Gold nanoparticles and angiogenesis: molecular mechanisms and biomedical applications

References

• Arboleda-Velasquez JF, D’Amore PA. Chapter 10 - Vasculogenesis and Angiogenesis In: Willis MS, Homeister JW, Stone JR, editors. Cellular and Molecular Pathobiology of Cardiovascular Disease. San Diego: Academic Press; 2014:181–196.
   Google Scholar
• Carmeliet P. Mechanisms of angiogenesis and arteriogenesis. Nat Med. 2000;6:389. doi:10.1038/7465110742145
   PubMed Web of Science ®Google Scholar
• Ribatti D. The discovery of tumor angiogenesis factors: a historical overview In: Ribatti. D, editor. Tumor Angiogenesis Assays: Methods and Protocols. New York: Springer New York; 2016:1–12.
   Google Scholar
• Adair TH, Montani JP. Integrated Systems Physiology: from Molecule to Function to Disease. In: Angiogenesis. San Rafael (CA); 2010.
   Google Scholar
• Bussolino F, Mantovani A, Persico G. Molecular mechanisms of blood vessel formation. Trends Biochem Sci. 1997;22(7):251–256.9255066
   PubMed Web of Science ®Google Scholar
• Mousa SA, Arias HR, Davis PJ. Role of non-neuronal nicotinic acetylcholine receptors in angiogenesis modulation In: Mousa SA, Davis PJ, editors. Angiogenesis Modulations in Health and Disease: Practical Applications of Pro- and Anti-angiogenesis Targets. Dordrecht: Springer Netherlands; 2013:55–75.
   Google Scholar
• Carmeliet P. Angiogenesis in health and disease. Nat Med. 2003;9(6):653–660. doi:10.1038/nm0603-65312778163
   PubMed Web of Science ®Google Scholar
• Carmeliet P, Jain RK. Molecular mechanisms and clinical applications of angiogenesis. Nature. 2011;473(7347):298–307. doi:10.1038/nature1014421593862
   PubMed Web of Science ®Google Scholar
• Carmeliet P. Angiogenesis in life, disease and medicine. Nature. 2005;438(7070):932–936. doi:10.1038/nature0447816355210
   PubMed Web of Science ®Google Scholar
• Maisonpierre PC, Suri C, Jones PF, et al. Angiopoietin-2, a natural antagonist for Tie2 that disrupts in vivo angiogenesis. Science. 1997;277(5322):55–60. doi:10.1126/science.277.5322.559204896
   PubMed Web of Science ®Google Scholar
• Gale NW, Yancopoulos GD. Growth factors acting via endothelial cell-specific receptor tyrosine kinases: VEGFs, angiopoietins, and ephrins in vascular development. Genes Dev. 1999;13(9):1055–1066. doi:10.1101/gad.13.9.105510323857
   PubMed Web of Science ®Google Scholar
• Coussens LM, Raymond WW, Bergers G, et al. Inflammatory mast cells up-regulate angiogenesis during squamous epithelial carcinogenesis. Genes Dev. 1999;13(11):1382–1397. doi:10.1101/gad.13.11.138210364156
   PubMed Web of Science ®Google Scholar
• Mousa SA. Survey of Pro-angiogenesis Strategies In: Mousa SA, Davis PJ, editors. Angiogenesis Modulations in Health and Disease: Practical Applications of Pro- and Anti-angiogenesis Targets. Dordrecht: Springer Netherlands; 2013:15–18.
   Google Scholar
• Gacche RN, Meshram RJ. Angiogenic factors as potential drug target: efficacy and limitations of anti-angiogenic therapy. Biochim Biophys Acta Rev Cancer. 2014;1846(1):161–179. doi:10.1016/j.bbcan.2014.05.002
   PubMed Web of Science ®Google Scholar
• Mousa SA. Survey of Anti-angiogenesis Strategies In: Mousa SA, Davis PJ, editors. Angiogenesis Modulations in Health and Disease: Practical Applications of Pro- and Anti-angiogenesis Targets. Dordrecht: Springer Netherlands; 2013:95–106.
   Google Scholar
• Gupta MK, Qin RY. Mechanism and its regulation of tumor-induced angiogenesis. World J Gastroenterol. 2003;9(6):1144–1155. doi:10.3748/wjg.v9.i6.114412800214
   PubMed Web of Science ®Google Scholar
• Nyberg P, Xie L, Kalluri R. Endogenous inhibitors of angiogenesis. Cancer Res. 2005;65(10):3967–3979. doi:10.1158/0008-5472.CAN-04-242715899784
   PubMed Web of Science ®Google Scholar
• Mousa SA, Anwar LH. Anti-angiogenesis therapy as an adjunct to chemotherapy in oncology In: Mousa SA, Davis PJ, editors. Angiogenesis Modulations in Health and Disease: Practical Applications of Pro- and Anti-angiogenesis Targets. Dordrecht: Springer Netherlands; 2013:143–155.
   Google Scholar
• Dvorak HF. Angiogenesis: update 2005. J Thromb Haemost. 2005;3(8):1835–1842. doi:10.1111/j.1538-7836.2005.01361.x16102050
   PubMed Web of Science ®Google Scholar
• Bergers G, Benjamin LE. Tumorigenesis and the angiogenic switch. Nat Rev Cancer. 2003;3(6):401–410. doi:10.1038/nrc109312778130
   PubMed Web of Science ®Google Scholar
• Folkman J, Hanahan D. Switch to the angiogenic phenotype during tumorigenesis. Princess Takamatsu Symp. 1991;22:339–347.1726933
   PubMedGoogle Scholar
• Nagy JA, Vasile E, Feng D, et al. VEGF-A induces angiogenesis, arteriogenesis, lymphangiogenesis, and vascular malformations. Cold Spring Harb Symp Quant Biol. 2002;67:227–237.12858545
   PubMedGoogle Scholar
• Bhattacharya R, Mukherjee P. Biological properties of “naked” metal nanoparticles. Adv Drug Deliv Rev. 2008;60(11):1289–1306. doi:10.1016/j.addr.2008.03.01318501989
   PubMed Web of Science ®Google Scholar
• Brown LF, Yeo KT, Berse B, et al. Expression of vascular permeability factor (vascular endothelial growth factor) by epidermal keratinocytes during wound healing. J Exp Med. 1992;176(5):1375–1379. doi:10.1084/jem.176.5.13751402682
   PubMed Web of Science ®Google Scholar
• Dvorak HF. How tumors make bad blood vessels and stroma. Am J Pathol. 2003;162(6):1747–1757. doi:10.1016/s0002-9440(10)64309-x12759232
   PubMed Web of Science ®Google Scholar
• Carmeliet P, Collen D. Role of vascular endothelial growth factor and vascular endothelial growth factor receptors in vascular development. Curr Top Microbiol Immunol. 1999;237:133–158.9893349
   PubMed Web of Science ®Google Scholar
• Chu H, Wang Y. Therapeutic angiogenesis: controlled delivery of angiogenic factors. Ther Deliv. 2012;3(6):693–714.22838066
   PubMedGoogle Scholar
• Simons M. Angiogenesis: where do we stand now? Circulation. 2005;111(12):1556–1566. doi:10.1161/01.CIR.0000159345.00591.8F15795364
   PubMed Web of Science ®Google Scholar
• Van Hove AH, Benoit DSW. Depot-based delivery systems for pro-angiogenic peptides: a review. Front Bioeng Biotechnol. 2015;3(102). doi:10.3389/fbioe.2015.00102
   PubMedGoogle Scholar
• Bader RA, Putnam DA. 2013 Engineering Polymer Systems for Improved Drug Delivery. Somerset, UNITED STATES: John Wiley & Sons, Incorporated.
   Google Scholar
• Hollister C, Li VW. Using angiogenesis in chronic wound care with becaplermin and oxidized regenerated cellulose/collagen. Nurs Clin North Am. 2007;42(3):457–465, vii. doi:10.1016/j.cnur.2007.05.00217825664
   PubMedGoogle Scholar
• The Angiogenesis Foundation. (2018). “Therapeutic angiogenesis.” Accessed 126, 2019, Available from: https://angio.org/learn/treatments/.
   Google Scholar
• Steed DLMD. Clinical evaluation of recombinant human platelet-derived growth factor for the treatment of lower extremity ulcers. Plastic & Reconstructive Surgery Current Concepts in Wound Healing. 2006;117(7S):143S–149S. doi:10.1097/01.prs.0000222526.21512.4c
   PubMedGoogle Scholar
• Papanas N, Maltezos E. Benefit-risk assessment of becaplermin in the treatment of diabetic foot ulcers. Drug Saf. 2010;33(6):455–461. doi:10.2165/11534570-000000000-0000020486728
   PubMed Web of Science ®Google Scholar
• Ebos JM, Lee CR, Cruz-Munoz W, Bjarnason GA, Christensen JG, Kerbel RS. Accelerated metastasis after short-term treatment with a potent inhibitor of tumor angiogenesis. Cancer Cell. 2009;15(3):232–239. doi:10.1016/j.ccr.2009.01.02119249681
   PubMed Web of Science ®Google Scholar
• Griffioen AW, Mans LA, de Graaf AMA, et al. Rapid angiogenesis onset after discontinuation of sunitinib treatment of renal cell carcinoma patients. Clin Cancer Res. 2012;18(14):3961–3971. doi:10.1158/1078-0432.CCR-12-000222573349
   PubMed Web of Science ®Google Scholar
• Kamba T, McDonald DM. Mechanisms of adverse effects of anti-VEGF therapy for cancer. Br J Cancer. 2007;96:1788. doi:10.1038/sj.bjc.660381317519900
   PubMed Web of Science ®Google Scholar
• Kubota Y. Tumor angiogenesis and anti-angiogenic therapy. Keio J Med. 2012;61(2):47–56.22760023
   PubMedGoogle Scholar
• Banerjee D, Harfouche R, Sengupta S. Nanotechnology-mediated targeting of tumor angiogenesis. Vasc Cell. 2011;3(1):3. doi:10.1186/2045-824X-3-321349160
   PubMedGoogle Scholar
• Verheul HMW, Pinedo HM. Possible molecular mechanisms involved in the toxicity of angiogenesis inhibition. Nat Rev Cancer. 2007;7:475. doi:10.1038/nrc215217522716
   PubMed Web of Science ®Google Scholar
• Clarke JM, Hurwitz HI. Understanding and targeting resistance to anti-angiogenic therapies. J Gastrointest Oncol. 2013;4(3):253–263. doi:10.3978/j.issn.2078-6891.2013.03623997938
   PubMedGoogle Scholar
• Bergers G, Hanahan D. Modes of resistance to anti-angiogenic therapy. Nat Rev Cancer. 2008;8(8):592–603. doi:10.1038/nrc244218650835
   PubMed Web of Science ®Google Scholar
• Huijbers EJ, van Beijnum JR, Thijssen VL, Sabrkhany S, Nowak-Sliwinska P, Griffioen AW. Role of the tumor stroma in resistance to anti-angiogenic therapy. Drug Resist Updat. 2016;25:26–37. doi:10.1016/j.drup.2016.02.00227155374
   PubMed Web of Science ®Google Scholar
• Davis ME, Chen Z, Shin DM. Nanoparticle therapeutics: an emerging treatment modality for cancer. Nat Rev Drug Discov. 2008;7:771. doi:10.1038/nrd261418758474
   PubMed Web of Science ®Google Scholar
• Arvizo R, Bhattacharya R, Mukherjee P. Gold nanoparticles: opportunities and challenges in nanomedicine. Expert Opin Drug Deliv. 2010;7(6):753–763. doi:10.1517/1742524100377701020408736
   PubMed Web of Science ®Google Scholar
• Seo D, Song H. Synthesis of gold nanoparticles in liquid phase. In Louis C, Pluchery O. Gold Nanoparticles for Physics, Chemistry and Biology. London: Imperial College Press; 2012;103–138.
   Google Scholar
• Mori T, Hegmann T. Determining the composition of gold nanoparticles: a compilation of shapes, sizes, and calculations using geometric considerations. J Nanopart Res. 2016;18(10):295. doi:10.1007/s11051-016-3587-727766020
   PubMedGoogle Scholar
• Zhang -S-S, Feng L, Senanayake RD, et al. Diphosphine-protected ultrasmall gold nanoclusters: opened icosahedral Au(13) and heart-shaped Au(8) clusters. Chem Sci. 2017;9(5):1251–1258. doi:10.1039/c7sc03566g29675171
   PubMedGoogle Scholar
• Huang R, Wen Y-H, Shao G-F, Zhu -Z-Z, Sun S-G. Single-crystalline and multiple-twinned gold nanoparticles: an atomistic perspective on structural and thermal stabilities. RSC Adv. 2014;4(15):7528–7537. doi:10.1039/c3ra46631k
   Web of Science ®Google Scholar
• Sun Y, Xia Y. Shape-controlled synthesis of gold and silver nanoparticles. Science. 2003;298:2176–2179. doi:10.1126/science.1077229
   Web of Science ®Google Scholar
• Zhang J, Langille MR, Personick ML, Zhang K, Li S, Mirkin CA. Concave cubic gold nanocrystals with high-index facets. J Am Chem Soc. 2010;132(40):14012–14014. doi:10.1021/ja106394k20853848
   PubMedGoogle Scholar
• Skrabalak SE, Chen J, Sun Y, et al. Gold nanocages: synthesis, properties, and applications. Acc Chem Res. 2008;41(12):1587–1595. doi:10.1021/ar800018v18570442
   PubMed Web of Science ®Google Scholar
• Zhang Q, Zhou Y, Villarreal E, Lin Y, Zou S, Wang H. Faceted gold nanorods: nanocuboids, convex nanocuboids, and concave nanocuboids. Nano Lett. 2015;15(6):4161–4169. doi:10.1021/acs.nanolett.5b0128625927399
   PubMedGoogle Scholar
• Personick ML, Langille MR, Zhang J, Harris N, Schatz GC, Mirkin CA. Synthesis and isolation of {110}-faceted gold bipyramids and rhombic dodecahedra. J Am Chem Soc. 2011;133(16):6170–6173. doi:10.1021/ja201826r21452816
   PubMedGoogle Scholar
• Wu H-L, Chen C-H, Huang MH. Seed-mediated synthesis of branched gold nanocrystals derived from the side growth of pentagonal bipyramids and the formation of gold nanostars. Chem Mater. 2009;21(1):110–114. doi:10.1021/cm802257e
   Web of Science ®Google Scholar
• Wu S, Yang X, Luo F, et al. Biosynthesis of flower-shaped Au nanoclusters with EGCG and their application for drug delivery. J Nanobiotechnology. 2018;16(1):90. doi:10.1186/s12951-018-0417-330424776
   PubMedGoogle Scholar
• Sau TK, Murphy CJ. Room temperature, high-yield synthesis of multiple shapes of gold nanoparticles in aqueous solution. J Am Chem Soc. 2004;126(28):8648–8649. doi:10.1021/ja047846d15250706
   PubMed Web of Science ®Google Scholar
• Chen S, Wang ZL, Ballato J, Foulger SH, Carroll DL. Monopod, bipod, tripod, and tetrapod gold nanocrystals. J Am Chem Soc. 2003;125(52):16186–16187. doi:10.1021/ja038927x14692749
   PubMed Web of Science ®Google Scholar
• Shakiba A, Zenasni O, Marquez M, Randall Lee T. Advanced drug delivery via self-assembled monolayer-coated nanoparticles. AIMS Bioeng. 2017;4:275–299. doi:10.3934/bioeng.2017.2.275
   Web of Science ®Google Scholar
• Sun T, Zhang YS, Pang B, Hyun DC, Yang M, Xia Y. Engineered nanoparticles for drug delivery in cancer therapy. Angew Chem Int Ed Engl. 2014;53(46):12320–12364. doi:10.1002/anie.20140303625294565
   PubMed Web of Science ®Google Scholar
• Webb JA, Bardhan R. Emerging advances in nanomedicine with engineered gold nanostructures. Nanoscale. 2014;6(5):2502–2530. doi:10.1039/c3nr05112a24445488
   PubMed Web of Science ®Google Scholar
• McIntosh CM, Esposito EA 3rd, Boal AK, Simard JM, Martin CT, Rotello VM. Inhibition of DNA transcription using cationic mixed monolayer protected gold clusters. J Am Chem Soc. 2001;123(31):7626–7629. doi:10.1021/ja015556g11480984
   PubMed Web of Science ®Google Scholar
• Conde J, Ambrosone A, Sanz V, et al. Design of multifunctional gold nanoparticles for in vitro and in vivo gene silencing. ACS Nano. 2012;6(9):8316–8324. doi:10.1021/nn303022322882598
   PubMed Web of Science ®Google Scholar
• Wu Z, Liu GQ, Yang XL, Jiang JH. Electrostatic nucleic acid nanoassembly enables hybridization chain reaction in living cells for ultrasensitive mRNA imaging. J Am Chem Soc. 2015;137(21):6829–6836. doi:10.1021/jacs.5b0177825969953
   PubMedGoogle Scholar
• Lin J, Zhang H, Chen Z, Zheng Y. Penetration of lipid membranes by gold nanoparticles: insights into cellular uptake, cytotoxicity, and their relationship. ACS Nano. 2010;4(9):5421–5429. doi:10.1021/nn101079220799717
   PubMed Web of Science ®Google Scholar
• Turkevich J, Stevenson PC, Hillier J. A study of the nucleation and growth processes in the synthesis of colloidal gold. Discuss Faraday Soc. 1951;11:55–75. doi:10.1039/df9511100055
   Google Scholar
• Frens G. Controlled nucleation for the regulation of the particle size in monodisperse gold suspensions. Nat Phys Sci. 1973;241(105):20–22. doi:10.1038/physci241020a0
   Web of Science ®Google Scholar
• Frens G. Particle size and sol stability in metal colloids. Kolloid-Zeitschrift und Zeitschrift für Polymere. 1972;250(7):736–741. doi:10.1007/BF01498565
   Google Scholar
• Brust M, Walker M, Bethell D, Schiffrin DJ, Whyman R. Synthesis of thiol-derivatised gold nanoparticles in a two-phase liquid–liquid system. J Chem Soc Chem Commun. 1994;7:801–802. doi:10.1039/C39940000801
   Google Scholar
• Shah M, Badwaik V, Kherde Y, et al. Gold nanoparticles: various methods of synthesis and antibacterial applications. Front Biosci. 2014;19:1320. doi:10.2741/4284
   Web of Science ®Google Scholar
• Giersig M, Mulvaney P. Preparation of ordered colloid monolayers by electrophoretic deposition. Langmuir. 1993;9(12):3408–3413. doi:10.1021/la00036a014
   Web of Science ®Google Scholar
• Hostetler MJ, Templeton AC, Murray RW. Dynamics of place-exchange reactions on monolayer-protected gold cluster molecules. Langmuir. 1999;15(11):3782–3789. doi:10.1021/la981598f
   Web of Science ®Google Scholar
• Murphy CJ, Jana NR. Controlling the aspect ratio of inorganic nanorods and nanowires. Adv Mater. 2002;14(1):80–82.
   Web of Science ®Google Scholar
• Shankar SS, Bhargava S, Sastry M. Synthesis of gold nanospheres and nanotriangles by the Turkevich approach. J Nanosci Nanotechnol. 2005;5(10):1721–1727. doi:10.1166/jnn.2005.19216245535
   PubMedGoogle Scholar
• Bridges CR, DiCarmine PM, Fokina A, Huesmann D, Seferos DS. Synthesis of gold nanotubes with variable wall thicknesses. J Mater Chem A. 2013;1(4):1127–1133. doi:10.1039/C2TA00729K
   Web of Science ®Google Scholar
• Shao L, Susha AS, Cheung LS, Sau TK, Rogach AL, Wang J. Plasmonic properties of single multispiked gold nanostars: correlating modeling with experiments. Langmuir. 2012;28(24):8979–8984. doi:10.1021/la204809722353020
   PubMedGoogle Scholar
• Jana NR, Gearheart L, Murphy CJ. Seed-mediated growth approach for shape-controlled synthesis of spheroidal and rod-like gold nanoparticles using a surfactant template. Adv Mater. 2001;13(18):1389–1393. doi:10.1002/(ISSN)1521-4095
   Web of Science ®Google Scholar
• Jana NR, Gearheart L, Murphy CJ. Seeding growth for size control of 5−40 nm diameter gold nanoparticles. Langmuir. 2001;17(22):6782–6786. doi:10.1021/la0104323
   Web of Science ®Google Scholar
• Isaeva EI, Svistunova OB, Gorbunova VV, Boitsova TB. Photochemical synthesis of gold nanoparticles in elastomer films of poly(butyl acrylate) latex. Russ J Gen Chem. 2007;77(12):2113–2116. doi:10.1134/S1070363207120067
   Web of Science ®Google Scholar
• Marin ML, McGilvray KL, Scaiano JC. Photochemical strategies for the synthesis of gold nanoparticles from Au(III) and Au(I) using photoinduced free radical generation. J Am Chem Soc. 2008;130(49):16572–16584. doi:10.1021/ja803490n19049456
   PubMedGoogle Scholar
• Niidome Y, Nishioka K, Kawasaki H, Yamada S. Rapid synthesis of gold nanorods by the combination of chemical reduction and photoirradiation processes; morphological changes depending on the growing processes. Chem Commun. 2003;18:2376–2377. doi:10.1039/B307836A
   PubMed Web of Science ®Google Scholar
• Yusof NS, Ashokkumar M. Sonochemical synthesis of gold nanoparticles by using high intensity focused ultrasound. Chemphyschem. 2015;16(4):775–781. doi:10.1002/cphc.20140269725598360
   PubMedGoogle Scholar
• Gutiérrez-Wing C, Esparza R, Vargas-Hernández C, Fernández García ME, José-Yacamán M. Microwave-assisted synthesis of gold nanoparticles self-assembled into self-supported superstructures. Nanoscale. 2012;4(7):2281–2287. doi:10.1039/c2nr12053d22398420
   PubMedGoogle Scholar
• Chen Y-S, Hung Y-C, Liau I, Huang GS. Assessment of the in vivo toxicity of gold nanoparticles. Nanoscale Res Lett. 2009;4(8):858–864. doi:10.1007/s11671-009-9334-620596373
   PubMed Web of Science ®Google Scholar
• Alkilany AM, Murphy CJ. Toxicity and cellular uptake of gold nanoparticles: what we have learned so far? J Nanopart Res. 2010;12(7):2313–2333. doi:10.1007/s11051-010-9911-821170131
   PubMed Web of Science ®Google Scholar
• Aljabali AAA, Akkam Y, Al Zoubi MS, et al. Synthesis of gold nanoparticles using leaf extract of ziziphus zizyphus and their antimicrobial activity. Nanomaterials (Basel). 2018;8(3):174. doi:10.3390/nano8030174
   PubMedGoogle Scholar
• Husen A. Gold nanoparticles from plant system: synthesis, characterization and their application. In: Ghorbanpour M, Manika K, Varma A, eds. Nanoscience and Plant–Soil Systems Cham: Springer International Publishing; 2017;48:455–479.
   Google Scholar
• Elia P, Zach R, Hazan S, Kolusheva S, Porat ZE, Zeiri Y. Green synthesis of gold nanoparticles using plant extracts as reducing agents. Int J Nanomedicine. 2014;9:4007–4021. doi:10.2147/IJN.S5734325187704
   PubMed Web of Science ®Google Scholar
• Singh PK, Kundu S. Biosynthesis of gold nanoparticles using bacteria. Proc Natl Acad Sci India Sect B Biol Sci. 2014;84(2):331–336. doi:10.1007/s40011-013-0230-6
   Google Scholar
• Zhang X, Qu Y, Shen W, et al. Biogenic synthesis of gold nanoparticles by yeast Magnusiomyces ingens LH-F1 for catalytic reduction of nitrophenols. Colloids Surf A Physicochem Eng Asp. 2016;497:280–285. doi:10.1016/j.colsurfa.2016.02.033
   Web of Science ®Google Scholar
• Pourali P, Badiee SH, Manafi S, Noorani T, Rezaei A, Yahyaei B. Biosynthesis of gold nanoparticles by two bacterial and fungal strains, Bacillus cereus and Fusarium oxysporum, and assessment and comparison of their nanotoxicity in vitro by direct and indirect assays. ELECTRON J BIOTECHN. 2017;29:86–93. doi:10.1016/j.ejbt.2017.07.005
   Web of Science ®Google Scholar
• Pei X, Qu Y, Shen W, et al. Green synthesis of gold nanoparticles using fungus Mariannaea sp. HJ and their catalysis in reduction of 4-nitrophenol. Environ Sci Pollut Res Int. 2017;24(27):21649–21659. doi:10.1007/s11356-017-9684-z28752308
   PubMedGoogle Scholar
• González-Ballesteros N, Prado-López S, Rodríguez-González JB, Lastra M, Rodríguez-Argüelles MC. Green synthesis of gold nanoparticles using brown algae Cystoseira baccata: its activity in colon cancer cells. Colloids Surf B Biointerfaces. 2017;153:190–198. doi:10.1016/j.colsurfb.2017.02.02028242372
   PubMed Web of Science ®Google Scholar
• Abdel-Raouf N, Al-Enazi NM, Ibraheem IBM. Green biosynthesis of gold nanoparticles using Galaxaura elongata and characterization of their antibacterial activity. Arab J Chem. 2017;10:S3029–S3039. doi:10.1016/j.arabjc.2013.11.044
   Web of Science ®Google Scholar
• Shao Y, Jin Y, Dong S. Synthesis of gold nanoplates by aspartate reduction of gold chloride. Chem Commun. 2004;9:1104–1105. doi:10.1039/b315732f
   PubMed Web of Science ®Google Scholar
• Maruyama T, Fujimoto Y, Maekawa T. Synthesis of gold nanoparticles using various amino acids. J Colloid Interface Sci. 2015;447:254–257. doi:10.1016/j.jcis.2014.12.04625591824
   PubMed Web of Science ®Google Scholar
• Tetgure SR, Borse AU, Sankapal BR, Garole VJ, Garole DJ. Green biochemistry approach for synthesis of silver and gold nanoparticles using Ficus racemosa latex and their pH-dependent binding study with different amino acids using UV/Vis absorption spectroscopy. Amino Acids. 2015;47(4):757–765. doi:10.1007/s00726-014-1906-925618751
   PubMed Web of Science ®Google Scholar
• Gholami-Shabani M, Shams-Ghahfarokhi M, Gholami-Shabani Z, et al. Enzymatic synthesis of gold nanoparticles using sulfite reductase purified from Escherichia coli: a green eco-friendly approach. Process Biochem. 2015;50(7):1076–1085. doi:10.1016/j.procbio.2015.04.004
   Web of Science ®Google Scholar
• Abraham S, Narine SS. A facile synthesis of lipid stabilized gold nanoparticles: a step towards biodegradable biosensors. J Nanosci Nanotechnol. 2011;11(8):7027–7032. doi:10.1166/jnn.2011.487822103117
   PubMedGoogle Scholar
• Rasch MR, Rossinyol E, Hueso JL, Goodfellow BW, Arbiol J, Korgel BA. Hydrophobic gold nanoparticle self-assembly with phosphatidylcholine lipid: membrane-loaded and janus vesicles. Nano Lett. 2010;10(9):3733–3739. doi:10.1021/nl102387n20731366
   PubMed Web of Science ®Google Scholar
• Sharma D. A biologically friendly single step method for gold nanoparticle formation. Colloids Surf B Biointerfaces. 2011;85(2):330–337. doi:10.1016/j.colsurfb.2011.03.00521459561
   PubMedGoogle Scholar
• Kunoh T, Takeda M, Matsumoto S, et al. Green synthesis of gold nanoparticles coupled with nucleic acid oxidation. ACS Sustain Chem Eng. 2018;6(1):364–373. doi:10.1021/acssuschemeng.7b02610
   Web of Science ®Google Scholar
• Anstaett P, Zheng Y, Thai T, Funston AM, Bach U, Gasser G. Synthesis of stable peptide nucleic acid-modified gold nanoparticles and their assembly onto gold surfaces. Angew Chem Int Ed Engl. 2013;52(15):4217–4220. doi:10.1002/anie.20120968423460137
   PubMedGoogle Scholar
• Das APDR, Nath SS, Bhattacharjee R. Preparation of linoleic acid capped gold nanoparticles and their spectra. Physica E Low Dimens Syst Nanostruct. 2010;43:224–227. doi:10.1016/j.physe.2010.07.008
   Web of Science ®Google Scholar
• Kitaoka T, Yokota S, Opietnik M, Rosenau T. Synthesis and bio-applications of carbohydrate–gold nanoconjugates with nanoparticle and nanolayer forms. Mat Sci Eng C Mater. 2011;31(6):1221–1229. doi:10.1016/j.msec.2010.10.009
   Web of Science ®Google Scholar
• Tagad CK, Rajdeo KS, Kulkarni A, More P, Aiyer RC, Sabharwal S. Green synthesis of polysaccharide stabilized gold nanoparticles: chemo catalytic and room temperature operable vapor sensing application. RSC Adv. 2014;4(46):24014–24019. doi:10.1039/c4ra02972k
   Web of Science ®Google Scholar
• Pandey S, Goswami GK, Nanda KK. Green synthesis of polysaccharide/gold nanoparticle nanocomposite: an efficient ammonia sensor. Carbohydr Polym. 2013;94(1):229–234. doi:10.1016/j.carbpol.2013.01.00923544533
   PubMedGoogle Scholar
• Mao Z, Zhou X, Gao C. Influence of structure and properties of colloidal biomaterials on cellular uptake and cell functions. Biomater Sci. 2013;1(9):896–911. doi:10.1039/c3bm00137g
   PubMed Web of Science ®Google Scholar
• Panzarini E, Mariano S, Carata E, Mura F, Rossi M, Dini L. Intracellular transport of silver and gold nanoparticles and biological responses: an update. Int J Mol Sci. 2018;19(5):1305. doi:10.3390/ijms19051305
   PubMed Web of Science ®Google Scholar
• Zhu M, Nie G, Meng H, Xia T, Nel A, Zhao Y. Physicochemical properties determine nanomaterial cellular uptake, transport, and fate. Acc Chem Res. 2013;46(3):622–631. doi:10.1021/ar300031y22891796
   PubMed Web of Science ®Google Scholar
• Chithrani BD, Ghazani AA, Chan WC. Determining the size and shape dependence of gold nanoparticle uptake into mammalian cells. Nano Lett. 2006;6(4):662–668. doi:10.1021/nl052396o16608261
   PubMed Web of Science ®Google Scholar
• Ko WK, Heo DN, Moon HJ, et al. The effect of gold nanoparticle size on osteogenic differentiation of adipose-derived stem cells. J Colloid Interface Sci. 2015;438:68–76. doi:10.1016/j.jcis.2014.08.05825454427
   PubMed Web of Science ®Google Scholar
• Fernandez TD, Pearson JR, Leal MP, et al. Intracellular accumulation and immunological properties of fluorescent gold nanoclusters in human dendritic cells. Biomaterials. 2015;43:1–12. doi:10.1016/j.biomaterials.2014.11.04525591956
   PubMedGoogle Scholar
• Le Guevel X, Perez Perrino M, Fernandez TD, et al. Multivalent glycosylation of fluorescent gold nanoclusters promotes increased human dendritic cell targeting via multiple endocytic pathways. ACS Appl Mater Interfaces. 2015;7(37):20945–20956. doi:10.1021/acsami.5b0654126329370
   PubMed Web of Science ®Google Scholar
• Saha K, Kim ST, Yan B, et al. Surface functionality of nanoparticles determines cellular uptake mechanisms in mammalian cells. Small. 2013;9(2):300–305. doi:10.1002/smll.20120112922972519
   PubMed Web of Science ®Google Scholar
• Fytianos K, Rodriguez-Lorenzo L, Clift MJ, et al. Uptake efficiency of surface modified gold nanoparticles does not correlate with functional changes and cytokine secretion in human dendritic cells in vitro. Nanomedicine. 2015;11(3):633–644. doi:10.1016/j.nano.2014.11.00425555350
   PubMed Web of Science ®Google Scholar
• Xie X, Liao J, Shao X, Li Q, Lin Y. The effect of shape on cellular uptake of gold nanoparticles in the forms of stars, rods, and triangles. Sci Rep. 2017;7(1):3827. doi:10.1038/s41598-017-04229-z28630477
   PubMed Web of Science ®Google Scholar
• Pan F, Yang W, Li W, et al. Conjugation of gold nanoparticles and recombinant human endostatin modulates vascular normalization via interruption of anterior gradient 2-mediated angiogenesis. Tumour Biol. 2017;39(7):1010428317708547. doi:10.1177/101042831770854728714365
   PubMedGoogle Scholar
• Balakrishnan S, Bhat FA, Raja Singh P, et al. Gold nanoparticle-conjugated quercetin inhibits epithelial-mesenchymal transition, angiogenesis and invasiveness via EGFR/VEGFR-2-mediated pathway in breast cancer. Cell Prolif. 2016;49(6):678–697. doi:10.1111/cpr.1229627641938
   PubMed Web of Science ®Google Scholar
• Saber MM, Bahrainian S, Dinarvand R, Atyabi F. Targeted drug delivery of Sunitinib Malate to tumor blood vessels by cRGD-chiotosan-gold nanoparticles. Int J Pharm. 2017;517(1–2):269–278. doi:10.1016/j.ijpharm.2016.12.01627956189
   PubMed Web of Science ®Google Scholar
• Pan Y, Ding H, Qin L, Zhao X, Cai J, Du B. Gold nanoparticles induce nanostructural reorganization of VEGFR2 to repress angiogenesis. J Biomed Nanotechnol. 2013;9(10):1746–1756.24015504
   PubMed Web of Science ®Google Scholar
• Shen N, Zhang R, Zhang HR, et al. Inhibition of retinal angiogenesis by gold nanoparticles via inducing autophagy. Int J Ophthalmol. 2018;11(8):1269–1276. doi:10.18240/ijo.2018.08.0430140628
   PubMedGoogle Scholar
• Jo DH, Hong JW, Kim JH, Han SW, Kim JH. Gold nanocrystals with well-defined crystallographic {111} facets suppress pathological neovascularization. J Biomed Nanotechnol. 2016;12(7):1520–1526.29337491
   PubMed Web of Science ®Google Scholar
• Pan Y, Wu Q, Qin L, Cai J, Du B. Gold nanoparticles inhibit VEGF165-induced migration and tube formation of endothelial cells via the Akt pathway. Biomed Res Int. 2014;(2014:418624.24987682
   PubMed Web of Science ®Google Scholar
• Reva GV, Reva IV, Yamamoto T, et al. Reaction of dermal structures to subcutaneous injection of gold nanoparticles to CBA mice. Bull Exp Biol Med. 2014;156(4):491–494. doi:10.1007/s10517-014-2382-724771435
   PubMedGoogle Scholar
• Kemp MM, Kumar A, Mousa S, et al. Gold and silver nanoparticles conjugated with heparin derivative possess anti-angiogenesis properties. Nanotechnology. 2009;20(45):455104. doi:10.1088/0957-4484/20/45/45510419822927
   PubMed Web of Science ®Google Scholar
• Song HB, Wi JS, Jo DH, et al. Intraocular application of gold nanodisks optically tuned for optical coherence tomography: inhibitory effect on retinal neovascularization without unbearable toxicity. Nanomedicine. 2017;13(6):1901–1911. doi:10.1016/j.nano.2017.03.01628400160
   PubMedGoogle Scholar
• Tan G, Onur MA. Cellular localization and biological effects of 20nm-gold nanoparticles. J Biomed Mater Res A. 2018;106(6):1708–1721. doi:10.1002/jbm.a.3637329468810
   PubMedGoogle Scholar
• Vimalraj S, Ashokkumar T, Saravanan S. Biogenic gold nanoparticles synthesis mediated by Mangifera indica seed aqueous extracts exhibits antibacterial, anticancer and anti-angiogenic properties. Biomed Pharmacother. 2018;105:440–448. doi:10.1016/j.biopha.2018.05.15129879628
   PubMed Web of Science ®Google Scholar
• Pan F, Li W, Yang W, et al. Anterior gradient 2 as a supervisory marker for tumor vessel normalization induced by anti-angiogenic treatment. Oncol Lett. 2018;16(3):3083–3091. doi:10.3892/ol.2018.899630127899
   PubMedGoogle Scholar
• Li W, Li X, Liu S, et al. Gold nanoparticles attenuate metastasis by tumor vasculature normalization and epithelial-mesenchymal transition inhibition. Int J Nanomedicine. 2017;12:3509–3520. doi:10.2147/IJN.S12880228496326
   PubMed Web of Science ®Google Scholar
• Mukherjee P, Bhattacharya R, Wang P, et al. Antiangiogenic properties of gold nanoparticles. Clin Cancer Res. 2005;11(9):3530–3534. doi:10.1158/1078-0432.CCR-04-248215867256
   PubMed Web of Science ®Google Scholar
• Arvizo RR, Rana S, Miranda OR, Bhattacharya R, Rotello VM, Mukherjee P. Mechanism of anti-angiogenic property of gold nanoparticles: role of nanoparticle size and surface charge. Nanomedicine. 2011;7(5):580–587. doi:10.1016/j.nano.2011.01.01121333757
   PubMed Web of Science ®Google Scholar
• Kim JH, Kim MH, Jo DH, Yu YS, Lee TG, Kim JH. The inhibition of retinal neovascularization by gold nanoparticles via suppression of VEGFR-2 activation. Biomaterials. 2011;32(7):1865–1871. doi:10.1016/j.biomaterials.2010.11.03021145587
   PubMedGoogle Scholar
• Satapathy SR, Nayak A, Siddharth S, Das S, Nayak D, Kundu CN. Metallic gold and bioactive quinacrine hybrid nanoparticles inhibit oral cancer stem cell and angiogenesis by deregulating inflammatory cytokines in p53 dependent manner. Nanomedicine. 2018;14(3):883–896. doi:10.1016/j.nano.2018.01.00729366881
   PubMed Web of Science ®Google Scholar
• Pivodova V, Frankova J, Galandakova A, Ulrichova J. In vitro AuNPs’ cytotoxicity and their effect on wound healing. Nanobiomedicine (Rij). 2015;2:7. doi:10.5772/6217429942372
   PubMedGoogle Scholar
• Connor EE, Mwamuka J, Gole A, Murphy CJ, Wyatt MD. Gold nanoparticles are taken up by human cells but do not cause acute cytotoxicity. Small. 2005;1(3):325–327. doi:10.1002/smll.20040009317193451
   PubMed Web of Science ®Google Scholar
• Mukherjee P, Bhattacharya R, Bone N, et al. Potential therapeutic application of gold nanoparticles in B-chronic lymphocytic leukemia (BCLL): enhancing apoptosis. J Nanobiotechnology. 2007;5:4. doi:10.1186/1477-3155-5-417488514
   PubMedGoogle Scholar
• Hainfeld JF, Slatkin DN, Focella TM, Smilowitz HM. Gold nanoparticles: a new X-ray contrast agent. Br J Radiol. 2006;79(939):248–253. doi:10.1259/bjr/1316988216498039
   PubMed Web of Science ®Google Scholar
• Amendola V, Pilot R, Frasconi M, Marago OM, Iati MA. Surface plasmon resonance in gold nanoparticles: a review. J Phys Condens Matter. 2017;29(20):203002. doi:10.1088/1361-648X/aa60f328426435
   PubMed Web of Science ®Google Scholar
• Lau P, Bidin N, Islam S, et al. Influence of gold nanoparticles on wound healing treatment in rat model: photobiomodulation therapy. Lasers Surg Med. 2017;49(4):380–386. doi:10.1002/lsm.2261427859389
   PubMed Web of Science ®Google Scholar
• Saha S, Xiong X, Chakraborty PK, et al. Gold nanoparticle reprograms pancreatic tumor microenvironment and inhibits tumor growth. ACS Nano. 2016;10(12):10636–10651. doi:10.1021/acsnano.6b0223127758098
   PubMed Web of Science ®Google Scholar
• Roma-Rodrigues C, Heuer-Jungemann A, Fernandes AR, Kanaras AG, Baptista PV. Peptide-coated gold nanoparticles for modulation of angiogenesis in vivo. Int J Nanomedicine. 2016;11:2633–2639. doi:10.2147/IJN.S10866127354794
   PubMed Web of Science ®Google Scholar
• Groult H, Ruiz-Cabello J, Pellico J, et al. Parallel multifunctionalization of nanoparticles: a one-step modular approach for in vivo imaging. Bioconjug Chem. 2015;26(1):153–160. doi:10.1021/bc500536y25494619
   PubMed Web of Science ®Google Scholar
• Vilchis-Juarez A, Ferro-Flores G, Santos-Cuevas C, et al. Molecular targeting radiotherapy with cyclo-RGDFK(C) peptides conjugated to 177Lu-labeled gold nanoparticles in tumor-bearing mice. J Biomed Nanotechnol. 2014;10(3):393–404.24730235
   PubMed Web of Science ®Google Scholar
• Li M, Li Y, Huang X, Lu X. Captopril-polyethyleneimine conjugate modified gold nanoparticles for co-delivery of drug and gene in anti-angiogenesis breast cancer therapy. J Biomater Sci Polym Ed. 2015;26(13):813–827. doi:10.1080/09205063.2015.105799126166244
   PubMed Web of Science ®Google Scholar
• Yang Y, Zhang L, Cai J, et al. Tumor angiogenesis targeted radiosensitization therapy using gold nanoprobes guided by MRI/SPECT imaging. ACS Appl Mater Interfaces. 2016;8(3):1718–1732. doi:10.1021/acsami.5b0927426731347
   PubMed Web of Science ®Google Scholar
• Mieszawska AJ, Kim Y, Gianella A, et al. Synthesis of polymer-lipid nanoparticles for image-guided delivery of dual modality therapy. Bioconjug Chem. 2013;24(9):1429–1434. doi:10.1021/bc400166j23957728
   PubMed Web of Science ®Google Scholar
• Bhowmik T, Saha PP, DasGupta AK, Gomes A. Influence of gold nanoparticle tagged snake venom protein toxin NKCT1 on Ehrlich ascites carcinoma (EAC) and EAC induced solid tumor bearing male albino mice. Curr Drug Deliv. 2014;11(5):652–664.24827982
   PubMed Web of Science ®Google Scholar
• Kim JE, Lee J, Jang M, et al. Accelerated healing of cutaneous wounds using phytochemically stabilized gold nanoparticle deposited hydrocolloid membranes. Biomater Sci. 2015;3(3):509–519. doi:10.1039/c4bm00390j26222294
   PubMed Web of Science ®Google Scholar
• Chen Y, Wu Y, Gao J, et al. Transdermal vascular endothelial growth factor delivery with surface engineered gold nanoparticles. ACS Appl Mater Interfaces. 2017;9(6):5173–5180. doi:10.1021/acsami.6b1591428112909
   PubMed Web of Science ®Google Scholar
• Chien CC, Chen HH, Lai SF, et al. Gold nanoparticles as high-resolution X-ray imaging contrast agents for the analysis of tumor-related micro-vasculature. J Nanobiotechnology. 2012;10:10. doi:10.1186/1477-3155-10-1022409971
   PubMed Web of Science ®Google Scholar
• Son S, Kim N, You DG, et al. Antitumor therapeutic application of self-assembled RNAi-AuNP nanoconstructs: combination of VEGF-RNAi and photothermal ablation. Theranostics. 2017;7(1):9–22. doi:10.7150/thno.1604228042312
   PubMedGoogle Scholar
• Nethi SK, Mukherjee S, Veeriah V, Barui AK, Chatterjee S, Patra CR. Bioconjugated gold nanoparticles accelerate the growth of new blood vessels through redox signaling. Chem Commun (Camb). 2014;50(92):14367–14370. doi:10.1039/c4cc06996j25298204
   PubMedGoogle Scholar
• Gomez-Beloz A, Rucinski JC, Balick MJ, Tipton C. Double incision wound healing bioassay using Hamelia patens from El Salvador. J Ethnopharmacol. 2003;88(2–3):169–173.12963138
   PubMed Web of Science ®Google Scholar
• Wang B, Wang W, Yu Y, Zhang Y, Zhang J, Yuan Z. The study of angiogenesis stimulated by multivalent peptide ligand-modified alginate. Colloids Surf B Biointerfaces. 2017;154:383–390. doi:10.1016/j.colsurfb.2017.03.04928384617
   PubMedGoogle Scholar
• Liu Y, Tan TTY, Yuan S, Choong C. Multifunctional P(PEGMA)–REDV conjugated titanium surfaces for improved endothelial cell selectivity and hemocompatibility. J Mater Chem B. 2013;1:(2):157–167. doi:10.1039/C2TB00014H
   Web of Science ®Google Scholar
• Chien CC, Chen HH, Lai SF, et al. X-ray imaging of tumor growth in live mice by detecting gold-nanoparticle-loaded cells. Sci Rep. 2012;2:610. doi:10.1038/srep0038622934133
   PubMedGoogle Scholar
• Clark DP, Ghaghada K, Moding EJ, Kirsch DG, Badea CT. In vivo characterization of tumor vasculature using iodine and gold nanoparticles and dual energy micro-CT. Phys Med Biol. 2013;58(6):1683–1704. doi:10.1088/0031-9155/58/6/168323422321
   PubMedGoogle Scholar
• Bao C, Beziere N, Del Pino P, et al. Gold nanoprisms as optoacoustic signal nanoamplifiers for in vivo bioimaging of gastrointestinal cancers. Small. 2013;9(1):68–74. doi:10.1002/smll.20120177923001862
   PubMed Web of Science ®Google Scholar
• Kim YH, Jeon J, Hong SH, et al. Tumor targeting and imaging using cyclic RGD-PEGylated gold nanoparticle probes with directly conjugated iodine-125. Small. 2011;7(14):2052–2060. doi:10.1002/smll.20110092721688390
   PubMedGoogle Scholar
• Morales-Avila E, Ferro-Flores G, Ocampo-Garcia BE, et al. Multimeric system of 99mTc-labeled gold nanoparticles conjugated to c[RGDfK(C)] for molecular imaging of tumor alpha(v)beta(3) expression. Bioconjug Chem. 2011;22(5):913–922. doi:10.1021/bc100551s21513349
   PubMed Web of Science ®Google Scholar
• Pan D, Pramanik M, Senpan A, et al. Molecular photoacoustic imaging of angiogenesis with integrin-targeted gold nanobeacons. Faseb J. 2011;25(3):875–882. doi:10.1096/fj.10-17172821097518
   PubMed Web of Science ®Google Scholar
• Zhang S, Gong M, Zhang D, Yang H, Gao F, Zou L. Thiol-PEG-carboxyl-stabilized Fe(2)O (3)/Au nanoparticles targeted to CD105: synthesis, characterization and application in MR imaging of tumor angiogenesis. Eur J Radiol. 2014;83(7):1190–1198. doi:10.1016/j.ejrad.2014.03.03424832501
   PubMedGoogle Scholar
• Kennedy LC, Bickford LR, Lewinski NA, et al. A new era for cancer treatment: gold-nanoparticle-mediated thermal therapies. Small. 2011;7(2):169–183. doi:10.1002/smll.20100013421213377
   PubMed Web of Science ®Google Scholar
• Kharlamov AN, Feinstein JA, Cramer JA, Boothroyd JA, Shishkina EV, Shur V. Plasmonic photothermal therapy of atherosclerosis with nanoparticles: long-term outcomes and safety in NANOM-FIM trial. Future Cardiol. 2017;13(4):345–363. doi:10.2217/fca-2017-000928644056
   PubMed Web of Science ®Google Scholar
• Mesicek J, Kuca K. Summary of numerical analyses for therapeutic uses of laser-activated gold nanoparticles. Int J Hyperthermia. 2018;34(8):1255–1264. doi:10.1080/02656736.2018.144001629447018
   PubMed Web of Science ®Google Scholar
• Riley RS, Day ES. Gold nanoparticle-mediated photothermal therapy: applications and opportunities for multimodal cancer treatment. Wiley Interdiscip Rev Nanomed Nanobiotechnol. 2017;9(4):e1449.
   Web of Science ®Google Scholar
• Gamal-Eldeen AM, Moustafa D, El-Daly SM, et al. Gum Arabic-encapsulated gold nanoparticles for a non-invasive photothermal ablation of lung tumor in mice. Biomed Pharmacother. 2017;89:1045–1054. doi:10.1016/j.biopha.2017.03.00628298068
   PubMed Web of Science ®Google Scholar
• Bai YY, Zheng S, Zhang L, et al. Non-invasively evaluating therapeutic response of nanorod-mediated photothermal therapy on tumor angiogenesis. J Biomed Nanotechnol. 2014;10(11):3351–3360.26000393
   PubMed Web of Science ®Google Scholar
• Pedrosa P, Heuer-Jungemann A, Kanaras AG, Fernandes AR, Baptista PV. Potentiating angiogenesis arrest in vivo via laser irradiation of peptide functionalised gold nanoparticles. J Nanobiotechnology. 2017;15(1):85. doi:10.1186/s12951-017-0305-229162137
   PubMedGoogle Scholar
• Nie L, Wang S, Wang X, et al. In vivo volumetric photoacoustic molecular angiography and therapeutic monitoring with targeted plasmonic nanostars. Small. 2014;10(8):1585–1593, 1441. doi:10.1002/smll.20130292424150920
   PubMed Web of Science ®Google Scholar
• Liu S, Li H, Xia L, et al. Anti-RhoJ antibody functionalized Au@I nanoparticles as CT-guided tumor vessel-targeting radiosensitizers in patient-derived tumor xenograft model. Biomaterials. 2017;141:1–12. doi:10.1016/j.biomaterials.2017.06.03628666098
   PubMedGoogle Scholar
• Abo-Elfadl MT, Gamal-Eldeen AM, Elshafey MM, et al. Photothermal therapeutic effect of PEGylated gold nano-semicubes in chemically-induced skin cancer in mice. J Photochem Photobiol B. 2016;164:21–29. doi:10.1016/j.jphotobiol.2016.09.01227636008
   PubMed Web of Science ®Google Scholar
• Jia Y-P, Ma B-Y, Wei X-W, Qian Z-Y. The in vitro and in vivo toxicity of gold nanoparticles. Chin Chem Lett. 2017;28(4):691–702. doi:10.1016/j.cclet.2017.01.021
   Web of Science ®Google Scholar
• Fratoddi I, Venditti I, Cametti C, Russo MV. How toxic are gold nanoparticles? The state-of-the-art. Nano Res. 2015;8(6):1771–1799. doi:10.1007/s12274-014-0697-3
   Web of Science ®Google Scholar
• Falagan-Lotsch P, Grzincic EM, Murphy CJ. One low-dose exposure of gold nanoparticles induces long-term changes in human cells. Proc Natl Acad Sci U S A. 2016;113(47):13318–13323. doi:10.1073/pnas.161640011327821760
   PubMed Web of Science ®Google Scholar
• Gerber A, Bundschuh M, Klingelhofer D, Groneberg DA. Gold nanoparticles: recent aspects for human toxicology. J Occup Med Toxicol. 2013;8:32. doi:10.1186/1745-6673-8-3224330512
   PubMed Web of Science ®Google Scholar
• Sabella S, Carney RP, Brunetti V, et al. A general mechanism for intracellular toxicity of metal-containing nanoparticles. Nanoscale. 2014;6(12):7052–7061. doi:10.1039/c4nr01234h24842463
   PubMed Web of Science ®Google Scholar
• Qu Y, Lu X. Aqueous synthesis of gold nanoparticles and their cytotoxicity in human dermal fibroblasts-fetal. Biomed Mater. 2009;4(2):025007. doi:10.1088/1748-6041/4/2/02500719258699
   PubMedGoogle Scholar
• Wei X-L, Mo Z-H, Li B, Wei J-M. Disruption of HepG2 cell adhesion by gold nanoparticle and Paclitaxel disclosed by in situ QCM measurement. Colloids Surf B Biointerfaces. 2007;59(1):100–104. doi:10.1016/j.colsurfb.2007.04.01617566716
   PubMed Web of Science ®Google Scholar
• Babin C, Gagnaire P-A, Pavey SA, Bernatchez L. RAD-seq reveals patterns of additive polygenic variation caused by spatially-varying selection in the american eel (Anguilla rostrata). Genome Biol Evol. 2017;9(11):2974–2986. doi:10.1093/gbe/evx22629136139
   PubMedGoogle Scholar
• Hwang JH, Kim SJ, Kim Y-H, et al. Susceptibility to gold nanoparticle-induced hepatotoxicity is enhanced in a mouse model of nonalcoholic steatohepatitis. Toxicology. 2012;294(1):27–35. doi:10.1016/j.tox.2012.01.01322330258
   PubMed Web of Science ®Google Scholar
• Kim KT, Zaikova T, Hutchison JE, Tanguay RL. Gold nanoparticles disrupt zebrafish eye development and pigmentation. Toxicological sciences: an official journal of the Society of Toxicology. 2013;133(2):275–288.23549158
   PubMed Web of Science ®Google Scholar
• Vecchio G, Galeone A, Brunetti V, et al. Mutagenic effects of gold nanoparticles induce aberrant phenotypes in Drosophila melanogaster. Nanomedicine. 2012;8(1):1–7. doi:10.1016/j.nano.2011.11.00122094122
   PubMed Web of Science ®Google Scholar
• Tsyusko OV, Unrine JM, Spurgeon D, et al. Toxicogenomic responses of the model organism Caenorhabditis elegans to gold nanoparticles. Environ Sci Technol. 2012;46(7):4115–4124. doi:10.1021/es203310822372763
   PubMed Web of Science ®Google Scholar
• Yang Y, Qin Z, Zeng W, et al. Toxicity assessment of nanoparticles in various systems and organs. Nanotechnol Rev. 2016;6:279–289.
   Web of Science ®Google Scholar