α-Bisabolol-Loaded Cross-Linked Zein Nanofibrous 3D-Scaffolds For Accelerating Wound Healing And Tissue Regeneration In Rats

References

• Rajkumar RJ, Nadar MM, Selvakumar PM. Nanotechnology in wound healing- a review. Glob J Nano. 2017;3(1):55560–55565.
   Google Scholar
• Saporito F, Sandri G, Bonferoni MC, et al. Essential oil-loaded lipid nanoparticles for wound healing. Int J Nanomedicine. 2017;13:175–186. doi:10.2147/IJN.S15252929343956
   PubMedGoogle Scholar
• Ma L, Gao C, Mao Z, et al. Collagen/chitosan porous scaffolds with improved biostability for skin tissue engineering. Biomaterials. 2003;24(26):4833–4841. doi:10.1016/s0142-9612(03)00374-014530080
   PubMed Web of Science ®Google Scholar
• Dhandayuthapani B, Poulose AC, Nagaoka Y, et al. Biomimetic smart nanocomposite: in vitro biological evaluation of zein electrospun fluorescent nanofiber encapsulated CdS quantum dots. Biofabrication. 2012;4(2):025008. doi:10.1088/1758-5082/4/2/02500822592161
   PubMedGoogle Scholar
• Li F, Chen Y, Liu S, et al. Size-controlled fabrication of zein nano/microparticles by modified anti-solvent precipitation with/without sodium caseinate. Int J Nanomedicine. 2017;12:8197. doi:10.2147/IJN.S14373329184408
   PubMed Web of Science ®Google Scholar
• Podaralla S, Averineni R, Alqahtani M, Perumal O. Synthesis of novel biodegradable methoxy poly(ethylene glycol)-zein micelles for effective delivery of curcumin. Mol Pharm. 2012;9(9):2778–2786. doi:10.1021/mp200645522770552
   PubMedGoogle Scholar
• Ashok P, Patricia H, Johan H, Ellen D, Krassimir V. Quercetin loaded biopolymeric colloidal particles prepared by simultaneous precipitation of quercetin with hydrophobic protein in aqueous medium. Food Chem. 2012;133(2):423–429. doi:10.1016/j.foodchem.2012.01.05425683415
   PubMedGoogle Scholar
• Zou T, Gu L. TPGS emulsified zein nanoparticles enhanced oral bioavailability of daidzin: in vitro characteristics and in vivo performance. Mol Pharm. 2013;10(5):2062–2070. doi:10.1021/mp400086n23557122
   PubMedGoogle Scholar
• El-Lakany SA, Elgindy NA, Helmy MW, Abu-Serie MM, Elzoghby AO. Lactoferrin-decorated vs PEGylated zein nanospheres for combined aromatase inhibitor and herbal therapy of breast cancer. Expert Opin Drug Deliv. 2018;15(9):835–850. doi:10.1080/17425247.2018.150585830067113
   PubMed Web of Science ®Google Scholar
• Elzoghby AO, El-Lakany SA, Helmy MW, Abu-Serie MM, Elgindy NA. Shell-crosslinked zein nanocapsules for oral codelivery of exemestane and resveratrol in breast cancer therapy. Nanomedicine (Lond). 2017;12(24):2785–2805. doi:10.2217/nnm-2017-024729094642
   PubMed Web of Science ®Google Scholar
• Lai L, Guo H. Preparation of new 5-fluorouracil-loaded zein nanoparticles for liver targeting. Int J Pharm. 2011;404(1–2):317–323. doi:10.1016/j.ijpharm.2010.11.02521094232
   PubMedGoogle Scholar
• Torres-Giner S, Ocio MJ, Lagaron JM. Novel antimicrobial ultrathin structures of zein/chitosan blends obtained by electrospinning. Carbohydr Polym. 2009;77(2):261–266. doi:10.1016/j.carbpol.2008.12.035
   Web of Science ®Google Scholar
• Fan W, Jie W, Changsheng L, Brian ON, Ngothai Y. Fabrication and properties of porous scaffold of zein/PCL biocomposite for bone tissue engineering. Compos Part B. 2012;43(5):2192–2197. doi:10.1016/j.compositesb.2012.02.040
   Web of Science ®Google Scholar
• Selling GW, Woods KK, Sessa D, Biswas A. Electrospun zein fibers using glutaraldehyde as the crosslinking reagent: effect of time and temperature. Macromol Chem Phys. 2008;209(10):1003–1011. doi:10.1002/(ISSN)1521-3935
   Web of Science ®Google Scholar
• Jiang Q, Yang Y. Water-stable electrospun zein fibers for potential drug delivery. J Biomat Sci-Polym E. 2011;22(10):1393–1408.
   PubMed Web of Science ®Google Scholar
• Kharaghani D, Khan MQ, Yamamoto T, Soo Kim I. Antibacterial properties of in situ and surface functionalized impregnation of silver sulfadiazine in polyacrylonitrile nanofiber mats. Int J Nanomed. 2019;14:2693–2703. doi:10.2147/IJN.S197665
   PubMed Web of Science ®Google Scholar
• Huang W, Zou T, Li S, Jing J, Xia X, Liu X. Drug-loaded zein nanofibers prepared using a modified coaxial electrospinning process. AAPS PharmSciTech. 2013;14(2):675–681. doi:10.1208/s12249-013-9953-123516111
   PubMedGoogle Scholar
• Marongiu L, Donini M, Bovi M, et al. The inclusion into PLGA nanoparticles enables α-bisabolol to efficiently inhibit the human dendritic cell pro-inflammatory activity. J Nanopart Res. 2014;16(8):2554. doi:10.1007/s11051-014-2554-4
   Web of Science ®Google Scholar
• Rocha NF, Rios ER, Carvalho AM, et al. Anti-nociceptive and anti-inflammatory activities of (-)-alpha-bisabolol in rodents. Naunyn-Schmiedeberg’s Arch Pharmacol. 2011;384(6):525–533. doi:10.1007/s00210-011-0679-x21870032
   PubMedGoogle Scholar
• Kim S, Jung E, Kim JH, Park YH, Lee J, Park D. Inhibitory effects of (-)-alpha-bisabolol on LPS-induced inflammatory response in RAW264.7 macrophages. Food Chem Toxicol. 2011;49(10):2580–2585. doi:10.1016/j.fct.2011.06.07621771629
   PubMed Web of Science ®Google Scholar
• Hotaling NA, Bharti K, Kriel H, Simon CG. DiameterJ: a validated open source nanofiber diameter measurement tool. Biomaterials. 2015;61:327–338. doi:10.1016/j.biomaterials.2015.05.01526043061
   PubMed Web of Science ®Google Scholar
• Bonthagarala B, Swain S, Rao PV, Dasari V. Design and characterization of controlled release lornoxicam nanofibers by electrospinning technique. IJABBR. 2015;6(03):220–232.
   Google Scholar
• Sathya S, Shanmuganathan B, Manirathinam G, Ruckmani K, Devi KP. α-bisabolol loaded solid lipid nanoparticles attenuates Aβ aggregation and protects neuro-2a cells from Aβ induced neurotoxicity. J Mol Liq. 2018;264:431–441. doi:10.1016/j.molliq.2018.05.075
   Web of Science ®Google Scholar
• Dash S, Murthy PN, Nath L, Chowdhury P. Kinetic modeling on drug release from controlled drug delivery systems. Acta Pol Pharm. 2010;67(3):217–223.20524422
   PubMed Web of Science ®Google Scholar
• Almahdy O, El-Fakharany EM, El-Dabaa E, Ng TB, Redwan EM. Examination of the activity of camel milk casein against hepatitis C virus (genotype-4a) and its apoptotic potential in hepatoma and hela cell lines. Hepat Mon. 2011;11(9):724–730. doi:10.5812/kowsar.1735143X.72222235215
   PubMed Web of Science ®Google Scholar
• Mosmann T. Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. J Immunol Methods. 1983;65(1–2):55–63. doi:10.1016/0022-1759(83)90303-46606682
   PubMed Web of Science ®Google Scholar
• Preet R, Mohapatra P, Mohanty S, et al. Quinacrine has anticancer activity in breast cancer cells through inhibition of topoisomerase activity. Int J Cancer. 2012;130(7):1660–1670. doi:10.1002/ijc.2615821544805
   PubMedGoogle Scholar
• You C, Li Q, Wang X, et al. Silver nanoparticle loaded collagen/chitosan scaffolds promote wound healing via regulating fibroblast migration and macrophage activation. Sci Rep. 2017;7(1):10489. doi:10.1038/s41598-017-10481-028874692
   PubMedGoogle Scholar
• Samy WM, Ghoneim AI, Elgindy NA. Novel microstructured sildenafil dosage forms as wound healing promoters. Expert Opin Drug Deliv. 2014;11(10):1525–1536. doi:10.1517/17425247.2014.92966224940608
   PubMed Web of Science ®Google Scholar
• Hajiaghaalipour F, Kanthimathi MS, Abdulla MA, Sanusi J. The effect of camellia sinensis on wound healing potential in an animal model. Evidence-based Complementary Altern Med. 2013;2013:386734. doi:10.1155/2013/386734
   PubMed Web of Science ®Google Scholar
• Abramov Y, Golden B, Sullivan M, et al. Histologic characterization of vaginal vs. abdominal surgical wound healing in a rabbit model. Wound Repair Regener. 2007;15(1):80–86. doi:10.1111/j.1524-475X.2006.00188.x
   PubMed Web of Science ®Google Scholar
• Babitha S, Korrapati PS. Biodegradable zein–polydopamine polymeric scaffold impregnated with TiO2 nanoparticles for skin tissue engineering. Biomed Mater. 2017;12(5):055008. doi:10.1088/1748-605X/aa7d5a28944761
   PubMedGoogle Scholar
• Jiang H, Zhao P, Zhu K. Fabrication and characterization of zein‐based nanofibrous scaffolds by an electrospinning method. Macromol Biosci. 2007;7(4):517–525. doi:10.1002/mabi.20060027717429829
   PubMed Web of Science ®Google Scholar
• Deitzel JM, Kleinmeyer J, Harris D, Beck Tan NC. The effect of processing variables on the morphology of electrospun nanofibers and textiles. Polymer. 2001;42(1):261–272. doi:10.1016/S0032-3861(00)00250-0
   Web of Science ®Google Scholar
• Zargham S, Bazgir S, Tavakoli A, Rashidi AS, Damerchely R. The effect of flow rate on morphology and deposition area of electrospun nylon 6 nanofiber. J Eng Fiber Fabr. 2012;7(4):155892501200700414.
   Web of Science ®Google Scholar
• Doane DP, Seward LE. Measuring skewness: a forgotten statistic? J Stat Educ. 2011;19:2. doi:10.1080/10691898.2011.11889611
   Google Scholar
• Torres-Giner S, Gimenez E, Lagarón JM. Characterization of the morphology and thermal properties of zein prolamine nanostructures obtained by electrospinning. Food Hydrocoll. 2008;22(4):601–614. doi:10.1016/j.foodhyd.2007.02.005
   Web of Science ®Google Scholar
• Reddy N, Li Y, Yang Y. Alkali‐catalyzed low temperature wet crosslinking of plant proteins using carboxylic acids. Biotechnol Prog. 2009;25(1):139–146. doi:10.1002/btpr.8619224570
   PubMedGoogle Scholar
• Pillay V, Dott C, Choonara YE, et al. A review of the effect of processing variables on the fabrication of electrospun nanofibers for drug delivery applications. J Nanomater. 2013;22:1–22.
   Web of Science ®Google Scholar
• de Oliveira Mori CL, Dos Passos NA, Oliveira JE, et al. Electrospinning of zein/tannin bio-nanofibers. Ind Crops Prod. 2014;52:298–304. doi:10.1016/j.indcrop.2013.10.047
   Web of Science ®Google Scholar
• Lee Y-F, Sridewi N, Ramanathan S, Sudesh K. The Influence of electrospinning parameters and drug loading on polyhydroxyalkanoate (PHA) nanofibers for drug delivery. Int J Biotech Wellness Ind. 2017;4(4):103–113.
   Google Scholar
• Khalil AA, Deraz SF, Elrahman SA, El-Fawal G. Enhancement of mechanical properties, microstructure, and antimicrobial activities of zein films cross-linked using succinic anhydride, eugenol, and citric Acid. Prep Biochem Biotech. 2015;45(6):551–567. doi:10.1080/10826068.2014.940967
   PubMed Web of Science ®Google Scholar
• Yao C, Li X, Song T. Electrospinning and crosslinking of zein nanofiber mats. J Appl Polym Sci. 2007;103(1):380–385. doi:10.1002/(ISSN)1097-4628
   Web of Science ®Google Scholar
• Jiang Q, Reddy N, Yang Y. Cytocompatible cross-linking of electrospun zein fibers for the development of water-stable tissue engineering scaffolds. Acta Biomater. 2010;6(10):4042–4051. doi:10.1016/j.actbio.2010.04.02420438870
   PubMedGoogle Scholar
• Sessa DJ, Mohamed A, Byars JA. Chemistry and physical properties of melt-processed and solution-cross-linked corn zein. J Agr Food Chem. 2008;56(16):7067–7075. doi:10.1021/jf800712k18636736
   PubMedGoogle Scholar
• Wu Y, Luo Y, Wang Q. Antioxidant and antimicrobial properties of essential oils encapsulated in zein nanoparticles prepared by liquid–liquid dispersion method. LWT - Food Sci Tech. 2012;48(2):283–290. doi:10.1016/j.lwt.2012.03.027
   Web of Science ®Google Scholar
• Garcia PS, Grossmann MVE, Yamashita F, Mali S, Dall’Antonia LH, Barreto WJ. Citric acid as multifunctional agent in blowing films of starch/PBAT. Química Nova. 2011;34:1507–1510. doi:10.1590/S0100-40422011000900005
   Web of Science ®Google Scholar
• Tavakolipour H, Bagheri L, Madadlou A. Pomegranate seed oil‐loaded particles of the zein cross‐linked with citric acid. J Food Process Eng. 2015;38(1):49–56. doi:10.1111/jfpe.12125
   Web of Science ®Google Scholar
• Souza F, Souza R, Moraes Â. Incorporation and release kinetics of alpha-bisabolol from PCL and chitosan/guar gum membranes. Braz J Chem Eng. 2016;33(3):453–467. doi:10.1590/0104-6632.20160333s20150083
   Web of Science ®Google Scholar
• Menzies KL, Jones L. The impact of contact angle on the biocompatibility of biomaterials. Optometry Vision Sci. 2010;87(6):387–399. doi:10.1097/OPX.0b013e3181da863e
   PubMed Web of Science ®Google Scholar
• Vogt L, Liverani L. Electrospun zein fibers incorporating Poly(glycerol sebacate) for soft tissue engineering. Nanomaterials. 2018;8(3):150.
   Google Scholar
• Samy W, Elgindy N, El-Gowelli HM. Biopolymeric nifedipine powder for acceleration of wound healing. Int J Pharm. 2012;422(1–2):323–331.22119966
   PubMedGoogle Scholar
• Grip J, Engstad RE, Skjæveland I, et al. Beta-glucan-loaded nanofiber dressing improves wound healing in diabetic mice. Eur J Pharm Sci. 2018;121:269–280. doi:10.1016/j.ejps.2018.05.03129864585
   PubMed Web of Science ®Google Scholar
• Jiang Q, Reddy N, Zhang S, Roscioli N, Yang Y. Water-stable electrospun collagen fibers from a non-toxic solvent and crosslinking system. J Biomed Mater Res Part A. 2013;101(5):1237–1247. doi:10.1002/jbm.a.34422
   PubMed Web of Science ®Google Scholar
• Cui H, Liu GL, Padua GW. Cell spreading and viability on zein films may be facilitated by transglutaminase. Colloids Surf. 2016;145:839–844. doi:10.1016/j.colsurfb.2016.05.048
   Google Scholar
• Chirumbolo S. Alpha-bisabolol, not a matter for cancer therapy. Commentary: “research on the immunosuppressive activity of ingredients contained in sunscreens”. Front Pharmacol. 2015;6(96). doi:10.3389/fphar.2015.00096
   PubMedGoogle Scholar
• Wang H, Radjendirane V, Wary KK, Chakrabarty S. Transforming growth factor beta regulates cell-cell adhesion through extracellular matrix remodeling and activation of focal adhesion kinase in human colon carcinoma Moser cells. Oncogene. 2004;23(32):5558–5561. doi:10.1038/sj.onc.120770115133493
   PubMedGoogle Scholar
• Dong J, Sun Q, Wang J. Basic study of corn protein, zein, as a biomaterial in tissue engineering, surface morphology and biocompatibility. Biomaterials. 2004;25(19):4691–4697. doi:10.1016/j.biomaterials.2003.10.08415120515
   PubMed Web of Science ®Google Scholar
• Yeh C-J, Chen -C-C, Leu Y-L, Lin M-W, Chiu -M-M, Wang S-H. The effects of artocarpin on wound healing: in vitro and in vivo studies. Sci Rep. 2017;7(1):15599. doi:10.1038/s41598-017-15876-729142215
   PubMedGoogle Scholar
• Mariggiò MA, Cassano A, Vinella A, et al. Enhancement of fibroblast proliferation, collagen biosynthesis and production of growth factors as a result of combining sodium hyaluronate and aminoacids. Int J Immunopath Ph. 2009;22(2):485–492. doi:10.1177/039463200902200225
   PubMed Web of Science ®Google Scholar
• Bezerra SB, Leal LKAM, Nogueira NAP, Campos AR. Bisabolol-induced gastroprotection against acute gastric lesions: role of prostaglandins, nitric oxide, and K+ATP channels. J Med Food. 2009;12(6):1403–1406. doi:10.1089/jmf.2008.029020041801
   PubMedGoogle Scholar
• Girault A, Brochiero E. Evidence of K+ channel function in epithelial cell migration, proliferation, and repair. M J Physiol Cell Physiol. 2014;306(4):C307–C319. doi:10.1152/ajpcell.00226.2013
   PubMed Web of Science ®Google Scholar
• Eming SA, Martin P, Tomic-Canic M. Wound repair and regeneration: mechanisms, signaling, and translation. Sci Transl Med. 2014;6(265):265sr266. doi:10.1126/scitranslmed.3009337
   Web of Science ®Google Scholar
• Martin P, Leibovich SJ. Inflammatory cells during wound repair: the good, the bad and the ugly. Trends Cell Biol. 2005;15(11):599–607. doi:10.1016/j.tcb.2005.09.00216202600
   PubMed Web of Science ®Google Scholar
• White ES, Mantovani AR. Inflammation, wound repair, and fibrosis: reassessing the spectrum of tissue injury and resolution. J Pathol. 2013;229(2):141–144. doi:10.1002/path.412623097196
   PubMed Web of Science ®Google Scholar
• Park DH, Kim SB, Lee JS, inventors; Biospecrum Inc, assignee. Compositions for improving skin conditions comprising alpha-bisabolol as an active ingredient In: Google Patents. 2010. No.12/527,756.
   Google Scholar
• Lawrence T. The nuclear factor NF-kappaB pathway in inflammation. Cold Spring Harb Perspect Biol. 2009;1(6):a001651–a001651. doi:10.1101/cshperspect.a00165120457564
   PubMed Web of Science ®Google Scholar
• Watanabe S, Osumi M, Ohnishi T, Ichikawa E, Takahashi H. Changes in cytokeratin expression in epidermal keratinocytes during wound healing. Histochem Cell Biol. 1995;103(6):425–433.7584549
   PubMed Web of Science ®Google Scholar
• Erwin E, Gunanti HE, Noviana D. Changes in histopathology and cytokeratin AE1/AE3 expression in skin graft with different time on Indonesian local cats. Vet World. 2017;10(6):662–666. doi:10.14202/vetworld.2017.662-66628717319
   PubMedGoogle Scholar
• Sabol F, Dancakova L, Gál P, et al. Immunohistological changes in skin wounds during the early periods of healing in a rat model. Vet Med (Praha). 2012;157(2):77–82.
   Google Scholar