126
Views
67
CrossRef citations to date
0
Altmetric
Original Research

Indomethacin-loaded lipid-core nanocapsules reduce the damage triggered by Aβ1-42 in Alzheimer’s disease models

, , , , , , & show all
Pages 4927-4942 | Published online: 13 Sep 2012

References

  • LeeYJHanSBNamSYOhKWHongJTInflammation and Alzheimer’s diseaseArch Pharm Res201033101539155621052932
  • McGeerEGMcGeerPLNeuroinflammation in Alzheimer’s disease and mild cognitive impairment: a field in its infancyJ Alzheimers Dis201019135536120061650
  • HensleyKNeuroinflammation in Alzheimer’s disease: mechanisms, pathologic consequences, and potential for therapeutic manipulationJ Alzheimers Dis201021111420182045
  • CagninABrooksDJKennedyAMIn-vivo measurement of activated microglia in dementiaLancet2001358928046146711513911
  • ParachikovaAAgadjanyanMGCribbsDHInflammatory changes parallel the early stages of Alzheimer diseaseNeurobiol Aging200728121821183317052803
  • SimardARSouletDGowingGJulienJPRivestSBone marrow-derived microglia play a critical role in restricting senile plaque formation in Alzheimer’s diseaseNeuron200649448950216476660
  • HickmanSEAllisonEKEl KhouryJMicroglial dysfunction and defective beta-amyloid clearance pathways in aging Alzheimer’s disease miceJ Neurosci200828338354836018701698
  • ChenYVartiainenNEYingWChanPHKoistinahoJSwansonRAAstrocytes protect neurons from nitric oxide toxicity by a glutathione-dependent mechanismJ Neurochem20017761601161011413243
  • JohnstoneMGearingAJMillerKMA central role for astrocytes in the inflammatory response to beta-amyloid; chemokines, cytokines and reactive oxygen species are producedJ Neuroimmunol1999931–218219310378882
  • WhitneyNPEidemTMPengHHuangYZhengJCInflammation mediates varying effects in neurogenesis: relevance to the pathogenesis of brain injury and neurodegenerative disordersJ Neurochem200910861343135919154336
  • AnismanHCascading effects of stressors and inflammatory immune system activation: implications for major depressive disorderJ Psychiatry Neurosci200934142019125209
  • McGeerPLMcGeerEGAnti-inflammatory drugs in the fight against Alzheimer’s diseaseAnn N Y Acad Sci1996777172132208624086
  • HoozemansJJRozemullerJMvan HaastertESVeerhuisREikelenboomPCyclooxygenase-1 and −2 in the different stages of Alzheimer’s disease pathologyCurr Pharm Des200814141419142718537664
  • KotilinekLAWestermanMAWangQCyclooxygenase-2 inhibition improves amyloid-beta-mediated suppression of memory and synaptic plasticityBrain2008131Pt 365166418292081
  • NetlandEENewtonJLMajochaRETateBAIndomethacin reverses the microglial response to amyloid beta-proteinNeurobiol Aging19981932012049661994
  • ParepallyJMMandulaHSmithQRBrain uptake of nonsteroidal anti-inflammatory drugs: ibuprofen, flurbiprofen, and indomethacinPharm Res200623587388116715377
  • SilvaGANanotechnology applications and approaches for neurore-generation and drug delivery to the central nervous systemAnn N Y Acad Sci2010119922123020633128
  • BrambillaDLe DroumaguetBNicolasJNanotechnologies for Alzheimer’s disease: diagnosis, therapy, and safety issuesNanomedicine20117552154021477665
  • BernardiABraganholEJägerEIndomethacin-loaded nano-capsules treatment reduces in vivo glioblastoma growth in a rat glioma modelCancer Lett20092811536319286307
  • BernardiAFrozzaRLHornAPProtective effects of indomethacin-loaded nanocapsules against oxygen-glucose deprivation in organotypic hippocampal slice cultures: involvement of neuroinflammationNeurochem Int201057662963620691236
  • FrozzaRLBernardiAPaeseKCharacterization of trans-resveratrol-loaded lipid-core nanocapsules and tissue distribution studies in ratsJ Biomed Nanotechnol20106669470321361135
  • JägerEVenturiniCGPolettoFSSustained release from lipidcore nanocapsules by varying the core viscosity and the particle surface areaJ Biomed Nanotechnol20095113014020055116
  • PohlmannARSoaresLUCruzLda SilveiraNPGuterresSSAlkaline hydrolysis as a tool to determine the association form of indomethacin in nanocapsules prepared with poly(eta-caprolactone)Curr Drug Deliv20041210311016305375
  • NIHGuide for the Care and Use of Laboratory AnimalsNIH Publication Vol. No. 85-23 Revised 1985. Available from: http://oacu.od.nih.gov/regs/guide/guide.pdfAccessed 24 April, 2011
  • StoppiniLBuchsPAMullerDA simple method for organotypic cultures of nervous tissueJ Neurosci Methods19913721731821715499
  • FrozzaRLHornAPHoppeJBA comparative study of beta-amyloid peptides Aβ1-42 and Aβ25–35 toxicity in organotypic hippocampal slice culturesNeurochem Res200934229530318686032
  • HoppeJBFrozzaRLHornAPAmyloid-β neurotoxicity in organotypic culture is attenuated by melatonin: involvement of GSK-3β, tau and neuroinflammationJ Pineal Res201048323023820136701
  • PaxinosGWatsonCThe Rat Brain in Stereotaxic Coordinates5th edBurlingtonElsevierAcademic Press2005
  • HughesRNThe value of spontaneous alternation behavior (SAB) as a test of retention in pharmacological investigations of memoryNeurosci Biobehav Rev200428549750515465137
  • BevinsRABesheerJObject recognition in rats and mice: a one-trial non-matching-to-sample learning task to study ‘recognition memory’Nat Protocol20061313061311
  • EnnaceurADelacourJA new one-trial test for neurobiological studies of memory in rats. 1. Behavioral dataBehav Brain Res198831147593228475
  • PetersonGLReview of the folin-phenol protein quantification method of Lowry, Rosebrough, Farr and RandallAnal Biochem19791002201220393128
  • WalshDMSelkoeDJDeciphering the molecular basis of memory failure in Alzheimer’s diseaseNeuron200444118119315450169
  • Wyss-CorayTInflammation in Alzheimer’s disease: driving force bystander or beneficial response?Nat Med20061291005101516960575
  • WalshDMKlyubinIFadeevaJVNaturally secreted oligomers of amyloid beta protein potently inhibit hippocampal long-term potentiation in vivoNature2002416688053553911932745
  • FerreiraSTKleinWLThe Aβ oligomer hypothesis for synapse failure and memory loss in Alzheimer’s diseaseNeurobiol Learn Mem201196452954321914486
  • SelkoeDJResolving controversies on the path to Alzheimer’s therapeuticsNat Med20111791060106521900936
  • MuckeLSelkoeDJNeurotoxicity of amyloid β-protein: synaptic and network dysfunctionCold Spring Harb Perspect Med201227a00633822762015
  • ShankarGMLiSMehtaTHAmyloid-b protein dimers isolated directly from Alzheimer’s brains impair synaptic plasticity and memoryNat Med200814883784218568035
  • FrotscherMZafirovSHeimrichBDevelopment of identified neuronal types and of specific synaptic connection in slice cultures of rat hippocampusProg Neurobiol19954561431647598766
  • HolopainenIEOrganotypic hippocampal slice cultures: a model system to study basic cellular and molecular mechanisms of neuronal cell death, neuroprotection, and synaptic plasticityNeurochem Res200530121521152816362771
  • Woodruff-PakDSAnimal models of Alzheimer’s disease: therapeutic implicationsJ Alzheimers Dis200815450752119096153
  • JongDFJansenRHoefnagelsWNo effect of one-year treatment with indomethacin on Alzheimer’s disease progression: a randomized controlled trialPlos One200831e147518213383
  • PotschkaHTargeting the brain – surmounting or bypassing the blood– brain barrierHandb Exp Pharmacol201019741143120217538
  • KeanWFBuchananWWThe use of NSAIDs in rheumatic disorders: a global perspectiveInflammopharmacology200513434337016354389
  • BernardiAZilbersteinACCVJagerEEffects of indomethacin-loaded nanocapsules in experimental model of inflammation in ratsBr J Pharmacol200915841104111119422380
  • DavdaJLabhasetwarVCharacterization of nanoparticle uptake by endothelial cellsInt J Pharm20022331–2515911897410
  • KayedRHeadEThompsonJLCommon structure of soluble amyloid oligomers implies common mechanism of pathogenesisScience2003300561848648912702875
  • MedeirosRPredigerRDPassosGFConnecting TNF-α signaling pathways to iNOS expression in a mouse model of Alzheimer’s disease: relevance for the behavioral and synaptic deficits induced by amyloid β proteinJ Neurosci200727205394540417507561
  • PassosGFFigueiredoCPPredigerRDSChemokine receptor 5 signaling pathway in the neuroinflammatory response and cognitive deficits induced by β-amyloid peptideAm J Pathol200917541586159719729478
  • LockmanPROyewumiMOKoziaraJMRoderKEMumperRJAllenDDBrain uptake of thiamine-coated nanoparticlesJ Control Release200393327128214644577
  • SahniJKDogguiSAliJBabootaSDaoLRamassamyCNeurotherapeutic applications of nanoparticles in Alzheimer’s diseaseJ Control Release2011152220823121134407
  • RamírezGToroRDöbeliHvon BernhardiRProtection of rat primary hippocampal cultures from AB cytotoxicity by pro-inflammatory molecules is mediated by astrocytesNeurobiol Dis2005191–224325415837580
  • SchultzbergMLindbergCAronssonAFHjorthESpulberSDOpricaMInflammation in the nervous system – physiological and pathophysiological aspectsPhysiol Behav2007921–212112817597167
  • Bozyczko-CoyneDO’KaneTMWuZLCEP-1347/KT-7515, an inhibitor of SAPK/JNK pathway activation, promotes survival and blocks multiple events associated with Abeta-induced cortical neuron apoptosisJ Neurochem200177384986311331414
  • WaetzigVHerdegenTNeurodegenerative and physiological actions of c-Jun N-terminal kinases in the mammalian brainNeurosci Lett20043611–3646715135894