Web of Science ®Google Scholar
• Gholamine B, Karimi I, Salimi A, et al. Neurobehavioral toxicity of carbon nanotubes in mice. Toxicol Ind Health. 2017;33:340–350. doi:10.1177/074823371664438127230352
   PubMedGoogle Scholar
• Larner SF, Wang J, Goodman J, et al. In vitro neurotoxicity resulting from exposure of cultured neural cells to several types of nanoparticles. J Cell Death. 2017;10:1179670717694523. doi:10.1177/117967071769452328469474
   PubMedGoogle Scholar
• Chen H, Zheng X, Nicholas J, et al. Single-walled carbon nanotubes modulate pulmonary immune responses and increase pandemic influenza a virus titers in mice. Virol J. 2017;14:242. doi:10.1186/s12985-017-0909-z29273069
   PubMedGoogle Scholar
• Park EJ, Choi J, Kim JH, et al. Subchronic immunotoxicity and screening of reproductive toxicity and developmental immunotoxicity following single instillation of HIPCO-single-walled carbon nanotubes: purity-based comparison. Nanotoxicology. 2016;10:1188–1202. doi:10.1080/17435390.2016.120234827310831
   PubMed Web of Science ®Google Scholar
• Lee S, Khang D, Kim S-H. High dispersity of carbon nanotubes diminishes immunotoxicity in spleen. Int J Nanomed. 2015;10:2697–2710.
   PubMed Web of Science ®Google Scholar
• Bottini M, Bruckner S, Nika K, et al. Multi-walled carbon nanotubes induce T lymphocyte apoptosis. Toxicol Lett. 2006;160:121–126. doi:10.1016/j.toxlet.2005.06.02016125885
   PubMed Web of Science ®Google Scholar
• Pietroiusti A, Massimiani M, Fenoglio I, et al. Low doses of pristine and oxidized single-wall carbon nanotubes affect mammalian embryonic development. ACS Nano. 2011;5:4624–4633. doi:10.1021/nn200372g21615177
   PubMed Web of Science ®Google Scholar
• Qi W, Bi J, Zhang X, et al. Damaging effects of multi-walled carbon nanotubes on pregnant mice with different pregnancy times. Sci Rep. 2014;4:4352. doi:10.1038/srep0435224619025
   PubMed Web of Science ®Google Scholar
• Cheng J, Cheng SH. Influence of carbon nanotube length on toxicity to zebrafish embryos. Int J Nanomed. 2012;7:3731–3739. doi:10.2147/IJN
   PubMed Web of Science ®Google Scholar
• Huang X, Zhang F, Sun X, et al. The genotype-dependent influence of functionalized multiwalled carbon nanotubes on fetal development. Biomaterials. 2014;35:856–865. doi:10.1016/j.biomaterials.2013.10.02724344357
   PubMed Web of Science ®Google Scholar
• Zhu B, Song Z, Jian L, et al. Developmental toxicity, bioaccumulation and distribution of oxidized single walled carbon nanotubes in Artemia salina. Toxicol Res (Camb). 2018;7:897–906.30310666
   PubMed Web of Science ®Google Scholar
• Bai Y, Zhang Y, Zhang J, et al. Repeated administrations of carbon nanotubes in male mice cause reversible testis damage without affecting fertility. Nat Nanotechnol. 2010;5:683–689. doi:10.1038/nnano.2010.15320693989
   PubMed Web of Science ®Google Scholar
• Lindberg HK, Falck GC, Singh R, et al. Genotoxicity of short single-wall and multi-wall carbon nanotubes in human bronchial epithelial and mesothelial cells in vitro. Toxicology. 2013;313:24–37. doi:10.1016/j.tox.2012.12.00823266321
   PubMed Web of Science ®Google Scholar
• Zhang D, Deng X, Ji Z, et al. Long-term hepatotoxicity of polyethylene-glycol functionalized multi-walled carbon nanotubes in mice. Nanotechnology. 2010;21:175101. doi:10.1088/0957-4484/21/17/17510120357413
   PubMed Web of Science ®Google Scholar
• Perez-Luna V, Moreno-Aguilar C, Arauz-Lara JL, et al. Interactions of functionalized multi-wall carbon nanotubes with giant phospholipid vesicles as model cellular membrane system. Sci Rep. 2018;8:17998. doi:10.1038/s41598-018-36531-930573758
   PubMedGoogle Scholar
• Adenuga AA, Truong L, Tanguay RL, et al. Preparation of water soluble carbon nanotubes and assessment of their biological activity in embryonic zebrafish. Int J Biomed Nanosci Nanotechnol. 2013;3:38–51. doi:10.1504/IJBNN.2013.05451425750663
   PubMedGoogle Scholar
• Au - Lin J, Au - Hu Y, Au - Zhao -J-J. Repression of multiple myeloma cell growth in vivo by Single-wall Carbon Nanotube (SWCNT)-delivered MALAT1 antisense oligos. JoVE. 2018;13:e58598.
   Google Scholar
• Suo N, Wang M, Jin Y, et al. Magnetic multiwalled carbon nanotubes with controlled release of epirubicin: an intravesical instillation system for bladder cancer. Int J Nanomedicine. 2019;14:1241–1254. doi:10.2147/IJN.S18968830863057
   PubMed Web of Science ®Google Scholar
• Lay CL, Liu HQ, Tan HR, et al. Delivery of paclitaxel by physically loading onto poly(ethylene glycol) (PEG)-graft-carbon nanotubes for potent cancer therapeutics. Nanotechnology. 2010;21:065101. doi:10.1088/0957-4484/21/6/06510120057024
   PubMed Web of Science ®Google Scholar
• Zhu Y, Li W, Li Q, et al. Effects of serum proteins on intracellular uptake and cytotoxicity of carbon nanoparticles. Carbon. 2009;47:1351–1358. doi:10.1016/j.carbon.2009.01.026
   Web of Science ®Google Scholar
• Schipper ML, Nakayama-Ratchford N, Davis CR, et al. A pilot toxicology study of single-walled carbon nanotubes in a small sample of mice. Nat Nanotechnol. 2008;3:216–221. doi:10.1038/nnano.2008.6818654506
   PubMed Web of Science ®Google Scholar
• Costa PM, Bourgognon M, Wang JT, et al. Functionalised carbon nanotubes: from intracellular uptake and cell-related toxicity to systemic brain delivery. J Control Release. 2016;241:200–219. doi:10.1016/j.jconrel.2016.09.03327693751
   PubMed Web of Science ®Google Scholar
• Dong X, Sun Z, Wang X, et al. An innovative MWCNTs/DOX/TC nanosystem for chemo-photothermal combination therapy of cancer. Nanomedicine. 2017;13:2271–2280. doi:10.1016/j.nano.2017.07.00228712919
   PubMed Web of Science ®Google Scholar
• Pardo J, Peng Z, Leblanc RM. Cancer targeting and drug delivery using carbon-based quantum dots and nanotubes. Molecules. 2018;23:378.
   PubMed Web of Science ®Google Scholar
• Huang H, Yuan Q, Shah JS, et al. A new family of folate-decorated and carbon nanotube-mediated drug delivery system: synthesis and drug delivery response. Adv Drug Deliv Rev. 2011;63:1332–1339. doi:10.1016/j.addr.2011.04.00121514336
   PubMed Web of Science ®Google Scholar
• Yan Y, Wang R, Hu Y, et al. Stacking of doxorubicin on folic acid-targeted multiwalled carbon nanotubes for in vivo chemotherapy of tumors. Drug Deliv. 2018;25:1607–1616. doi:10.1080/10717544.2018.150112030348025
   PubMed Web of Science ®Google Scholar
• Ji Z, Lin G, Lu Q, et al. Targeted therapy of SMMC-7721 liver cancer in vitro and in vivo with carbon nanotubes based drug delivery system. J Colloid Interface Sci. 2012;365:143–149. doi:10.1016/j.jcis.2011.09.01321974923
   PubMed Web of Science ®Google Scholar
• Wu W, Li R, Bian X, et al. Covalently combining carbon nanotubes with anticancer agent: preparation and antitumor activity. ACS Nano. 2009;3:2740–2750. doi:10.1021/nn900568619702292
   PubMed Web of Science ®Google Scholar
• Ma X, Zare Y, Rhee KY. A two-step methodology to study the influence of aggregation/agglomeration of nanoparticles on Young’s modulus of polymer nanocomposites. Nanoscale Res Lett. 2017;12:621. doi:10.1186/s11671-017-2386-029247323
   PubMedGoogle Scholar
• Demming A. Nanotechnology under the skin. Nanotechnol. 2011;22:260201. doi:10.1088/0957-4484/22/26/260201
   PubMed Web of Science ®Google Scholar
• Medepalli K, Alphenaar B, Raj A, et al. Evaluation of the direct and indirect response of blood leukocytes to carbon nanotubes (CNTs). Nanomedicine. 2011;7:983–991. doi:10.1016/j.nano.2011.04.00221616167
   PubMedGoogle Scholar
• Alshehri R, Ilyas AM, Hasan A, et al. Carbon nanotubes in biomedical applications: factors, mechanisms, and remedies of toxicity. J Med Chem. 2016;59:8149–8167. doi:10.1021/acs.jmedchem.5b0177027142556
   PubMed Web of Science ®Google Scholar
• Niezabitowska E, Smith J, Prestly MR, et al. Facile production of nanocomposites of carbon nanotubes and polycaprolactone with high aspect ratios with potential applications in drug delivery. RSC Adv. 2018;8:16444–16454. doi:10.1039/C7RA13553J30009019
   PubMed Web of Science ®Google Scholar
• Kim JS, Song KS, Joo HJ, et al. Determination of cytotoxicity attributed to multiwall carbon nanotubes (MWCNT) in normal human embryonic lung cell (WI-38) line. J Toxicol Environ Health A. 2010;73:1521–1529. doi:10.1080/15287394.2010.51157720954078
   PubMed Web of Science ®Google Scholar
• Wick P, Manser P, Limbach LK, et al. The degree and kind of agglomeration affect carbon nanotube cytotoxicity. Toxicol Lett. 2007;168:121–131. doi:10.1016/j.toxlet.2006.08.01917169512
   PubMed Web of Science ®Google Scholar
• Belyanskaya L, Weigel S, Hirsch C, et al. Effects of carbon nanotubes on primary neurons and glial cells. Neurotoxicology. 2009;30:702–711. doi:10.1016/j.neuro.2009.05.00519465056
   PubMed Web of Science ®Google Scholar
• Ryman-Rasmussen JP, Cesta MF, Brody AR, et al. Inhaled carbon nanotubes reach the sub-pleural tissue in mice. Nat Nanotechnol. 2009;4:747–751. doi:10.1038/nnano.2009.30519893520
   PubMed Web of Science ®Google Scholar
• Poland CA, Duffin R, Kinloch I, et al. Carbon nanotubes introduced into the abdominal cavity of mice show asbestos-like pathogenicity in a pilot study. Nat Nanotechnol. 2008;3:423–428. doi:10.1038/nnano.2008.11118654567
   PubMed Web of Science ®Google Scholar
• Girardi FA, Bruch GE, Peixoto CS, et al. Toxicity of single-wall carbon nanotubes functionalized with polyethylene glycol in zebrafish (Danio rerio) embryos. J Appl Toxicol. 2017;37:214–221. doi:10.1002/jat.v37.227320845
   PubMedGoogle Scholar
• Fanizza C, Paba E, Casciardi S, et al. Cytotoxic and genotoxic effects of multi-walled carbon nanotubes on human bronchial normal cells (BEAS-2B). Toxicol Lett. 2009;189:S186. doi:10.1016/j.toxlet.2009.06.648
   Web of Science ®Google Scholar
• Sweeney S, Berhanu D, Misra SK, et al. Multi-walled carbon nanotube length as a critical determinant of bioreactivity with primary human pulmonary alveolar cells. Carbon N Y. 2014;78:26–37. doi:10.1016/j.carbon.2014.06.03325780270
   PubMedGoogle Scholar
• Liu D, Wang L, Wang Z, et al. Different cellular response mechanisms contribute to the length-dependent cytotoxicity of multi-walled carbon nanotubes. Nanoscale Res Lett. 2012;7:361. doi:10.1186/1556-276X-7-36122748010
   PubMed Web of Science ®Google Scholar
• Fujita K, Fukuda M, Endoh S, et al. Size effects of single-walled carbon nanotubes on in vivo and in vitro pulmonary toxicity. Inhal Toxicol. 2015;27:207–223. doi:10.3109/08958378.2015.102662025865113
   PubMed Web of Science ®Google Scholar
• Meng J, Cheng X, Liu J, et al. Effects of long and short carboxylated or aminated multiwalled carbon nanotubes on blood coagulation. PLoS One. 2012;7:e38995. doi:10.1371/journal.pone.003899522808023
   PubMedGoogle Scholar
• Louro H, Pinhao M, Santos J, et al. Evaluation of the cytotoxic and genotoxic effects of benchmark multi-walled carbon nanotubes in relation to their physicochemical properties. Toxicol Lett. 2016;262:123–134. doi:10.1016/j.toxlet.2016.09.01627702663
   PubMed Web of Science ®Google Scholar
• Kavosi A, Hosseini Ghale Noei S, Madani S, et al. The toxicity and therapeutic effects of single-and multi-wall carbon nanotubes on mice breast cancer. Sci Rep. 2018;8:8375. doi:10.1038/s41598-018-26790-x29849103
   PubMedGoogle Scholar
• Sohaebuddin SK, Thevenot PT, Baker D, et al. Nanomaterial cytotoxicity is composition, size, and cell type dependent. Part Fibre Toxicol. 2010;7:22. doi:10.1186/1743-8977-7-2220727197
   PubMed Web of Science ®Google Scholar
• Martinez CS, Igartua DE, Czarnowski I, et al. Biological response and developmental toxicity of zebrafish embryo and larvae exposed to multi-walled carbon nanotubes with different dimension. Heliyon. 2019;5:e02308. doi:10.1016/j.heliyon.2019.e0230831485519
   PubMedGoogle Scholar
• Shen Z, Wu J, Yu Y, et al. Comparison of cytotoxicity and membrane efflux pump inhibition in HepG2 cells induced by single-walled carbon nanotubes with different length and functional groups. Sci Rep. 2019;9:7557. doi:10.1038/s41598-019-43900-531101842
   PubMedGoogle Scholar
• Harik VM. Geometry of carbon nanotubes and mechanisms of phagocytosis and toxic effects. Toxicol Lett. 2017;273:69–85. doi:10.1016/j.toxlet.2017.03.01628341208
   PubMed Web of Science ®Google Scholar
• Sasaki T, Asakura M, Ishioka C, et al. In vitro chromosomal aberrations induced by various shapes of multi-walled carbon nanotubes (MWCNTs). J Occup Health. 2016;58:16–99.26498979
   PubMed Web of Science ®Google Scholar
• Allegri M, Perivoliotis DK, Bianchi MG, et al. Toxicity determinants of multi-walled carbon nanotubes: the relationship between functionalization and agglomeration. Toxicol Rep. 2016;3:230–243. doi:10.1016/j.toxrep.2016.01.01128959543
   PubMed Web of Science ®Google Scholar
• Haniu H, Saito N, Matsuda Y, et al. Biological responses according to the shape and size of carbon nanotubes in BEAS-2B and MESO-1 cells. Int J Nanomedicine. 2014;9:1979–1990. doi:10.2147/IJN24790438
   PubMedGoogle Scholar
• Hu X, Cook S, Wang P, et al. In vitro evaluation of cytotoxicity of engineered carbon nanotubes in selected human cell lines. Sci Total Environ. 2010;408:1812–1817. doi:10.1016/j.scitotenv.2010.01.03520167353
   PubMed Web of Science ®Google Scholar
• El-Gazzar AM, Abdelgied M, Alexander DB, et al. Comparative pulmonary toxicity of a DWCNT and MWCNT-7 in rats. Arch Toxicol. 2019;93:49–59. doi:10.1007/s00204-018-2336-330341734
   PubMedGoogle Scholar
• Fenoglio I, Aldieri E, Gazzano E, et al. Thickness of multiwalled carbon nanotubes affects their lung toxicity. Chem Res Toxicol. 2012;25:74–82. doi:10.1021/tx200255h22128750
   PubMed Web of Science ®Google Scholar
• Rittinghausen S, Hackbarth A, Creutzenberg O, et al. The carcinogenic effect of various multi-walled carbon nanotubes (MWCNTs) after intraperitoneal injection in rats. Particle & Fibre Toxicology. 2014;11:59. doi:10.1186/s12989-014-0059-z25410479
   PubMed Web of Science ®Google Scholar
• Di Cristo L, Bianchi MG, Chiu M, et al. Comparative in vitro cytotoxicity of realistic doses of benchmark multi-walled carbon nanotubes towards macrophages and airway epithelial cells. Nanomaterials (Basel). 2019;9:982.
   PubMedGoogle Scholar
• Sakamoto Y, Hojo M, Kosugi Y, et al. Comparative study for carcinogenicity of 7 different multi-wall carbon nanotubes with different physicochemical characteristics by a single intraperitoneal injection in male Fischer 344 rats. J Toxicol Sci. 2018;43:587–600. doi:10.2131/jts.43.58730298847
   PubMedGoogle Scholar