Nanomedicine: An Emerging Novel Therapeutic Strategy for Hemorrhagic Stroke

References

• Smith SD, Eskey CJ. Hemorrhagic stroke. Radiol Clin North Am. 2011;49(1):27–45. doi:10.1016/j.rcl.2010.07.011
   PubMed Web of Science ®Google Scholar
• Yang Q, Tong X, Schieb L, et al. Vital signs: recent trends in stroke death rates—United States, 2000–2015. Morb Mortal Wkly Rep. 2017;66(35):933. doi:10.15585/mmwr.mm6635e1
   PubMed Web of Science ®Google Scholar
• Chen S, Zeng L, Hu Z. Progressing haemorrhagic stroke: categories, causes, mechanisms and managements. J Neurol. 2014;261(11):2061–2078. doi:10.1007/s00415-014-7291-1
   PubMed Web of Science ®Google Scholar
• Caceres JA, Goldstein JN. Intracranial hemorrhage. Emerg Med Clin North Am. 2012;30(3):771–794. doi:10.1016/j.emc.2012.06.003
   PubMed Web of Science ®Google Scholar
• Mendelow AD, Gregson BA, Fernandes HM, et al. Early surgery versus initial conservative treatment in patients with spontaneous supratentorial intracerebral haematomas in the International Surgical Trial in Intracerebral Haemorrhage (STICH): a randomised trial. Lancet. 2005;365(9457):387–397. doi:10.1016/S0140-6736(05)70233-6
   PubMed Web of Science ®Google Scholar
• Mayer SA, Brun NC, Begtrup K, et al. Efficacy and safety of recombinant activated factor VII for acute intracerebral hemorrhage. N Engl J Med. 2008;358(20):2127–2137. doi:10.1056/NEJMoa0707534
   PubMed Web of Science ®Google Scholar
• Post R, Germans MR, Tjerkstra MA, et al. Ultra-early tranexamic acid after subarachnoid haemorrhage (ULTRA): a randomised controlled trial. Lancet. 2021;397(10269):112–118. doi:10.1016/S0140-6736(20)32518-6
   PubMed Web of Science ®Google Scholar
• Vergouwen MD, Meijers JC, Geskus RB, et al. Biologic effects of simvastatin in patients with aneurysmal subarachnoid hemorrhage: a double-blind, placebo-controlled randomized trial. J Cereb Blood Flow Metab. 2009;29(8):1444–1453. doi:10.1038/jcbfm.2009.59
   PubMed Web of Science ®Google Scholar
• Selim M, Foster LD, Moy CS, et al. Deferoxamine mesylate in patients with intracerebral haemorrhage (i-DEF): a multicentre, randomised, placebo-controlled, double-blind Phase 2 trial. Lancet Neurol. 2019;18(5):428–438. doi:10.1016/S1474-4422(19)30069-9
   PubMed Web of Science ®Google Scholar
• Dilnawaz F, Acharya S, Sahoo SK. Recent trends of nanomedicinal approaches in clinics. Int J Pharm. 2018;538(1–2):263–278. doi:10.1016/j.ijpharm.2018.01.016
   PubMed Web of Science ®Google Scholar
• Su S, Kang P. Recent advances in nanocarrier-assisted therapeutics delivery systems. Pharmaceutics. 2020;12(9):837. doi:10.3390/pharmaceutics12090837
   PubMed Web of Science ®Google Scholar
• Zheng H, Chen C, Zhang J, Hu Z. Mechanism and therapy of brain edema after intracerebral hemorrhage. Cerebrovasc Dis. 2016;42(3–4):155–169. doi:10.1159/000445170
   PubMed Web of Science ®Google Scholar
• Hayman EG, Wessell A, Gerzanich V, Sheth KN, Simard JM. Mechanisms of global cerebral edema formation in aneurysmal subarachnoid hemorrhage. Neurocrit Care. 2017;26(2):301–310. doi:10.1007/s12028-016-0354-7
   PubMed Web of Science ®Google Scholar
• Keep RF, Andjelkovic AV, Xiang J, et al. Brain endothelial cell junctions after cerebral hemorrhage: changes, mechanisms and therapeutic targets. J Cereb Blood Flow Metab. 2018;38(8):1255–1275. doi:10.1177/0271678X18774666
   PubMed Web of Science ®Google Scholar
• Chen S, Xu P, Fang Y, Lenahan C. The updated role of the blood brain barrier in subarachnoid hemorrhage: from basic and clinical studies. Curr Neuropharmacol. 2020;18(12):1266–1278. doi:10.2174/1570159X18666200914161231
   PubMed Web of Science ®Google Scholar
• Hu X, Tao C, Gan Q, Zheng J, Li H, You C. Oxidative stress in intracerebral hemorrhage: sources, mechanisms, and therapeutic targets. Oxid Med Cell Longev. 2016;2016:3215391. doi:10.1155/2016/3215391
   PubMed Web of Science ®Google Scholar
• Ayer R, Zhang JH. Oxidative stress in subarachnoid haemorrhage: significance in acute brain injury and vasospasm. In: Acta Neurochir Suppl. Springer; 2008:33–41.
   Google Scholar
• Khey KMW, Huard A, Mahmoud SH. Inflammatory pathways following subarachnoid hemorrhage. Cell Mol Neurobiol. 2020;40(5):675–693. doi:10.1007/s10571-019-00767-4
   PubMed Web of Science ®Google Scholar
• Zhang Z, Zhang Z, Lu H, Yang Q, Wu H, Wang J. Microglial polarization and inflammatory mediators after intracerebral hemorrhage. Mol Neurobiol. 2017;54(3):1874–1886. doi:10.1007/s12035-016-9785-6
   PubMed Web of Science ®Google Scholar
• van Lieshout JH, Dibue-Adjei M, Cornelius JF, et al. An introduction to the pathophysiology of aneurysmal subarachnoid hemorrhage. Neurosurg Rev. 2018;41(4):917–930. doi:10.1007/s10143-017-0827-y
   PubMed Web of Science ®Google Scholar
• Ciurea A, Palade C, Voinescu D, Nica D. Subarachnoid hemorrhage and cerebral vasospasm–literature review. J Med Life. 2013;6(2):120.
   PubMedGoogle Scholar
• Cordonnier C, Demchuk A, Ziai W, Anderson CS. Intracerebral haemorrhage: current approaches to acute management. Lancet. 2018;392(10154):1257–1268. doi:10.1016/S0140-6736(18)31878-6
   PubMed Web of Science ®Google Scholar
• Sharma D. Perioperative management of aneurysmal subarachnoid hemorrhage. Anesthesiology. 2020;133(6):1283–1305. doi:10.1097/ALN.0000000000003558
   PubMed Web of Science ®Google Scholar
• Liu‐DeRyke X, Rhoney D. Hemostatic therapy for the treatment of intracranial hemorrhage. Pharmacotherapy. 2008;28(4):485–495. doi:10.1592/phco.28.4.485
   PubMed Web of Science ®Google Scholar
• Marcolini E, Stretz C, DeWitt KM. Intracranial hemorrhage and intracranial hypertension. Emerg Med Clin North Am. 2019;37(3):529–544. doi:10.1016/j.emc.2019.04.001
   PubMed Web of Science ®Google Scholar
• Rajajee V, Pandey AS, Williamson CA. Subarachnoid hemorrhage and therapy formerly known as “Triple-H”-new directions. World Neurosurg. 2019;127:500–501. doi:10.1016/j.wneu.2019.04.212
   PubMed Web of Science ®Google Scholar
• Chakravarthi SS, Lyons L, Orozco AR, et al. Combined decompressive hemicraniectomy and port-based minimally invasive parafascicular surgery for the treatment of subcortical intracerebral hemorrhage: case series, technical note, and review of literature. World Neurosurg. 2021;146:e1226–e1235. doi:10.1016/j.wneu.2020.11.130
   PubMed Web of Science ®Google Scholar
• Zipfel GJ. Ultra-early surgery for aneurysmal subarachnoid hemorrhage. J Neurosurg. 2015;122(2):381–382. doi:10.3171/2014.8.JNS141613
   PubMed Web of Science ®Google Scholar
• Yang L, Wang F, Han H, Yang L, Zhang G, Fan Z. Functionalized graphene oxide as a drug carrier for loading pirfenidone in treatment of subarachnoid hemorrhage. Colloids Surf B Biointerfaces. 2015;129:21–29. doi:10.1016/j.colsurfb.2015.03.022
   PubMed Web of Science ®Google Scholar
• Dharmalingam P, Talakatta G, Mitra J, et al. Pervasive genomic damage in experimental intracerebral hemorrhage: therapeutic potential of a mechanistic-based carbon nanoparticle. ACS Nano. 2020;14(3):2827–2846. doi:10.1021/acsnano.9b05821
   PubMed Web of Science ®Google Scholar
• Zheng J, Lu J, Mei S, et al. Ceria nanoparticles ameliorate white matter injury after intracerebral hemorrhage: microglia-astrocyte involvement in remyelination. J Neuroinflammation. 2021;18(1):43. doi:10.1186/s12974-021-02101-6
   PubMed Web of Science ®Google Scholar
• Jeong HG, Cha BG, Kang DW, et al. Ceria nanoparticles synthesized with aminocaproic acid for the treatment of subarachnoid hemorrhage. Stroke. 2018;49(12):3030–3038. doi:10.1161/STROKEAHA.118.022631
   PubMed Web of Science ®Google Scholar
• Cha BG, Jeong H-G, Kang D-W, et al. Customized lipid-coated magnetic mesoporous silica nanoparticle doped with ceria nanoparticles for theragnosis of intracerebral hemorrhage. Nano Res. 2018;11(7):3582–3592. doi:10.1007/s12274-017-1924-5
   Web of Science ®Google Scholar
• Yang Y, Deng G, Wang P, et al. A selenium nanocomposite protects the mouse brain from oxidative injury following intracerebral hemorrhage. Int J Nanomedicine. 2021;16:775–788. doi:10.2147/IJN.S293681
   PubMed Web of Science ®Google Scholar
• Kang MK, Kim TJ, Kim YJ, et al. Targeted delivery of iron oxide nanoparticle-loaded human embryonic stem cell-derived spherical neural masses for treating intracerebral hemorrhage. Int J Mol Sci. 2020;21(10):3658.
   PubMed Web of Science ®Google Scholar
• Xu C, Qu X. Cerium oxide nanoparticle: a remarkably versatile rare earth nanomaterial for biological applications. NPG Asia Materials. 2014;6(3):e90–e90. doi:10.1038/am.2013.88
   Web of Science ®Google Scholar
• Kim CK, Kim T, Choi IY, et al. Ceria nanoparticles that can protect against ischemic stroke. Angew Chem Int Ed Engl. 2012;51(44):11039–11043. doi:10.1002/anie.201203780
   PubMed Web of Science ®Google Scholar
• Kwon HJ, Cha MY, Kim D, et al. Mitochondria-targeting ceria nanoparticles as antioxidants for alzheimer’s disease. ACS Nano. 2016;10(2):2860–2870. doi:10.1021/acsnano.5b08045
   PubMed Web of Science ®Google Scholar
• Kwon HJ, Kim D, Seo K, et al. Ceria nanoparticle systems for selective scavenging of mitochondrial, intracellular, and extracellular reactive oxygen species in parkinson’s disease. Angew Chem Int Ed Engl. 2018;57(30):9408–9412. doi:10.1002/anie.201805052
   PubMed Web of Science ®Google Scholar
• Zachara BA. Selenium and selenium-dependent antioxidants in chronic kidney disease. Adv Clin Chem. 2015;68:131–151.
   PubMed Web of Science ®Google Scholar
• Estelrich J, Escribano E, Queralt J, Busquets MA. Iron oxide nanoparticles for magnetically-guided and magnetically-responsive drug delivery. Int J Mol Sci. 2015;16(4):8070–8101. doi:10.3390/ijms16048070
   PubMed Web of Science ®Google Scholar
• Samuel EL, Duong MT, Bitner BR, Marcano DC, Tour JM, Kent TA. Hydrophilic carbon clusters as therapeutic, high-capacity antioxidants. Trends Biotechnol. 2014;32(10):501–505. doi:10.1016/j.tibtech.2014.08.005
   PubMed Web of Science ®Google Scholar
• Liu J, Cui L, Losic D. Graphene and graphene oxide as new nanocarriers for drug delivery applications. Acta Biomater. 2013;9(12):9243–9257. doi:10.1016/j.actbio.2013.08.016
   PubMed Web of Science ®Google Scholar
• Kiew SF, Kiew LV, Lee HB, Imae T, Chung LY. Assessing biocompatibility of graphene oxide-based nanocarriers: a review. J Control Release. 2016;226:217–228. doi:10.1016/j.jconrel.2016.02.015
   PubMed Web of Science ®Google Scholar
• Chang CZ, Wu SC, Lin CL, Kwan AL. Curcumin, encapsulated in nano-sized PLGA, down-regulates nuclear factor kappaB (p65) and subarachnoid hemorrhage induced early brain injury in a rat model. Brain Res. 2015;1608:215–224. doi:10.1016/j.brainres.2015.02.039
   PubMed Web of Science ®Google Scholar
• Zhang Z-Y, Jiang M, Fang J, et al. Enhanced therapeutic potential of nano-curcumin against subarachnoid hemorrhage-induced blood–brain barrier disruption through inhibition of inflammatory response and oxidative stress. Mol Neurobiol. 2017;54(1):1–14. doi:10.1007/s12035-015-9635-y
   PubMed Web of Science ®Google Scholar
• Li M, Liu G, Wang K, et al. Metal ion-responsive nanocarrier derived from phosphonated calix[4]arenes for delivering dauricine specifically to sites of brain injury in a mouse model of intracerebral hemorrhage. J Nanobiotechnology. 2020;18(1):61. doi:10.1186/s12951-020-00616-3
   PubMed Web of Science ®Google Scholar
• Mo Y, Duan L, Yang Y, et al. Nanoparticles improved resveratrol brain delivery and its therapeutic efficacy against intracerebral hemorrhage. Nanoscale. 2021;13(6):3827–3840. doi:10.1039/D0NR06249A
   PubMed Web of Science ®Google Scholar
• Chung CY, Yang JT, Kuo YC. Polybutylcyanoacrylate nanoparticles for delivering hormone response element-conjugated neurotrophin-3 to the brain of intracerebral hemorrhagic rats. Biomaterials. 2013;34(37):9717–9727. doi:10.1016/j.biomaterials.2013.08.083
   PubMed Web of Science ®Google Scholar
• You ZQ, Wu Q, Zhou XM, et al. Receptor-mediated delivery of astaxanthin-loaded nanoparticles to neurons: an enhanced potential for subarachnoid hemorrhage treatment. Front Neurosci. 2019;13:989. doi:10.3389/fnins.2019.00989
   PubMed Web of Science ®Google Scholar
• Zi L, Zhou W, Xu J, et al. Rosuvastatin nanomicelles target neuroinflammation and improve neurological deficit in a mouse model of intracerebral hemorrhage. Int J Nanomedicine. 2021;16:2933–2947. doi:10.2147/IJN.S294916
   PubMed Web of Science ®Google Scholar
• Zhu F, Zi L, Yang P, et al. Efficient Iron and ROS nanoscavengers for brain protection after intracerebral hemorrhage. ACS Appl Mater Interfaces. 2021;13(8):9729–9738. doi:10.1021/acsami.1c00491
   PubMed Web of Science ®Google Scholar
• Chonpathompikunlert P, Fan C-H, Ozaki Y, Yoshitomi T, Yeh C-K, Nagasaki Y. Redox nanoparticle treatment protects against neurological deficit in focused ultrasound-induced intracerebral hemorrhage. Nanomedicine. 2012;7(7):1029–1043. doi:10.2217/nnm.12.2
   PubMed Web of Science ®Google Scholar
• Tian XH, Wang ZG, Meng H, et al. Tat peptide-decorated gelatin-siloxane nanoparticles for delivery of CGRP transgene in treatment of cerebral vasospasm. Int J Nanomedicine. 2013;8:865–876. doi:10.2147/IJN.S39951
   PubMed Web of Science ®Google Scholar
• El-Say KM, El-Sawy HS. Polymeric nanoparticles: promising platform for drug delivery. Int J Pharm. 2017;528(1–2):675–691. doi:10.1016/j.ijpharm.2017.06.052
   PubMed Web of Science ®Google Scholar
• Danhier F, Ansorena E, Silva JM, Coco R, Le Breton A, Preat V. PLGA-based nanoparticles: an overview of biomedical applications. J Control Release. 2012;161(2):505–522. doi:10.1016/j.jconrel.2012.01.043
   PubMed Web of Science ®Google Scholar
• Dash TK, Konkimalla VB. Poly-small je, Ukrainian-caprolactone based formulations for drug delivery and tissue engineering: a review. J Control Release. 2012;158(1):15–33.
   PubMed Web of Science ®Google Scholar
• Grossen P, Witzigmann D, Sieber S, Huwyler J. PEG-PCL-based nanomedicines: a biodegradable drug delivery system and its application. J Control Release. 2017;260:46–60. doi:10.1016/j.jconrel.2017.05.028
   PubMed Web of Science ®Google Scholar
• Li Y, Gao J, Zhang C, et al. Stimuli-responsive polymeric nanocarriers for efficient gene delivery. Top Curr Chem. 2017;375(2):27. doi:10.1007/s41061-017-0119-6
   Web of Science ®Google Scholar
• Duan J, Zhang Y, Chen W, et al. Cationic polybutyl cyanoacrylate nanoparticles for DNA delivery. J Biomed Biotechnol. 2009;2009:149254. doi:10.1155/2009/149254
   PubMedGoogle Scholar
• Lin Y, Pan Y, Shi Y, Huang X, Jia N, Jiang JY. Delivery of large molecules via poly(butyl cyanoacrylate) nanoparticles into the injured rat brain. Nanotechnology. 2012;23(16):165101. doi:10.1088/0957-4484/23/16/165101
   PubMed Web of Science ®Google Scholar
• Madkhali O, Mekhail G, Wettig SD. Modified gelatin nanoparticles for gene delivery. Int J Pharm. 2019;554:224–234. doi:10.1016/j.ijpharm.2018.11.001
   PubMed Web of Science ®Google Scholar
• Galho AR, Cordeiro MF, Ribeiro SA, et al. Protective role of free and quercetin-loaded nanoemulsion against damage induced by intracerebral haemorrhage in rats. Nanotechnology. 2016;27(17):175101. doi:10.1088/0957-4484/27/17/175101
   PubMed Web of Science ®Google Scholar
• Marques MS, Cordeiro MF, Marinho MAG, et al. Curcumin-loaded nanoemulsion improves haemorrhagic stroke recovery in wistar rats. Brain Res. 2020;1746:147007. doi:10.1016/j.brainres.2020.147007
   PubMed Web of Science ®Google Scholar
• Wang F, Teng Z, Liu D, Wang Y, Lou J, Dong Z. beta-caryophyllene liposomes attenuate neurovascular unit damage after subarachnoid hemorrhage in rats. Neurochem Res. 2020;45(8):1758–1768. doi:10.1007/s11064-020-03037-8
   PubMed Web of Science ®Google Scholar
• Miao YF, Peng T, Moody MR, et al. Delivery of xenon-containing echogenic liposomes inhibits early brain injury following subarachnoid hemorrhage. Sci Rep. 2018;8(1):450. doi:10.1038/s41598-017-18914-6
   PubMed Web of Science ®Google Scholar
• Takanashi Y, Ishida T, Meguro T, Kiwada H, Zhang JH, Yamamoto I. Efficacy of intrathecal liposomal fasudil for experimental cerebral vasospasm after subarachnoid hemorrhage. Neurosurgery. 2001;48(4):894–901. doi:10.1097/00006123-200104000-00041
   PubMed Web of Science ®Google Scholar
• Mohsen K, Azzazy HME, Allam NK, Basalious EB. Intranasal lipid nanocapsules for systemic delivery of nimodipine into the brain: in vitro optimization and in vivo pharmacokinetic study. Mater Sci Eng C Mater Biol Appl. 2020;116:111236. doi:10.1016/j.msec.2020.111236
   PubMed Web of Science ®Google Scholar
• Kim H, Britton GL, Peng T, Holland CK, McPherson DD, Huang SL. Nitric oxide-loaded echogenic liposomes for treatment of vasospasm following subarachnoid hemorrhage. Int J Nanomedicine. 2014;9:155–165. doi:10.2147/IJN.S48856
   PubMed Web of Science ®Google Scholar
• Allen TM, Cullis PR. Liposomal drug delivery systems: from concept to clinical applications. Adv Drug Deliv Rev. 2013;65(1):36–48. doi:10.1016/j.addr.2012.09.037
   PubMed Web of Science ®Google Scholar
• Ishida T, Harashima H, Kiwada H. Liposome clearance. Biosci Rep. 2002;22(2):197–224. doi:10.1023/A:1020134521778
   PubMed Web of Science ®Google Scholar
• Yan X, Scherphof GL, Kamps JA. Liposome opsonization. J Liposome Res. 2005;15(1–2):109–139. doi:10.1081/LPR-64971
   PubMed Web of Science ®Google Scholar
• Hosny KM, Khallaf RA, Asfour HZ, et al. Development and optimization of cinnamon oil nanoemulgel for enhancement of solubility and evaluation of antibacterial, antifungal and analgesic effects against oral microbiota. Pharmaceutics. 2021;13(7):1008. doi:10.3390/pharmaceutics13071008
   PubMed Web of Science ®Google Scholar
• Jaromin A, Parapini S, Basilico N, et al. Azacarbazole n-3 and n-6 polyunsaturated fatty acids ethyl esters nanoemulsion with enhanced efficacy against Plasmodium falciparum. Bioact Mater. 2021;6(4):1163–1174. doi:10.1016/j.bioactmat.2020.10.004
   PubMed Web of Science ®Google Scholar
• Nel J, Desmet CM, Driesschaert B, Saulnier P, Lemaire L, Gallez B. Preparation and evaluation of trityl-loaded lipid nanocapsules as oxygen sensors for electron paramagnetic resonance oximetry. Int J Pharm. 2019;554:87–92. doi:10.1016/j.ijpharm.2018.11.007
   PubMed Web of Science ®Google Scholar
• Moura RP, Pacheco C, Pego AP, Des Rieux A, Sarmento B. Lipid nanocapsules to enhance drug bioavailability to the central nervous system. J Control Release. 2020;322:390–400. doi:10.1016/j.jconrel.2020.03.042
   PubMed Web of Science ®Google Scholar
• Sang LY, Liang YX, Li Y, et al. A self-assembling nanomaterial reduces acute brain injury and enhances functional recovery in a rat model of intracerebral hemorrhage. Nanomedicine. 2015;11(3):611–620. doi:10.1016/j.nano.2014.05.012
   PubMed Web of Science ®Google Scholar
• Zhang N, Luo Y, He L, Zhou L, Wu W. A self-assembly peptide nanofibrous scaffold reduces inflammatory response and promotes functional recovery in a mouse model of intracerebral hemorrhage. Nanomedicine. 2016;12(5):1205–1217. doi:10.1016/j.nano.2015.12.387
   PubMed Web of Science ®Google Scholar
• Park J, Kim JY, Choi SK, et al. Thermo-sensitive assembly of the biomaterial REP reduces hematoma volume following collagenase-induced intracerebral hemorrhage in rats. Nanomedicine. 2017;13(6):1853–1862. doi:10.1016/j.nano.2017.04.001
   PubMed Web of Science ®Google Scholar
• Gelain F, Luo Z, Zhang S. Self-assembling peptide EAK16 and RADA16 nanofiber scaffold hydrogel. Chem Rev. 2020;120(24):13434–13460. doi:10.1021/acs.chemrev.0c00690
   PubMed Web of Science ®Google Scholar
• Somaa FA, Wang TY, Niclis JC, et al. Peptide-based scaffolds support human cortical progenitor graft integration to reduce atrophy and promote functional repair in a model of stroke. Cell Rep. 2017;20(8):1964–1977. doi:10.1016/j.celrep.2017.07.069
   PubMed Web of Science ®Google Scholar
• Yokoi H, Kinoshita T, Zhang S. Dynamic reassembly of peptide RADA16 nanofiber scaffold. Proc Natl Acad Sci U S A. 2005;102(24):8414–8419. doi:10.1073/pnas.0407843102
   PubMed Web of Science ®Google Scholar
• Ellis-Behnke RG, Liang YX, You SW, et al. Nano neuro knitting: peptide nanofiber scaffold for brain repair and axon regeneration with functional return of vision. Proc Natl Acad Sci U S A. 2006;103(13):5054–5059. doi:10.1073/pnas.0600559103
   PubMed Web of Science ®Google Scholar
• Guo J, Su H, Zeng Y, et al. Reknitting the injured spinal cord by self-assembling peptide nanofiber scaffold. Nanomedicine. 2007;3(4):311–321. doi:10.1016/j.nano.2007.09.003
   PubMed Web of Science ®Google Scholar
• Holmes TC, de Lacalle S, Su X, Liu G, Rich A, Zhang S. Extensive neurite outgrowth and active synapse formation on self-assembling peptide scaffolds. Proc Natl Acad Sci. 2000;97(12):6728–6733. doi:10.1073/pnas.97.12.6728
   PubMed Web of Science ®Google Scholar
• Cao H, Liu T, Chew SY. The application of nanofibrous scaffolds in neural tissue engineering. Adv Drug Deliv Rev. 2009;61(12):1055–1064. doi:10.1016/j.addr.2009.07.009
   PubMed Web of Science ®Google Scholar
• Kam L, Shain W, Turner J, Bizios R. Axonal outgrowth of hippocampal neurons on micro-scale networks of polylysine-conjugated laminin. Biomaterials. 2001;22(10):1049–1054. doi:10.1016/S0142-9612(00)00352-5
   PubMed Web of Science ®Google Scholar
• Otero-Ortega L, Gomez de Frutos MC, Laso-Garcia F, et al. Exosomes promote restoration after an experimental animal model of intracerebral hemorrhage. J Cereb Blood Flow Metab. 2018;38(5):767–779. doi:10.1177/0271678X17708917
   PubMed Web of Science ®Google Scholar
• Shen H, Yao X, Li H, et al. Role of exosomes derived from miR-133b modified MSCs in an experimental rat model of intracerebral hemorrhage. J Mol Neurosci. 2018;64(3):421–430. doi:10.1007/s12031-018-1041-2
   PubMed Web of Science ®Google Scholar
• Gong Y, Wang Y, Qu Q, et al. Nanoparticle encapsulated core-shell hydrogel for on-site BMSCs delivery protects from iron overload and enhances functional recovery. J Control Release. 2020;320:381–391. doi:10.1016/j.jconrel.2020.01.029
   PubMed Web of Science ®Google Scholar
• Lim TC, Mandeville E, Weng D, et al. Hydrogel-based therapy for brain repair after intracerebral hemorrhage. Transl Stroke Res. 2020;11(3):412–417. doi:10.1007/s12975-019-00721-y
   PubMed Web of Science ®Google Scholar
• Zhu Q, Gong Y, Guo T, et al. Thermo-sensitive keratin hydrogel against iron-induced brain injury after experimental intracerebral hemorrhage. Int J Pharm. 2019;566:342–351. doi:10.1016/j.ijpharm.2019.05.076
   PubMed Web of Science ®Google Scholar
• Guo T, Guo Y, Gong Y, et al. An enhanced charge-driven intranasal delivery of nicardipine attenuates brain injury after intracerebral hemorrhage. Int J Pharm. 2019;566:46–56. doi:10.1016/j.ijpharm.2019.05.050
   PubMed Web of Science ®Google Scholar
• Xu J, Duan Z, Qi X, et al. Injectable gelatin hydrogel suppresses inflammation and enhances functional recovery in a mouse model of intracerebral hemorrhage. Front Bioeng Biotechnol. 2020;8:785. doi:10.3389/fbioe.2020.00785
   PubMed Web of Science ®Google Scholar
• He Y, Qu Q, Luo T, et al. Human hair keratin hydrogels alleviate rebleeding after intracerebral hemorrhage in a rat model. ACS Biomater Sci Eng. 2019;5(2):1113–1122. doi:10.1021/acsbiomaterials.8b01609
   PubMed Web of Science ®Google Scholar
• Liao W, Du Y, Zhang C, et al. Exosomes: the next generation of endogenous nanomaterials for advanced drug delivery and therapy. Acta Biomater. 2019;86:1–14. doi:10.1016/j.actbio.2018.12.045
   PubMed Web of Science ®Google Scholar
• Karavasili C, Fatouros DG. Smart materials: in situ gel-forming systems for nasal delivery. Drug Discov Today. 2016;21(1):157–166. doi:10.1016/j.drudis.2015.10.016
   PubMed Web of Science ®Google Scholar
• Anselmo AC, Mitragotri S. Nanoparticles in the clinic. Bioeng Transl Med. 2016;1(1):10–29. doi:10.1002/btm2.10003
   PubMed Web of Science ®Google Scholar
• Pedard M, El Amki M, Lefevre-Scelles A, Compere V, Castel H. Double direct injection of blood into the cisterna magna as a model of subarachnoid hemorrhage. J Vis Exp. 2020;162:e61322.
   Google Scholar
• Kirkman MA, Allan SM, Parry-Jones AR. Experimental intracerebral hemorrhage: avoiding pitfalls in translational research. J Cereb Blood Flow Metab. 2011;31(11):2135–2151. doi:10.1038/jcbfm.2011.124
   PubMed Web of Science ®Google Scholar
• James ML, Warner DS, Laskowitz DT. Preclinical models of intracerebral hemorrhage: a translational perspective. Neurocrit Care. 2008;9(1):139–152. doi:10.1007/s12028-007-9030-2
   PubMed Web of Science ®Google Scholar
• Sehba FA. The rat endovascular perforation model of subarachnoid hemorrhage. Acta Neurochir Suppl. 2015;120:321–324. doi:10.1007/978-3-319-04981-6_55
   PubMedGoogle Scholar
• Jia P, He J, Li Z, et al. Profiling of blood-brain barrier disruption in mouse intracerebral hemorrhage models: collagenase injection vs. autologous arterial whole blood infusion. Front Cell Neurosci. 2021;15:699736. doi:10.3389/fncel.2021.699736
   PubMed Web of Science ®Google Scholar
• Li Z, Liang G, Ma T, et al. Blood-brain barrier permeability change and regulation mechanism after subarachnoid hemorrhage. Metab Brain Dis. 2015;30(2):597–603. doi:10.1007/s11011-014-9609-1
   PubMed Web of Science ®Google Scholar
• Germano A, d’Avella D, Imperatore C, Caruso G, Tomasello F. Time-course of blood-brain barrier permeability changes after experimental subarachnoid haemorrhage. Acta neurochirurgica. 2000;142(5):575–581. doi:10.1007/s007010050472
   PubMed Web of Science ®Google Scholar
• Wu D, Ma Y, Cao Y, Zhang T. Mitochondrial toxicity of nanomaterials. Sci Total Environ. 2020;702:134994. doi:10.1016/j.scitotenv.2019.134994
   PubMed Web of Science ®Google Scholar
• Croissant JG, Fatieiev Y, Khashab NM. Degradability and clearance of silicon, organosilica, silsesquioxane, silica mixed oxide, and mesoporous silica nanoparticles. Adv Mater. 2017;29(9). doi:10.1002/adma.201604634
   PubMed Web of Science ®Google Scholar
• Bonnard T, Jayapadman A, Putri JA, et al. Low-fouling and biodegradable protein-based particles for thrombus imaging. ACS Nano. 2018;12(7):6988–6996. doi:10.1021/acsnano.8b02588
   PubMed Web of Science ®Google Scholar
• Starsich FH, Herrmann IK, Pratsinis SE. Nanoparticles for biomedicine: coagulation during synthesis and applications. Annu Rev Chem Biomol Eng. 2019;10:155–174. doi:10.1146/annurev-chembioeng-060718-030203
   PubMed Web of Science ®Google Scholar
• Bourquin J, Milosevic A, Hauser D, et al. Biodistribution, clearance, and long-term fate of clinically relevant nanomaterials. Adv Mater. 2018;30(19):e1704307. doi:10.1002/adma.201704307
   PubMed Web of Science ®Google Scholar
• Luk BT, Zhang L. Cell membrane-camouflaged nanoparticles for drug delivery. J Control Release. 2015;220:600–607. doi:10.1016/j.jconrel.2015.07.019
   PubMed Web of Science ®Google Scholar
• Dong X, Gao J, Zhang CY, Hayworth C, Frank M, Wang Z. Neutrophil membrane-derived nanovesicles alleviate inflammation to protect mouse brain injury from ischemic stroke. ACS Nano. 2019;13(2):1272–1283. doi:10.1021/acsnano.8b06572
   PubMed Web of Science ®Google Scholar
• Zhang CY, Dong X, Gao J, Lin W, Liu Z, Wang Z. Nanoparticle-induced neutrophil apoptosis increases survival in sepsis and alleviates neurological damage in stroke. Sci Adv. 2019;5(11):eaax7964. doi:10.1126/sciadv.aax7964
   PubMed Web of Science ®Google Scholar
• Mi P. Stimuli-responsive nanocarriers for drug delivery, tumor imaging, therapy and theranostics. Theranostics. 2020;10(10):4557–4588. doi:10.7150/thno.38069
   PubMed Web of Science ®Google Scholar