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Original Research

Cascade search for HSV-1 combinatorial drugs with high antiviral efficacy and low toxicity

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Pages 2281-2292 | Published online: 10 May 2012

References

  • ImmingPSinningCMeyerADrugs, their targets and the nature and number of drug targetsNat Rev Drug Discov200651082183417016423
  • ZhengCJHanLYYapCWJiZLCaoZWChenYZTherapeutic targets: Progress of their exploration and investigation of their characteristicsPharmacol Rev200658325927916714488
  • PappBPalCHurstLDMetabolic network analysis of the causes and evolution of enzyme dispensability in yeastNature2004429699266166415190353
  • PilpelYSudarsanamPChurchGMIdentifying regulatory networks by combinatorial analysis of promoter elementsNat Genet200129215315911547334
  • PengXHKarnaPCaoZHJiangBHZhouMXYangLCross-talk between epidermal growth factor receptor and hypoxia-inducible factor-1 alpha signal pathways increases resistance to apoptosis by up-regulating survivin gene expressionJ Biol Chem200628136259032591416847054
  • OverallCMKleifeldOTumour microenvironment – Opinion – Validating matrix metalloproteinases as drug targets and anti-targets for cancer therapyNat Rev Cancer20066322723916498445
  • KeithCTBorisyAAStockwellBRMulticomponent therapeutics for networked systemsNat Rev Drug Discov200541711015688074
  • KitanoHInnovation – a robustness-based approach to systems-oriented drug designNat Rev Drug Discov20076320221017318209
  • HuangSRational drug discovery: what can we learn from regulatory networks?Drug Discov Today2002720S16316912546900
  • RyanQIbrahimACohenMHFDA drug approval summary: Lapatinib in combination with capecitabine for previously treated metastatic breast cancer that overexpresses HER-2Oncologist200813101114111918849320
  • BorisyAAElliottPJHurstNWSystematic discovery of multicomponent therapeuticsP Natl Acad Sci U S A20031001379777982
  • O’HaraMKieferDFarrellKKemperKA review of 12 commonly used medicinal herbsArch Fam Med1998765235369821826
  • TugwellPPincusTYocumDCombination therapy with cyclosporine and methotrexate in severe rheumatoid arthritisNew Engl J Med199533331371417791814
  • LawMRWaldNJMorrisJKJordanREValue of low dose combination treatment with blood pressure lowering drugs: analysis of 354 randomised trialsBrit Med J200332674041427143112829555
  • GuptaRWarrenTWaldAGenital herpesLancet200737096052127213718156035
  • KoelleDMCoreyLHerpes simplex: Insights on pathogenesis and possible vaccinesAnnu Rev Med20085938139518186706
  • BurnsWHSantosGWSaralRIsolation and characterization of resistant herpes-simplex virus after acyclovir therapyLancet1982182694214236121091
  • De ClercqEAntiviral drugs in current clinical useJ Clin Virol200430211513315125867
  • RongQAlexanderTSKoskiGKRosenthalKSMultiple mechanisms for HSV-1 induction of interferon alpha production by peripheral blood mononuclear cellsArch Virol2003148232934412556996
  • ChenSHOakesJELauschRNSynergistic anti-HSV effect of tumor-necrosis-factor-alpha and interferon-gamma in human corneal fibroblasts is associated with interferon-beta inductionAntivir Res199322115298250541
  • FeduchiECarrascoLMechanism of inhibition of HSV-1 replication by tumor-necrosis-factor and interferon-gammaVirology199118028228251846503
  • DempseyPWDoyleSEHeJQChengGHThe signaling adaptors and pathways activated by TNF superfamilyCytokine Growth F R2003143–4193209
  • WongPKYuFQShahangianAChengGHSunRHoCMClosed-loop control of cellular functions using combinatory drugs guided by a stochastic search algorithmP Natl Acad Sci U S A20081051351055110
  • TsutsuiHValamehrBHindoyanAAn optimized small molecule inhibitor cocktail supports long-term maintenance of human embryonic stem cellsNat Commun2011216721266967
  • SunCPUsuiTYuFIntegrative systems control approach for reactivating Kaposi’s sarcoma-associated herpesvirus (KSHV) with combinatory drugsIntegr Biol (Camb)20091112313019851479
  • LiuMYRakowskiBGershburgEICP0 antagonizes ICP4-dependent silencing of the herpes simplex virus ICP0 genePlos One201051e883720098619
  • ElliottGO’HarePLive-cell analysis of a green fluorescent protein-tagged herpes simplex virus infectionJ Virol19997354110411910196307
  • StornRPriceKDifferential evolution – a simple and efficient heuristic for global optimization over continuous spacesJ Global Optim1997114341359
  • KakudaTNBrinkmanKMitochondrial toxic effects and ribavirinLancet200135792701802180311407388
  • De FranceschiLFattovichGTurriniFHemolytic anemia induced by ribavirin therapy in patients with chronic hepatitis C virus infection: role of membrane oxidative damageHepatology2000314997100410733558