Two-Pronged Anti-Tumor Therapy by a New Polymer-Paclitaxel Conjugate Micelle with an Anti-Multidrug Resistance Effect

References

• Smith RA, Andrews KS, Brooks D, et al. Cancer screening in the United States, 2019: a review of current American Cancer Society guidelines and current issues in cancer screening. CA Cancer J Clin. 2019;69(3):184–210. doi:10.3322/caac.21557
   PubMed Web of Science ®Google Scholar
• Zheng P, Liu Y, Chen J, Xu W, Li G, Ding J. Targeted pH-responsive polyion complex micelle for controlled intracellular drug delivery. Chin Chem Letters. 2020;31(5):1178–1182. doi:10.1016/j.cclet.2019.12.001
   Web of Science ®Google Scholar
• Wang Y, Wang X, Zhang J, et al. Gambogic acid-encapsulated polymeric micelles improved therapeutic effects on pancreatic cancer. Chin Chem Letters. 2019;30(4):885–888. doi:10.1016/j.cclet.2019.02.018
   Web of Science ®Google Scholar
• Paul S, Moye-Rowley WS. Multidrug resistance in fungi: regulation of transporter-encoding gene expression. Front Physiol. 2014;5(143). doi:10.3389/fphys.2014.00143
   PubMed Web of Science ®Google Scholar
• Wu J, Lu Y, Lee A, et al. Reversal of multidrug resistance by transferrin-conjugated liposomes co-encapsulating doxorubicin and verapamil. J Pharm Pharm Sci. 2007;10(3):350–357.
   PubMed Web of Science ®Google Scholar
• Huo Q, Zhu J, Niu Y, et al. pH-triggered surface charge-switchable polymer micelles for the co-delivery of paclitaxel/disulfiram and overcoming multidrug resistance in cancer. Int J Nanomedicine. 2017;12:8631–8647. doi:10.2147/ijn.s144452
   PubMed Web of Science ®Google Scholar
• Wang J, Wang F, Li F, et al. A multifunctional poly(curcumin) nanomedicine for dual-modal targeted delivery, intracellular responsive release, dual-drug treatment and imaging of multidrug resistant cancer cells. J Mater Chem B. 2016;4(17):2954–2962. doi:10.1039/C5TB02450A
   PubMed Web of Science ®Google Scholar
• Zhou Y, Wang S, Ying X, et al. Doxorubicin-loaded redox-responsive micelles based on dextran and indomethacin for resistant breast cancer. Int J Nanomedicine. 2017;12:6153–6168. doi:10.2147/IJN.S141229
   PubMed Web of Science ®Google Scholar
• Zhang X, He F, Xiang K, et al. CD44-targeted facile enzymatic activatable chitosan nanoparticles for efficient antitumor therapy and reversal of multidrug resistance. Biomacromolecules. 2018;19(3):883–895. doi:10.1021/acs.biomac.7b01676
   PubMed Web of Science ®Google Scholar
• Yin S, Huai J, Chen X, et al. Intracellular delivery and antitumor effects of a redox-responsive polymeric paclitaxel conjugate based on hyaluronic acid. Acta Biomater. 2015;26:274–285. doi:10.1016/j.actbio.2015.08.029
   PubMed Web of Science ®Google Scholar
• Zhong Y, Goltsche K, Cheng L, et al. Hyaluronic acid-shelled acid-activatable paclitaxel prodrug micelles effectively target and treat CD44-overexpressing human breast tumor xenografts in vivo. Biomaterials. 2016;84:250–261. doi:10.1016/j.biomaterials.2016.01.049
   PubMed Web of Science ®Google Scholar
• Zhang X, Wang S, Cheng G, Yu P, Chang J, Chen: X. Cascade drug-release strategy for enhanced anticancer therapy. Matter. 2021;4(1):26–53. doi:10.1016/j.matt.2020.10.002
   PubMed Web of Science ®Google Scholar
• Cao Y, Wei Z, Li M, et al. Formulation, pharmacokinetic evaluation and cytotoxicity of an enhanced-penetration paclitaxel nanosuspension. Curr Cancer Drug Targets. 2019;19(4):338–347. doi:10.2174/1568009618666180629150927
   PubMed Web of Science ®Google Scholar
• Zong L, Wang H, Hou X, et al. A novel GSH-triggered polymeric nanomicelles for reversing MDR and enhancing antitumor efficiency of hydroxycamptothecin. Int J Pharm. 2021;600:120528. doi:10.1016/j.ijpharm.2021.120528
   PubMed Web of Science ®Google Scholar
• Huizing MT, Misser VHS, Pieters RC, et al. Taxanes: a new class of antitumor agents. Cancer Invest. 1995;13(4):381–404. doi:10.3109/07357909509031919
   PubMed Web of Science ®Google Scholar
• Kou L, Sun R, Xiao S, et al. OCTN2-targeted nanoparticles for oral delivery of paclitaxel: differential impact of the polyethylene glycol linker size on drug delivery in vitro, in situ, and in vivo. Drug Deliv. 2020;27(1):170–179. doi:10.1080/10717544.2019.1710623
   PubMed Web of Science ®Google Scholar
• Li H, Li J, He X, et al. Histology and antitumor activity study of PTX-loaded micelle, a fluorescent drug delivery system prepared by PEG-TPP. Chin Chem Letters. 2019;30(5):1083–1088. doi:10.1016/j.cclet.2019.01.003
   Web of Science ®Google Scholar
• Zhang B, Xue A, Zhang C, Yu J, Chen W, Sun: D. Bile salt liposomes for enhanced lymphatic transport and oral bioavailability of paclitaxel. Pharmazie. 2016;71(6):320–326.
   PubMed Web of Science ®Google Scholar
• Jang SH, Wientjes MG, Au: JLS. Kinetics of P-glycoprotein-mediated efflux of paclitaxel. J Pharmacol Exp Ther. 2001;298(3):1236–1242.
   PubMed Web of Science ®Google Scholar
• Gallo JM, Li S, Guo P, Reed K, Ma: J. The effect of P-glycoprotein on paclitaxel brain and brain tumor distribution in mice. Cancer Res. 2003;63(16):5114–5117.
   PubMed Web of Science ®Google Scholar
• Li M, Chen Y, Yin L, et al. Formulation and stability evaluation of structure-altered paclitaxel nanosuspensions stabilized by a biocompatible amino acid copolymer. Sci Adv Mater. 2017;9(10):1713–1723. doi:10.1166/sam.2017.3229
   Web of Science ®Google Scholar
• Yu M, Su D, Yang Y, et al. D-T7 peptide-modified PEGylated bilirubin nanoparticles loaded with cediranib and paclitaxel for antiangiogenesis and chemotherapy of glioma. ACS Appl Mater Interfaces. 2019;11(1):176–186. doi:10.1021/acsami.8b16219
   PubMed Web of Science ®Google Scholar
• Zhang J, Du Q, Song X, et al. Evaluation of the tumor-targeting efficiency and intratumor heterogeneity of anticancer drugs using quantitative mass spectrometry imaging. Theranostics. 2020;10(6):2621–2630. doi:10.7150/thno.41763
   PubMed Web of Science ®Google Scholar
• Ding D, Sun B, Cui W, et al. Integration of phospholipid-drug complex into self-nanoemulsifying drug delivery system to facilitate oral delivery of paclitaxel. Asian J Pharmaceut Sci. 2019;14(5):552–558. doi:10.1016/j.ajps.2018.10.003
   PubMed Web of Science ®Google Scholar
• Liu Y, Sun J, Cao W, et al. Dual targeting folate-conjugated hyaluronic acid polymeric micelles for paclitaxel delivery. Int J Pharm. 2011;421(1):160–169. doi:10.1016/j.ijpharm.2011.09.006
   PubMed Web of Science ®Google Scholar
• Chang S, Wang Y, Zhang T, et al. Redox-responsive disulfide bond-bridged mpeg-pbla prodrug micelles for enhanced paclitaxel biosafety and antitumor efficacy. Front Oncol. 2019;9(823). doi:10.3389/fonc.2019.00823
   Web of Science ®Google Scholar
• Luo C, Sun B, Wang C, et al. Self-facilitated ROS-responsive nanoassembly of heterotypic dimer for synergistic chemo-photodynamic therapy. J Controlled Release. 2019;302:79–89. doi:10.1016/j.jconrel.2019.04.001
   PubMed Web of Science ®Google Scholar
• Zong L, Wang Y, Qiao P, et al. Reduction-sensitive poly(ethylene glycol)–polypeptide conjugate micelles for highly efficient intracellular delivery and enhanced antitumor efficacy of hydroxycamptothecin. Nanotechnology. 2020;31(16):165102. doi:10.1088/1361-6528/ab6749
   PubMed Web of Science ®Google Scholar
• Pu X, Zhao L, Li J, et al. A polymeric micelle with an endosomal pH-sensitivity for intracellular delivery and enhanced antitumor efficacy of hydroxycamptothecin. Acta Biomater. 2019;88:357–369. doi:10.1016/j.actbio.2019.02.039
   PubMed Web of Science ®Google Scholar
• Qiao Y, Wei Z, Qin T, et al. Combined nanosuspensions from two natural active ingredients for cancer therapy with reduced side effects. Chin Chem Letters. 2021;32(9):2877–2881. doi:10.1016/j.cclet.2021.03.049
   Web of Science ®Google Scholar
• Luo C, Sun J, Sun B, et al. Facile fabrication of tumor redox-sensitive nanoassemblies of small-molecule oleate prodrug as potent chemotherapeutic nanomedicine. Small. 2016;12(46):6353–6362. doi:10.1002/smll.201601597
   PubMed Web of Science ®Google Scholar
• Liu H, Wu S, Yu J, et al. Reduction-sensitive micelles self-assembled from amphiphilic chondroitin sulfate A-deoxycholic acid conjugate for triggered release of doxorubicin. Mater Sci Eng C Mater Biol Appl. 2017;75:55–63. doi:10.1016/j.msec.2017.02.030
   PubMed Web of Science ®Google Scholar
• Collnot EM, Baldes C, Wempe MF, et al. Mechanism of inhibition of P-glycoprotein mediated efflux by vitamin E TPGS: influence on ATPase activity and membrane fluidity. Mol Pharm. 2007;4(3):465–474. doi:10.1021/mp060121r
   PubMed Web of Science ®Google Scholar
• Gao Y, Li LB, Zhai: G. Preparation and characterization of Pluronic/TPGS mixed micelles for solubilization of camptothecin. Colloids Surf B Biointerfaces. 2008;64(2):194–199. doi:10.1016/j.colsurfb.2008.01.021
   PubMed Web of Science ®Google Scholar
• Tung NT, Tran CS, Pham TM, et al. Development of solidified self-microemulsifying drug delivery systems containing l-tetrahydropalmatine: design of experiment approach and bioavailability comparison. Int J Pharm. 2018;537(1–2):9–21. doi:10.1016/j.ijpharm.2017.12.027
   PubMed Web of Science ®Google Scholar
• Taheri M, Bagheri M, Moazeni-Pourasil RS, Ghassempour: A. Response surface methodology based on central composite design accompanied by multivariate curve resolution to model gradient hydrophilic interaction liquid chromatography: prediction of separation for five major opium alkaloids. J Sep Sci. 2017;40(18):3602–3611. doi:10.1002/jssc.201700416
   PubMed Web of Science ®Google Scholar
• Alavi M, Nokhodchi: A. Micro- and nanoformulations of paclitaxel based on micelles, liposomes, cubosomes, and lipid nanoparticles: recent advances and challenges. Drug Discov Today. 2021. doi:10.1016/j.drudis.2021.10.007
   Web of Science ®Google Scholar
• Sun B, Luo C, Yu H, et al. Disulfide bond-driven oxidation- and reduction-responsive prodrug nanoassemblies for cancer therapy. Nano Lett. 2018;18(6):3643–3650. doi:10.1021/acs.nanolett.8b00737
   PubMed Web of Science ®Google Scholar
• Yu W, Shevtsov M, Chen X, Gao: H. Advances in aggregatable nanoparticles for tumor-targeted drug delivery. Chin Chem Letters. 2020;31(6):1366–1374. doi:10.1016/j.cclet.2020.02.036
   Web of Science ®Google Scholar
• Chi Y, Yin X, Sun K, et al. Redox-sensitive and hyaluronic acid functionalized liposomes for cytoplasmic drug delivery to osteosarcoma in animal models. J Control Release. 2017;261:113–125. doi:10.1016/j.jconrel.2017.06.027
   PubMed Web of Science ®Google Scholar
• Liu MC, Liu B, Sun XY, et al. Core/Shell structured Fe(3)O(4)@TiO(2)-DNM nanospheres as multifunctional anticancer platform: chemotherapy and photodynamic therapy research. J Nanosci Nanotechnol. 2018;18(7):4445–4456. doi:10.1166/jnn.2018.15338
   PubMed Web of Science ®Google Scholar
• Yang X, Cai X, Yu A, Xi Y, Zhai: G. Redox-sensitive self-assembled nanoparticles based on alpha-tocopherol succinate-modified heparin for intracellular delivery of paclitaxel. J Colloid Interface Sci. 2017;496:311–326. doi:10.1016/j.jcis.2017.02.033
   PubMed Web of Science ®Google Scholar
• Zhang J, Zhao X, Chen Q, et al. Systematic evaluation of multifunctional paclitaxel-loaded polymeric mixed micelles as a potential anticancer remedy to overcome multidrug resistance. Acta Biomater. 2017;50:381–395. doi:10.1016/j.actbio.2016.12.021
   PubMed Web of Science ®Google Scholar
• Gu Y, Zhong Y, Meng F, Cheng R, Deng C, Zhong: Z. Acetal-linked paclitaxel prodrug micellar nanoparticles as a versatile and potent platform for cancer therapy. Biomacromolecules. 2013;14(8):2772–2780. doi:10.1021/bm400615n
   PubMed Web of Science ®Google Scholar
• Yang B, Wang K, Zhang D, et al. Polydopamine-modified ROS-responsive prodrug nanoplatform with enhanced stability for precise treatment of breast cancer. RSC Adv. 2019;9(16):9260–9269. doi:10.1039/c9ra01230c
   PubMed Web of Science ®Google Scholar
• Sun B, Luo C, Zhang X, et al. Probing the impact of sulfur/selenium/carbon linkages on prodrug nanoassemblies for cancer therapy. Nat Commun. 2019;10(1):3211. doi:10.1038/s41467-019-11193-x
   PubMed Web of Science ®Google Scholar
• Fjallskog ML, Frii L, Bergh: J, Is Cremophor EL. Solvent for paclitaxel, cytotoxic? Lancet. 1993;342(8875):873. doi:10.1016/0140-6736(93)92735-C
   PubMed Web of Science ®Google Scholar
• Rowinsky EK, Donehower: RC. Paclitaxel (taxol). N Engl J Med. 1995;332(15):1004–1014. doi:10.1056/NEJM199504133321507
   PubMed Web of Science ®Google Scholar
• Malingrг© MM, Terwogt JM, Beijnen JH, et al. Phase I and pharmacokinetic study of oral paclitaxel. J clin oncol. 2000;18(12):2468. doi:10.1200/JCO.2000.18.12.2468
   PubMed Web of Science ®Google Scholar
• Chen ZP, Zhu JB, Chen HX, et al. Synthesis of a novel polymer bile salts-(polyethylene glycol)2000-bile salts and its application to the liver-selective targeting of liposomal DDB. Drug Dev Ind Pharm. 2010;36(6):657–665. doi:10.3109/03639040903410342
   PubMed Web of Science ®Google Scholar
• Chen ZP, Xiao L, Liu W, et al. Novel materials which possess the ability to target liver cells. Expert Opin Drug Deliv. 2012;9(6):649–656. doi:10.1517/17425247.2012.679261
   PubMed Web of Science ®Google Scholar
• Putz G, Schmider W, Nitschke R, Kurz G, Blum: HE. Synthesis of phospholipid-conjugated bile salts and interaction of bile salt-coated liposomes with cultured hepatocytes. J Lipid Res. 2005;46(11):2325–2338. doi:10.1194/jlr.M500144-JLR200
   PubMed Web of Science ®Google Scholar
• Parks DJ, Blanchard SG, Bledsoe RK, et al. Bile acids: natural ligands for an orphan nuclear receptor. Science. 1999;284(5418):1365–1368. doi:10.1126/science.284.5418.1365
   PubMed Web of Science ®Google Scholar
• Li Z, Zhu J, Wang Y, et al. In situ apolipoprotein E-enriched Corona guides dihydroartemisinin-decorating nanoparticles towards LDLr-mediated tumor-homing chemotherapy. Asian J Pharm Sci. 2020;15(4):482–491. doi:10.1016/j.ajps.2019.05.002
   PubMed Web of Science ®Google Scholar
• Wang Y, Song J, Chow SF, Chow AH, Zheng: Y. Particle size tailoring of ursolic acid nanosuspensions for improved anticancer activity by controlled antisolvent precipitation. Int J Pharm. 2015;494(1):479–489. doi:10.1016/j.ijpharm.2015.08.052
   PubMed Web of Science ®Google Scholar
• Hashizume H, Baluk P, Morikawa S, et al. Openings between defective endothelial cells explain tumor vessel leakiness. Am J Pathol. 2000;156(4):1363–1380. doi:10.1016/s0002-9440(10)65006-7
   PubMed Web of Science ®Google Scholar