136
Views
17
CrossRef citations to date
0
Altmetric
Original Research

Low molecular weight chitosan nanoparticulate system at low N:P ratio for nontoxic polynucleotide delivery

, , , , , , & show all
Pages 1399-1414 | Published online: 13 Mar 2012

References

  • de FougerollesAVornlocherHPMaraganoreJLiebermanJInterfering with disease: a progress report on siRNA-based therapeuticsNat Rev Drug Discov20076644345317541417
  • FireAXuSMontgomeryMKKostasSADriverSEMelloCCPotent and specific genetic interference by double-stranded RNA in Caenorhabditis elegansNature199839166698068119486653
  • AlamehMJeanMDeJesusDBuschmannMDMerzoukiAChitosanase-based method for RNA isolation from cells transfected with chitosan/siRNA nanocomplexes for real-time RT-PCR in gene silencingInt J Nanomedicine2010547320957169
  • BantounasIPhylactouLAUneyJBRNA interference and the use of small interfering RNA to study gene function in mammalian systemsJ Mol Endocrinol200433354555715591019
  • CastanottoDRossiJJThe promises and pitfalls of RNA-interference-based therapeuticsNature2009457722842643319158789
  • FutamiKKumagaiEMakinoHInduction of mitotic cell death in cancer cells by small interference RNA suppressing the expression of RecQL1 helicaseCancer Sci2008991718017953710
  • FutamiKKumagaiEMakinoHAnticancer activity of RecQL1 helicase siRNA in mouse xenograft modelsCancer Sci20089961227123618422747
  • HowardKARahbekULLiuXRNA interference in vitro and in vivo using a novel chitosan/siRNA nanoparticle systemMol Ther200614447648416829204
  • SoutschekJAkincABramlageBTherapeutic silencing of an endogenous gene by systemic administration of modified siRNAsNature2004432701417317815538359
  • ZimmermannTSLeeACAkincARNAi-mediated gene silencing in non-human primatesNature2006441708911111416565705
  • ElbashirSMHarborthJLendeckelWYalcinAWeberKTuschlTDuplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cellsNature2001411683649449811373684
  • WhelanJFirst clinical data on RNAiDrug Discov Today200510151014101516055013
  • CoreyDRRNA learns from antisenseNat Chem Biol20073181117173018
  • CoreyDRChemical modification: the key to clinical application of RNA interference?J Clin Invest2007117123615362218060019
  • SteinCAPhosphorothioate antisense oligodeoxynucleotides: questions of specificityTrends Biotechnol19961451471498645447
  • Urban-KleinBWerthSAbuharbeidSCzubaykoFAignerARNAi-mediated gene-targeting throught systemic application of polyethylenimine (PEI)-complexed siRNA in vivoGene Ther200412546146615616603
  • KatasHAlparHODevelopment and characterisation of chitosan nanoparticles for siRNA deliveryJ Control Release2006115221622516959358
  • ElmenJThonbergHLjungbergKLocked nucleic acid (LNA) mediated improvements in siRNA stability and functionalityNucleic Acids Res200533143944715653644
  • JudgeADBolaGLeeACMacLachlanIDesign of noninflammatory synthetic siRNA mediating potent gene silencing in vivoMol Ther200613349450516343994
  • WhiteheadKALangerRAndersonDGKnocking down barriers: advances in siRNA deliveryNat Rev Drug Discov20098212913819180106
  • BramsenJBLaursenMBNielsenAFA large-scale chemical modification screen identifies design rules to generate siRNAs with high activity, high stability and low toxicityNucleic Acids Res20093792867288119282453
  • LayzerJMMcCaffreyAPTannerAKHuangZKayMASullengerBAIn vivo activity of nuclease-resistant siRNAsRNA200410576677115100431
  • WeyermannJLochmannDGeorgensCZimmerAAlbumin-protamine- oligonucleotide-nanoparticles as a new antisense delivery system. Part 2: cellular uptake and effectEur J Pharm Biopharm200559343143815760723
  • AmarzguiouiMHolenTBabaieEPrydzHTolerance for mutations and chemical modifications in a siRNANucleic Acids Res200331258959512527766
  • ParrishSFleenorJXuSMelloCFireAFunctional anatomy of a dsRNA trigger: differential requirement for the two trigger strands in RNA interferenceMol Cell2000651077108711106747
  • BraaschDAJensenSLiuYRNA interference in mammalian cells by chemically-modified RNABiochemistry200342267967797512834349
  • HarborthJElbashirSMVandenburghKSequence, chemical, and structural variation of small interfering RNAs and short hairpin RNAs and the effect on mammalian gene silencingAntisense Nucleic Acid Drug Dev20031328310512804036
  • ReasorMJKacewSDrug-induced phospholipidosis: are there functional consequences?Exp Biol Med (Maywood)2001226982583011568304
  • TousignantJDGatesALIngramLAComprehensive analysis of the acute toxicities induced by systemic administration of cationic lipid:plasmid DNA complexes in miceHum Gene Ther200011182493251311119421
  • IshidaTIchiharaMWangXInjection of PEGylated liposomes in rats elicits PEG-specific IgM, which is responsible for rapid elimination of a second dose of PEGylated liposomesJ Control Release20061121152516515818
  • JudgeAMcClintockKPhelpsJRMacLachlanIHypersensitivity and loss of disease site targeting caused by antibody responses to PEGylated liposomesMol Ther2006132328337 Epub November 7, 200516275098
  • SempleSCHarasymTOClowKAAnsellSMKlimukSKHopeMJImmunogenicity and rapid blood clearance of liposomes containing polyethylene glycol-lipid conjugates and nucleic acidJ Pharmacol Exp Ther2005312310201026 Epub November 3, 200415525796
  • BoeckleSvon GersdorffKvan der PiepenSCulmseeCWagnerEOgrisMPurification of polyethylenimine polyplexes highlights the role of free polycations in gene transferJ Gene Med20046101102111115386739
  • MoghimiSMSymondsPMurrayJCHunterACDebskaGSzewczykAA two-stage poly(ethylenimine)-mediated cytotoxicity: implications for gene transfer/therapyMol Ther200511699099515922971
  • HunterACMoghimiSMCationic carriers of genetic material and cell death: a mitochondrial taleBiochim Biophys Acta201017976–71203120920381448
  • Al-DosariMSGaoXNonviral gene delivery: principle, limitations, and recent progressAAPS J20094671681 Epub October 16, 200919834816
  • JeanMSmaouiFLavertuMChitosan-plasmid nanoparticle formulations for IM and SC delivery of recombinant FGF-2 and PDGF-BB or generation of antibodiesGene Ther20091691097111019440230
  • LavertuMMéthotSTran-KhanhNBuschmannMDHigh efficiency gene transfer using chitosan/DNA nanoparticles with specific combinations of molecular weight and degree of deacetylationBiomaterials200627274815482416725196
  • NimeshSThibaultMMLavertuMBuschmannMDEnhanced gene delivery mediated by low molecular weight chitosan/DNA complexes: effect of pH and serumMol Biotechnol201046218219620454872
  • ThibaultMNimeshSLavertuMBuschmannMDIntracellular trafficking and decondensation kinetics of chitosan-pDNA polyplexesMol Ther201018101787179520628361
  • JeanMAlamehMBuschmannMDMerzoukiAEffective and safe gene-based delivery of GLP-1 using chitosan/plasmid-DNA therapeutic nanocomplexes in an animal model of Type 2 DiabetesGene Ther201118880781621412280
  • HowardKAKjemsJPolycation-based nanoparticle delivery for improved RNA interference therapeuticsExpert Opin Biol Ther20077121811182218034647
  • LiuXHowardKADongMThe influence of polymeric properties on chitosan/siRNA nanoparticle formulation and gene silencingBiomaterials20072861280128817126901
  • de CamposAMDieboldYCarvalhoELSanchezAAlonsoMJChitosan nanoparticles as new ocular drug delivery systems: in vitro stability, in vivo fate, and cellular toxicityPharm Res200421580381015180338
  • OnishiHMachidaYBiodegradation and distribution of water-soluble chitosan in miceBiomaterials199920217518210022787
  • MaoSSunWKisselTChitosan-based formulations for delivery of DNA and siRNAAdv Drug Deliv Rev2010621122719796660
  • RichardsonSCKolbeHVDuncanRPotential of low molecular mass chitosan as a DNA delivery system: biocompatibility, body distribution and ability to complex and protect DNAInt J Pharm1999178223124310205643
  • HuangMKhorELimLYUptake and cytotoxicity of chitosan molecules and nanoparticles: effects of molecular weight and degree of deacetylationPharm Res200421234435315032318
  • WiegandCWinterDHiplerUCMolecular-weight-dependent toxic effects of chitosans on the human keratinocyte cell line HaCaTSkin Pharmacol Physiol201023316417020110767
  • MaPLBuschmannMDWinnikFMOne-step analysis of DNA/ chitosan complexes by field-flow fractionation reveals particle size and free chitosan contentBiomacromolecules201011354955420158194
  • OlofssonSOBorenJApolipoprotein B: a clinically important apolipoprotein which assembles atherogenic lipoproteins and promotes the development of atherosclerosisJ Intern Med2005258539541016238675
  • SharmaSDohertyKMBroshRMJrMechanisms of RecQ helicases in pathways of DNA metabolism and maintenance of genomic stabilityBiochem J2006398331933716925525
  • ScaringeSAWincottFECaruthersMHNovel RNA synthesis method using 5′-silyl-2′-orthoester protecting groupsJ Am Chem Soc19981201182011821
  • NguyenSHisigerSJolicoeurMWinnikFMBuschmannMDFractionation and characterization of chitosan by analytical SEC and 1H-NMR after semi-preparative SECCarbohydr Polym200975636646
  • NguyenSWinnikFMBuschmannMDImproved reproducibility in the determination of the molecular weight of chitosan by analytical size exclusion chromatographyCarbohydr Polym200975528533
  • LavertuMXiaZSerreqiANA validated 1H-NMR method for the determination of the degree of deacetylation of chitosanJ Pharm Biomed Anal20033261149115812907258
  • SkrypinaNATimofeevaAVKhaspekovGLSavochkinaLPBeabealashvilliRTotal RNA suitable for molecular biology analysisJ Biotechnol20031051–21914511905
  • QuongDNeufeldRJDNA protection from extracapsular nucleases, within chitosan- or poly-L-lysine-coated alginate beadsBiotechnol Bioeng199860112413410099413
  • MaPLLavertuMWinnikFMBuschmannMDNew insights into chitosan-DNA interactions using isothermal titration microcalorimetryBiomacromolecules20091061490149919419142
  • NelAEMadlerLVelegolDUnderstanding biophysicochemical interactions at the nano-bio interfaceNat Mater20098754355719525947
  • WuLHicksonIDDNA helicases required for homologous recombination and repair of damaged replication forksAnnu Rev Genet20064027930616856806
  • KawabeTTsuyamaNKitaoSDifferential regulation of human RecQ family helicases in cell transformation and cell cycleOncogene200019414764477211032027
  • SchaeferJRScharnaglHBaumstarkMWHomozygous familial defective apolipoprotein B-100. Enhanced removal of apolipoprotein E-containing VLDLs and decreased production of LDLsArterioscler Thromb Vasc Biol19971723483539081691
  • ItabeHOxidative modification of LDL: its pathological role in atherosclerosisClin Rev Allergy Immunol200937141118987785
  • GrefRDombAQuellecPThe controlled intravenous delivery of drugs using PEG-coated sterically stabilized nanospheresAdv Drug Deliv Rev199516215233
  • Bivas-BenitaMRomeijnSJungingerHEBorchardGPLGA-PEI nanoparticles for gene delivery to pulmonary epitheliumEur J Pharm Biopharm20045811615207531
  • PanyamJLabhasetwarVBiodegradable nanoparticles for drug and gene delivery to cells and tissueAdv Drug Deliv Rev200355332934712628320
  • GuyJDrabekDAntoniouMDelivery of DNA into mammalian cells by receptor-mediated endocytosis and gene therapyMol Biotechnol1995332372487552693
  • DesaiMPLabhasetwarVAmidonGLLevyRJGastrointestinal uptake of biodegradable microparticles: effect of particle sizePharm Res19961312183818458987081
  • SeymourLWPassive tumor targeting of soluble macromolecules and drug conjugatesCrit Rev Ther Drug Carrier Syst1992921351871386002
  • JeanMAlamehMDe JesusDChitosan-based therapeutic nanocomplexes for combination gene therapy and gene silencing of in vitro cell lines relevant to type 2 diabetesEur J Pharm Sci2011451–2138149 Epub November 9, 201122085632
  • ChithraniBDChanWCElucidating the mechanism of cellular uptake and removal of protein-coated gold nanoparticles of different sizes and shapesNano Lett2007761542155017465586
  • ChithraniBDGhazaniAAChanWCDetermining the size and shape dependence of gold nanoparticle uptake into mammalian cellsNano Lett20066466266816608261
  • VermaAStellacciFEffect of surface properties on nanoparticle-cell interactionsSmall201061122119844908
  • LiuWSunSCaoZAn investigation on the physicochemical properties of chitosan/DNA polyelectrolyte complexesBiomaterials200526152705271115585274
  • ErbacherPZouSBettingerTSteffanAMRemyJSChitosan-based vector/DNA complexes for gene delivery: biophysical characteristics and transfection abilityPharm Res1998159133213399755882
  • DanielsenSStrandSde Lange DaviesCStokkeBTGlycosaminoglycan destabilization of DNA-chitosan polyplexes for gene delivery depends on chitosan chain length and GAG propertiesBiochim Biophys Acta200517211–34454 Epub November 2, 200415652178
  • Köping-HöggårdMMel’nikovaYSVårumKMLindmanBArturssonPRelationship between the physical shape and the efficiency of oligomeric chitosan as a gene delivery system in vitro and in vivoJ Gene Med20035213014112539151
  • GaoSDagnaes-HansenFNielsenEJThe effect of chemical modification and nanoparticle formulation on stability and biodistribution of siRNA in miceMol Ther20091771225123319401674
  • JiAMSuDCheOFunctional gene silencing mediated by chitosan/ siRNA nanocomplexesNanotechnology2009204040510319752491
  • BishopNEAn Update on Non-clathrin-coated EndocytosisRev Med Virol19977419920910398484
  • HuangMMaZKhorELimLYUptake of FITC-chitosan nanoparticles by A549 cellsPharm Res200219101488149412425466
  • Center for Biologics Evaluation and Research, US Food and Drug AdministrationGuidance for Industry: Considerations for Plasmid DNA Vaccines for Infectious Disease IndicationsRockville, MD2007 Available from: http://www.fda.gov/BiologicsBloodVaccines/GuidanceComplianceRegulatoryInformation/Guidances/Vaccines/ucm074770.htmAccessed January 1, 2012
  • Center for Biologics Evaluation and ResearchGuidance for Industry: Considerations for Plasmid DNA Vaccines for Infectious Disease IndicationsRockville, MDUS FDA2007 Available from: http://iccvam.niehs.nih.gov/SuppDocs/FedDocs/FDA/FDA_plasdnavac.pdfAccessed February 23, 2012
  • Center for Biologics Evaluation and ResearchGuidance for FDA Reviewers and Sponsors: Content and Review of Chemistry, Manufacturing, and Control (CMC) Information for Human Gene Therapy Investigational New Drug Applications (INDs)Rockville, MDUS FDA2008 Available from: http://www.fda.gov/downloads/BiologicsBloodVaccines/GuidanceComplianceRegulatoryInformation/Guidances/CellularandGeneTherapy/ucm078694.pdfAccessed February 23, 2012
  • US Pharmacopeial ConventionGene therapy productsSecond Supplement to USP 34-NF 29Rockville, MDUnited States Pharmacopeial201151355158