Magnet-Guided Bionic System with LIFU Responsiveness and Natural Thrombus Tropism for Enhanced Thrombus-Targeting Ability

References

• Anderson JL, Halperin JL, Albert NM, et al. Management of patients with peripheral artery disease (compilation of 2005 and 2011 ACCF/AHA guideline recommendations): a report of the American college of cardiology foundation/American heart association task force on practice guidelines. Circulation. 2013;127(13):1425–1443. doi:10.1161/CIR.0b013e31828b82aa
   PubMed Web of Science ®Google Scholar
• Refaat A, Del Rosal B, Palasubramaniam J, et al. Near-infrared light-responsive liposomes for protein delivery: towards bleeding-free photothermally-assisted thrombolysis. J Control Release. 2021;337:212–223. doi:10.1016/j.jconrel.2021.07.024
   PubMed Web of Science ®Google Scholar
• Sun M, Miyazawa K, Pendekanti T, et al. Combination targeting of ‘platelets + fibrin’ enhances clot Anchorage efficiency of nanoparticles for vascular drug delivery. Nanoscale. 2020;12(41):21255–21270. doi:10.1039/d0nr03633a
   PubMed Web of Science ®Google Scholar
• Chung TW, Wang SS, Tsai WJ. Accelerating thrombolysis with chitosan-coated plasminogen activators encapsulated in poly-(lactide-co-glycolide) (PLGA) nanoparticles. Biomaterials. 2008;29(2):228–237. doi:10.1016/j.biomaterials.2007.09.027
   PubMed Web of Science ®Google Scholar
• Lu TY, Chiang CY, Fan YJ, et al. Dual-targeting glycol chitosan/heparin-decorated polypyrrole nanoparticle for augmented photothermal thrombolytic therapy. ACS Appl Mater Interfaces. 2021;13(8):10287–10300. doi:10.1021/acsami.0c20940
   PubMed Web of Science ®Google Scholar
• Wang Y, Xu X, Zhao X, Yin Z. Functionalized polymeric hybrid micelles as an efficient nanotheranostic agent for thrombus imaging and thrombolysis. Acta Biomater. 2021;122:278–290. doi:10.1016/j.actbio.2020.10.015
   PubMed Web of Science ®Google Scholar
• de Saint Victor M, Crake C, Coussios CC, Stride E. Properties, characteristics and applications of microbubbles for sonothrombolysis. Expert Opin Drug Deliv. 2014;11(2):187–209. doi:10.1517/17425247.2014.868434
   PubMed Web of Science ®Google Scholar
• Wang S, Guo X, Xiu W, et al. Accelerating thrombolysis using a precision and clot-penetrating drug delivery strategy by nanoparticle-shelled microbubbles. Sci Adv. 2020;6(31):eaaz8204. doi:10.1126/sciadv.aaz8204
   PubMed Web of Science ®Google Scholar
• Doelare SAN, Jean Pierre DM, Nederhoed JH, et al. Microbubbles and ultrasound accelerated thrombolysis for peripheral arterial occlusions: the outcomes of a single arm phase II trial. Eur J Vasc Endovasc Surg. 2021;62(3):463–468. doi:10.1016/j.ejvs.2021.05.030
   PubMed Web of Science ®Google Scholar
• Chen JP, Yang PC, Ma YH, et al. Characterization of chitosan magnetic nanoparticles for in situ delivery of tissue plasminogen activator. Carbohydr Polym. 2011;84(1):364–372. doi:10.1016/j.carbpol.2010.11.052
   Web of Science ®Google Scholar
• Moghanizadeh A, Ashrafizadeh F, Varshosaz J, Ferreira A. Study the effect of static magnetic field intensity on drug delivery by magnetic nanoparticles. Sci Rep. 2021;11(1):18056. doi:10.1038/s41598-021-97499-7
   PubMed Web of Science ®Google Scholar
• Ouyang H, Zheng Z, Chen Y, et al. A magnetically modified black phosphorus nanosheet-based heparin delivery platform for preventing DVT accurately. J Mater Chem B. 2019;7(40):6099–6108. doi:10.1039/c9tb01459d
   PubMed Web of Science ®Google Scholar
• Zhang Y, Zhou J, Guo D, Ao M, Zheng Y, Wang Z. Preparation and characterization of gadolinium-loaded PLGA particles surface modified with RGDS for the detection of thrombus. Int J Nanomedicine. 2013;8:3745–3756. doi:10.2147/IJN.S49835
   PubMed Web of Science ®Google Scholar
• Zhou J, Guo D, Zhang Y, Wu W, Ran H, Wang Z. Construction and evaluation of Fe3O4-based PLGA nanoparticles carrying rtPA used in the detection of thrombosis and in targeted thrombolysis. ACS Appl Mater Interfaces. 2014;6(8):5566–5576. doi:10.1021/am406008k
   PubMed Web of Science ®Google Scholar
• Xu J, Zhou J, Zhong Y, et al. Phase transition nanoparticles as multimodality contrast agents for the detection of thrombi and for targeting thrombolysis: in vitro and in vivo experiments. ACS Appl Mater Interfaces. 2017;9(49):42525–42535. doi:10.1021/acsami.7b12689
   PubMed Web of Science ®Google Scholar
• Zhong Y, Zhang Y, Xu J, et al. Low-intensity focused ultrasound-responsive phase-transitional nanoparticles for thrombolysis without vascular damage: a synergistic nonpharmaceutical strategy. ACS Nano. 2019;13(3):3387–3403. doi:10.1021/acsnano.8b09277
   PubMed Web of Science ®Google Scholar
• Ta HT, Li Z, Hagemeyer CE, et al. Molecular imaging of activated platelets via antibody-targeted ultra-small iron oxide nanoparticles displaying unique dual MRI contrast. Biomaterials. 2017;134:31–42. doi:10.1016/j.biomaterials.2017.04.037
   PubMed Web of Science ®Google Scholar
• Ta HT, Prabhu S, Leitner E, et al. Enzymatic single-chain antibody tagging: a universal approach to targeted molecular imaging and cell homing in cardiovascular disease. Circ Res. 2011;109(4):365–373. doi:10.1161/CIRCRESAHA.111.249375
   PubMed Web of Science ®Google Scholar
• Zhang Y, Zhong Y, Ye M, et al. Polydopamine-modified dual-ligand nanoparticles as highly effective and targeted magnetic resonance/photoacoustic dual-modality thrombus imaging agents. Int J Nanomedicine. 2019;14:7155–7171. doi:10.2147/IJN.S216603
   PubMed Web of Science ®Google Scholar
• Korin N, Kanapathipillai M, Matthews BD, et al. Shear-activated nanotherapeutics for drug targeting to obstructed blood vessels. Science. 2012;337(6095):738–742. doi:10.1126/science.1217815
   PubMed Web of Science ®Google Scholar
• Zhang W, Wang M, Tang W, et al. Nanoparticle-laden macrophages for tumor-tropic drug delivery. Adv Mater. 2018;30(50):e1805557. doi:10.1002/adma.201805557
   PubMed Web of Science ®Google Scholar
• Wang Q, Cheng H, Peng H, Zhou H, Li PY, Langer R. Non-genetic engineering of cells for drug delivery and cell-based therapy. Adv Drug Deliv Rev. 2015;91:125–140. doi:10.1016/j.addr.2014.12.003
   PubMed Web of Science ®Google Scholar
• Gao WJ, Liu JX, Liu MN, et al. Macrophage 3D migration: a potential therapeutic target for inflammation and deleterious progression in diseases. Pharmacol Res. 2021;167:105563. doi:10.1016/j.phrs.2021.105563
   PubMed Web of Science ®Google Scholar
• Yao Q, Yang G, Wang H, et al. Aging erythrocyte membranes as biomimetic nanometer carriers of liver-targeting chromium poisoning treatment. Drug Deliv. 2021;28(1):1455–1465. doi:10.1080/10717544.2021.1949075
   PubMed Web of Science ®Google Scholar
• Ding N, Dou C, Wang Y, et al. Antishear stress bionic carbon nanotube mesh coating with intracellular controlled drug delivery constructing small-diameter tissue-engineered vascular grafts. Adv Healthc Mater. 2018;7(11):e1800026. doi:10.1002/adhm.201800026
   PubMed Web of Science ®Google Scholar
• Albalawi AE, Khalaf AK, Alyousif MS, et al. Fe3O4@piroctone olamine magnetic nanoparticles: synthesize and therapeutic potential in cutaneous leishmaniasis. Biomed Pharmacother. 2021;139:111566. doi:10.1016/j.biopha.2021.111566
   PubMed Web of Science ®Google Scholar
• Li Q, Liu X, Chang M, Lu Z. Thrombolysis enhancing by magnetic manipulation of fe3o4 nanoparticles. Materials. 2018;11(11):2313. doi:10.3390/ma11112313
   PubMed Web of Science ®Google Scholar
• Heid S, Unterweger H, Tietze R, et al. Synthesis and characterization of tissue plasminogen activator-functionalized superparamagnetic iron oxide nanoparticles for targeted fibrin clot dissolution. Int J Mol Sci. 2017;18(9):1837. doi:10.3390/ijms18091837
   PubMed Web of Science ®Google Scholar
• Chen JP, Yang PC, Ma YH, Tu SJ, Lu YJ. Targeted delivery of tissue plasminogen activator by binding to silica-coated magnetic nanoparticle. Int J Nanomedicine. 2012;7:5137–5149. doi:10.2147/IJN.S36197
   PubMed Web of Science ®Google Scholar
• Ma YH, Wu SY, Wu T, Chang YJ, Hua MY, Chen JP. Magnetically targeted thrombolysis with recombinant tissue plasminogen activator bound to polyacrylic acid-coated nanoparticles. Biomaterials. 2009;30(19):3343–3351. doi:10.1016/j.biomaterials.2009.02.034
   PubMed Web of Science ®Google Scholar
• Zan P, Yang C, Sun H, Zhao L, Lv Z, He Y. One-pot fabricating Fe3O4/graphene nanocomposite with excellent biocompatibility and non-toxicity as a negative MR contrast agent. Colloids Surf B Biointerfaces. 2016;145:208–216. doi:10.1016/j.colsurfb.2016.04.049
   PubMed Web of Science ®Google Scholar
• Burtea C, Laurent S, Vander Elst L, Muller RN. Contrast agents: magnetic resonance. Handb Exp Pharmacol. 2008;(185 Pt 1):135–165. doi:10.1007/978-3-540-72718-7_7
   PubMedGoogle Scholar
• Bowary P, Greenberg BD. Noninvasive focused ultrasound for neuromodulation: a review. Psychiatr Clin North Am. 2018;41(3):505–514. doi:10.1016/j.psc.2018.04.010
   PubMed Web of Science ®Google Scholar
• Wang S, Li B, Li X, et al. Low-intensity ultrasound modulation may prevent myocardial infarction-induced sympathetic neural activation and ventricular arrhythmia. J Cardiovasc Pharmacol. 2020;75(5):432–438. doi:10.1097/FJC.0000000000000810
   PubMed Web of Science ®Google Scholar
• Bai S, Liao J, Zhang B, et al. Multimodal and multifunctional nanoparticles with platelet targeting ability and phase transition efficiency for the molecular imaging and thrombolysis of coronary microthrombi. Biomater Sci. 2020;8(18):5047–5060. doi:10.1039/d0bm00818d
   PubMed Web of Science ®Google Scholar
• Song F, Gao H, Li D, et al. Low intensity focused ultrasound responsive microcapsules for non-ablative ultrafast intracellular release of small molecules. J Mater Chem B. 2021;9(10):2384–2393. doi:10.1039/d0tb02788j
   PubMed Web of Science ®Google Scholar
• Ikehara Y, Niwa T, Biao L, et al. A carbohydrate recognition-based drug delivery and controlled release system using intraperitoneal macrophages as a cellular vehicle. Cancer Res. 2006;66(17):8740–8748. doi:10.1158/0008-5472.CAN-06-0470
   PubMed Web of Science ®Google Scholar
• Li X, Bottini M, Zhang L, et al. Core-satellite nanomedicines for in vivo real-time monitoring of enzyme-activatable drug release by fluorescence and photoacoustic dual-modal imaging. ACS Nano. 2019;13(1):176–186. doi:10.1021/acsnano.8b05136
   PubMed Web of Science ®Google Scholar
• Xu J, Zhou J, Zhong Y, et al. EWVDV-mediated platelet-targeting nanoparticles for the multimodal imaging of thrombi at different blood flow velocities. Int J Nanomedicine. 2020;15:1759–1770. doi:10.2147/IJN.S233968
   PubMed Web of Science ®Google Scholar
• Hathcock JJ. Flow effects on coagulation and thrombosis. Arterioscler Thromb Vasc Biol. 2006;26(8):1729–1737. doi:10.1161/01.ATV.0000229658.76797.30
   PubMed Web of Science ®Google Scholar
• Clifford PS. Local control of blood flow. Adv Physiol Educ. 2011;35(1):5–15. doi:10.1152/advan.00074.2010
   PubMed Web of Science ®Google Scholar
• Sahoo N, Sahoo RK, Biswas N, Guha A, Kuotsu K. Recent advancement of gelatin nanoparticles in drug and vaccine delivery. Int J Biol Macromol. 2015;81:317–331. doi:10.1016/j.ijbiomac.2015.08.006
   PubMed Web of Science ®Google Scholar
• Echave MC, Saenz Del Burgo L, Pedraz JL, Orive G. Gelatin as biomaterial for tissue engineering. Curr Pharm Des. 2017;23(24):3567–3584. doi:10.2174/0929867324666170511123101
   PubMed Web of Science ®Google Scholar
• Uesugi Y, Kawata H, Saito Y, Tabata Y. Ultrasound-responsive thrombus treatment with zinc-stabilized gelatin nano-complexes of tissue-type plasminogen activator. J Drug Target. 2012;20(3):224–234. doi:10.3109/1061186X.2011.633259
   PubMed Web of Science ®Google Scholar
• Kawata H, Uesugi Y, Soeda T, et al. A new drug delivery system for intravenous coronary thrombolysis with thrombus targeting and stealth activity recoverable by ultrasound. J Am Coll Cardiol. 2012;60(24):2550–2557. doi:10.1016/j.jacc.2012.08.1008
   PubMed Web of Science ®Google Scholar
• Ye M, Zhou J, Zhong Y, et al. SR-A-targeted phase-transition nanoparticles for the detection and treatment of atherosclerotic vulnerable plaques. ACS Appl Mater Interfaces. 2019;11(10):9702–9715. doi:10.1021/acsami.8b18190
   PubMed Web of Science ®Google Scholar
• Yi BG, Park OK, Jeong MS, et al. In vitro photodynamic effects of scavenger receptor targeted-photoactivatable nanoagents on activated macrophages. Int J Biol Macromol. 2017;97:181–189. doi:10.1016/j.ijbiomac.2017.01.037
   PubMed Web of Science ®Google Scholar
• Roszkowski W, Szmigielski S, Janiak M, Wrembel JK, Roszkowski K, Hryniewicz W. Effect of hyperthermia on rabbit macrophages. Immunobiology. 1980;157(2):122–131. doi:10.1016/S0171-2985(80)80094-5
   PubMed Web of Science ®Google Scholar
• Jiang N, Hu B, Cao S, et al. Stable low-dose oxygen release using h2o2/perfluoropentane phase-change nanoparticles with low-intensity focused ultrasound for coronary thrombolysis. Ultrasound Med Biol. 2020;46(10):2765–2774. doi:10.1016/j.ultrasmedbio.2020.06.004
   PubMed Web of Science ®Google Scholar
• Pyrillou K, Burzynski LC, Clarke MCH. Alternative pathways of IL-1 activation, and its role in health and disease. Front Immunol. 2020;11:613170. doi:10.3389/fimmu.2020.613170
   PubMed Web of Science ®Google Scholar
• Sah H, Thoma LA, Desu HR, Sah E, Wood GC. Concepts and practices used to develop functional PLGA-based nanoparticulate systems. Int J Nanomedicine. 2013;8:747–765. doi:10.2147/IJN.S40579
   PubMed Web of Science ®Google Scholar
• Rezvantalab S, Drude NI, Moraveji MK, et al. PLGA-based nanoparticles in cancer treatment. Front Pharmacol. 2018;9:1260. doi:10.3389/fphar.2018.01260
   PubMed Web of Science ®Google Scholar
• Hournkumnuard K, Natenapit M. Magnetic drug targeting by ferromagnetic microwires implanted within blood vessels. Med Phys. 2013;40(6):062302. doi:10.1118/1.4805097
   PubMed Web of Science ®Google Scholar