Pomegranate Juice Diminishes The Mitochondria-Dependent Cell Death And NF-kB Signaling Pathway Induced By Copper Oxide Nanoparticles On Liver And Kidneys Of Rats

References

• Bhattacharya S, Alkharfy KM, Janardhanan R, Mukhopadhyay D. Nanomedicine: pharmacological perspectives. Nanotechnol Rev. 2012;1(3):235–253. doi:10.1515/ntrev-2011-0010
   Web of Science ®Google Scholar
• Khalaf AA, Hassanen EI, Azouz RA, et al. Ameliorative effect of zinc oxide nanoparticles against dermal toxicity induced by lead oxide in rats. Int J Nanomedicine. 2019;14:7729–7741. doi:10.2147/IJN.S220572
   PubMed Web of Science ®Google Scholar
• Johnson BM, Fraietta JA, Gracias DT, et al. Acute exposure to ZnO nanoparticles induces autophagic immune cell death. Nanotoxicology. 2015;9(6):737–748. doi:10.3109/17435390.2014.97470925378273
   PubMed Web of Science ®Google Scholar
• Hassanen EI, Khalaf AA, Tohamy AF, Mohammed ER, Farroh KY. Toxicopathological and immunological studies on different concentrations of chitosan-coated silver nanoparticles in rats. Int J Nanomedicine. 2019;14:4723. doi:10.2147/IJN.S20764431308655
   PubMed Web of Science ®Google Scholar
• Galdiero S, Falanga A, Vitiello M, et al. Silver nanoparticles as potential antiviral agents. Molecules. 2011;16(10):8894–8918. doi:10.3390/molecules1610889422024958
   PubMed Web of Science ®Google Scholar
• Jang GH, Hwang MP, Kim SY, Jang HS, Lee KH. A systematic in-vivo toxicity evaluation of nanophosphor particles via zebrafish models. Biomaterials. 2014;35(1):440–449. doi:10.1016/j.biomaterials.2013.09.05424094937
   PubMedGoogle Scholar
• ATSDR U. Toxicological profile for copper. 2004.
   Google Scholar
• Meng H, Chen Z, Xing G, et al. Ultrahigh reactivity provokes nanotoxicity: explanation of oral toxicity of nano-copper particles. Toxicol Lett. 2007;175(1–3):102–110. doi:10.1016/j.toxlet.2007.09.01518024012
   PubMed Web of Science ®Google Scholar
• Chen Z, Meng H, Xing G, et al. Acute toxicological effects of copper nanoparticles in vivo. Toxicol Lett. 2006;163(2):109–120. doi:10.1016/j.toxlet.2005.10.00316289865
   PubMed Web of Science ®Google Scholar
• Ahamed M, Alhadlaq HA, Khan M, Karuppiah P, Al-Dhabi NA. Synthesis, characterization, and antimicrobial activity of copper oxide nanoparticles. J Nanomater. 2014;2014:17. doi:10.1155/2014/637858
   Web of Science ®Google Scholar
• Adam N, Vakurov A, Knapen D, Blust R. The chronic toxicity of CuO nanoparticles and copper salt to Daphnia magna. J Hazard Mater. 2015;283:416–422. doi:10.1016/j.jhazmat.2014.09.03725464278
   PubMed Web of Science ®Google Scholar
• Rim K-T, Song S-W, Kim H-Y. Oxidative DNA damage from nanoparticle exposure and its application to workers’ health: a literature review. Saf Health Work. 2013;4(4):177–186. doi:10.1016/j.shaw.2013.07.00624422173
   PubMedGoogle Scholar
• Ebrahimnia-Bajestan E, Niazmand H, Duangthongsuk W, Wongwises S. Numerical investigation of effective parameters in convective heat transfer of nanofluids flowing under a laminar flow regime. Int J Heat Mass Transf. 2011;54(19–20):4376–4388. doi:10.1016/j.ijheatmasstransfer.2011.05.006
   Web of Science ®Google Scholar
• Das R, Gang S, Nath SS, Bhattacharjee R. Linoleic acid capped copper nanoparticles for antibacterial activity. J Bionanosci. 2010;4(1–2):82–86. doi:10.1166/jbns.2010.1035
   Google Scholar
• Janrao K, Gadhave M, Banerjee S, Gaikwad D. Nanoparticle induced nanotoxicity: an overview. AJBPS. 2014;4(32):1. doi:10.15272/ajbps.v4i32.480
   Google Scholar
• Keller AA, Wang H, Zhou D, et al. Stability and aggregation of metal oxide nanoparticles in natural aqueous matrices. Environ Sci Technol. 2010;44(6):1962–1967. doi:10.1021/es902987d20151631
   PubMed Web of Science ®Google Scholar
• Misra SK, Nuseibeh S, Dybowska A, et al. Comparative study using spheres, rods and spindle-shaped nanoplatelets on dispersion stability, dissolution and toxicity of CuO nanomaterials. Nanotoxicology. 2014;8(4):422–432. doi:10.3109/17435390.2013.79601723590525
   PubMed Web of Science ®Google Scholar
• Chattopadhyay RR. Possible mechanism of hepatoprotective activity of Azadirachta indica leaf extract: part II. J Ethnopharmacol. 2003;89(2–3):217–219. doi:10.1016/j.jep.2003.08.00614611885
   PubMedGoogle Scholar
• Jeong HG, You HJ, Park SJ, et al. Hepatoprotective effects of 18β-glycyrrhetinic acid on carbon tetrachloride-induced liver injury: inhibition of cytochrome P450 2E1 expression. Pharmacol Res. 2002;46(3):221–227. doi:10.1016/S1043-6618(02)00121-412220964
   PubMed Web of Science ®Google Scholar
• Ricci D, Giamperi L, Bucchini A, Fraternale D. Antioxidant activity of Punica granatum fruits. Fitoterapia. 2006;77(4):310–312. doi:10.1016/j.fitote.2006.01.00816698192
   PubMed Web of Science ®Google Scholar
• Lansky E, Shubert S, Neeman I, editors. Pharmacological and therapeutic properties of pomegranate. Symposium on production, processing and marketing of pomegranate in the Mediterranean region: advances in research and technology Séminaires Méditerranéens (CIHEAM) PP; 2000. Orihuela (Spain).
   Google Scholar
• Karimi M, Sadeghi R, Kokini J. Pomegranate as a promising opportunity in medicine and nanotechnology. Trends Food Sci Tech. 2017;69:59–73. doi:10.1016/j.tifs.2017.08.019
   Web of Science ®Google Scholar
• Cerdá B, Cerón JJ, Tomás-Barberán FA, Espín JC. Repeated oral administration of high doses of the pomegranate ellagitannin punicalagin to rats for 37 days is not toxic. J Agric Food Chem. 2003;51(11):3493–3501. doi:10.1021/jf020842c12744688
   PubMed Web of Science ®Google Scholar
• Chidambara Murthy KN, Jayaprakasha GK, Singh RP. Studies on antioxidant activity of pomegranate (Punicagranatum) peel extract using in vivo models. J Agric Food Chem. 2002;50(17):4791–4795. doi:10.1021/jf025573512166961
   PubMed Web of Science ®Google Scholar
• Faria A, Calhau C, de Freitas V, Mateus N. Procyanidins as antioxidants and tumor cell growth modulators. J Agric Food Chem. 2006;54(6):2392–2397. doi:10.1021/jf052648716536624
   PubMed Web of Science ®Google Scholar
• Luna IZ, Hilary LN, Chowdhury AS, et al. Preparation and characterization of copper oxide nanoparticles synthesized via chemical precipitation method. Open Access Lib J. 2015;2(03):1.
   Google Scholar
• Faria A, Monteiro R, Mateus N, Azevedo I, Calhau C. Effect of pomegranate (Punica granatum) juice intake on hepatic oxidative stress. Eur J Nutr. 2007;46(5):271–278. doi:10.1007/s00394-007-0661-z17514376
   PubMed Web of Science ®Google Scholar
• Albus U. Guide for the Care and Use of Laboratory Animals. 8th ed. SAGE Publications Sage UK: London, England; 2012.
   Google Scholar
• Guardado-Mendoza R, Prioletta A, Jiménez-Ceja LM, Sosale A, Folli F. The role of nateglinide and repaglinide, derivatives of meglitinide, in the treatment of type 2 diabetes mellitus. Arch Med Sci. 2013;9(5):936. doi:10.5114/aoms.2013.3499124273582
   PubMedGoogle Scholar
• Chakraborty M, Ahmed MG, Bhattacharjee A. Potential pharmacodynamic and pharmacokinetic interaction of pomegranate juice and nateglinide against diabetes induced complications in rats. Synergy. 2017;5:1–6. doi:10.1016/j.synres.2017.11.002
   Google Scholar
• Doudi M, Setorki M. Acute effect of nano-copper on liver tissue and function in rat. Nanomed J. 2014;1(5).
   Google Scholar
• Bancroft JD. Histochemical Techniques. Butterworth-Heinemann; 2013.
   Google Scholar
• Khalaf AA, Hassanen EI, Zaki AR Tohamy AF, Ibrahim MA. Histopathological, immunohistochemical, and molecular studies for determination of wound age and vitality in rats. Inter wound j. 2019 doi.org/10.1111/iwj.13206
   Google Scholar
• BALIGA R, UEDA N, WALKER PD, SHAH SV. Oxidant mechanisms in toxic acute renal failure. Drug Metab Rev. 1999;31(4):971–997. doi:10.1081/DMR-10010194710575556
   PubMed Web of Science ®Google Scholar
• Ohkawa H, Ohishi N, Yagi K. Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Anal Biochem. 1979;95(2):351–358. doi:10.1016/0003-2697(79)90738-336810
   PubMed Web of Science ®Google Scholar
• Beutler E. Improved method for the determination of blood glutathione. J Lab Clin Med. 1963;61:882–888.13967893
   PubMed Web of Science ®Google Scholar
• Abdel-Aziz RL, Abdel-Wahab A, El-Ela FIA, et al. Dose-dependent ameliorative effects of quercetin and l-Carnitine against atrazine-induced reproductive toxicity in adult male Albino rats. Biomed Pharmcother. 2018;102:855–864. doi:10.1016/j.biopha.2018.03.136
   PubMed Web of Science ®Google Scholar
• Khalaf A, Ahmed W, Moselhy W, Abdel-Halim B, Ibrahim M. Protective effects of selenium and nano-selenium on bisphenol-induced reproductive toxicity in male rats. Hum Exp Toxicol. 2019;38(4):398–408. doi:10.1177/096032711881613430526071
   PubMed Web of Science ®Google Scholar
• Zheng W, Jiang Y-M, Zhang Y, et al. Chelation therapy of manganese intoxication with para-aminosalicylic acid (PAS) in Sprague–Dawley rats. Neurotoxicology. 2009;30(2):240–248. doi:10.1016/j.neuro.2008.12.00719150464
   PubMed Web of Science ®Google Scholar
• Khalid S, Afzal N, Khan JA, et al. Antioxidant resveratrol protects against copper oxide nanoparticle toxicity in vivo. Naunyn Schmiedebergs Arch Pharmacol. 2018;391(10):1053–1062. doi:10.1007/s00210-018-1526-029936585
   PubMedGoogle Scholar
• Sangha G, Kaur K. Cypermethrin lnduced changes in biochemical constituents of plasma of female albino rats. Indian J Anim Res. 2011;45(3):186–191.
   Google Scholar
• Xu P, Xu J, Liu S, Yang Z. Nano copper induced apoptosis in podocytes via increasing oxidative stress. J Hazard Mater. 2012;241:279–286. doi:10.1016/j.jhazmat.2012.09.04123063557
   PubMedGoogle Scholar
• Wang J-X, Fan Y-B, Gao Y, Hu Q-H, Wang T-C. TiO2 nanoparticles translocation and potential toxicological effect in rats after intraarticular injection. Biomaterials. 2009;30(27):4590–4600. doi:10.1016/j.biomaterials.2009.05.00819500841
   PubMedGoogle Scholar
• Ma L, Zhao J, Wang J, et al. The acute liver injury in mice caused by nano-anatase TiO2. Nanoscale Res Lett. 2009;4(11):1275. doi:10.1007/s11671-009-9393-820628458
   PubMed Web of Science ®Google Scholar
• Sadauskas E, Wallin H, Stoltenberg M, et al. Kupffer cells are central in the removal of nanoparticles from the organism. Part Fibre Toxicol. 2007;4(1):10. doi:10.1186/1743-8977-4-1017949501
   PubMedGoogle Scholar
• Wang Z, Li N, Zhao J, et al. CuO nanoparticle interaction with human epithelial cells: cellular uptake, location, export, and genotoxicity. Chem Res Toxicol. 2012;25(7):1512–1521. doi:10.1021/tx300209322686560
   PubMed Web of Science ®Google Scholar
• Møller P, Jacobsen NR, Folkmann JK, et al. Role of oxidative damage in toxicity of particulates. Free Radic Res. 2010;44(1):1–46.19886744
   PubMed Web of Science ®Google Scholar
• Fahmy B, Cormier SA. Copper oxide nanoparticles induce oxidative stress and cytotoxicity in airway epithelial cells. Toxicol In Vitro. 2009;23(7):1365–1371. doi:10.1016/j.tiv.2009.08.00519699289
   PubMed Web of Science ®Google Scholar
• Hockenbery DM, Oltvai ZN, Yin X-M, Milliman CL, Korsmeyer SJ. Bcl-2 functions in an antioxidant pathway to prevent apoptosis. Cell. 1993;75(2):241–251. doi:10.1016/0092-8674(93)80066-N7503812
   PubMed Web of Science ®Google Scholar
• Wang T, Chen X, Long X, Liu Z, Yan S. Copper nanoparticles and copper sulphate induced cytotoxicity in hepatocyte primary cultures of Epinephelus coioides. PLoS One. 2016;11(2):e0149484. doi:10.1371/journal.pone.014948426890000
   PubMedGoogle Scholar
• Sarkar A, Das J, Manna P, Sil PC. Nano-copper induces oxidative stress and apoptosis in kidney via both extrinsic and intrinsic pathways. Toxicology. 2011;290(2–3):208–217. doi:10.1016/j.tox.2011.09.08622000994
   PubMed Web of Science ®Google Scholar
• Nel A, Xia T, Mädler L, Li N. Toxic potential of materials at the nanolevel. Science. 2006;311(5761):622–627. doi:10.1126/science.111439716456071
   PubMed Web of Science ®Google Scholar
• Hu R, Zheng L, Zhang T, et al. Molecular mechanism of hippocampal apoptosis of mice following exposure to titanium dioxide nanoparticles. J Hazard Mater. 2011;191(1–3):32–40. doi:10.1016/j.jhazmat.2011.04.02721570177
   PubMed Web of Science ®Google Scholar
• Jiang J, Wang J, Zhang X, et al. Activation of mitogen-activated protein kinases cellular signal transduction pathway in mammalian cells induced by silicon carbide nanowires. Biomaterials. 2010;31(31):7856–7862. doi:10.1016/j.biomaterials.2010.07.02420674003
   PubMedGoogle Scholar
• Suliman A, Lam A, Datta R, Srivastava RK. Intracellular mechanisms of TRAIL: apoptosis through mitochondrial-dependent and-independent pathways. Oncogene. 2001;20(17):2122. doi:10.1038/sj.onc.120428211360196
   PubMedGoogle Scholar
• Laha D, Pramanik A, Maity J, et al. Interplay between autophagy and apoptosis mediated by copper oxide nanoparticles in human breast cancer cells MCF7. Biochim Biophys Acta Bioenerg. 2014;1840(1):1–9. doi:10.1016/j.bbagen.2013.08.011
   PubMed Web of Science ®Google Scholar
• An L, Liu S, Yang Z, Zhang T. Cognitive impairment in rats induced by nano-CuO and its possible mechanisms. Toxicol Lett. 2012;213(2):220–227. doi:10.1016/j.toxlet.2012.07.00722820425
   PubMed Web of Science ®Google Scholar
• Siddiqui MA, Alhadlaq HA, Ahmad J, et al. Copper oxide nanoparticles induced mitochondria mediated apoptosis in human hepatocarcinoma cells. PLoS One. 2013;8(8):e69534. doi:10.1371/journal.pone.006953423940521
   PubMed Web of Science ®Google Scholar
• Semisch A, Ohle J, Witt B, Hartwig A. Cytotoxicity and genotoxicity of nano-and microparticulate copper oxide: role of solubility and intracellular bioavailability. Part Fibre Toxicol. 2014;11(1):10. doi:10.1186/1743-8977-11-1024520990
   PubMedGoogle Scholar
• Sen R, Baltimore D. Multiple nuclear factors interact with the immunoglobulin enhancer sequences. cell. 1986;46(5):705–716. doi:10.1016/0092-8674(86)90346-63091258
   PubMed Web of Science ®Google Scholar
• Garg A, Aggarwal B. Nuclear transcription factor-κB as a target for cancer drug development. Leukemia. 2002;16(6):1053.12040437
   PubMed Web of Science ®Google Scholar
• Smith KR, Klei LR, Barchowsky A. Arsenite stimulates plasma membrane NADPH oxidase in vascular endothelial cells. Am J Physiol Lung Cell Mol Physiol. 2001;280(3):L442–L9. doi:10.1152/ajplung.2001.280.3.L44211159027
   PubMedGoogle Scholar
• Thannickal VJ, Fanburg BL. Reactive oxygen species in cell signaling. Am J Physiol Lung Cell Mol Physiol. 2000;279(6):L1005–L28. doi:10.1152/ajplung.2000.279.6.L100511076791
   PubMed Web of Science ®Google Scholar
• Allen R, Tresini M. Oxidative stress and gene regulation. Free Radical Biol Med. 2000;28(3):463–499. doi:10.1016/S0891-5849(99)00242-710699758
   PubMed Web of Science ®Google Scholar
• Byrne JD, Baugh JA. The significance of nanoparticles in particle-induced pulmonary fibrosis. Mcgill J Med. 2008;11(1):43.18523535
   PubMedGoogle Scholar
• Murray AR, Kisin ER, Tkach AV, et al. Factoring-in agglomeration of carbon nanotubes and nanofibers for better prediction of their toxicity versus asbestos. Part Fibre Toxicol. 2012;9(1):10. doi:10.1186/1743-8977-9-1022490147
   PubMedGoogle Scholar
• Medjakovic S, Jungbauer A. Pomegranate: a fruit that ameliorates metabolic syndrome. Food Funct. 2013;4(1):19–39.23060097
   PubMed Web of Science ®Google Scholar
• Yehia HM, Elkhadragy MF, Moneim AEA. Antimicrobial activity of pomegranate rind peel extracts. Afr J Microbiol Res. 2011;5(22):3664–3668.
   Google Scholar
• Lansky EP, Harrison G, Froom P, Jiang WG. Pomegranate (Punica granatum) pure chemicals show possible synergistic inhibition of human PC-3 prostate cancer cell invasion across Matrigel™. Invest New Drugs. 2005;23(2):121–122. doi:10.1007/s10637-005-5856-715744587
   PubMedGoogle Scholar
• Van Elswijk DA, Schobel UP, Lansky EP, Irth H, van der Greef J. Rapid dereplication of estrogenic compounds in pomegranate (Punica granatum) using on-line biochemical detection coupled to mass spectrometry. Phytochemistry. 2004;65(2):233–241. doi:10.1016/j.phytochem.2003.07.00114732284
   PubMed Web of Science ®Google Scholar
• Schubert SY, Lansky EP, Neeman I. Antioxidant and eicosanoid enzyme inhibition properties of pomegranate seed oil and fermented juice flavonoids. J Ethnopharmacol. 1999;66(1):11–17. doi:10.1016/S0378-8741(98)00222-010432202
   PubMed Web of Science ®Google Scholar
• Abdel Moneim AEA, El-Khadragy MF. The potential effects of pomegranate (Punica granatum) juice on carbon tetrachloride-induced nephrotoxicity in rats. J Physiol Biochem. 2013;69(3):359–370. doi:10.1007/s13105-012-0218-323132170
   PubMedGoogle Scholar
• Coballase-Urrutia E, Pedraza-Chaverri J, Cárdenas-Rodríguez N, et al. Hepatoprotective effect of acetonic and methanolic extracts of Heterotheca inuloides against CCl4-induced toxicity in rats. Exp Toxicol Pathol. 2011;63(4):363–370. doi:10.1016/j.etp.2010.02.01220227265
   PubMedGoogle Scholar
• Raja S, Ahamed KN, Kumar V, et al. Antioxidant effect of Cytisus scoparius against carbon tetrachloride treated liver injury in rats. J Ethnopharmacol. 2007;109(1):41–47. doi:10.1016/j.jep.2006.06.01216930896
   PubMed Web of Science ®Google Scholar
• Yuan L, Chen F, Ling L, et al. Protective effects of total flavonoids of Bidens bipinnata L. against carbon tetrachloride‐induced liver fibrosis in rats. J Pharm Pharmacol. 2008;60(10):1393–1402.18812033
   PubMed Web of Science ®Google Scholar
• Lin H-M, Tseng H-C, Wang C-J, et al. Hepatoprotective effects of Solanum nigrum Linn extract against CCl4-induced oxidative damage in rats. Chem Biol Interact. 2008;171(3):283–293. doi:10.1016/j.cbi.2007.08.00818045581
   PubMedGoogle Scholar
• Larrosa M, González-Sarrías A, Yáñez-Gascón MJ, et al. Anti-inflammatory properties of a pomegranate extract and its metabolite urolithin-A in a colitis rat model and the effect of colon inflammation on phenolic metabolism. J Nutr Biochem. 2010;21(8):717–725. doi:10.1016/j.jnutbio.2009.04.01219616930
   PubMed Web of Science ®Google Scholar
• de Nigris F, Balestrieri ML, Williams-Ignarro S, et al. The influence of pomegranate fruit extract in comparison to regular pomegranate juice and seed oil on nitric oxide and arterial function in obese Zucker rats. Nitric Oxide. 2007;17(1):50–54. doi:10.1016/j.niox.2007.04.00517553710
   PubMed Web of Science ®Google Scholar
• Rasheed Z, Akhtar N, Anbazhagan AN, et al. Polyphenol-rich pomegranate fruit extract (POMx) suppresses PMACI-induced expression of pro-inflammatory cytokines by inhibiting the activation of MAP Kinases and NF-κB in human KU812 cells. J Inflamm. 2009;6(1):1. doi:10.1186/1476-9255-6-1
   Google Scholar