Controlled Release of TGF-β3 for Effective Local Endogenous Repair in IDD Using Rat Model

References

• Bonnevie E, Gullbrand S, Ashinsky B, et al. Aberrant mechanosensing in injured intervertebral discs as a result of boundary-constraint disruption and residual-strain loss. Nat Biomed Eng. 2019;3(12):998–1008. doi:10.1038/s41551-019-0458-4
   PubMed Web of Science ®Google Scholar
• Ji M, Jiang H, Zhang X, et al. Preclinical development of a microRNA-based therapy for intervertebral disc degeneration. Nat Commun. 2018;9(1):5051. doi:10.1038/s41467-018-07360-1
   PubMed Web of Science ®Google Scholar
• Schwarzer A, Aprill C, Derby R, Fortin J, Kine G, Bogduk N. The prevalence and clinical features of internal disc disruption in patients with chronic low back pain. Spine. 1995;20(17):1878–1883. doi:10.1097/00007632-199509000-00007
   PubMed Web of Science ®Google Scholar
• Wang S, Rui Y, Lu J, Wang C. Cell and molecular biology of intervertebral disc degeneration: current understanding and implications for potential therapeutic strategies. Cell Prolif. 2014;47(5):381–390. doi:10.1111/cpr.12121
   PubMed Web of Science ®Google Scholar
• Le Maitre C, Freemont A, Hoyland J. Accelerated cellular senescence in degenerate intervertebral discs: a possible role in the pathogenesis of intervertebral disc degeneration. Arthritis Res Ther. 2007;9(3):R45. doi:10.1186/ar2198
   PubMed Web of Science ®Google Scholar
• Zhao C, Jiang L, Dai L. Programmed cell death in intervertebral disc degeneration. Apoptosis. 2006;11(12):2079–2088. doi:10.1007/s10495-006-0290-7
   PubMed Web of Science ®Google Scholar
• Feng C, Liu H, Yang Y, Huang B, Zhou Y. Growth and differentiation factor-5 contributes to the structural and functional maintenance of the intervertebral disc. Cell Physiol Biochem. 2015;35(1):1–16. doi:10.1159/000369670
   PubMedGoogle Scholar
• Feng C, Yang M, Lan M, et al. ROS: crucial intermediators in the pathogenesis of intervertebral disc degeneration. Oxid Med Cell Longev. 2017;2017:5601593. doi:10.1155/2017/5601593
   PubMed Web of Science ®Google Scholar
• Wang F, Shi R, Cai F, Wang Y, Wu X. Stem cell approaches to intervertebral disc regeneration: obstacles from the disc microenvironment. Stem Cells Dev. 2015;24(21):2479–2495. doi:10.1089/scd.2015.0158
   PubMed Web of Science ®Google Scholar
• Roger Y, Sydow S, Burmeister L, Menzel H, Hoffmann A. Sustained release of TGF-β from polysaccharide nanoparticles induces chondrogenic differentiation of human mesenchymal stromal cells. Colloids Surf B Biointerfaces. 2020;189:110843. doi:10.1016/j.colsurfb.2020.110843
   PubMed Web of Science ®Google Scholar
• Kimbrough-Allah M, Millena A, Khan S. Differential role of PTEN in transforming growth factor β (TGF-β) effects on proliferation and migration in prostate cancer cells. Prostate. 2018;78(5):377–389. doi:10.1002/pros.23482
   PubMed Web of Science ®Google Scholar
• Kazemnejad S, Khanmohammadi M, Mobini S, et al. Comparative repair capacity of knee osteochondral defects using regenerated silk fiber scaffolds and fibrin glue with/without autologous chondrocytes during 36 weeks in rabbit model. Cell Tissue Res. 2016;364(3):559–572. doi:10.1007/s00441-015-2355-9
   PubMed Web of Science ®Google Scholar
• Ma X, Ma X, Qian W, Zhao H, Ding J, Zhao T. Co-culture of adipose-derived stem cells and chondrocytes with transforming growth factor-beta 3 promotes chondrogenic differentiation. J Craniofac Surg. 2020;31(8):2355–2359. doi:10.1097/SCS.0000000000006748
   PubMed Web of Science ®Google Scholar
• Haberstroh K, Enz A, Zenclussen M, et al. Human intervertebral disc-derived cells are recruited by human serum and form nucleus pulposus-like tissue upon stimulation with TGF-beta3 or hyaluronan in vitro. Tissue Cell. 2009;41(6):414–420. doi:10.1016/j.tice.2009.05.006
   PubMed Web of Science ®Google Scholar
• Risbud M, Di Martino A, Guttapalli A, et al. Toward an optimum system for intervertebral disc organ culture: TGF-beta 3 enhances nucleus pulposus and anulus fibrosus survival and function through modulation of TGF-beta-R expression and ERK signaling. Spine. 2006;31(8):884–890. doi:10.1097/01.brs.0000209335.57767.b5
   PubMed Web of Science ®Google Scholar
• Mitchell M, Billingsley M, Haley R, Wechsler M, Peppas N, Langer R. Engineering precision nanoparticles for drug delivery. Nat Rev Drug Discov. 2021;20(2):101–124. doi:10.1038/s41573-020-0090-8
   PubMed Web of Science ®Google Scholar
• Blanco E, Shen H, Ferrari M. Principles of nanoparticle design for overcoming biological barriers to drug delivery. Nat Biotechnol. 2015;33(9):941–951. doi:10.1038/nbt.3330
   PubMed Web of Science ®Google Scholar
• Chang C, Qiu J, O’Sullivan D, et al. Metabolic competition in the tumor microenvironment is a driver of cancer progression. Cell. 2015;162(6):1229–1241. doi:10.1016/j.cell.2015.08.016
   PubMed Web of Science ®Google Scholar
• Ansari M, Ahmad N, Haqqi T. Oxidative stress and inflammation in osteoarthritis pathogenesis: role of polyphenols. Biomed Pharmacother. 2020;129:110452. doi:10.1016/j.biopha.2020.110452
   PubMed Web of Science ®Google Scholar
• Jiang L, Yuan F, Yin X, Dong J. Responses and adaptations of intervertebral disc cells to microenvironmental stress: a possible central role of autophagy in the adaptive mechanism. Connect Tissue Res. 2014;55(5–6):311–321. doi:10.3109/03008207.2014.942419
   PubMed Web of Science ®Google Scholar
• Yang G, Xu L, Chao Y, et al. Hollow MnO as a tumor-microenvironment-responsive biodegradable nano-platform for combination therapy favoring antitumor immune responses. Nat Commun. 2017;8(1):902. doi:10.1038/s41467-017-01050-0
   PubMed Web of Science ®Google Scholar
• Kumar S, Adjei IM, Brown SB, Liseth O, Sharma B. Manganese dioxide nanoparticles protect cartilage from inflammation-induced oxidative stress. Biomaterials. 2019;224:119467. doi:10.1016/j.biomaterials.2019.119467
   PubMed Web of Science ®Google Scholar
• Zhang G, Deng Y, Xie Q, et al. Sirtuins and intervertebral disc degeneration: roles in inflammation, oxidative stress, and mitochondrial function. Clin Chim Acta. 2020;508:33–42. doi:10.1016/j.cca.2020.04.016
   PubMed Web of Science ®Google Scholar
• Che H, Li J, Li Y, et al. p16 deficiency attenuates intervertebral disc degeneration by adjusting oxidative stress and nucleus pulposus cell cycle. eLife. 2020;9. DOI:10.7554/eLife.52570
   Web of Science ®Google Scholar
• Zeng W, Zhang H, Deng Y, Jiang A, Mei L. Dual-response oxygen-generating MnO2 nanoparticles with polydopamine modification for combined photothermal-photodynamic therapy. Chem Eng J. 2020;389:124494. doi:10.1016/j.cej.2020.124494
   Web of Science ®Google Scholar
• Pfirrmann C, Metzdorf A, Zanetti M, Hodler J, Boos N. Magnetic resonance classification of lumbar intervertebral disc degeneration. Spine. 2001;26(17):1873–1878. doi:10.1097/00007632-200109010-00011
   PubMed Web of Science ®Google Scholar
• Masuda K, Aota Y, Muehleman C, et al. A novel rabbit model of mild, reproducible disc degeneration by an anulus needle puncture: correlation between the degree of disc injury and radiological and histological appearances of disc degeneration. Spine. 2005;30(1):5–14. doi:10.1097/01.brs.0000148152.04401.20
   PubMed Web of Science ®Google Scholar
• Wang X, Niu D, Wu Q, et al. Iron oxide/manganese oxide co-loaded hybrid nanogels as pH-responsive magnetic resonance contrast agents. Biomaterials. 2015;53:349–357. doi:10.1016/j.biomaterials.2015.02.101
   PubMed Web of Science ®Google Scholar
• Wang F, Cai F, Shi R, Wang X, Wu X. Aging and age related stresses: a senescence mechanism of intervertebral disc degeneration. Osteoarthritis Cartilage. 2016;24(3):398–408. doi:10.1016/j.joca.2015.09.019
   PubMed Web of Science ®Google Scholar
• Grunhagen T, Shirazi-Adl A, Fairbank J, Urban J. Intervertebral disk nutrition: a review of factors influencing concentrations of nutrients and metabolites. Orthop Clin North Am. 2011;42(4):465–477. doi:10.1016/j.ocl.2011.07.010
   PubMed Web of Science ®Google Scholar
• Li Z, Peroglio M, Alini M, Grad S. Potential and limitations of intervertebral disc endogenous repair. Curr Stem Cell Res Ther. 2015;10(4):329–338. doi:10.2174/1574888X10666150305105114
   PubMed Web of Science ®Google Scholar
• Vergroesen P, Kingma I, Emanuel K, et al. Mechanics and biology in intervertebral disc degeneration: a vicious circle. Osteoarthritis Cartilage. 2015;23(7):1057–1070. doi:10.1016/j.joca.2015.03.028
   PubMed Web of Science ®Google Scholar
• Ma K, Chen S, Li Z, et al. Mechanisms of endogenous repair failure during intervertebral disc degeneration. Osteoarthritis Cartilage. 2019;27(1):41–48. doi:10.1016/j.joca.2018.08.021
   PubMed Web of Science ®Google Scholar
• Yi W, Lan H, Wen Y, et al. HO-1 overexpression alleviates senescence by inducing autophagy via the mitochondrial route in human nucleus pulposus cells. J Cell Physiol. 2020;235(11):8402–8415. doi:10.1002/jcp.29684
   PubMed Web of Science ®Google Scholar
• Chen J, Xie J, Jin M, et al. Sirt6 overexpression suppresses senescence and apoptosis of nucleus pulposus cells by inducing autophagy in a model of intervertebral disc degeneration. Cell Death Dis. 2018;9(2):56. doi:10.1038/s41419-017-0085-5
   PubMed Web of Science ®Google Scholar
• Henry N, Clouet J, Le Bideau J, Le Visage C, Guicheux J. Innovative strategies for intervertebral disc regenerative medicine: from cell therapies to multiscale delivery systems. Biotechnol Adv. 2018;36(1):281–294. doi:10.1016/j.biotechadv.2017.11.009
   PubMed Web of Science ®Google Scholar
• Frapin L, Clouet J, Chédeville C, et al. Controlled release of biological factors for endogenous progenitor cell migration and intervertebral disc extracellular matrix remodelling. Biomaterials. 2020;253:120107. doi:10.1016/j.biomaterials.2020.120107
   PubMed Web of Science ®Google Scholar
• Tao Y, Zhou X, Liang C, et al. TGF-β3 and IGF-1 synergy ameliorates nucleus pulposus mesenchymal stem cell differentiation towards the nucleus pulposus cell type through MAPK/ERK signaling. Growth Factors. 2015;33:326–336. doi:10.3109/08977194.2015.1088532
   PubMed Web of Science ®Google Scholar
• Peck S, Bendigo J, Tobias J, et al. Hypoxic preconditioning enhances bone marrow-derived mesenchymal stem cell survival in a low oxygen and nutrient-limited 3D microenvironment. Cartilage. 2019;12(4):512–525.
   PubMed Web of Science ®Google Scholar
• Ashraf S, Chatoor K, Chong J, Pilliar R, Santerre P, Kandel R. Transforming growth factor β enhances tissue formation by passaged nucleus pulposus cells in vitro. J Orthop Res. 2020;38(2):438–449. doi:10.1002/jor.24476
   PubMed Web of Science ®Google Scholar
• Blanquer S, Grijpma D, Poot A. Delivery systems for the treatment of degenerated intervertebral discs. Adv Drug Deliv Rev. 2015;84:172–187. doi:10.1016/j.addr.2014.10.024
   PubMed Web of Science ®Google Scholar
• Sakai D, Andersson G. Stem cell therapy for intervertebral disc regeneration: obstacles and solutions. Nat Rev Rheumatol. 2015;11(4):243–256. doi:10.1038/nrrheum.2015.13
   PubMed Web of Science ®Google Scholar
• Han Y, Li X, Yan M, et al. Oxidative damage induces apoptosis and promotes calcification in disc cartilage endplate cell through ROS/MAPK/NF-κB pathway: implications for disc degeneration. Biochem Biophys Res Commun. 2019;516(3):1026–1032. doi:10.1016/j.bbrc.2017.03.111
   PubMed Web of Science ®Google Scholar
• Song D, Ge J, Wang Y, et al. Tea polyphenol attenuates oxidative stress-induced degeneration of intervertebral discs by regulating the Keap1/Nrf2/ARE pathway. Oxid Med Cell Longev. 2021;2021:6684147. doi:10.1155/2021/6684147
   PubMed Web of Science ®Google Scholar
• Wang B, Ke W, Wang K, et al. Mechanosensitive ion channel piezo1 activated by matrix stiffness regulates oxidative stress-induced senescence and apoptosis in human intervertebral disc degeneration. Oxid Med Cell Longev. 2021;2021:8884922. doi:10.1155/2021/8884922
   PubMed Web of Science ®Google Scholar
• Suzuki S, Fujita N, Hosogane N, et al. Excessive reactive oxygen species are therapeutic targets for intervertebral disc degeneration. Arthritis Res Ther. 2015;17(1):316. doi:10.1186/s13075-015-0834-8
   PubMed Web of Science ®Google Scholar
• Razaq S, Wilkins R, Urban J. The effect of extracellular pH on matrix turnover by cells of the bovine nucleus pulposus. Eur Spine J. 2003;12(4):341–349. doi:10.1007/s00586-003-0582-3
   PubMed Web of Science ®Google Scholar
• Diamant B, Karlsson J, Nachemson A. Correlation between lactate levels and pH in discs of patients with lumbar rhizopathies. Experientia. 1968;24(12):1195–1196. doi:10.1007/BF02146615
   PubMedGoogle Scholar
• Nachemson A. Intradiscal measurements of pH in patients with lumbar rhizopathies. Acta Orthop Scand. 1969;40(1):23–42. doi:10.3109/17453676908989482
   PubMed Web of Science ®Google Scholar
• Liu J, Tao H, Wang H, et al. Biological behavior of human nucleus pulposus mesenchymal stem cells in response to changes in the acidic environment during intervertebral disc degeneration. Stem Cells Dev. 2017;26(12):901–911. doi:10.1089/scd.2016.0314
   PubMed Web of Science ®Google Scholar
• Gilbert H, Hodson N, Baird P, Richardson S, Hoyland J. Acidic pH promotes intervertebral disc degeneration: acid-sensing ion channel −3 as a potential therapeutic target. Sci Rep. 2016;6:37360. doi:10.1038/srep37360
   PubMed Web of Science ®Google Scholar
• Fan W, Bu W, Shen B, et al. Intelligent MnO2 nanosheets anchored with upconversion nanoprobes for concurrent pH-/H2O2-Responsive UCL imaging and oxygen-elevated synergetic therapy. Adv Mater. 2015;27(28):4155–4161. doi:10.1002/adma.201405141
   PubMed Web of Science ®Google Scholar
• Gordijo CR, Abbasi AZ, Amini MA, et al. Hybrid nanoparticles: design of hybrid MnO2-Polymer-Lipid nanoparticles with tunable oxygen generation rates and tumor accumulation for cancer treatment. Adv Funct Mater. 2015;25(12):1857–1587.
   Web of Science ®Google Scholar
• Chen L, Tiwari SR, Zhang Y, Zhang J, Sun Y. Facile synthesis of hollow MnO2 nanoparticles for reactive oxygen species scavenging in osteoarthritis. ACS Biomater Sci Eng. 2021;7(4):1686–1692. doi:10.1021/acsbiomaterials.1c00005
   PubMed Web of Science ®Google Scholar
• Prasad P, Gordijo C, Abbasi A, et al. Multifunctional albumin-MnO2 nanoparticles modulate solid tumor microenvironment by attenuating hypoxia, acidosis, vascular endothelial growth factor and enhance radiation response. ACS nano. 2014;8(4):3202–3212. doi:10.1021/nn405773r
   PubMed Web of Science ®Google Scholar
• Keorochana G, Johnson J, Taghavi C, et al. The effect of needle size inducing degeneration in the rat caudal disc: evaluation using radiograph, magnetic resonance imaging, histology, and immunohistochemistry. Spine J. 2010;10(11):1014–1023. doi:10.1016/j.spinee.2010.08.013
   PubMed Web of Science ®Google Scholar