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Review

The role of surface charge in cellular uptake and cytotoxicity of medical nanoparticles

Pages 5577-5591 | Published online: 02 Nov 2012

References

  • El OuahabiAThiryMPectorVFuksRRuysschaertJMVandenbrandenMThe role of endosome destabilizing activity in the gene transfer process mediated by cationic lipidsFEBS Lett199741421871929315683
  • XuYSzokaFCJrMechanism of DNA release from cationic liposome/DNA complexes used in cell transfectionBiochemistry19963518561656238639519
  • NafeeNSchneiderMSchaeferUFLehrCMRelevance of the colloidal stability of chitosan/PLGA nanoparticles on their cytotoxicity profileInt J Pharm2009381213013919450671
  • AgasheHBDuttaTGargMJainNKInvestigations on the toxicological profile of functionalized fifth-generation poly (propylene imine) dendrimerJ Pharm Pharmacol200658111491149817132212
  • DuttaTGargMJainNKPoly(propyleneimine) dendrimer and dendrosome mediated genetic immunization against hepatitis BVaccine20082627–283389339418511160
  • Al-RawiMDiabateSWeissCUptake and intracellular localization of submicron and nano-sized SiO(2) particles in HeLa cellsArch Toxicol201185781382621240478
  • AlbersCEHofstetterWSiebenrockKALandmannRKlenkeFMIn vitro cytotoxicity of silver nanoparticles on osteoblasts and osteoclasts at antibacterial concentrationsNanotoxicology Epub October 21, 2011
  • FröhlichEKueznikTSambergerCRobleggEWrightonCPieberTRSize-dependent effects of nanoparticles on the activity of cytochrome P450 isoenzymesToxicol Appl Pharmacol2010242332633219909766
  • FröhlichEMeindlCRobleggEGriesbacherAPieberTRCytotoxicity of nanoparticles is influenced by size, proliferation and embryonic origin of the cells used for testingNanotoxicology20126442442321627401
  • FröhlichESambergerCKueznikTCytotoxicity of nanoparticles independent from oxidative stressJ Toxicol Sci200934436337519652459
  • HeQZhangZGaoYShiJLiYIntracellular localization and cytotoxicity of spherical mesoporous silica nano- and microparticlesSmall20095232722272919780070
  • LinWHuangYWZhouXDMaYIn vitro toxicity of silica nanoparticles in human lung cancer cellsToxicol Appl Pharmacol2006217325225917112558
  • NairSSasidharanADivya RaniVVMenonDManzoorKRainaSRole of size scale of ZnO nanoparticles and microparticles on toxicity toward bacteria and osteoblast cancer cellsJ Mater Sci Mater Med200920Suppl 1S235S24118716714
  • PatilGKhanMIPatelDKSultanaSPrasadRAhmadIEvaluation of cytotoxic, oxidative stress, proinflammatory and genotoxic responses of micro- and nano-particles of dolomite on human lung epithelial cells A(549)Environ Toxicol Pharmacol201234243644522785077
  • PietruskaJRLiuXSmithABioavailability, intracellular mobilization of nickel, and HIF-1alpha activation in human lung epithelial cells exposed to metallic nickel and nickel oxide nanoparticlesToxicol Sci2011124113814821828359
  • LovricJBazziHSCuieYFortinGRWinnikFMMaysingerDDifferences in subcellular distribution and toxicity of green and red emitting CdTe quantum dotsJ Mol Med200583537738515688234
  • ZhangYYuWJiangXLvKSunSZhangFAnalysis of the cytotoxicity of differentially sized titanium dioxide nanoparticles in murine MC3T3-E1 preosteoblastsJ Mater Sci201122819331945
  • ChaKEMyungHCytotoxic effects of nanoparticles assessed in vitro and in vivoJ Microbiol Biotechnol20071791573157818062241
  • YinHTooHPChowGMThe effects of particle size and surface coating on the cytotoxicity of nickel ferriteBiomaterials200526295818582615949547
  • Okuda-ShimazakiJTakakuSKanehiraKSonezakiSTaniguchiAEffects of titanium dioxide nanoparticle aggregate size on gene expressionInt J Mol Sci20101162383239220640159
  • ChongCSCaoMWongWWEnhancement of T helper type 1 immune responses against hepatitis B virus core antigen by PLGA nanoparticle vaccine deliveryJ Control Release20051021859915653136
  • MorishigeTYoshiokaYInakuraHCytotoxicity of amorphous silica particles against macrophage-like THP-1 cells depends on particle-size and surface propertiesPharmazie201065859659920824960
  • LankoffASandbergWJWegierek-CiukAThe effect of agglomeration state of silver and titanium dioxide nanoparticles on cellular response of HepG2, A549 and THP-1 cellsToxicol Lett2012208319721322108609
  • KatsnelsonBADegtyarevaTDMinigalievaIISubchronic systemic toxicity and bioaccumulation of Fe3O4 nano- and microparticles following repeated intraperitoneal administration to ratsInt J Toxicol2011301596821398218
  • RajuHBHuYVedulaADubovySRGoldbergJLEvaluation of magnetic micro- and nanoparticle toxicity to ocular tissuesPloS One201165e1745221637340
  • PolandCADuffinRKinlochICarbon nanotubes introduced into the abdominal cavity of mice show asbestos-like pathogenicity in a pilot studyNat Nanotechnol20083742342818654567
  • TakagiAHiroseANishimuraTInduction of mesothelioma in p53+/– mouse by intraperitoneal application of multi-wall carbon nanotubeJ Toxicol Sci200833110511618303189
  • OnumaKSatoYOgawaraSNano-scaled particles of titanium dioxide convert benign mouse fibrosarcoma cells into aggressive tumor cellsAm J Pathol200917552171218319815711
  • SchaeublinNMBraydich-StolleLKSchrandAMSurface charge of gold nanoparticles mediates mechanism of toxicityNanoscale20113241042021229159
  • BaekMKimISYuJChungHEChoyJHChoiSJEffect of different forms of anionic nanoclays on cytotoxicityJ Nanosci Nanotechnol20111121803180621456296
  • BhattacharjeeSde HaanLHEversNMRole of surface charge and oxidative stress in cytotoxicity of organic monolayer-coated silicon nanoparticles towards macrophage NR8383 cellsPart Fibre Toxicol201072520831820
  • GoodmanCMMcCuskerCDYilmazTRotelloVMToxicity of gold nanoparticles functionalized with cationic and anionic side chainsBioconjug Chem200415489790015264879
  • OhWKKimSChoiMCellular uptake, cytotoxicity, and innate immune response of silica-titania hollow nanoparticles based on size and surface functionalityACS Nano2010495301531320698555
  • RuizendaalLBhattacharjeeSPournazariKSynthesis and cytotoxicity of silicon nanoparticles with covalently attached organic monolayersNanotoxicology200934339347
  • NahaPCDavorenMLyngFMByrneHJReactive oxygen species (ROS) induced cytokine production and cytotoxicity of PAMAM dendrimers in J774A.1 cellsToxicol Appl Pharmacol20102461–2919920420846
  • McNernyDQLeroueilPRBakerJRUnderstanding specific and nonspecific toxicities: a requirement for the development of dendrimer-based pharmaceuticalsNanomed Nanobiotechnol201023249259
  • ChauhanASDiwanPVJainNKTomaliaDAUnexpected in vivo anti-inflammatory activity observed for simple, surface functionalized poly(amidoamine) dendrimersBiomacromolecules20091051195120219348417
  • MuraSHillaireauHNicolasJInfluence of surface charge on the potential toxicity of PLGA nanoparticles towards Calu-3 cellsInt J Nanomedicine201162591260522114491
  • YuTMaluginAGhandehariHImpact of silica nanoparticle design on cellular toxicity and hemolytic activityACS Nano2011575717572821630682
  • LuoXFengMPanSWenYZhangWWuCCharge shielding effects on gene delivery of polyethylenimine/DNA complexes: PEGylation and phospholipid coatingJ Mater Sci Mater Med20122371685169522481628
  • CorpeWAttachment of Marine Bacteria to Solid SurfacesNew YorkAcademic Press19701
  • TomitaYRikimaru-KanekoAHashiguchiKShirotakeSEffect of anionic and cationic n-butylcyanoacrylate nanoparticles on NO and cytokine production in Raw264.7 cellsImmunopharmacol Immunotoxicol201133473073721457109
  • HoskinsCWangLChengWPCuschieriADilemmas in the reliable estimation of the in-vitro cell viability in magnetic nanoparticle engineering: which tests and what protocols?Nanoscale Res Lett201277722247975
  • ChungYIKimJCKimYHThe effect of surface functionalization of PLGA nanoparticles by heparin- or chitosan-conjugated Pluronic on tumor targetingJ Control Release2010143337438220109508
  • Panessa-WarrenBWarrenJWongSMisewichJBiological cellular response to carbon nanoparticle toxicityJ Phys Condens Matter20061833S2185
  • RyabchikovaEMazurkovaNShikinaNIsmagilovZThe crystalline forms of titanium dioxide nanoparticles affect their interactions with individual cellsJ Med Chem Biol Radiol Def20108
  • WangTBaiJJiangXNienhausGUCellular uptake of nanoparticles by membrane penetration: a study combining confocal microscopy with FTIR spectroelectrochemistryACS Nano2012621251125922250809
  • DraegerAMonastyrskayaKBabiychukEBPlasma membrane repair and cellular damage control: the annexin survival kitBiochem Pharmacol201181670371221219882
  • MellgrenRLA new twist on plasma membrane repairCommun Integr Biol20114219820021655439
  • de PlanqueMRAghdaeiSRooseTMorganHElectrophysiological characterization of membrane disruption by nanoparticlesACS Nano2011553599360621517083
  • MuQHondowNSKrzemiskiLBrownAPJeukenLJRoutledgeMNMechanism of cellular uptake of genotoxic silica nanoparticlesPart Fibre Toxicol2012912922823932
  • LinJZhangHChenZZhengYPenetration of lipid membranes by gold nanoparticles: insights into cellular uptake, cytotoxicity, and their relationshipACS Nano2010495421542920799717
  • LinJQZhengYGZhangHWChenZA simulation study on nanoscale holes generated by gold nanoparticles on negative lipid bilayersLangmuir201127138323833221634406
  • HongSHesslerJBanaszak HollMLeroueilPMeckeAOrrBPhysical interactions of nanoparticles with biological membranes: the observation of nanoscale hole formationChem Health Saf20061331620
  • MeckeAMajorosIJPatriAKBakerJRJrHollMMOrrBGLipid bilayer disruption by polycationic polymers: the roles of size and chemical functional groupLangmuir20052123103481035416262291
  • MeckeAUppuluriSSassanellaTMDirect observation of lipid bilayer disruption by poly(amidoamine) dendrimersChem Phys Lipids2004132131415530443
  • KlotzLSiesHCellular Generation of Oxidants: Relation to Oxidative StressWeinheimWiley2009
  • BrownDMHutchisonLDonaldsonKStoneVThe effects of PM10 particles and oxidative stress on macrophages and lung epithelial cells: modulating effects of calcium-signaling antagonistsAm J Physiol20072926L1444L1451
  • PeuschelHSydlikUHaendelerJc-Src-mediated activation of Erk1/2 is a reaction of epithelial cells to carbon nanoparticle treatment and may be a target for a molecular preventive strategyBiol Chem2010391111327133220868224
  • SydlikUBierhalsKSoufiMAbelJSchinsRPUnfriedKUltrafine carbon particles induce apoptosis and proliferation in rat lung epithelial cells via specific signaling pathways both using EGF-RAm J Physiol Lung Cell Mol Physiol20062914L725L73316751223
  • JiangWKimBYRutkaJTChanWCNanoparticle-mediated cellular response is size-dependentNat Nanotechnol20083314515018654486
  • UnfriedKSydlikUBierhalsKWeissenbergAAbelJCarbon nanoparticle-induced lung epithelial cell proliferation is mediated by receptor-dependent Akt activationAm J Physiol Lung Cell Mol Physiol20082942L358L36718083769
  • LovricJChoSJWinnikFMMaysingerDUnmodified cadmium telluride quantum dots induce reactive oxygen species formation leading to multiple organelle damage and cell deathChem Biol200512111227123416298302
  • ChenLYokelRAHennigBToborekMManufactured aluminum oxide nanoparticles decrease expression of tight junction proteins in brain vasculatureJ Neuroimmune Pharmacol20083428629518830698
  • Freyre-FonsecaVDelgado-BuenrostroNLGutierrez-CirlosEBTitanium dioxide nanoparticles impair lung mitochondrial functionToxicol Lett2011202211111921315139
  • TeodoroJSSimoesAMDuarteFVAssessment of the toxicity of silver nanoparticles in vitro: a mitochondrial perspectiveToxicol in Vitro201125366467021232593
  • AshaRaniPVLowKahMunGHandeMPValiyaveettilSCytotoxicity and genotoxicity of silver nanoparticles in human cellsACS Nano20093227929019236062
  • PiaoMJKangKALeeIKSilver nanoparticles induce oxidative cell damage in human liver cells through inhibition of reduced glutathione and induction of mitochondria-involved apoptosisToxicol Lett201120119210021182908
  • BexigaMGVarelaJAWangFCationic nanoparticles induce caspase 3-, 7- and 9-mediated cytotoxicity in a human astrocytoma cell lineNanotoxicology20115455756721142842
  • BairdSKKurzTBrunkUTMetallothionein protects against oxidative stress-induced lysosomal destabilizationBiochem J2006394Pt 127528316236025
  • SoenenSRivera-GilPMontenegroJParakWDe SmedtSBraeckmansKCellular toxicity of inorganic nanoparticles: common aspects and guidelines for improved nanotoxicity evaluationNanotoday201165446465
  • FunnellWRMaysingerDThree-dimensional reconstruction of cell nuclei, internalized quantum dots and sites of lipid peroxidationJ Nanobiotechnol200641010
  • ThibodeauMSGiardinaCKnechtDAHelbleJHubbardAKSilica-induced apoptosis in mouse alveolar macrophages is initiated by lysosomal enzyme activityToxicol Sci2004801344815056807
  • NelAEMadlerLVelegolDUnderstanding biophysico-chemical interactions at the nano-bio interfaceNat Mater20098754355719525947
  • AsatiASantraSKaittanisCPerezJMSurface-charge-dependent cell localization and cytotoxicity of cerium oxide nanoparticlesACS Nano2010495321533120690607
  • Johnson-LylesDNPeifleyKLockettSFullerenol cytotoxicity in kidney cells is associated with cytoskeleton disruption, autophagic vacuole accumulation, and mitochondrial dysfunctionToxicol Appl Pharmacol2010248324925820713077
  • LiJJHartonoDOngCNBayBHYungLYAutophagy and oxidative stress associated with gold nanoparticlesBiomaterials201031235996600320466420
  • KhanMIMohammadAPatilGNaqviSAChauhanLKAhmadIInduction of ROS, mitochondrial damage and autophagy in lung epithelial cancer cells by iron oxide nanoparticlesBiomaterials20123351477148822098780
  • SternSTZolnikBSMcLelandCBClogstonJZhengJMcNeilSEInduction of autophagy in porcine kidney cells by quantum dots: a common cellular response to nanomaterials?Toxicol Sci2008106114015218632727
  • EidiHJoubertONemosCDrug delivery by polymeric nanoparticles induces autophagy in macrophagesInt J Pharm20124221–249550322119964
  • VercauterenDDeschoutHRemautKDynamic colocalization microscopy to characterize intracellular trafficking of nanomedicinesACS Nano20115107874788421923168
  • LiCLiuHSunYPAMAM nanoparticles promote acute lung injury by inducing autophagic cell death through the Akt-TSC2-mTOR signaling pathwayJ Mol Cell Biol200911374519516051
  • BoyogluCBoyoglu-BarnumSSoniSThe intracellular co-localizations of different size of gold nanoparticles NSTINanotechnology 2011: Bio Sensors, Instruments, Medical, Environment and EnergyCRC Press20123489492
  • AdamSAThe nuclear pore complexGenome Biol200129REVIEWS000711574060
  • PetersRTranslocation through the nuclear pore complex: selectivity and speed by reduction-of-dimensionalityTraffic20056542142715813752
  • NitinNLaConteLRheeWJBaoGTat peptide is capable of importing large nanoparticles across nuclear membrane in digitonin permeabilized cellsAnn Biomed Eng200937102018202719657743
  • NabeshiHYoshikawaTArimoriAEffect of surface properties of silica nanoparticles on their cytotoxicity and cellular distribution in murine macrophagesNanoscale Res Lett2011619321711578
  • KamataHZinchenkoAMurataSEffects of cationic and anionic nanoparticles on the stability of the secondary structure of DNAColloid Polymer Sci20112891213291335
  • ZinchenkoAALuckelFYoshikawaKTranscription of giant DNA complexed with cationic nanoparticles as a simple model of chromatinBiophys J20079241318132517142281
  • ChenMvon MikeczAFormation of nucleoplasmic protein aggregates impairs nuclear function in response to SiO2 nanoparticlesExp Cell Res20053051516215777787
  • LiNMaLWangJInteraction between nano-anatase TiO2 and liver DNA from mice in vivoNanoscale Res Lett20095110811520652136
  • LiuYLiWLaoFIntracellular dynamics of cationic and anionic polystyrene nanoparticles without direct interaction with mitotic spindle and chromosomesBiomaterials201132328291830321810539
  • LynchIDawsonKAProtein-nanoparticle interactionsNanotoday200831–24047
  • GheshlaghiZNRiaziGHAhmadianSGhafariMMahinpourRToxicity and interaction of titanium dioxide nanoparticles with microtubule proteinActa Biochim Biophys Sin200840977778218776989
  • LinseSCabaleiro-LagoCXueWFNucleation of protein fibrillation by nanoparticlesProc Natl Acad Sci U S A2007104218691869617485668
  • MakarovaEGGordonRYPodolskiIYFullerene C60 prevents neurotoxicity induced by intrahippocampal microinjection of amyloid-beta peptideJ Nanosci Nanotechnol201212111912622523954
  • Cabaleiro-LagoCQuinlan-PluckFLynchIInhibition of amyloid beta protein fibrillation by polymeric nanoparticlesJ Am Chem Soc200813046154371544318954050
  • YooSIYangMBrenderJRInhibition of amyloid peptide fibrillation by inorganic nanoparticles: functional similarities with proteinsAngew Chem Int Ed Engl201150225110511521495130
  • GoldbergDSGhandehariHSwaanPWCellular entry of G3.5 poly (amido amine) dendrimers by clathrin- and dynamin-dependent endocytosis promotes tight junctional opening in intestinal epitheliaPharm Res20102781547155720411406
  • CoyucoJCLiuYTanBJChiuGNFunctionalized carbon nanomaterials: exploring the interactions with Caco-2 cells for potential oral drug deliveryInt J Nanomedicine201162253226322125408
  • VllasaliuDExposito-HarrisRHerasATight junction modulation by chitosan nanoparticles: comparison with chitosan solutionInt J Pharm20104001–218319320727955
  • RogerELagarceFGarcionEBenoitJPLipid nanocarriers improve paclitaxel transport throughout human intestinal epithelial cells by using vesicle-mediated transcytosisJ Control Release2009140217418119699246
  • SheikpranbabuSKalishwaralalKLeeKJVaidyanathanREomSHGurunathanSThe inhibition of advanced glycation end-products- induced retinal vascular permeability by silver nanoparticlesBiomaterials20103182260227119963272
  • PetushkovAIntraJGrahamJBLarsenSCSalemAKEffect of crystal size and surface functionalization on the cytotoxicity of silicalite-1 nanoparticlesChem Res Toxicol20092271359136819580308
  • BaierGCostaCZellerABSA adsorption on differently charged polystyrene nanoparticles using isothermal titration calorimetry and the influence on cellular uptakeMacromol Biosci201111562863821384550
  • Petri-FinkASteitzBFinkaASalaklangJHofmannHEffect of cell media on polymer coated superparamagnetic iron oxide nanoparticles (SPIONs): colloidal stability, cytotoxicity, and cellular uptake studiesEur J Pharm Biopharm200868112913717881203
  • CliftMJBhattacharjeeSBrownDMStoneVThe effects of serum on the toxicity of manufactured nanoparticlesToxicol Lett2010198335836520705123
  • RogersWJBasuPFactors regulating macrophage endocytosis of nanoparticles: implications for targeted magnetic resonance plaque imagingAtherosclerosis20051781677315585202
  • ChithraniBDGhazaniAAChanWCDetermining the size and shape dependence of gold nanoparticle uptake into mammalian cellsNano Lett20066466266816608261
  • GaoHShiWFreundLBMechanics of receptor-mediated endocytosisProc Natl Acad Sci U S A2005102279469947415972807
  • LuFWuSHHungYMouCYSize effect on cell uptake in well-suspended, uniform mesoporous silica nanoparticlesSmall20095121408141319296554
  • WangSHLeeCWChiouAWeiPKSize-dependent endocytosis of gold nanoparticles studied by three-dimensional mapping of plasmonic scattering imagesJ Nanobiotechnol2010833
  • WinKYFengSSEffects of particle size and surface coating on cellular uptake of polymeric nanoparticles for oral delivery of anticancer drugsBiomaterials200526152713272215585275
  • ChampionJAWalkerAMitragotriSRole of particle size in phagocytosis of polymeric microspheresPharm Res20082581815182118373181
  • RaynalIPrigentPPeyramaureSNajidARebuzziCCorotCMacrophage endocytosis of superparamagnetic iron oxide nanoparticles: mechanisms and comparison of ferumoxides and ferumoxtran-10Invest Radiol2004391566314701989
  • GonzalezOSmithRLGoodmanSBEffect of size, concentration, surface area, and volume of polymethylmethacrylate particles on human macrophages in vitroJ Biomed Mater Res19963044634738847354
  • WangHWuLReinhardBMScavenger receptor mediated endocytosis of silver nanoparticles into J774A1 macrophages is heterogeneousACS Nano2012687122713222799499
  • YuSSLauCMThomasSNSize- and charge-dependent nonspecific uptake of PEGylated nanoparticles by macrophagesInt J Nanomedicine2012779981322359457
  • JiangXMusyanovychARockerCLandfesterKMailanderVNienhausGUSpecific effects of surface carboxyl groups on anionic polystyrene particles in their interactions with mesenchymal stem cellsNanoscale2011352028203521409242
  • ThorekDLTsourkasASize, charge and concentration dependent uptake of iron oxide particles by non-phagocytic cellsBiomaterials200829263583359018533252
  • VillanuevaACaneteMRocaAGThe influence of surface functionalization on the enhanced internalization of magnetic nanoparticles in cancer cellsNanotechnology2009201111510319420433
  • BrandenbergerCRothen-RutishauserBMuhlfeldCEffects and uptake of gold nanoparticles deposited at the air-liquid interface of a human epithelial airway modelToxicol Appl Pharmacol20102421566519796648
  • ChenLMcCrateJMLeeJCLiHThe role of surface charge on the uptake and biocompatibility of hydroxyapatite nanoparticles with osteoblast cellsNanotechnology2011221010570821289408
  • ChoJCarusoFInvestigation of the interactions between ligand-stabilized gold nanoparticles and polyelectrolyte multilayer filmsChem Mater2005171745474553
  • MarquisBJLiuZBraunKLHaynesCLInvestigation of noble metal nanoparticle ζ-potential effects on single-cell exocytosis function in vitro with carbon-fiber microelectrode amperometryAnalyst2011136173478348621170444
  • LorenzMRHolzapfelVMusyanovychAUptake of functionalized, fluorescent-labeled polymeric particles in different cell lines and stem cellsBiomaterials200627142820282816430958
  • MillerCRBondurantBMcLeanSDMcGovernKAO’BrienDFLiposome-cell interactions in vitro: effect of liposome surface charge on the binding and endocytosis of conventional and sterically stabilized liposomesBiochemistry1998373712875128839737866
  • GeYZhangYXiaJEffect of surface charge and agglomerate degree of magnetic iron oxide nanoparticles on KB cellular uptake in vitroColloids Surf B Biointerfaces200973229430119564099
  • Harush-FrenkelORozenturEBenitaSAltschulerYSurface charge of nanoparticles determines their endocytic and transcytotic pathway in polarized MDCK cellsBiomacromolecules20089243544318189360
  • YueZGWeiWLvPPSurface charge affects cellular uptake and intracellular trafficking of chitosan-based nanoparticlesBiomacromolecules20111272440244621657799
  • MailanderVLandfesterKInteraction of nanoparticles with cellsBiomacromolecules20091092379240019637907
  • LunovOSyrovetsTLoosCDifferential uptake of functionalized polystyrene nanoparticles by human macrophages and a monocytic cell lineACS Nano2011531657166921344890
  • DrutzDJIntracellular fate of Neisseria gonorrhoeaeBrooksGGotschlichEHolmesKSawyerWYoungFImmunobiology of Neisseria gonorrhoeaeWashingtonAmerican Society for Microbiology19781232235
  • KempSJThorleyAJGorelikJImmortalization of human alveolar epithelial cells to investigate nanoparticle uptakeAm J Respir Cell Mol Biol200839559159718539954
  • FazlollahiFAngelowSYacobiNRPolystyrene nanoparticle trafficking across MDCK-IINanomedicine20117558859421310266
  • JaiswalJKMattoussiHMauroJMSimonSMLong-term multiple color imaging of live cells using quantum dot bioconjugatesNat Biotechnol2003211475112459736
  • SakaiNMatsuiYNakayamaATsudaAYonedaMFunctional-dependent and size-dependent uptake of nanoparticles in PC12J Phys Conf Ser201130412049
  • DuanHNieSCell-penetrating quantum dots based on multivalent and endosome-disrupting surface coatingsJ Am Chem Soc2007129113333333817319667
  • Ryman-RasmussenJPRiviereJEMonteiro-RiviereNASurface coatings determine cytotoxicity and irritation potential of quantum dot nanoparticles in epidermal keratinocytesJ Invest Dermatol2007127114315316902417
  • BuQYanGDengPNMR-based metabonomic study of the sub-acute toxicity of titanium dioxide nanoparticles in rats after oral administrationNanotechnology2010211212510520203358
  • MakinoKYamamotoNHiguchiKHaradaNOhshimaHTeradaHPhagocytic uptake of polystyrene microspheres by alveolar macrophages: effects of the size and surface properties of the microspheresColloids Surf B Biointerfaces20032713339
  • EhrenbergMSFriedmanAEFinkelsteinJNOberdorsterGMcGrathJLThe influence of protein adsorption on nanoparticle association with cultured endothelial cellsBiomaterials200930460361019012960
  • PatilSSandbergAHeckertESelfWSealSProtein adsorption and cellular uptake of cerium oxide nanoparticles as a function of zeta potentialBiomaterials200728314600460717675227
  • FerratiSMackAChiappiniCIntracellular trafficking of silicon particles and logic-embedded vectorsNanoscale2010281512152020820744
  • TaylorUKleinSPetersenSKuesWBarcikowskiSRathDNonendosomal cellular uptake of ligand-free, positively charged gold nanoparticlesCytometry A201077543944620104575
  • ArvizoRRMirandaORThompsonMAEffect of nanoparticle surface charge at the plasma membrane and beyondNano Lett20101072543254820533851
  • CarneyRPCarneyTMMuellerMStellacciFDynamic cellular uptake of mixed-monolayer protected nanoparticlesBiointerphases201271–41722589060
  • LiYLiXLiZGaoHSurface-structure-regulated penetration of nanoparticles across a cell membraneNanoscale20124123768377522609866
  • VermaAUzunOHuYSurface-structure-regulated cell-membrane penetration by monolayer-protected nanoparticlesNat Mater20087758859518500347
  • DohertyGJMcMahonHTMechanisms of endocytosisAnnu Rev Biochem20097885790219317650
  • HowesMTMayorSPartonRGMolecules, mechanisms, and cellular roles of clathrin-independent endocytosisCurr Opin Cell Biol201022451952720439156
  • SahayGAlakhovaDYKabanovAVEndocytosis of nanomedicinesJ Control Release2010145318219520226220
  • SandvigKPustSSkotlandTvan DeursBClathrin-independent endocytosis: mechanisms and functionCurr Opin Cell Biol201123441342021466956
  • Perez-MartinezFCGuerraJPosadasICenaVBarriers to non-viral vector-mediated gene delivery in the nervous systemPharm Res20112881843185821225319
  • KhalilIAKogureKAkitaHHarashimaHUptake pathways and subsequent intracellular trafficking in nonviral gene deliveryPharmacol Rev2006581324516507881
  • PartonRGCaveolae meet endosomes: a stable relationship?Dev Cell20047445846015469832
  • LuWTanYZHuKLJiangXGCationic albumin conjugated pegylated nanoparticle with its transcytosis ability and little toxicity against blood-brain barrierInt J Pharm20052951–224726015848009
  • KitchensKMKolhatkarRBSwaanPWEddingtonNDGhandehariHTransport of poly(amidoamine) dendrimers across Caco-2 cell monolayers: influence of size, charge and fluorescent labelingPharm Res200623122818282617094034
  • ZakiNMNastiATirelliNNanocarriers for cytoplasmic delivery: cellular uptake and intracellular fate of chitosan and hyaluronic acid-coated chitosan nanoparticles in a phagocytic cell modelMacromol Biosci201111121747176021954171
  • Harush-FrenkelODebottonNBenitaSAltschulerYTargeting of nanoparticles to the clathrin-mediated endocytic pathwayBiochem Biophys Res Commun20073531263217184736
  • IversenTFrerkerNSandvigKEndocytosis and Intracellular Trafficking of Quantum Dot–Ligand BioconjugatesHobokenJohn Wiley & Sons2010
  • MiglioreLCoppedeFEnvironmental-induced oxidative stress in neurodegenerative disorders and agingMutat Res20096741–2738418952194
  • KitchensKMForakerABKolhatkarRBSwaanPWGhandehariHEndocytosis and interaction of poly (amidoamine) dendrimers with Caco-2 cellsPharm Res200724112138214517701324
  • PerumalOPInapagollaRKannanSKannanRMThe effect of surface functionality on cellular trafficking of dendrimersBiomaterials20082924–253469347618501424
  • FosterKAYazdanianMAudusKLMicroparticulate uptake mechanisms of in-vitro cell culture models of the respiratory epitheliumJ Pharm Pharmacol2001531576611206193
  • IvanovAPharmacological Inhibition of Endocytotic Pathways: is it Specific Enough to be useful?New YorkHumana Press200840
  • PartonRGSimonsKThe multiple faces of caveolaeNat Rev Mol Cell Biol20078318519417318224
  • ChenYChenHZhangSStructure-property relationships in manganese oxide – mesoporous silica nanoparticles used for T1-weighted MRI and simultaneous anti-cancer drug deliveryBiomaterials20123372388239822177841
  • ClemedsonCDierickxPJSjostromMThe prediction of human acute systemic toxicity by the EDIT/MEIC in vitro test battery: the importance of protein binding and of partitioning into lipidsAltern Lab Anim200331324525615612867
  • KrollAPillukatMHHahnDSchnekenburgerJCurrent in vitro methods in nanoparticle risk assessment: limitations and challengesEur J Pharm Biopharm200972237037718775492
  • LiYLiuJZhongYBiocompatibility of Fe(3)O(4)@Au composite magnetic nanoparticles in vitro and in vivoInt J Nanomedicine201162805281922131827
  • LedetGMandalTNanomedicine: emerging therapeutics for the 21st centuryUS Pharm2012373711
  • XiaoYForrySPGaoXHolbrookRDTelfordWGTonaADynamics and mechanisms of quantum dot nanoparticle cellular uptakeJ Nanobiotechnol2010813
  • ZhangLWMonteiro-RiviereNAMechanisms of quantum dot nanoparticle cellular uptakeToxicol Sci2009110113815519414515
  • JiangXDausendJHafnerMSpecific effects of surface amines on polystyrene nanoparticles in their interactions with mesenchymal stem cellsBiomacromolecules201011374875320166675
  • LaiSKHidaKManSTPrivileged delivery of polymer nanoparticles to the perinuclear region of live cells via a nonclathrin, non-degradative pathwayBiomaterials200728182876288417363053
  • DausendJMusyanovychADassMUptake mechanism of oppositely charged fluorescent nanoparticles in HeLa cellsMacromol Biosci20088121135114318698581
  • XiaTKovochichMLiongMZinkJINelAECationic polystyrene nanosphere toxicity depends on cell-specific endocytic and mitochondrial injury pathwaysACS Nano200821859619206551
  • FröhlichERobleggEModels for oral uptake of nanoparticles in consumer productsToxicology20122911–38