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Review

Structure-dependent immunostimulatory effect of CpG oligodeoxynucleotides and their delivery system

Pages 2181-2195 | Published online: 27 Apr 2012

References

  • TokunagaTYamamotoHShimadaSAntitumor activity of deoxyribonucleic acid fraction from Mycobacterium bovis BCG: I. Isolation, physicochemical characterization, and antitumor activityJ Natl Cancer Inst19847249559626200641
  • KriegAMYiAKMatsonSCpG motifs in bacterial DNA trigger direct B-cell activationNature199537465225465497700380
  • HemmiHTakeuchiOKawaiTA Toll-like receptor recognizes bacterial DNANature2000408681374074511130078
  • HornungVRothenfusserSBritschSQuantitative expression of Toll-like receptor 1–10 mRNA in cellular subsets of human peripheral blood mononuclear cells and sensitivity to CpG oligonucleatidesJ Immunol200216894531453711970999
  • KlinmanDMYiAKBeaucageSLConoverJKriegAMCpG motifs present in bacteria DNA rapidly induce lymphocytes to secrete interleukin 6, interleukin 12, and interferon gammaProc Natl Acad Sci U S A1996937287928838610135
  • AkiraSUematsuSTakeuchiOPathogen recognition and innate immunityCell2006124478380116497588
  • JungJYiAKZhangXChoeJLiLChoiYSDistinct response of human B cell subpopulations in recognition of an innate immune signal, CpG DNAJ Immunol200216952368237312193703
  • BernasconiNLTraggiaiELanzavecchiaAMaintenance of serological memory by polyclonal activation of human memory B cellsScience200229856012199220212481138
  • Asselin-PaturelCBrizardGCheminKType I interferon dependence of plasmacytoid dendritic cell activation and migrationJ Exp Med200520171157116715795237
  • BallasZKRasmussenWLKriegAMInduction of NK activity in murine and human cells by CpG motifs in oligodeoxynucleotides and bacterial DNAJ Immunol19961575184018458757300
  • NapolitaniGRinaldiABertoniFSallustoFLanzavecchiaASelected Toll-like receptor agonist combinations synergistically trigger a T helper type 1-polarizing program in dendritic cellsNat Immunol20056876977615995707
  • RomanMMartin-OrozcoEGoodmanJSImmunostimulatory DNA sequences function as T helper-1-promoting adjuvantsNat Med1997388498549256274
  • HartmannGWeinerGJKriegAMCpG DNA: a potent signal for growth activation, and maturation of human dendritic cellsProc Natl Acad Sci U S A199996169305931910430938
  • BlackwellSEKriegAMCpG-A-induced monocyte IFN-gamma-inducible protein-10 production is regulated by plasmacytoid dendritic cell-derived IFN-alphaJ Immunol200317084061406812682235
  • VollmerJJurkMSamulowitzUCpG oligodeoxynucleotides stimulate IFN-gamma-inducible protein-10 production in human B cellsJ Endotoxin Res200410643143815588427
  • SchwarzKStorniTManolovaVRole of Toll-like receptors in costimulating cytotoxic T cell responsesEur J Immunol20033361465147012778463
  • HeitAMaurerTHochreinHCutting edge: Toll-like receptor 9 expression is not required for CpG DNA-aided cross-presentation of DNA-conjugated antigens but essential for cross-priming of CD8 T cellsJ Immunol200317062802280512626528
  • KriegAMTherapeutic potential of Toll-like receptor 9 activationNat Rev Drug Discov20065647148416763660
  • JahrsdörferBWeinerGJCpG oligodeoxynucleotides for immune stimulation in cancer immunotherapyCurr Opin Investig Drugs200346686690
  • FonsecaDEKlineJNUse of CpG oligonucleotides in treatment of asthma and allergic diseaseAdv Drug Deliv Rev200961325626219167442
  • KlinmanDMKlaschikSSatoTTrossDCpG oligonucleotides as adjuvants for vaccines targeting infectious diseasesAdv Drug Deliv Rev200961324825519272313
  • HeikenwalderMPolymenidouMJuntTLymphoid follicle destruction and immunosuppression after repeated CpG oligodeoxy-nucleotide administrationNat Med200410218719214745443
  • FogedCBrodinBFrokjaerSSundbladAParticle size and surface charge affect particle uptake by human dendritic cells in an in vitro modelInt J Pharm2005298231532215961266
  • KurreckJAntisense technologies: improvement through novel chemical modificationsEur J Biochem200327081628164412694176
  • AgrawalSZhaoQAntisense therapeuticsCurr Opin Chem Biol1998245195289736926
  • MalyalaPO’HaganDTSinghMEnhancing the therapeutic efficacy of CpG oligonucleotides using biodegradable microparticlesAdv Drug Deliv Rev200961321822519168103
  • WilsonKDde JongSDTamYKLipid-based delivery of CpG oligonucleotides enhances immunotherapeutic efficacyAdv Drug Deliv Rev200961323324219232375
  • BiancoAHoebekeJGodefroySCationic carbon nanotubes bind to CpG oligodeoxynucleotides and enhance their immunostimulatory propertiesJ Am Chem Soc20051271585915631447
  • StandleySMMendeLGohSLIncorporation of CpG oligonucleotide ligand into protein-loaded particle vaccines promotes antigen-specific CD8 T-cell immunityBioconjug Chem2007181778317226959
  • RattanakiatSNishikawaMFunabashiHLuoDTakakuraYThe assembly of a short linear natural cytosine-phosphate-guanine DNA into dendritic structures and its effect on immunostimulatory activityBiomaterials200930295701570619604576
  • MutwiriGKNichaniAKBabiukSBabiukLAStrategies for enhancing the immunostimulatory effects of CpG oligodeoxynucleotidesJ Control Release200497111715147800
  • KrugARothenfusserSHornungVIdentification of CpG oligonucleotide sequences with high induction of IFN-alpha/beta in plasmacytoid dendritic cellsEur J Immunol20013172154216311449369
  • KriegAMCpG motifs in bacterial DNA and their immune effectsAnnu Rev Immunol20022070976011861616
  • GürselMVerthelyiDGürselIIshiiKJKlinmanDMDifferential and competitive activation of human immune cells by distinct classes of CpG oligonucleotideJ Leukoc Biol200271581382011994506
  • HartmannGWeeratnaRDBallasZKDelineation of a CpG phosphorothioate oligodeoxynucleotide for activating primate immune responses in vitro and in vivoJ Immunol200016431617162410640783
  • HartmannGKriegAMMechanism and function of a newly identified CpG DNA motif in human primary B cellsJ Immunol2000164294495310623843
  • KrugATowarowskiABritschSToll-like receptor expression reveals CpG DNA as a unique microbial stimulus for plasmacytoid dendritic cells which synergizes with CD40 ligand to induce high amount of IL–12Eur J Immunol200131103026303711592079
  • HartmannGBattianyJPoeckHRational design of new CpG oligonucleotides that combine B cell activation with high IFN-α induction in plasmacytoiddendritic cellsEur J Immunol20033361633164112778481
  • MarshallJDFearonKAbbateCIdentification of a novel CpG DNA class and motif that optimally stimulate B cell and plasmacytoid dendritic cell functionsJ Leukoc Biol200373678179212773511
  • PoeckHWagnerMBattianyJPlasmacytoid dendritic cells, antigen, and CpG-C license human B cells for plasma cell differentiation and immunoglobulin production in the absence of T-cell helpBlood200410383058306415070685
  • VollmerJWeeratnaRPayettePCharacterization of three CpG oligodeoxynucleotide classes with distinct immunostimulatory activitiesEur J Immunol200434125126214971051
  • SamulowitzUWeberMWeeratnaRA novel class of immune-stimulatory CpG oligodeoxynucleotides unifies high potency in type I interferon induction with preferred structural propertiesOligonucleotides20102029310120384481
  • SheehanJPLanHCPhosphorothioate oligonucleotides inhibit the intrinsic tenase complexBlood1998925161716259716589
  • BrownDAKangSHGryaznovSMEffect of phosphorothioate modification of oligodeoxynucleotides on specific protein bindingJ Biol Chem19942694326801268057929417
  • LevinAAA review of the issues in the pharmacokinetics and toxicology of phosphorothioate antisense of oligonucleotidesBiochim Biophys Acta199914891698410806998
  • HenrySPBeattieGYehGComplement activation is responsible for acute toxicities in rhesus monkeys treated with a phosphorothioate oligonucleotideInt Immunopharmacol20022121657166612469940
  • ChavanyCConnellYNeckersLContribution of sequence and phosphorothioate content to inhibition of cell growth and adhesion caused by c-myc antisense oligomersMol Pharmarcol1995484738746
  • CrookeRMIn vitro toxicology and pharmacokinetics of antisense oligonucleotidesAnticancer Drug Des1991666096461772572
  • ErieDSinhaNOlsonWJonesRBreslauerKADumbbell-shaped, double-hairpin structure of DNA: a thermodynamic investigationBiochemistry19872622715071593427065
  • ChuBCOrgelLEThe stability of different forms of double-stranded decoy DNA in serum and nuclear extractsNucleic Acids Res19922021585758581454556
  • CluselCUgarteEEnjolrasNVasseurMBlumenfeldMEx vivo regulation of specific gene expression by nanomolar concentration of double-stranded dumbbell oligonucleotidesNucleic Acids Res19932115340534117688452
  • SchmidtMAntonKNordhausCJunghansCWittigBWormMCytokine and Ig-production by CG-containing sequences with phosphorodiester backbone and dumbbell-shapeAllergy2006611566316364157
  • NishikawaMMatonoMRattanakiatSMatsuokaNTakakuraYEnhanced immunostimulatory activity of oligodeoxynucleotides by Y-shape formationImmunology2008124224725518217956
  • NishikawaMMizunoYMohriKBiodegradable CpG DNA hydrogels for sustained delivery of doxorubicin and immunostimulatory signals in tumor-bearing miceBiomaterials201132248849420932569
  • LiJPeiHZhuBSelf-assembled multivalent DNA nanostructures for noninvasive intracellular delivery of immunostimulatory CpG oligonucleotidesACS Nano20115118783878921988181
  • MengWYamazakiTNishidaYHanagataNNuclease-resistant immunostimulatory phosphodiester CpG oligodeoxynucleotides as human Toll-like receptor 9 agonistsBMC Biotechnol201111889621943407
  • KerkmannMCostaLTRichterCSpontaneous formation of nucleic acid-based nanoparticles is responsible for high interferon-alpha induction by CpG-A in plasmacytoid dendritic cellsJ Biol Chem200528098086809315591070
  • KleinDCLatzEEspevikTStokkeBTHigher order structure of short immunostimulatory oligonucleotides studied by atomic force microscopyUltramicroscopy2010110668969320202756
  • LeeSWSongMKBaekKHEffects of a hexameric deoxyriboguanosine run conjugation into CpG oligodeoxynucleotides on their immunostimulatory potentialsJ Immunol200016573631363911034366
  • DalpkeAHZimmermannSAlbrechtIHeegKPhosphodiester CpG oligonucleotides as adjuvants: polyguanosine runs enhance cellular uptake and improve immunostimulative activity of phosphodiester CpG oligonucleotides in vitro and in vivoImmunology2002106110211211972638
  • HondaKOhbaYYanaiHSpatiotemporal regulation of MyD88-IRF-7 signaling for robust type-I interferon inductionNature200543470361035104015815647
  • MarshallJDHesselEMGregorioJNovel chimeric immunomodulatory compounds containing short CpG oligodeoxynucleotides have differential activities in human cellsNucleic Acids Res200331175122513312930963
  • FearonKMarshallJDAbbateCA minimal human immunostimulatory CpG motif that potently induces IFN-gamma and IFN-alpha productionEur J Immunol20033382114212212884285
  • AoyamaYKanamoriTNakaiTArtificial viruses and their application to gene delivery: size-controlled gene coating with glycocluster nanoparticlesJ Am Chem Soc2003125123455345712643707
  • NakaiTKanamoriTSandoSAoyamaYRemarkably size-regulated cell invasion by artificial viruses: saccharide-dependent self-aggregation of glycoviruses and its consequences in glycoviral gene deliveryJ Am Chem Soc2003125288465846712848552
  • OsakiFKanamoriTSandoSSeraTAoyamaYA quantum dot conjugated sugar ball and its cellular uptake: on the size effects of endocytosis in the subviral regionJ Am Chem Soc2004126216520652115161257
  • GaoHShiWFreundLBMechanics of receptor-mediated endocytosisProc Natl Acad Sci U S A2005102279469947415972807
  • RobertsTLDunnJATerryTDDifferences in macrophage activation by bacterial DNA and CpG-containing oligonucleotidesJ Immunol200517563569357616148100
  • TakeshitaFLeiferCAGurselICutting edge: role of Toll-like receptor 9 in CpG DNA-induced activation of human cellsJ Immunol200116773555355811564765
  • SempleSCKlimukSKHarasymTOHopeMJLipid-based formulations of antisense oligonucleotides for systemic delivery applicationsMethods Enzymol200031332234110595364
  • ZhuYMengWLiXGaoHHanagataNDesign of mesoporous silica/ cytosine-phosphodiester-guanin oligodeoxynucleotide complexes to enhance delivery efficiencyJ Phys Chem C20111152447452
  • DementoSLBonaféNCuiWTLR9-targeted biodegradable nanoparticles as immunization vectors protect against West Nile encephalitisJ Immunol201018552989299720660705
  • PanXChenLLiuSYangXGaoJXLeeRJAntitumor activity of G3139 lipid nanoparticles (LNPs)Mol Pharm20096121122019072654
  • SempleSCKlimukSKHarasymTOEfficient encapsulation of antisense oligonucleotides in lipid vesicles using ionizeable aminolipids: formation of novel small multilamellar vesicle structuresBiochim Biophys Acta200115101–215216611342155
  • YuRZGearyRSLeedsJMPharmacokinetics and tissue disposition in monkeys of an antisense oligonucleotide inhibitor of Ha-ras encapsulated in stealth liposomesPharm Res19991681309131510468036
  • ZhiCMengWYamazakiTBN nanospheres as CpG ODN carriers for activation of Toll-like receptor 9J Mater Chem2011211452195222
  • BourquinCAnzDZwiorekKTargeting CpG oligonucleotides to the lymph node by nanoparticles elicits efficient antitumoral immunityJ Immunol200818152990299818713969
  • KlierJMayAFuchsSImmunostimulation of bronchoalveolar lavage cells from recurrent airway obstruction-affected horses by different CpG-classes bound to gelatin nanoparticlesVet Immunol Immunopathol20111441–2798721831455
  • ChenHCSunBTranKKShenHEffects of particle size on Toll-like receptor 9-mediated cytokine profilesBiomaterials20113261731173721126760
  • SokolovaVKnuschkeTKovtunABuerJEppleMWestendorfAMThe use of calcium phosphate nanoparticles encapsulating Toll-like receptor ligands and the antigen hemagglutinin to induce dendritic cell maturation and T cell activationBiomaterials201031215627563320417963
  • ZhuYMengWGaoHHanagataNHollow mesoporous silica/poly(L-lysine) particles for codelivery of drug and gene with enzyme-triggered release propertyJ Phys Chem C2011115281363013636
  • BallardBEBiopharmaceutical considerations in subcutaneous and intra-muscular drug administrationJ Pharm Sci19685733573784871917
  • HiranoKHuntCALymphatic transport of liposome-encapsulated agents: effects of liposome size following intraperitoneal administrationJ Pharm Sci19857499159214067845
  • KuramotoYNishikawaMHyoudouKYamashitaFHashidaMInhibition of peritoneal dissemination of tumor cells by single dosing of phosphodiester CpG oligonucleotide/cationic liposome complexJ Control Release2006115222623316996162
  • KuramotoYKawakamiSZhouSFukudaKYamashitaFHashidaMUse of mannosylated cationic liposomes/immunostimulatory CpG DNA complex for effective inhibition of peritoneal dissemination in miceJ Gene Med200810439239918181219
  • ChenXWuPRousseasMBoron nitride nanotubes are non-cytotoxic and can be functionalized for interaction with proteins and cellsJ Am Chem Soc2009131389089119119844
  • TigheHTakabayashiKSchwartzDConjugation of protein to immunostimulatory DNA results in a rapid, long-lasting and potent induction of cell-mediated and humoral immunityEur J Immunol20003071939194710940883
  • GürselMTuncaSOzkanMOzcengizGAlaeddinogluGImmunoadjuvant action of plasmid DNA in liposomesVaccine19991711–121376138310195773
  • GürselIGürselMIshiiKJKlinmanDMSterically stabilized cationic liposomes improve the uptake and immunostimulatory activity of CpG oligonucleotidesJ Immunol200116763324332811544321
  • Kaiser-SchulzGHeitAQuintanilla-MartinezLPolyactide-coglycolide microspheres co-encapsulating recombinant tandem prion protein with CpG-oligonucleotide break self-tolerance to prion protein in wild-type mice and induce CD4 and CD8 T cell responsesJ Immunol200717952797280717709493
  • NierkensSden BrokMHSutmullerRPIn vivo colocalization of antigen and CpG [corrected] within dendritic cells is associated the efficacy of cancer immunotherapyCancer Res200868135390539618593941
  • LeeYRLeeYHImSABiodegradable nanoparticles containing TLR3 or TLR9 agonists together with antigen enhance MHC-restricted presentation of the antigenArch Pharm Res201033111859186621116790
  • ErikçiEGürselMGürselIDifferential immune activation following encapsulation of immunostimulatory CpG oligodeoxynucleotide in nanoliposomesBiomaterials20113261715172321112627
  • SlütterBJiskootWDual role of CpG as immune modulator and physical crosslinker in ovalbumin loaded N-trimethyl chitosan (TMC) nanoparticles for nasal vaccinationJ Control Release2010148111712120600405
  • BalSMSlütterBVerheulRBouwstraJAJiskootWAdjuvanted, antigen loaded N-trimethyl chitosan nanoparticles for nasal and intradermal vaccination: adjuvant- and site-dependent immunogenicity in miceEur J Pharm Sci201245447548122009113
  • SinghMOttGKazzazJCationic microparticles are an effective delivery system for immune stimulatory CpG DNAPharm Res200118101476147911697476
  • DiwanMTafaghodiMSamuelJEnhancement of immune responses by co-delivery of a CpG oligodeoxynucleotide and tetanus toxoid in biodegradable nanospheresJ Control Release2002851–324726212480329
  • ZhangXQDahleCEBamanNKRichNWeinerGJSalemAKPotent antigen-specific immune responses stimulated by codelivery of CpG ODN and antigens in degradable microparticlesJ Immunother200730546947817589287
  • BorgesOCordeiro-da-SilvaATavaresJImmune response by nasal delivery of hepatitis B surface antigen and codelivery of a CpG ODN in alginate coated chitosan nanoparticlesEur J Pharm Biopharm200869240541618364251
  • XieHGurselIIvinsBECpG oligodeoxynucleotides adsorbed onto polylactide-co-glycolide microparticles improve the immunogenicity and protective activity of the licensed anthrax vaccineInfect Immun200573282883315664922
  • HeitASchmitzFHaasTBuschDHWagnerHAntigen co-encapsulated with adjuvants efficiently drive protective T cell immunityEur J Immunol20073782063207417628858
  • KwongBLiuHIrvineDJInduction of potent anti-tumor responses while eliminating systemic side effects via liposome-anchored combinatorial immunotherapyBiomaterials201132225134514721514665
  • StoneGWBarzeeSSnarskyVNanoparticle-delivered multimeric soluble CD40L DNA combined with Toll-like receptor agonists as a treatment for melanomaPLoS One2009410e733419812695
  • WellsJWCowledCJFarzanehFNobleACombined triggering of dendritic cell receptors results in synergistic activation and potent cytotoxic immunityJ Immunol200818153422343118714014
  • HaradaAKawamuraMMatsuoTTakahashiTKonoKSynthesis and characterization of a head-tail type polycation block copolymer as a nonviral gene vectorBioconjug Chem20061713516417245
  • WagnerEKloecknerJGene delivery using polymer therapeuticsAdv Polym Sci2006192135173
  • NguyenDNGreenJJChanJMLangerRAndersonDGPolymeric materials for gene delivery and DNA vaccinationAdv Mater2009218847867
  • MeyerOKirpotinDHongKCationic liposomes coated with polyethylene glycol as carriers for oligonucleotidesJ Biol Chem19982732515621156279624154
  • MahatoRIAnwerKTagliaferriFBiodistribution and gene expression of lipid/plasmid complexes after systemic administrationHum Gene Ther1998914208320999759935
  • KimHAkagiTAkashiMPreparation of CpG ODN-encapsulated anionic poly(amino acid) nanoparticles for gene deliveryChem Lett2010393278279
  • PackDWHoffmanASPunSStaytonPSDesign and development of polymers for gene deliveryNat Rev Drug Discov20054758159316052241
  • TrubetskoyVSWongSCSubbotinVRecharging cationic DNA complexes with highly charged polyanions for in vitro and in vivo gene deliveryGene Ther200310326127112571634
  • KurosakiTKitaharaTFumotoSTernary complexes of pDNA, polyethylenimine, and gamma-polyglutamic acid for gene delivery systemsBiomaterials200930142846285319232715
  • KimHAkagiTAkashiMPreparation of size tunable amphiphilic poly(amino acid) nanoparticlesMacromol Biosci20099984284819422015
  • YanaiHBanTWangZHMGB proteins function as universal sentinels for nucleic-acid-mediated innate immune responsesNature200946272699910319890330
  • YanaiHChibaSBanTSuppression of immune responses by nonimmunogenic oligodeoxynucleotides with high affinity for high-mobility group box proteins (HMGBs)Proc Natl Acad Sci U S A201110828115421154721709231