Co-Delivery Of Dihydroartemisinin And HMGB1 siRNA By TAT-Modified Cationic Liposomes Through The TLR4 Signaling Pathway For Treatment Of Lupus Nephritis

References

• Lee S-Y, Lee SH, Seo H-B, et al. Inhibition of IL-17 ameliorates systemic lupus erythematosus in Roquinsan/san mice through regulating the balance of TFH cells, GC B cells, Treg and Breg. Sci Rep. 2019;9(1):5227–5234. doi:10.1038/s41598-019-41534-1.30914691
   PubMedGoogle Scholar
• Liu J, Huang X, Hao S, et al. Peli1 negatively regulates noncanonical NF-κB signaling to restrain systemic lupus erythematosus. Nat Commun. 2018;9(1):1136–1148. doi:10.1038/s41467-018-03530-3.29555915
   PubMedGoogle Scholar
• Dall’Era M. Treatment of lupus nephritis: current paradigms and emerging strategies. Curr Opin Rheumatol. 2017;29(3):241–247. doi:10.1097/bor.0000000000000381.28207493
   PubMedGoogle Scholar
• Zhang H, Fu R, Guo C, et al. Anti-dsDNA antibodies bind to TLR4 and activate NLRP3 inflammasome in lupus monocytes/ macrophages. J Transl Med. 2016;14(1):156–167. doi:10.1186/s12967-016-0911-z.27250627
   PubMedGoogle Scholar
• Kajubi R, Ochieng T, Kakuru A, et al. Monthly sulfadoxine-pyrimethamine versus dihydroartemisinin-piperaquine for intermittent preventive treatment of malaria in pregnancy: a double-blind, randomised, controlled, superiority trial. Lancet. 2019;393(10179):1428–1439. doi:10.1016/S0140-6736(18)32224-4.30910321
   PubMedGoogle Scholar
• Zhang Z, Guo M, Zhao S, Shao J, Zheng S. ROS-JNK1/2-dependent activation of autophagy is required for the induction of anti-inflammatory effect of dihydroartemisinin in liver fibrosis. Free Radic Biol Med. 2016;101:272–283. doi:10.1016/j.freeradbiomed.2016.10.498.27989749
   PubMed Web of Science ®Google Scholar
• Wu Y, He S, Bai B, et al. Therapeutic effects of the artemisinin analog SM934 on lupus-prone MRL/lpr mice via inhibition of TLR-triggered B-cell activation and plasma cell formation. Cell Mol Immunol. 2016;13(3):379–390. doi:10.1038/cmi.2015.13.25942599
   PubMed Web of Science ®Google Scholar
• Li WD, Dong YJ, Tu YY, Lin ZB. Dihydroarteannuin ameliorates lupus symptom of BXSB mice by inhibiting production of TNF-alpha and blocking the signaling pathway NF-kappa B translocation. Int Immunopharmacol. 2006;6(8):1243–1250. doi:10.1016/j.intimp.2006.03.004.16782536
   PubMedGoogle Scholar
• Shi C, Li H, Yang Y, Hou L. Anti-inflammatory and immunoregulatory functions of artemisinin and its derivatives. Mediators Inflamm. 2015;2015:435713–435720. doi:10.1155/2015/435713.25960615
   PubMed Web of Science ®Google Scholar
• Zhang LX, Xie XX, Liu DQ, Xu ZP, Liu RT. Efficient co-delivery of neo-epitopes using dispersion-stable layered double hydroxide nanoparticles for enhanced melanoma immunotherapy. Biomaterials. 2018;174:54–66. doi:10.1016/j.biomaterials.2018.05.015.29778982
   PubMed Web of Science ®Google Scholar
• Sajeesh S, Lee TY, Kim JK, et al. Efficient intracellular delivery and multiple-target gene silencing triggered by tripodal RNA based nanoparticles: a promising approach in liver-specific RNAi delivery. J Controlled Release. 2014;196:28–36. doi:10.1016/j.jconrel.2014.09.016.
   PubMed Web of Science ®Google Scholar
• Cao Y, Huang HY, Chen LQ, et al. Enhanced lysosomal escape of pH-responsive polyethylenimine-betaine functionalized carbon nanotube for the codelivery of survivin small interfering RNA and doxorubicin. ACS Appl Mater Interfaces. 2019;11(10):9763–9776. doi:10.1021/acsami.8b20810.30776886
   PubMed Web of Science ®Google Scholar
• Chen Q, Guan X, Zuo X, Wang J, Yin W. The role of high mobility group box 1 (HMGB1) in the pathogenesis of kidney diseases. Acta Pharm Sin B. 2016;6(3):183–188. doi:10.1016/j.apsb.2016.02.004.27175328
   PubMed Web of Science ®Google Scholar
• Pan HF, Wu GC, Li WP, Li XP, Ye DQ. High Mobility Group Box 1: a potential therapeutic target for systemic lupus erythematosus. Mol Biol Rep. 2010;37(3):1191–1195. doi:10.1007/s11033-009-9485-7.19247800
   PubMedGoogle Scholar
• Xu B, Zhu YJ, Wang CH, et al. Improved cell transfection of siRNA by pH-responsive nanomicelles self-assembled with mPEG- b-PHis- b-PEI copolymers. ACS Appl Mater Interfaces. 2018;10(26):21847–21860. doi:10.1021/acsami.8b04301.29882640
   PubMedGoogle Scholar
• Zheng M, Tao W, Zou Y, Farokhzad OC, Shi B. Nanotechnology-based strategies for siRNA brain delivery for disease therapy. Trends Biotechnol. 2018;36(5):562–575. doi:10.1016/j.tibtech.2018.01.006.29422412
   PubMedGoogle Scholar
• Bi Y, Lee RJ, Wang X, et al. Liposomal codelivery of an SN38 prodrug and a survivin siRNA for tumor therapy. Int J Nanomedicine. 2018;13:5811–5822. doi:10.2147/ijn.s173279.30323583
   PubMed Web of Science ®Google Scholar
• Han W, Yin G, Pu X, Chen X, Liao X, Huang Z. Glioma targeted delivery strategy of doxorubicin-loaded liposomes by dual-ligand modification. J Biomater Sci Polym Ed. 2017;28(15):1695–1712. doi:10.1080/09205063.2017.1348739.28699828
   PubMed Web of Science ®Google Scholar
• Alemi A, Zavar Reza J, Haghiralsadat F, et al. Paclitaxel and curcumin coadministration in novel cationic PEGylated niosomal formulations exhibit enhanced synergistic antitumor efficacy. J Nanobiotechnology. 2018;16(1):28–48. doi:10.1186/s12951-018-0351-4.29571289
   PubMed Web of Science ®Google Scholar
• Devarapu S, Anders H. Toll-like receptors in lupus nephritis. J Biomed Sci. 2018;25(1):35. doi:10.1177/0961203319828518.29650017
   PubMed Web of Science ®Google Scholar
• Ma K, Li J, Wang X, et al. TLR4+CXCR4+ plasma cells drive nephritis development in systemic lupus erythematosus. Ann Rheum Dis. 2018;77(10):1498–1506. doi:10.1136/annrheumdis-2018-213615.29925508
   PubMedGoogle Scholar
• Hu W, Wu S, Zhang Y, Sigdel KR, Lin Y, Zhong H. Association between Toll-like receptor 4 polymorphisms and systemic lupus erythematosus susceptibility: a meta-analysis. Biomed Res Int. 2016;2016:7842587. doi:10.1155/2016/7842587.27652268
   PubMedGoogle Scholar
• Sheng ZX, Yao H, Cai ZY. The role of miR-146b-5p in TLR4 pathway of glomerular mesangial cells with lupus nephritis. Eur Rev Med Pharmacol Sci. 2018;22(6):1737–1743. doi:10.26355/eurrev_201803_14589.29630120
   PubMed Web of Science ®Google Scholar
• Zhang F, Wu L, Qian J, et al. Identification of the long noncoding RNA NEAT1 as a novel inflammatory regulator acting through MAPK pathway in human lupus. J Autoimmun. 2016;75(undefined):96–104. doi:10.1007/s11515-016-1433-z.27481557
   PubMedGoogle Scholar
• Lee T, Tang S, Wu M, Song Y, Yu C, Sun K. Transgenic overexpression of anti-double-stranded DNA autoantibody and activation of Toll-like receptor 4 in mice induce severe systemic lupus erythematosus syndromes. J Autoimmun. 2010;35(4):358–367. doi:10.1016/j.jaut.2010.07.007.20833510
   PubMed Web of Science ®Google Scholar
• Musumeci D, Roviello G, Montesarchio D. An overview on HMGB1 inhibitors as potential therapeutic agents in HMGB1-related pathologies. Pharmacol Ther. 2014;141(3):347–357. doi:10.1016/j.pharmthera.2013.11.001.24220159
   PubMed Web of Science ®Google Scholar
• Ji J, Fu T, Dong C, et al. Targeting HMGB1 by ethyl pyruvate ameliorates systemic lupus erythematosus and reverses the senescent phenotype of bone marrow-mesenchymal stem cells. Aging. 2019;11(13):4338–4353. doi:10.18632/aging.102052.31303606
   PubMedGoogle Scholar
• Xue J, Ge H, Lin Z, et al. The role of dendritic cells regulated by HMGB1/TLR4 signalling pathway in myocardial ischaemia reperfusion injury. J Cell Mol Med. 2019;23(4):2849–2862. doi:10.1111/jcmm.14192.30784177
   PubMedGoogle Scholar
• Huang X, Xie Z, Liu F, et al. Dihydroartemisinin inhibits activation of the Toll-like receptor 4 signaling pathway and production of type I interferon in spleen cells from lupus-prone MRL/lpr mice. Int Immunopharmacol. 2014;22(1):266–272. doi:10.1016/j.intimp.2014.07.001.25027631
   PubMed Web of Science ®Google Scholar
• Xiong Y, Zhao Y, Miao L, Lin C, Huang L. Co-delivery of polymeric metformin and cisplatin by self-assembled core-membrane nanoparticles to treat non-small cell lung cancer. J Controlled Release. 2016;244:63–73. doi:10.1016/j.jconrel.2016.11.005.
   PubMed Web of Science ®Google Scholar
• Duarte S, Faneca H, Lima M. Non-covalent association of folate to lipoplexes: a promising strategy to improve gene delivery in the presence of serum. J Controlled Release. 2011;149(3):264–272. doi:10.1016/j.jconrel.2010.10.032.
   PubMed Web of Science ®Google Scholar
• Liu E, Zhang M, Cui H, et al. Tat-functionalized Ag-FeO nano-composites as tissue-penetrating vehicles for tumor magnetic targeting and drug delivery. Acta Pharm Sin B. 2018;8(6):956–968. doi:10.1016/j.apsb.2018.07.012.30505664
   PubMedGoogle Scholar
• Pescina S, Ostacolo C, Gomez-Monterrey IM, et al. Cell penetrating peptides in ocular drug delivery: state of the art. J Controlled Release. 2018;284:84–102. doi:10.1016/j.jconrel.2018.06.023.
   PubMed Web of Science ®Google Scholar
• Moku G, Layek B, Trautman L, Putnam S, Panyam J, Prabha S. Improving payload capacity and anti-tumor efficacy of mesenchymal stem cells using TAT peptide functionalized polymeric nanoparticles. Cancers. 2019;11(4):491. doi:10.3390/cancers11040491.
   PubMed Web of Science ®Google Scholar
• Li XQ, Tian W, Liu XX, et al. Corosolic acid inhibits the proliferation of glomerular mesangial cells and protects against diabetic renal damage. Sci Rep. 2016;6:26854. doi:10.1038/srep26854.27229751
   PubMed Web of Science ®Google Scholar
• Burbano C, Gómez‐Puerta JA, Muñoz‐Vahos C, et al. HMGB1 microparticles present in urine are hallmarks of nephritis in patients with systemic lupus erythematosus. Eur J Immunol. 2019;49(2):323–335. doi:10.1002/eji.201847747.30537116
   PubMedGoogle Scholar
• Qingjuan L, Xiaojuan F, Wei Z, et al. miR-148a-3p overexpression contributes to glomerular cell proliferation by targeting PTEN in lupus nephritis. Am J Physiol Cell Physiol. 2016;310(6):C470–478. doi:10.1152/ajpcell.00129.2015.26791485
   PubMed Web of Science ®Google Scholar
• Feng XJ, Liu SX, Wu C, et al. The PTEN/PI3K/Akt signaling pathway mediates HMGB1-induced cell proliferation by regulating the NF-κB/cyclin D1 pathway in mouse mesangial cells. Am J Physiol Cell Physiol. 2014;306(12):C1119–1128. doi:10.1152/ajpcell.00385.2013.24760979
   PubMedGoogle Scholar
• Yi Y, Jian J, Gonzalez-Gugel E, et al. p204 is required for canonical lipopolysaccharide-induced TLR4 signaling in mice. EBioMedicine. 2018;29:78–91. doi:10.1016/j.ebiom.2018.02.012.29472103
   PubMedGoogle Scholar
• Mai C, Yap K, Kho M, et al. Mechanisms underlying the anti-inflammatory effects of clinacanthus nutans lindau extracts: inhibition of cytokine production and Toll-like receptor-4 activation. Front Pharmacol. 2016;7:7. doi:10.3389/fphar.2016.0000726869924
   PubMed Web of Science ®Google Scholar