Investigating the Impact of Optimized Trans-Cinnamic Acid-Loaded PLGA Nanoparticles on Epithelial to Mesenchymal Transition in Breast Cancer

References

• Sun Y-S, Zhao Z, Yang Z-N, et al. Risk factors and preventions of breast cancer. Int J Biol Sci. 2017;13(11):1387. doi:10.7150/ijbs.21635
   PubMed Web of Science ®Google Scholar
• El-Kersh DM, Ezzat SM, Salama MM, et al. Anti-estrogenic and anti-aromatase activities of citrus peels major compounds in breast cancer. Sci Rep. 2021;11(1):1–14. doi:10.1038/s41598-021-86599-z
   PubMed Web of Science ®Google Scholar
• Chowdhury P, Ghosh U, Samanta K, Jaggi M, Chauhan SC, Yallapu MM. Bioactive nanotherapeutic trends to combat triple negative breast cancer. Bioact Mater. 2021;6(10):3269–3287. doi:10.1016/j.bioactmat.2021.02.037
   PubMed Web of Science ®Google Scholar
• Yuan Y, Cai T, Xia X, Zhang R, Chiba P, Cai Y. Nanoparticle delivery of anticancer drugs overcomes multidrug resistance in breast cancer. Drug Deliv. 2016;23(9):3350–3357. doi:10.1080/10717544.2016.1178825
   PubMed Web of Science ®Google Scholar
• Wang S, Zhou Y, Tao W, Liu J, Chen H, Zhao Z. Fe3O4-modified amphiphilic polyurethane nanoparticles with good stability as magnetic-targeted drug carriers. Polym Bull. 2021:1–15. doi:10.1007/s00289-021-03931-3
   Web of Science ®Google Scholar
• Hunke M, Martinez W, Kashyap A, Bokoskie T, Pattabiraman M, Chandra S. Antineoplastic actions of cinnamic acids and their dimers in breast cancer cells: a comparative study. Anticancer Res. 2018;38(8):4469–4474. doi:10.21873/anticanres.12749
   PubMed Web of Science ®Google Scholar
• Khaled N, Bidet Y. New insights into the implication of epigenetic alterations in the EMT of triple negative breast cancer. Cancers. 2019;11(4):559. doi:10.3390/cancers11040559
   PubMed Web of Science ®Google Scholar
• Xu X, Zhang L, He X, et al. TGF-β plays a vital role in triple-negative breast cancer (TNBC) drug-resistance through regulating stemness, EMT and apoptosis. Biochem Biophys Res Commun. 2018;502(1):160–165. doi:10.1016/j.bbrc.2018.05.139
   PubMed Web of Science ®Google Scholar
• Du B, Shim JS. Targeting epithelial–mesenchymal transition (EMT) to overcome drug resistance in cancer. Molecules. 2016;21(7):965. doi:10.3390/molecules21070965
   PubMed Web of Science ®Google Scholar
• Ruwizhi N, Aderibigbe BA. Cinnamic acid derivatives and their biological efficacy. Int J Mol Sci. 2020;21(16):5712. doi:10.3390/ijms21165712
   PubMed Web of Science ®Google Scholar
• Letsididi KS, Lou Z, Letsididi R, Mohammed K, Maguy BL. Antimicrobial and antibiofilm effects of trans-cinnamic acid nanoemulsion and its potential application on lettuce. LWT. 2018;94:25–32. doi:10.1016/j.lwt.2018.04.018
   Web of Science ®Google Scholar
• Martínez-Rosas JR, Díaz-Torres R, Ramírez-Noguera P, López-Barrera LD, Escobar-Chavez JJ, Ángeles ER. PLGA nanoparticles of a new cinnamic acid derivative inhibits cellular proliferation on breast cancer cell line MCF-7 in a PPARγ dependent way. Die Pharmazie. 2020;75(7):324–328.
   PubMed Web of Science ®Google Scholar
• Li W, Zhao X, Sun X, Zu Y, Liu Y, Ge Y. Evaluation of antioxidant ability in vitro and bioavailability of trans-cinnamic acid nanoparticle by liquid antisolvent precipitate. J Nanomater. 2016;2016:1–11. doi:10.1155/2016/9518362
   Web of Science ®Google Scholar
• Sathya S, Shanmuganathan B, Saranya S, Vaidevi S, Ruckmani K, Pandima Devi K. Phytol-loaded PLGA nanoparticle as a modulator of Alzheimer’s toxic Aβ peptide aggregation and fibrillation associated with impaired neuronal cell function. Artif Cells Nanomed Biotechnol. 2018;46(8):1719–1730. doi:10.1080/21691401.2017.1391822
   PubMed Web of Science ®Google Scholar
• Al-Jubori AA, Sulaiman GM, Tawfeeq AT, Mohammed HA, Khan RA, Mohammed SA. Layer-by-layer nanoparticles of tamoxifen and resveratrol for dual drug delivery system and potential triple-negative breast cancer treatment. Pharmaceutics. 2021;13(7):1098. doi:10.3390/pharmaceutics13071098
   PubMed Web of Science ®Google Scholar
• Brigger I, Dubernet C, Couvreur P. Nanoparticles in cancer therapy and diagnosis. Adv Drug Deliv Rev. 2012;64:24–36. doi:10.1016/j.addr.2012.09.006
   Web of Science ®Google Scholar
• Haggag YA, Abosalha AK, Tambuwala MM, et al. Polymeric nanoencapsulation of zaleplon into PLGA nanoparticles for enhanced pharmacokinetics and pharmacological activity. Biopharm Drug Dispos. 2021;42(1):12–23. doi:10.1002/bdd.2255
   PubMed Web of Science ®Google Scholar
• Kamaly N, Xiao Z, Valencia PM, Radovic-Moreno AF, Farokhzad OC. Targeted polymeric therapeutic nanoparticles: design, development and clinical translation. Chem Soc Rev. 2012;41(7):2971–3010. doi:10.1039/c2cs15344k
   PubMed Web of Science ®Google Scholar
• De Vita A, Liverani C, Molinaro R, et al. Lysyl oxidase engineered lipid nanovesicles for the treatment of triple negative breast cancer. Sci Rep. 2021;11(1):1–12. doi:10.1038/s41598-021-84492-3
   PubMed Web of Science ®Google Scholar
• Zou T, Lan M, Liu F, et al. Emodin-loaded polymer-lipid hybrid nanoparticles enhance the sensitivity of breast cancer to doxorubicin by inhibiting epithelial–mesenchymal transition. Cancer Nanotechnol. 2021;12(1):1–15. doi:10.1186/s12645-021-00093-9
   PubMed Web of Science ®Google Scholar
• Ahmad N, Alam MA, Ahmad R, Naqvi AA, Ahmad FJ Preparation and characterisation of surface-modified PLGA-polymeric nanoparticles used to target treatment of intestinal cancer (Retraction of Vol 46, Pg 432, 2018). Abingdon, Oxon: Taylor & Francis Ltd; 2020.
   Google Scholar
• Li Z, Jiang H, Xu C, Gu L. A review: using nanoparticles to enhance absorption and bioavailability of phenolic phytochemicals. Food Hydrocoll. 2015;43:153–164. doi:10.1016/j.foodhyd.2014.05.010
   Web of Science ®Google Scholar
• Shirsat AE, Chitlange SS. Application of quality by design approach to optimize process and formulation parameters of rizatriptan loaded chitosan nanoparticles. J Adv Pharm Technol Res. 2015;6(3):88. doi:10.4103/2231-4040.157983
   PubMedGoogle Scholar
• Budhian A, Siegel SJ, Winey KI. Haloperidol-loaded PLGA nanoparticles: systematic study of particle size and drug content. Int J Pharm. 2007;336(2):367–375. doi:10.1016/j.ijpharm.2006.11.061
   PubMed Web of Science ®Google Scholar
• Lancheros R, Guerrero CA, Godoy-Silva RD. Improvement of N-acetylcysteine loaded in PLGA nanoparticles by nanoprecipitation method. J Nanotechnol. 2018;2018:1–11. doi:10.1155/2018/3620373
   Web of Science ®Google Scholar
• Sah AK, Suresh PK, Verma VK. PLGA nanoparticles for ocular delivery of loteprednol etabonate: a corneal penetration study. Artif Cells, Nanomed Biotechnol. 2017;45(6):1156–1164. doi:10.1080/21691401.2016.1203794
   Web of Science ®Google Scholar
• Zhang Y-T, Xu Y-M, Zhang S-J, et al. In vivo microdialysis for the evaluation of transfersomes as a novel transdermal delivery vehicle for cinnamic acid. Drug Dev Ind Pharm. 2014;40(3):301–307. doi:10.3109/03639045.2012.756888
   PubMed Web of Science ®Google Scholar
• Pandit J, Sultana Y, Aqil M. Chitosan-coated PLGA nanoparticles of bevacizumab as novel drug delivery to target retina: optimization, characterization, and in vitro toxicity evaluation. Artif Cells Nanomed Biotechnol. 2017;45(7):1397–1407. doi:10.1080/21691401.2016.1243545
   PubMed Web of Science ®Google Scholar
• Khalifa MK, Salem HA, Shawky SM, Eassa HA, Elaidy AM. Enhancement of zaleplon oral bioavailability using optimized self-nano emulsifying drug delivery systems and its effect on sleep quality among a sample of psychiatric patients. Drug Deliv. 2019;26(1):1243–1253. doi:10.1080/10717544.2019.1687613
   PubMed Web of Science ®Google Scholar
• Panda BP, Krishnamoorthy R, Shivashekaregowda NKH, Patnaik S. Influence of Poloxamer-188 on design and development of second generation PLGA nanocrystals of metformin hydrochloride. Nano Biomed Eng. 2018;10(4):334–343. doi:10.5101/nbe.v10i4.p334-343
   Google Scholar
• Yang SC, Lu LF, Cai Y, Zhu JB, Liang BW, Yang CZ. Body distribution in mice of intravenously injected camptothecin solid lipid nanoparticles and targeting effect on brain. J Control Release. 1999;59(3):299–307. doi:10.1016/S0168-3659(99)00007-3
   PubMed Web of Science ®Google Scholar
• Nasr AM, Elhady SS, Swidan SA, Badawi NM. Celecoxib loaded in-situ provesicular powder and its in-vitro cytotoxic effect for cancer therapy: fabrication, characterization, optimization and pharmacokinetic evaluation. Pharmaceutics. 2020;12(12):1157. doi:10.3390/pharmaceutics12121157
   PubMed Web of Science ®Google Scholar
• Mosdam T. Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxic assay. J Immunol Methods. 1983;65(1–2):55–63. doi:10.1016/0022-1759(83)90303-4
   PubMed Web of Science ®Google Scholar
• Liang -C-C, Park AY, Guan J-L. In vitro scratch assay: a convenient and inexpensive method for analysis of cell migration in vitro. Nat Protoc. 2007;2(2):329–333. doi:10.1038/nprot.2007.30
   PubMed Web of Science ®Google Scholar
• Jaganathan SK, Mondhe D, Wani ZA, Pal HC, Mandal M. Effect of honey and eugenol on Ehrlich ascites and solid carcinoma. J Biomed Biotechnol. 2010;2010:1–5. doi:10.1155/2010/989163
   Google Scholar
• Hsu S-M, Raine L, Fanger H. Use of avidin-biotin-peroxidase complex (ABC) in immunoperoxidase techniques: a comparison between ABC and unlabeled antibody (PAP) procedures. J Histochem Cytochem. 1981;29(4):577–580. doi:10.1177/29.4.6166661
   PubMed Web of Science ®Google Scholar
• Tefas LR, Tomuţă I, Achim M, Vlase L. Development and optimization of quercetin-loaded PLGA nanoparticles by experimental design. Clujul Med. 2015;88(2):214. doi:10.15386/cjmed-418
   PubMedGoogle Scholar
• Bian X, Liang S, John J, et al. Development of PLGA-based itraconazole injectable nanospheres for sustained release. Int J Nanomedicine. 2013;8:4521. doi:10.2147/IJN.S54040
   PubMed Web of Science ®Google Scholar
• Jonderian A, Maalouf R. Formulation and in vitro interaction of rhodamine-B loaded PLGA nanoparticles with cardiac myocytes. Front Pharmacol. 2016;7:458. doi:10.3389/fphar.2016.00458
   PubMed Web of Science ®Google Scholar
• Schwarz C, Mehnert W, Lucks JS, Müller RH. Solid lipid nanoparticles (SLN) for controlled drug delivery. I. Production, characterization and sterilization. J Control Release. 1994;30(1):83–96. doi:10.1016/0168-3659(94)90047-7
   Web of Science ®Google Scholar
• García-Díaz M, Foged C, Nielsen HM. Improved insulin loading in poly (lactic-co-glycolic) acid (PLGA) nanoparticles upon self-assembly with lipids. Int J Pharm. 2015;482(1–2):84–91. doi:10.1016/j.ijpharm.2014.11.047
   PubMed Web of Science ®Google Scholar
• Anwer MK, Mohammad M, Ezzeldin E, Fatima F, Alalaiwe A, Iqbal M. Preparation of sustained release apremilast-loaded PLGA nanoparticles: in vitro characterization and in vivo pharmacokinetic study in rats. Int J Nanomedicine. 2019;14:1587. doi:10.2147/IJN.S195048
   PubMed Web of Science ®Google Scholar
• Öztürk AA, Martin-Banderas L, Cayero-Otero MD, Yenilmez E, Yazan Y. New approach to hypertension treatment: carvediol-loaded PLGA nanoparticles, preparation, in vitro characterization and gastrointestinal stability. Lat Am J Pharm. 2018;37(9):1730–1741.
   Web of Science ®Google Scholar
• Kesisoglou F, Panmai S, Wu Y. Nanosizing—oral formulation development and biopharmaceutical evaluation. Adv Drug Deliv Rev. 2007;59(7):631–644. doi:10.1016/j.addr.2007.05.003
   PubMed Web of Science ®Google Scholar
• Sansdrap P, Moës AJ. In vitro evaluation of the hydrolytic degradation of dispersed and aggregated poly (DL-lactide-co-glycolide) microspheres. J Control Release. 1997;43(1):47–58. doi:10.1016/S0168-3659(96)01469-1
   Web of Science ®Google Scholar
• Wang L, Wang Y, Wang X, et al. Encapsulation of low lipophilic and slightly water-soluble dihydroartemisinin in PLGA nanoparticles with phospholipid to enhance encapsulation efficiency and in vitro bioactivity. J Microencapsul. 2016;33(1):43–52. doi:10.3109/02652048.2015.1114042
   PubMed Web of Science ®Google Scholar
• Mohammadi G, Valizadeh H, Barzegar-Jalali M, et al. Development of azithromycin–PLGA nanoparticles: physicochemical characterization and antibacterial effect against Salmonella typhi. Colloids Surf B Biointerfaces. 2010;80(1):34–39. doi:10.1016/j.colsurfb.2010.05.027
   PubMed Web of Science ®Google Scholar
• Wang H, Li Q, Deng W, et al. Self‐nanoemulsifying drug delivery system of trans‐cinnamic acid: formulation development and pharmacodynamic evaluation in alloxan‐induced type 2 diabetic rat model. Drug Dev Res. 2015;76(2):82–93. doi:10.1002/ddr.21244
   PubMed Web of Science ®Google Scholar
• Pal A, Tapadar P, Pal R. Exploring the molecular mechanism of cinnamic acid-mediated cytotoxicity in triple negative MDA-MB-231 breast cancer cells. Curr Med Chem Anticancer Agents. 2021;21(9):1141–1150.
   Google Scholar
• Imai M, Yokoe H, Tsubuki M, Takahashi N. Growth inhibition of human breast and prostate cancer cells by cinnamic acid derivatives and their mechanism of action. Biol Pharm Bull. 2019:b18–01002. doi:10.1248/bpb.b18-01002
   PubMed Web of Science ®Google Scholar
• De Aquino FLT, Da Silva JP, de Souza Ferro JN, Lagente V, Barreto E. Trans-Cinnamic acid, but not p-coumaric acid or methyl cinnamate, induces fibroblast migration through PKA-and p38-MAPK signalling pathways. J Tissue Viability. 2021;30:363–371. doi:10.1016/j.jtv.2021.05.003
   PubMed Web of Science ®Google Scholar
• Almeer RS, Aref AM, Hussein RA, Othman MS, Abdel Moneim AE. Antitumor potential of berberine and cinnamic acid against solid Ehrlich carcinoma in mice. Curr Med Chem Anticancer Agents. 2019;19(3):356–364.
   Google Scholar
• Pu X, Storr SJ, Zhang Y, et al. Caspase-3 and caspase-8 expression in breast cancer: caspase-3 is associated with survival. Apoptosis. 2017;22(3):357–368. doi:10.1007/s10495-016-1323-5
   PubMed Web of Science ®Google Scholar
• Lamouille S, Xu J, Derynck R. Molecular mechanisms of epithelial–mesenchymal transition. Nat Rev Mol Cell Biol. 2014;15(3):178–196. doi:10.1038/nrm3758
   PubMed Web of Science ®Google Scholar