Chitosan-Coated-PLGA Nanoparticles Enhance the Antitumor and Antimigration Activity of Stattic – A STAT3 Dimerization Blocker

References

• Steeg PS. Targeting metastasis. Nat Rev Cancer. 2016;16(4):201–218. doi:10.1038/nrc.2016.25
   PubMed Web of Science ®Google Scholar
• Ma J, Kala S, Yung S, et al. Blocking stemness and metastatic properties of ovarian cancer cells by targeting p70(S6K) with dendrimer nanovector-based sirna delivery. Mol Ther. 2018;26(1):70–83. doi:10.1016/j.ymthe.2017.11.006
   PubMed Web of Science ®Google Scholar
• Gong N, Teng X, Li J, Liang XJ. Antisense oligonucleotide-conjugated nanostructure-targeting lncrna MALAT1 inhibits cancer metastasis. ACS Appl Mater Interfaces. 2019;11(1):37–42. doi:10.1021/acsami.8b18288
   PubMed Web of Science ®Google Scholar
• Yang CL, Chao YJ, Wang HC, et al. Local ablation of gastric cancer by reconstituted apolipoprotein B lipoparticles carrying epigenetic drugs. Nanomedicine. 2021;37:102450. doi:10.1016/j.nano.2021.102450
   PubMed Web of Science ®Google Scholar
• Chu HL, Cheng TM, Chen HW, et al. Synthesis of apolipoprotein B lipoparticles to deliver hydrophobic/amphiphilic materials. ACS Appl Mater Interfaces. 2013;5(15):7509–7516. doi:10.1021/am401808e
   PubMed Web of Science ®Google Scholar
• Hanafy NAN, Quarta A, Ferraro MM, et al. Polymeric nano-micelles as novel cargo-carriers for Ly2157299 liver cancer cells delivery. Int J Mol Sci. 2018;19(3):748–760. doi:10.3390/ijms19030748
   PubMed Web of Science ®Google Scholar
• Chiba T. STAT3 inhibitors for cancer therapy - the rationale and remained problems. EC Cancer. 2016;1:S1–S8.
   Google Scholar
• Kim MS, Lee WS, Jeong J, Kim SJ, Jin W. Induction of metastatic potential by trkb via activation of IL6/JAK2/STAT3 and PI3K/AKT signaling in breast cancer. Oncotarget. 2015;6(37):40158–40171. doi:10.18632/oncotarget.5522
   PubMedGoogle Scholar
• Pan Y, Zhou F, Zhang R, Claret FX. Stat3 inhibitor stattic exhibits potent antitumor activity and induces chemo- and radio-sensitivity in nasopharyngeal carcinoma. PLoS One. 2013;8(1):e54565. doi:10.1371/journal.pone.0054565
   PubMed Web of Science ®Google Scholar
• Schust J, Sperl B, Hollis A, Mayer TU, Berg T. Stattic: a small-molecule inhibitor of Stat3 activation and dimerization. Chem Biol. 2006;13(11):1235–1242. doi:10.1016/j.chembiol.2006.09.018
   PubMed Web of Science ®Google Scholar
• Yue P, Turkson J. Targeting STAT3 in cancer: how successful are we? Expert Opin Investig Drugs. 2009;18(1):45–56. doi:10.1517/13543780802565791
   PubMed Web of Science ®Google Scholar
• Bohrer LR, Chuntova P, Bade LK, et al. Activation of the FGFR-STAT3 pathway in breast cancer cells induces a hyaluronan-rich microenvironment that licenses tumor formation. Cancer Res. 2014;74(1):374–386. doi:10.1158/0008-5472.CAN-13-2469
   PubMed Web of Science ®Google Scholar
• Vicent MJ, Duncan R. Polymer conjugates: nanosized medicines for treating cancer. Trends Biotechnol. 2006;24(1):39–47. doi:10.1016/j.tibtech.2005.11.006
   PubMed Web of Science ®Google Scholar
• Hanafy NAN, Quarta A, Di Corato R, et al. Hybrid polymeric-protein nano-carriers (HPPNC) for targeted delivery of TGFβ inhibitors to hepatocellular carcinoma cells. Mater Sci Mater Med. 2017;28(8):120–130. doi:10.1007/s10856-017-5930-7
   PubMed Web of Science ®Google Scholar
• Hu Q, Sun W, Wang C, Gu Z. Recent advances of cocktail chemotherapy by combination drug delivery systems. Adv Drug Deliv Rev. 2016;98:19–34. doi:10.1016/j.addr.2015.10.022
   PubMed Web of Science ®Google Scholar
• Maeda H, Nakamura H, Fang J. The EPR effect for macromolecular drug delivery to solid tumors: improvement of tumor uptake, lowering of systemic toxicity, and distinct tumor imaging in vivo. Adv Drug Deliv Rev. 2013;65(1):71–79. doi:10.1016/j.addr.2012.10.002
   PubMed Web of Science ®Google Scholar
• Voon SH, Tiew SX, Kue CS, et al. Chitosan-coated poly(lactic-co-glycolic acid)-diiodinated boron-dipyrromethene nanoparticles improve tumor selectivity and stealth properties in photodynamic cancer therapy. J Biomed Nanotechnol. 2016;12(7):1431–1452. doi:10.1166/jbn.2016.2263
   PubMed Web of Science ®Google Scholar
• Tiew SX, Misni M. Thermal properties of acylated low molecular weight chitosans. J Chem Soc Pak. 2019;41:207–218.
   Web of Science ®Google Scholar
• Fessi H, Puisieux F, Devissaguet JP, Ammoury N, Benita S. Nanocapsule formation by interfacial polymer deposition following solvent displacement. Int J Pharm. 1989;55(1):R1–R4. doi:10.1016/0378-5173(89)90281-0
   Web of Science ®Google Scholar
• Kefayat A, Vaezifar S. Biodegradable PLGA implants containing doxorubicin-loaded chitosan nanoparticles for treatment of breast tumor-bearing mice. Int J Biol Macromol. 2019;136:48–56. doi:10.1016/j.ijbiomac.2019.06.055
   PubMed Web of Science ®Google Scholar
• Liang CC, Park AY, Guan JL. In vitro scratch assay: a convenient and inexpensive method for analysis of cell migration in vitro. Nat Protoc. 2007;2(2):329–333. doi:10.1038/nprot.2007.30
   PubMed Web of Science ®Google Scholar
• Anasamy T, Thy CK, Lo KM, et al. Tribenzyltin carboxylates as anticancer drug candidates: effect on the cytotoxicity, motility and invasiveness of breast cancer cell lines. Eur J Med Chem. 2017;125:770–783. doi:10.1016/j.ejmech.2016.09.061
   PubMed Web of Science ®Google Scholar
• Holen I, Lawson MA. Chapter 43 - In vivo models used in studies of bone metastases. In: Heymann D, editor. Bone Cancer. 2nd ed. San Diego: Academic Press; 2015:503–518.
   Google Scholar
• Delgado-SanMartin J, Ehrhardt B, Paczkowski M, et al. An innovative non-invasive technique for subcutaneous tumour measurements. PLoS One. 2019;14(10):e0216690. doi:10.1371/journal.pone.0216690
   PubMed Web of Science ®Google Scholar
• Faustino-Rocha A, Oliveira PA, Pinho-Oliveira J, et al. Estimation of rat mammary tumor volume using caliper and ultrasonography measurements. Lab Anim. 2013;42(6):217–224. doi:10.1038/laban.254
   PubMed Web of Science ®Google Scholar
• Foo YY, Periasamy V, Kiew LV, Kumar GG, Malek SNA. Curcuma mangga-mediated synthesis of gold nanoparticles: characterization, stability, cytotoxicity, and blood compatibility. Nanomaterials. 2017;7(6):1–14. doi:10.3390/nano7060123
   Web of Science ®Google Scholar
• Fissan H, Ristig S, Kaminski H, Asbach C, Epple M. Comparison of different characterization methods for nanoparticle dispersions before and after aerosolization. Anal Methods. 2014;6(18):7324–7334. doi:10.1039/C4AY01203H
   Web of Science ®Google Scholar
• Blanco E, Shen H, Ferrari M. Principles of nanoparticle design for overcoming biological barriers to drug delivery. Nat Biotechnol. 2015;33(9):941–951. doi:10.1038/nbt.3330
   PubMed Web of Science ®Google Scholar
• Wang Q, Tan L, Yang K. Cytocompatibility and hemolysis of AZ31B magnesium alloy with Si-containing coating. J Mater Sci Technol. 2015;31(8):845–851. doi:10.1016/j.jmst.2015.07.008
   Web of Science ®Google Scholar
• Badran MM, Alomrani AH, Harisa GI, Ashour AE, Kumar A, Yassin AE. Novel docetaxel chitosan-coated PLGA/PCL nanoparticles with magnified cytotoxicity and bioavailability. Biomed Pharmacother. 2018;106:1461–1468. doi:10.1016/j.biopha.2018.07.102
   PubMed Web of Science ®Google Scholar
• Affandi ISM, Lee WQ, Feroz SR, Mohamad SB, Tayyab S. Interaction of stattic, a STAT3 inhibitor with human serum albumin: spectroscopic and computational study. J Biomol Struct Dyn. 2017;35(16):3581–3590. doi:10.1080/07391102.2016.1264887
   PubMed Web of Science ®Google Scholar
• Viswanathan G, Hsu YH, Voon SH, et al. A comparative study of cellular uptake and subcellular localization of doxorubicin loaded in self-assemblies of amphiphilic copolymers with pendant dendron by MDA-MB-231 human breast cancer cells. Macromol Biosci. 2016;16(6):882–895. doi:10.1002/mabi.201500435
   PubMed Web of Science ®Google Scholar
• Kwa YC, Tan YF, Foo YY, et al. Improved delivery and antimetastatic effects of Stattic by self-assembled amphiphilic pendant-dendron copolymer micelles in breast cancer cell lines. J Drug Deliv Sci Technol. 2020;59:101905–101916. doi:10.1016/j.jddst.2020.101905
   Web of Science ®Google Scholar
• Noori Koopaei M, Khoshayand MR, Mostafavi SH, et al. Docetaxel loaded PEG-PLGA nanoparticles: optimized drug loading, in-vitro cytotoxicity and in-vivo antitumor effect. Iran J Pharm Res. 2014;13(3):819–833.
   PubMed Web of Science ®Google Scholar
• Palocci C, Valletta A, Chronopoulou L, et al. Endocytic pathways involved in PLGA nanoparticle uptake by grapevine cells and role of cell wall and membrane in size selection. Plant Cell Rep. 2017;36(12):1917–1928. doi:10.1007/s00299-017-2206-0
   PubMed Web of Science ®Google Scholar
• Welch DR, Hurst DR. Defining the hallmarks of metastasis. Cancer Res. 2019;79(12):3011–3027. doi:10.1158/0008-5472.CAN-19-0458
   PubMed Web of Science ®Google Scholar
• Liu Y-L, Chou C-K, Kim M, et al. Assessing metastatic potential of breast cancer cells based on EGFR dynamics. Sci Rep. 2019;9(1):3395–3407. doi:10.1038/s41598-018-37625-0
   PubMed Web of Science ®Google Scholar
• Hanafy NAN. Optimally designed theranostic system based folic acids and chitosan as a promising mucoadhesive delivery system for encapsulating curcumin LbL nano-template against invasiveness of breast cancer. Int J Biol Macromol. 2021;182:1981–1993. doi:10.1016/j.ijbiomac.2021.05.149
   PubMed Web of Science ®Google Scholar
• Mu X, Shi W, Xu Y, et al. Tumor-derived lactate induces M2 macrophage polarization via the activation of the ERK/STAT3 signaling pathway in breast cancer. Cell Cycle. 2018;17(4):428–438. doi:10.1080/15384101.2018.1444305
   PubMed Web of Science ®Google Scholar
• Jayasingam SD, Citartan M, Thang TH, Mat Zin AA, Ang KC, Ch’ng ES. Evaluating the polarization of tumor-associated macrophages into m1 and m2 phenotypes in human cancer tissue: technicalities and challenges in routine clinical practice. Front Oncol. 2020;9:1512. doi:10.3389/fonc.2019.01512
   PubMed Web of Science ®Google Scholar
• Lv R, Bao Q, Li Y. Regulation of M1‑type and M2‑type macrophage polarization in RAW264.7 cells by Galectin‑9. Mol Med Rep. 2017;16(6):9111–9119. doi:10.3892/mmr.2017.7719
   PubMed Web of Science ®Google Scholar
• Yin Z, Ma T, Lin Y, et al. IL-6/STAT3 pathway intermediates M1/M2 macrophage polarization during the development of hepatocellular carcinoma. J Cell Biochem. 2018;119(11):9419–9432. doi:10.1002/jcb.27259
   PubMed Web of Science ®Google Scholar
• Liu Z, Ge X, Gu Y, et al. Small molecule STAT3 inhibitor, 6Br-6a suppresses breast cancer growth in vitro and in vivo. Biomed Pharmacother. 2020;121:109502–109510. doi:10.1016/j.biopha.2019.109502
   PubMed Web of Science ®Google Scholar
• Adachi M, Cui C, Dodge CT, Bhayani MK, Lai SY. Targeting STAT3 inhibits growth and enhances radiosensitivity in head and neck squamous cell carcinoma. Oral Oncol. 2012;48(12):1220–1226. doi:10.1016/j.oraloncology.2012.06.006
   PubMed Web of Science ®Google Scholar
• Gao D, Du J, Cong L, Liu Q. Risk factors for initial lung metastasis from breast invasive ductal carcinoma in stages I–III of operable patients. Jpn J Clin Oncol. 2008;39(2):97–104. doi:10.1093/jjco/hyn133
   PubMed Web of Science ®Google Scholar
• Ross MH, Esser AK, Fox GC, et al. Bone-induced expression of integrin β3 enables targeted nanotherapy of breast cancer metastases. Cancer Res. 2017;77(22):6299–6312. doi:10.1158/0008-5472.CAN-17-1225
   PubMed Web of Science ®Google Scholar
• Lee SY, Koo JS, Yang M, Cho HJ. Application of temporary agglomeration of chitosan-coated nanoparticles for the treatment of lung metastasis of melanoma. J Colloid Interface Sci. 2019;544:266–275. doi:10.1016/j.jcis.2019.02.092
   PubMed Web of Science ®Google Scholar
• Hess LM, Brnabic A, Mason O, Lee P, Barker S. Relationship between progression-free survival and overall survival in randomized clinical trials of targeted and biologic agents in oncology. J Cancer. 2019;10(16):3717–3727. doi:10.7150/jca.32205
   PubMed Web of Science ®Google Scholar
• Murthy RK, Loi S, Okines A, et al. Tucatinib, trastuzumab, and capecitabine for HER2-positive metastatic breast cancer. N Engl J Med. 2020;382(7):597–609. doi:10.1056/nejmoa1914609
   PubMed Web of Science ®Google Scholar
• Geyer CE, Forster J, Lindquist D, et al. Lapatinib plus capecitabine for HER2-positive advanced breast cancer. N Engl J Med. 2006;355(26):2733–2743. doi:10.1056/nejmoa064320
   PubMed Web of Science ®Google Scholar
• Saw WS, Anasamy T, Foo YY, et al. Delivery of nanoconstructs in cancer therapy: challenges and therapeutic opportunities. Adv Ther. 2021;4(3):2000206. doi:10.1002/adtp.202000206.
   Web of Science ®Google Scholar
• Gonciar D, Mocan T, Matea CT, et al. Nanotechnology in metastatic cancer treatment: current achievements and future research trends. J Cancer. 2019;10(6):1358–1369. doi:10.7150/jca.28394
   PubMed Web of Science ®Google Scholar