Functional Autophagic Flux Regulates AgNP Uptake And The Internalized Nanoparticles Determine Tumor Cell Fate By Temporally Regulating Flux

References

• Sriram MI, Kanth SB, Kalishwaralal K, Gurunathan S. Antitumor activity of silver nanoparticles in Dalton’s lymphoma ascites tumor model. Int J Nanomedicine. 2010;5:753–762. doi:10.2147/IJN.S1172721042421
   PubMed Web of Science ®Google Scholar
• Liu P, Huang Z, Chen Z, et al. Silver nanoparticles: a novel radiation sensitizer for glioma? Nanoscale. 2013;5(23):11829–11836. doi:10.1039/c3nr01351k24126539
   PubMed Web of Science ®Google Scholar
• Cui Z, Zhang Y, Xia K, et al. Nanodiamond autophagy inhibitor allosterically improves the arsenical-based therapy of solid tumors. Nat Commun. 2018;9(1):4347. doi:10.1038/s41467-018-06749-230341298
   PubMedGoogle Scholar
• Yang F, Huang W, Li Y, et al. Anti-tumor effects in mice induced by survivin-targeted siRNA delivered through polysaccharide nanoparticles. Biomaterials. 2013;34(22):5689–5699. doi:10.1016/j.biomaterials.2013.03.04723632321
   PubMedGoogle Scholar
• Fageria L, Pareek V, Dilip RV, et al. Biosynthesized protein-capped silver nanoparticles induce ros-dependent proapoptotic signals and prosurvival autophagy in cancer cells. ACS Omega. 2017;2(4):1489–1504. doi:10.1021/acsomega.7b0004530023637
   PubMedGoogle Scholar
• Hussain SM, Hess KL, Gearhart JM, Geiss KT, Schlager JJ. In vitro toxicity of nanoparticles in BRL 3A rat liver cells. Toxicol In Vitro. 2005;19(7):975–983. doi:10.1016/j.tiv.2005.06.03416125895
   PubMed Web of Science ®Google Scholar
• Hsiao I-L, Hsieh Y-K, Chuang C-Y, Wang C-F, Huang Y-J. Effects of silver nanoparticles on the interactions of neuron- and glia-like cells: toxicity, uptake mechanisms, and lysosomal tracking. Environ Toxicol. 2017;32(6):1742–1753. doi:10.1002/tox.2239728181394
   PubMedGoogle Scholar
• Sahay G, Alakhova DY, Kabanov AV. Endocytosis of nanomedicines. J Control Release. 2010;145(3):182–195. doi:10.1016/j.jconrel.2010.01.03620226220
   PubMed Web of Science ®Google Scholar
• Kou L, Sun J, Zhai Y, He Z. The endocytosis and intracellular fate of nanomedicines: implication for rational design. Asian J Pharm Sci. 2013;8(1):1–10. doi:10.1016/j.ajps.2013.07.001
   Google Scholar
• Lamb CA, Dooley HC, Tooze SA. Endocytosis and autophagy: shared machinery for degradation. Bioessays. 2013;35(1):34–45. doi:10.1002/bies.20120013023147242
   PubMed Web of Science ®Google Scholar
• Galluzzi L, Baehrecke EH, Ballabio A, et al. Molecular definitions of autophagy and related processes. EMBO J. 2017;36(13):1811–1836. doi:10.15252/embj.20179669728596378
   PubMed Web of Science ®Google Scholar
• Xu Y, Wang L, Bai R, Zhang T, Chen C. Silver nanoparticles impede phorbol myristate acetate-induced monocyte–macrophage differentiation and autophagy. Nanoscale. 2015;7(38):16100–16109. doi:10.1039/C5NR04200C26372376
   PubMedGoogle Scholar
• Pande S, Ghosh SK, Praharaj S, et al. Synthesis of normal and inverted gold− silver core− shell architectures in β-cyclodextrin and their applications in SERS. J Phys Chem C. 2007;111(29):10806–10813. doi:10.1021/jp0702393
   Web of Science ®Google Scholar
• Adeoye O, Cabral-Marques H. Cyclodextrin nanosystems in oral drug delivery: a mini review. Int J Pharm. 2017;531(2):521–531. doi:10.1016/j.ijpharm.2017.04.05028455134
   PubMed Web of Science ®Google Scholar
• Saini H, Hakeem I, Mukherjee S. Autophagy regulated by gain of function mutant p53 enhances proteasomal inhibitor-mediated cell death through induction of ROS and ERK in lung cancer cells. J Oncol. 2019;2019:6164807. doi:10.1155/2019/616480730723502
   PubMed Web of Science ®Google Scholar
• Mukherjee S, Dash S, Lohitesh K, Chowdhury R. The dynamic role of autophagy and MAPK signaling in determining cell fate under cisplatin stress in osteosarcoma cells. PLoS One 2017;12(6):e0179203.
   Google Scholar
• Zucker RM, Daniel KM, Massaro EJ, Karafas SJ, Degn LL, Boyes WK. Detection of silver nanoparticles in cells by flow cytometry using light scatter and far-red fluorescence. Cytometry A. 2013;83(10):962–972. doi:10.1002/cyto.a.2234223943267
   PubMedGoogle Scholar
• Mo L, Hou L, Guo D, Xiao X, Mao P, Yang X. Preparation and characterization of teniposide PLGA nanoparticles and their uptake in human glioblastoma U87MG cells. Int J Pharm. 2012;436(1–2):815–824. doi:10.1016/j.ijpharm.2012.07.05022846410
   PubMedGoogle Scholar
• Vercauteren D, Vandenbroucke RE, Jones AT, et al. The use of inhibitors to study endocytic pathways of gene carriers: optimization and pitfalls. Mol Ther. 2010;18(3):561–569. doi:10.1038/mt.2009.28120010917
   PubMed Web of Science ®Google Scholar
• Yang Y, Qu R, Fan T, et al. Cross-talk between microtubules and the linker of nucleoskeleton complex plays a critical role in the adipogenesis of human adipose-derived stem cells. Stem Cell Res Ther. 2018;9(1):125–139. doi:10.1186/s13287-018-0836-y29720241
   PubMed Web of Science ®Google Scholar
• Sun J, Liu Y, Ge M, et al. A distinct endocytic mechanism of functionalized-silica nanoparticles in breast cancer stem cells. Sci Rep. 2017;7(1):16236. doi:10.1038/s41598-017-16591-z29176652
   PubMedGoogle Scholar
• Harush-Frenkel O, Debotton N, Benita S, Altschuler Y. Targeting of nanoparticles to the clathrin-mediated endocytic pathway. Biochem Biophys Res Commun. 2007;353(1):26–32. doi:10.1016/j.bbrc.2006.11.13517184736
   PubMed Web of Science ®Google Scholar
• Takei K, Slepnev VI, Haucke V, De Camilli P. Functional partnership between amphiphysin and dynamin in clathrin-mediated endocytosis. Nat Cell Biol. 1999;1(1):33–39. doi:10.1038/900410559861
   PubMedGoogle Scholar
• Macia E, Ehrlich M, Massol R, Boucrot E, Brunner C, Kirchhausen T. Dynasore, a cell-permeable inhibitor of dynamin. Dev Cell. 2006;10(6):839–850. doi:10.1016/j.devcel.2006.04.00216740485
   PubMed Web of Science ®Google Scholar
• Preta G, Cronin JG, Sheldon IM. Dynasore-not just a dynamin inhibitor. Cell Commun Signal. 2015;13(1):24–31. doi:10.1186/s12964-015-0102-125889964
   PubMedGoogle Scholar
• Basagiannis D, Zografou S, Galanopoulou K, Christoforidis S. Dynasore impairs VEGFR2 signalling in an endocytosis-independent manner. Sci Rep. 2017;7:45035. doi:10.1038/srep4503528327657
   PubMedGoogle Scholar
• Tooze SA, Abada A, Elazar Z. Endocytosis and autophagy: exploitation or cooperation? Cold Spring Harb Perspect Biol. 2014;6(5):a018358. doi:10.1101/cshperspect.a01835824789822
   PubMed Web of Science ®Google Scholar
• Zhang XJ, Chen S, Huang KX, Le WD. Why should autophagic flux be assessed? Acta Pharmacol Sin. 2013;34(5):595–599. doi:10.1038/aps.2012.18423474710
   PubMed Web of Science ®Google Scholar
• Jager S, Bucci C, Tanida I, et al. Role for Rab7 in maturation of late autophagic vacuoles. J Cell Sci. 2004;117(Pt 20):4837–4848. doi:10.1242/jcs.0137015340014
   PubMed Web of Science ®Google Scholar
• Lee Y-H, Cheng F-Y, Chiu H-W, et al. Cytotoxicity, oxidative stress, apoptosis and the autophagic effects of silver nanoparticles in mouse embryonic fibroblasts. Biomaterials. 2014;35(16):4706–4715. doi:10.1016/j.biomaterials.2014.02.02124630838
   PubMed Web of Science ®Google Scholar
• Paglin S, Hollister T, Delohery T, et al. A novel response of cancer cells to radiation involves autophagy and formation of acidic vesicles. Cancer Res. 2001;61(2):439–444.11212227
   PubMed Web of Science ®Google Scholar
• Dash S, Sarashetti PM, Rajashekar B, Chowdhury R, Mukherjee S. TGF-β2-induced EMT is dampened by inhibition of autophagy and TNF-α treatment. Oncotarget. 2018;9(5):6433. doi:10.18632/oncotarget.2394229464083
   PubMedGoogle Scholar
• Miyayama T, Matsuoka M. Involvement of lysosomal dysfunction in silver nanoparticle-induced cellular damage in A549 human lung alveolar epithelial cells. J Occup Med Toxicol. 2016;1(1):1–6. doi:10.1186/s12995-016-0090-0
   Google Scholar