Preparation of a Nanobody Specific to Dectin 1 and Its Anti-inflammatory Effects on Fungal Keratitis

References

• Hu LT, Du ZD, Zhao GQ, et al. Role of TREM-1 in response to aspergillus fumigatus infection in corneal epithelial cells. Int Immunopharmacol. 2014;23(1):288–293. doi:10.1016/j.intimp.2014.09.011
   PubMed Web of Science ®Google Scholar
• Fan Y, Li C, Peng X, et al. Perillaldehyde ameliorates aspergillus fumigatus keratitis by activating the Nrf2/HO-1 signaling pathway and inhibiting dectin-1-mediated inflammation. Invest Ophthalmol Vis Sci. 2020;61(6):51. doi:10.1167/iovs.61.6.51
   PubMed Web of Science ®Google Scholar
• Nielsen SE, Nielsen E, Julian HO, et al. Incidence and clinical characteristics of fungal keratitis in a Danish population from 2000 to 2013. Acta Ophthalmol. 2015;93(1):54–58. doi:10.1111/aos.12440
   PubMed Web of Science ®Google Scholar
• Garg P, Roy A, Roy S. Update on fungal keratitis. Curr Opin Ophthalmol. 2016;27(4):333–339. doi:10.1097/ICU.0000000000000272
   PubMed Web of Science ®Google Scholar
• Niu Y, Zhao G, Li C, et al. Aspergillus fumigatus increased PAR-2 expression and elevated proinflammatory cytokines expression through the pathway of PAR-2/ERK1/2 in cornea. Invest Ophthalmol Vis Sci. 2018;59:166–175.
   PubMed Web of Science ®Google Scholar
• Xie L, Zhong W, Shi W, et al. Spectrum of fungal keratitis in north China. Ophthalmology. 2006;113(11):1943–1948. doi:10.1016/j.ophtha.2006.05.035
   PubMed Web of Science ®Google Scholar
• van de Veerdonk FL, Gresnigt MS, Romani L, Netea MG, Latge JP. Aspergillus fumigatus morphology and dynamic host interactions. Nat Rev Microbiol. 2017;15:661–674. doi:10.1038/nrmicro.2017.90
   PubMed Web of Science ®Google Scholar
• Yuan K, Zhao G, Che C, et al. Dectin-1 is essential for IL-1β production through JNK activation and apoptosis in Aspergillus fumigatus keratitis. Int Immunopharmacol. 2017;52:168–175. doi:10.1016/j.intimp.2017.09.008
   PubMed Web of Science ®Google Scholar
• Slowik M, Biernat M, Urbaniak-Kujda D, et al. Mycotic infections of the eye. Adv Clin Exp Med. 2015;24(6):1113–1117. doi:10.17219/acem/50572
   PubMed Web of Science ®Google Scholar
• FlorCruz NV, Evans JR. Medical interventions for fungal keratitis. Cochrane Database Syst Rev. 2015;4:Cd004241.
   Google Scholar
• Bajracharya L, Gurung R. Outcome of therapeutic penetrating keratoplasty in a tertiary eye care center in Nepal. Clin Ophthalmol. 2015;9:2299–2304. doi:10.2147/OPTH.S92176
   PubMedGoogle Scholar
• Lee JE, Sun Y, Gjorstrup P, et al. Inhibition of corneal inflammation by the resolvin e1. Invest Ophthalmol Vis Sci. 2015;56(4):2728–2736. doi:10.1167/iovs.14-15982
   PubMed Web of Science ®Google Scholar
• Ebrahimizadeh W, Mousavi Gargari S, Rajabibazl M, Safaee Ardekani L, Zare H, Bakherad H. Isolation and characterization of protective anti-LPS nanobody against V. cholerae O1 recognizing Inaba and Ogawa serotypes. Appl Microbiol Biotechnol. 2013;97(10):4457–4466. doi:10.1007/s00253-012-4518-x
   PubMed Web of Science ®Google Scholar
• Bao F, Wang L, Zhao X, et al. Preparation and characterization of a single-domain antibody specific for the porcine epidemic diarrhea virus spike protein. AMB Express. 2019;9(1):104. doi:10.1186/s13568-019-0834-1
   PubMed Web of Science ®Google Scholar
• Bailon Calderon H, Yaniro Coronel VO, Cáceres Rey OA, et al. Development of nanobodies against hemorrhagic and myotoxic components of Bothrops atrox snake venom. Front Immunol. 2020;11:655. doi:10.3389/fimmu.2020.00655
   PubMed Web of Science ®Google Scholar
• Kovaleva M, Ferguson L, Steven J, Porter A, Barelle C. Shark variable new antigen receptor biologics - a novel technology platform for therapeutic drug development. Expert Opin Biol Ther. 2014;14(10):1527–1539. doi:10.1517/14712598.2014.937701
   PubMed Web of Science ®Google Scholar
• Müller MR, Saunders K, Grace C, et al. Improving the pharmacokinetic properties of biologics by fusion to an anti-HSA shark VNAR domain. MAbs. 2012;4(6):673–685. doi:10.4161/mabs.22242
   PubMed Web of Science ®Google Scholar
• Grzeschik J, Könning D, Hinz SC, et al. Generation of semi-synthetic shark IgNAR single-domain antibody libraries. Methods Mol Biol. 2018;1701:147–167.
   PubMedGoogle Scholar
• Vandenbroucke K, de Haard H, Beirnaert E, et al. Orally administered L. lactis secreting an anti-TNF nanobody demonstrate efficacy in chronic colitis. Mucosal Immunol. 2010;3(1):49–56. doi:10.1038/mi.2009.116
   PubMed Web of Science ®Google Scholar
• Danquah W, Meyer-Schwesinger C, Rissiek B, et al. Nanobodies that block gating of the P2X7 ion channel ameliorate inflammation. Sci Transl Med. 2016;8(366):366ra162. doi:10.1126/scitranslmed.aaf8463
   PubMed Web of Science ®Google Scholar
• Rissiek B, Koch-Nolte F, Magnus T. Nanobodies as modulators of inflammation: potential applications for acute brain injury. Front Cell Neurosci. 2014;8:344. doi:10.3389/fncel.2014.00344
   PubMed Web of Science ®Google Scholar
• Dooley H, Flajnik MF, Porter AJ. Selection and characterization of naturally occurring single-domain (IgNAR) antibody fragments from immunized sharks by phage display. Mol Immunol. 2003;40:25–33. doi:10.1016/S0161-5890(03)00084-1
   PubMed Web of Science ®Google Scholar
• Xia Y, Zhao G, Lin J, et al. 1,25(OH)2D3 and VDR signaling pathways regulate the inhibition of Dectin-1 caused by Cyclosporine A in response to aspergillus fumigatus in human corneal epithelial cells. PLoS One. 2016;11(10):e0164717. doi:10.1371/journal.pone.0164717
   PubMed Web of Science ®Google Scholar
• Wu TG, Wilhelmus KR, Mitchell BM. Experimental keratomycosis in a mouse model. Invest Ophthalmol Vis Sci. 2003;44(1):210–216. doi:10.1167/iovs.02-0446
   PubMed Web of Science ®Google Scholar
• Xia L, Teng Q, Chen Q, Zhang F. Preparation and characterization of anti-GPC3 nanobody against hepatocellular carcinoma. Int J Nanomedicine. 2020;15:2197–2205. doi:10.2147/IJN.S235058
   PubMed Web of Science ®Google Scholar
• Gu L, Lin J, Wang Q, et al. Dimethyl itaconate protects against fungal keratitis by activating the Nrf2/HO-1 signaling pathway. Immunol Cell Biol. 2020;98(3):229–241. doi:10.1111/imcb.12316
   PubMed Web of Science ®Google Scholar
• Jiang N, Zhao G, Lin J, et al. Indoleamine 2,3-dioxygenase is involved in the inflammation response of corneal epithelial cells to aspergillus fumigatus infections. PLoS One. 2015;10(9):e0137423. doi:10.1371/journal.pone.0137423
   PubMed Web of Science ®Google Scholar
• Liu X, You J, Peng X, et al. Mammalian Ste20-like kinase 4 inhibits the inflammatory response in Aspergillus fumigatus keratitis. Int Immunopharmacol. 2020;88:107021. doi:10.1016/j.intimp.2020.107021
   PubMed Web of Science ®Google Scholar
• Huang X, Liu X, Peng X, et al. Production of egg yolk antibody against A.fumigatus and its therapeutic potential for treating A.fumigatus keratitis. Microb Pathog. 2021;158:105081. doi:10.1016/j.micpath.2021.105081
   PubMed Web of Science ®Google Scholar
• Zhu Y, Peng X, Zhang Y, Lin J, Zhao G. Baicalein protects against aspergillus fumigatus keratitis by reducing fungal load and inhibiting TSLP-induced inflammatory response. Invest Ophthalmol Vis Sci. 2021;62(6):26. doi:10.1167/iovs.62.6.26
   PubMed Web of Science ®Google Scholar
• Niu Y, Lin J, Li C, et al. Galectin-3 plays an important pro-inflammatory role in A. fumigatus keratitis by recruiting neutrophils and activating p38 in neutrophils. Int Immunopharmacol. 2021;97:107706. doi:10.1016/j.intimp.2021.107706
   PubMed Web of Science ®Google Scholar
• Tian X, Peng X, Lin J, et al. Isorhamnetin ameliorates aspergillus fumigatus keratitis by reducing fungal load, Inhibiting pattern-recognition receptors and inflammatory cytokines. Invest Ophthalmol Vis Sci. 2021;62(3):38. doi:10.1167/iovs.62.3.38
   PubMed Web of Science ®Google Scholar
• Yin J, Peng X, Lin J, et al. Quercetin amelioratesAspergillus fumigatuskeratitis by inhibiting fungal growth, toll-like receptors and inflammatory cytokines. Int Immunopharmacol. 2021;93:107435. doi:10.1016/j.intimp.2021.107435
   PubMed Web of Science ®Google Scholar
• Zhan L, Peng X, Lin J, et al. Honokiol reduces fungal load, toll-like receptor-2, and inflammatory cytokines in Aspergillus fumigatus keratitis. Invest Ophthalmol Vis Sci. 2020;61(4):48. doi:10.1167/iovs.61.4.48
   PubMed Web of Science ®Google Scholar
• Ye G, Gallant J, Zheng J, et al. The development of Nanosota-1 as anti-SARS-CoV-2 nanobody drug candidates. Elife. 2021;10:e64815. doi:10.7554/eLife.64815
   PubMed Web of Science ®Google Scholar
• Li L, Zhu Y, Liu M, et al. Conjugation of oxaliplatin with PEGylated-nanobody for enhancing tumor targeting and prolonging circulation. J Inorg Biochem. 2021;223:111553. doi:10.1016/j.jinorgbio.2021.111553
   PubMed Web of Science ®Google Scholar
• Zhang Q, Wu L, Liu S, et al. Moderating hypoxia and promoting immunogenic photodynamic therapy by HER-2 nanobody conjugate nanoparticles for ovarian cancer treatment. Nanotechnology. 2021;32(42):425101. doi:10.1088/1361-6528/ac07d1
   Web of Science ®Google Scholar
• Weng D, Yin ZF, Chen SS, et al. Development and assessment of the efficacy and safety of human lung-targeting liposomal methylprednisolone crosslinked with nanobody. Drug Deliv. 2021;28(1):1419–1431. doi:10.1080/10717544.2021.1921073
   PubMed Web of Science ®Google Scholar
• Gow NA, Netea MG, Munro CA, et al. Immune recognition of candida albicans β-glucan by Dectin-1. J Infect Dis. 2007;196(10):1565–1571. doi:10.1086/523110
   PubMed Web of Science ®Google Scholar
• Zhong J, Huang W, Deng Q, et al. Inhibition of TREM-1 and Dectin-1 alleviates the severity of fungal keratitis by modulating innate immune responses. PLoS One. 2016;11:e0150114. doi:10.1371/journal.pone.0150114
   PubMed Web of Science ®Google Scholar
• Sokullu E, Gauthier MS, Coulombe B. Discovery of antivirals using phage display. Viruses. 2021;13(6):1120. doi:10.3390/v13061120
   PubMed Web of Science ®Google Scholar
• Moeglin E, Desplancq D, Stoessel A, et al. A novel nanobody precisely visualizes phosphorylated histone H2AX in living cancer cells under drug-induced replication stress. Cancers. 2021;13(13):3317. doi:10.3390/cancers13133317
   PubMed Web of Science ®Google Scholar
• Ákos Z, Dunipace L, Stathopoulos A. NaNuTrap, a technique for in vivo cell nucleus labelling using nanobodies. Development. 2021;148:dev199822. doi:10.1242/dev.199822
   PubMed Web of Science ®Google Scholar
• Wagner TR, Ostertag E, Kaiser PD, et al. NeutrobodyPlex-monitoring SARS-CoV-2 neutralizing immune responses using nanobodies. EMBO Rep. 2021;22(5):e52325. doi:10.15252/embr.202052325
   PubMed Web of Science ®Google Scholar
• Zhang W, Lin M, Yan Q, et al. An intracellular nanobody targeting T4SS effector inhibits Ehrlichia infection. Proc Natl Acad Sci U S A. 2021;118(18):e2024102118. doi:10.1073/pnas.2024102118
   PubMed Web of Science ®Google Scholar
• Papp KA, Weinberg MA, Morris A, Reich K. IL17A/F nanobody sonelokimab in patients with plaque psoriasis: a multicentre, randomised, placebo-controlled, phase 2b study. Lancet. 2021;397(10284):1564–1575. doi:10.1016/S0140-6736(21)00440-2
   PubMed Web of Science ®Google Scholar
• Liao S, Liu S, Zhang Y. Preparation of anti toll-like receptor-4 nano-antibody and Its effect on gram negative sepsis. J Nanosci Nanotechnol. 2021;21(2):1048–1053. doi:10.1166/jnn.2021.18664
   PubMedGoogle Scholar