The 3D-Printed Ordered Bredigite Scaffold Promotes Pro-Healing of Critical-Sized Bone Defects by Regulating Macrophage Polarization

References

• Zhang W, Feng C, Yang G, et al. 3D-printed scaffolds with synergistic effect of hollow-pipe structure and bioactive ions for vascularized bone regeneration. Biomaterials. 2017;135:85–95. doi:10.1016/j.biomaterials.2017.05.005
   PubMed Web of Science ®Google Scholar
• Feng Y, Zhu S, Mei D, et al. Application of 3D printing technology in bone tissue engineering: a review. Curr Drug Deliv. 2021;18(7):847–861. doi:10.2174/1567201817999201113100322
   PubMed Web of Science ®Google Scholar
• Cheng L, Suresh KS, He H, et al. 3D printing of micro- and nanoscale bone substitutes: a review on technical and translational perspectives. Int J Nanomedicine. 2021;16:4289–4319. doi:10.2147/ijn.S311001
   PubMed Web of Science ®Google Scholar
• Zhang L, Yang G, Johnson BN, Jia X. Three-dimensional (3D) printed scaffold and material selection for bone repair. Acta Biomater. 2019;84:16–33. doi:10.1016/j.actbio.2018.11.039
   PubMed Web of Science ®Google Scholar
• Shao H, Sun M, Zhang F, et al. Custom repair of mandibular bone defects with 3D printed bioceramic scaffolds. J Dent Res. 2018;97(1):68–76. doi:10.1177/0022034517734846
   PubMed Web of Science ®Google Scholar
• Bose S, Roy M, Bandyopadhyay A. Recent advances in bone tissue engineering scaffolds. Trends Biotechnol. 2012;30(10):546–554. doi:10.1016/j.tibtech.2012.07.005
   PubMed Web of Science ®Google Scholar
• Zafar MS, Khurshid Z, Almas K. Oral tissue engineering progress and challenges. Tissue Eng Regen Med. 2015;12(6):387–397. doi:10.1007/s13770-015-0030-6
   Web of Science ®Google Scholar
• Eilbagi M, Emadi R, Raeissi K, Kharaziha M, Valiani A. Mechanical and cytotoxicity evaluation of nanostructured hydroxyapatite-bredigite scaffolds for bone regeneration. Mater Sci Eng C Mater Biol Appl. 2016;68:603–612. doi:10.1016/j.msec.2016.06.030
   PubMed Web of Science ®Google Scholar
• Wu C, Chang J, Wang J, Ni S, Zhai W. Preparation and characteristics of a calcium magnesium silicate (bredigite) bioactive ceramic. Biomaterials. 2005;26(16):2925–2931. doi:10.1016/j.biomaterials.2004.09.019
   PubMed Web of Science ®Google Scholar
• Wu C, Chang J, Zhai W, Ni S. A novel bioactive porous bredigite (Ca7MgSi4O16) scaffold with biomimetic apatite layer for bone tissue engineering. J Mater Sci Mater Med. 2007;18(5):857–864. doi:10.1007/s10856-006-0083-0
   PubMed Web of Science ®Google Scholar
• Wu C, Chang J. Synthesis and in vitro bioactivity of bredigite powders. J Biomater Appl. 2007;21(3):251–263. doi:10.1177/0885328206062360
   PubMed Web of Science ®Google Scholar
• Yi D, Wu C, Ma B, Ji H, Zheng X, Chang J. Bioactive bredigite coating with improved bonding strength, rapid apatite mineralization and excellent cytocompatibility. J Biomater Appl. 2014;28(9):1343–1353. doi:10.1177/0885328213508165
   PubMed Web of Science ®Google Scholar
• Chen L, Liu L, Wu C, Yang R, Chang J, Wei X. The extracts of bredigite bioceramics enhanced the pluripotency of human dental pulp cells. J Biomed Mater Res A. 2017;105(12):3465–3474. doi:10.1002/jbm.a.36191
   PubMed Web of Science ®Google Scholar
• Zhou Y, Wu C, Zhang X, Han P, Xiao Y. The ionic products from bredigite bioceramics induced cementogenic differentiation of periodontal ligament cells via activation of the Wnt/β-catenin signalling pathway. J Mater Chem B. 2013;1(27):3380–3389. doi:10.1039/c3tb20445f
   PubMed Web of Science ®Google Scholar
• Zheng Z, Chen Y, Wu D, et al. Development of an accurate and proactive immunomodulatory strategy to improve bone substitute material-mediated osteogenesis and angiogenesis. Theranostics. 2018;8(19):5482–5500. doi:10.7150/thno.28315
   PubMed Web of Science ®Google Scholar
• Luttikhuizen D, Harmsen M, Van Luyn M. Cellular and molecular dynamics in the foreign body reaction. Tissue Eng. 2006;12(7):1955–1970. doi:10.1089/ten.2006.12.1955
   PubMedGoogle Scholar
• Londono R, Badylak S. Biologic scaffolds for regenerative medicine: mechanisms of in vivo remodeling. Ann Biomed Eng. 2015;43(3):577–592. doi:10.1007/s10439-014-1103-8
   PubMed Web of Science ®Google Scholar
• Xie Y, Hu C, Feng Y, et al. Osteoimmunomodulatory effects of biomaterial modification strategies on macrophage polarization and bone regeneration. Regen Biomater. 2020;7(3):233–245. doi:10.1093/rb/rbaa006
   PubMed Web of Science ®Google Scholar
• Anderson J, Rodriguez A, Chang D. Foreign body reaction to biomaterials. Semin Immunol. 2008;20(2):86–100. doi:10.1016/j.smim.2007.11.004
   PubMed Web of Science ®Google Scholar
• Mantovani A, Biswas SK, Galdiero MR, Sica A, Locati M. Macrophage plasticity and polarization in tissue repair and remodelling. J Pathol. 2013;229(2):176–185. doi:10.1002/path.4133
   PubMed Web of Science ®Google Scholar
• Jin SS, He DQ, Luo D, et al. A biomimetic hierarchical nanointerface orchestrates macrophage polarization and mesenchymal stem cell recruitment to promote endogenous bone regeneration. ACS Nano. 2019;13(6):6581–6595. doi:10.1021/acsnano.9b00489
   PubMed Web of Science ®Google Scholar
• Locati M, Curtale G, Mantovani A. Diversity, mechanisms, and significance of macrophage plasticity. Annu Rev Pathol. 2020;15:123–147. doi:10.1146/annurev-pathmechdis-012418-012718
   PubMed Web of Science ®Google Scholar
• Rostam H, Singh S, Vrana N, Alexander M, Ghaemmaghami A. Impact of surface chemistry and topography on the function of antigen presenting cells. Biomater Sci. 2015;3(3):424–441. doi:10.1039/c4bm00375f
   PubMed Web of Science ®Google Scholar
• Hasan A, Byambaa B, Morshed M, et al. Advances in osteobiologic materials for bone substitutes. J Tissue Eng Regen Med. 2018;12(6):1448–1468. doi:10.1002/term.2677
   PubMed Web of Science ®Google Scholar
• Chen Z, Bachhuka A, Wei F, et al. Nanotopography-based strategy for the precise manipulation of osteoimmunomodulation in bone regeneration. Nanoscale. 2017;9(46):18129–18152. doi:10.1039/c7nr05913b
   PubMed Web of Science ®Google Scholar
• Yang Y, Lin Y, Zhang Z, Xu R, Yu X, Deng F. Micro/nano-net guides M2-pattern macrophage cytoskeleton distribution via Src-ROCK signalling for enhanced angiogenesis. Biomater Sci. 2021;9(9):3334–3347. doi:10.1039/d1bm00116g
   PubMed Web of Science ®Google Scholar
• McMurray RJ, Gadegaard N, Tsimbouri PM, et al. Nanoscale surfaces for the long-term maintenance of mesenchymal stem cell phenotype and multipotency. Nat Mater. 2011;10(8):637–644. doi:10.1038/nmat3058
   PubMed Web of Science ®Google Scholar
• Prendergast M, Burdick J. Recent advances in enabling technologies in 3D printing for precision medicine. Adv Mater. 2020;32(13):e1902516. doi:10.1002/adma.201902516
   PubMed Web of Science ®Google Scholar
• Seo SJ, Mahapatra C, Singh RK, Knowles JC, Kim HW. Strategies for osteochondral repair: focus on scaffolds. J Tissue Eng. 2014;5:2041731414541850. doi:10.1177/2041731414541850
   Google Scholar
• Daghrery A, Ferreira JA, Xu J, et al. Tissue-specific melt electrowritten polymeric scaffolds for coordinated regeneration of soft and hard periodontal tissues. Bioact Mater. 2023;19:268–281. doi:10.1016/j.bioactmat.2022.04.013
   PubMed Web of Science ®Google Scholar
• Jia Y, Yang W, Zhang K, et al. Nanofiber arrangement regulates peripheral nerve regeneration through differential modulation of macrophage phenotypes. Acta Biomater. 2019;83:291–301. doi:10.1016/j.actbio.2018.10.040
   PubMed Web of Science ®Google Scholar
• Hu S, Ning C, Zhou Y, Chen L, Lin K, Chang J. Antibacterial activity of silicate bioceramics. J Wuhan Univ Technol Mater Sci Ed. 2011;26(2):226–230. doi:10.1007/s11595-011-0202-8
   Web of Science ®Google Scholar
• McWhorter FY, Wang T, Nguyen P, Chung T, Liu WF. Modulation of macrophage phenotype by cell shape. Proc Natl Acad Sci USA. 2013;110(43):17253–17258. doi:10.1073/pnas.1308887110
   PubMed Web of Science ®Google Scholar
• Li K, Lv L, Shao D, Xie Y, Cao Y, Zheng X. Engineering nanopatterned structures to orchestrate macrophage phenotype by cell shape. J Funct Biomater. 2022;13(1):31. doi:10.3390/jfb13010031
   PubMed Web of Science ®Google Scholar
• Pajarinen J, Lin T, Gibon E, et al. Mesenchymal stem cell-macrophage crosstalk and bone healing. Biomaterials. 2019;196:80–89. doi:10.1016/j.biomaterials.2017.12.025
   PubMed Web of Science ®Google Scholar
• Li J, Jiang X, Li H, Gelinsky M, Gu Z. Tailoring materials for modulation of macrophage fate. Adv Mater. 2021;33(12):e2004172. doi:10.1002/adma.202004172
   PubMed Web of Science ®Google Scholar
• Larochette N, El-Hafci H, Potier E, et al. Osteogenic-differentiated mesenchymal stem cell-secreted extracellular matrix as a bone morphogenetic protein-2 delivery system for ectopic bone formation. Acta Biomater. 2020;116:186–200. doi:10.1016/j.actbio.2020.09.003
   PubMed Web of Science ®Google Scholar
• Wu M, Chen G, Li YP. TGF-β and BMP signaling in osteoblast, skeletal development, and bone formation, homeostasis and disease. Bone Res. 2016;4:16009. doi:10.1038/boneres.2016.9
   PubMed Web of Science ®Google Scholar
• Chen Z, Wu C, Gu W, Klein T, Crawford R, Xiao Y. Osteogenic differentiation of bone marrow MSCs by β-tricalcium phosphate stimulating macrophages via BMP2 signalling pathway. Biomaterials. 2014;35(5):1507–1518. doi:10.1016/j.biomaterials.2013.11.014
   PubMed Web of Science ®Google Scholar
• Kim YH, Oreffo ROC, Dawson JI. From hurdle to springboard: the macrophage as target in biomaterial-based bone regeneration strategies. Bone. 2022;159:116389. doi:10.1016/j.bone.2022.116389
   PubMed Web of Science ®Google Scholar
• Kang H, Zhang K, Wong DSH, Han F, Li B, Bian L. Near-infrared light-controlled regulation of intracellular calcium to modulate macrophage polarization. Biomaterials. 2018;178:681–696. doi:10.1016/j.biomaterials.2018.03.007
   PubMed Web of Science ®Google Scholar
• Qiao X, Yang J, Shang Y, et al. Magnesium-doped nanostructured titanium surface modulates macrophage-mediated inflammatory response for ameliorative osseointegration. Int J Nanomedicine. 2020;15:7185–7198. doi:10.2147/ijn.S239550
   PubMed Web of Science ®Google Scholar
• Schwarz K, Milne D. Growth-promoting effects of silicon in rats. Nature. 1972;239(5371):333–334. doi:10.1038/239333a0
   PubMed Web of Science ®Google Scholar
• Carlisle E. Silicon: a possible factor in bone calcification. Science. 1970;167(3916):279–280. doi:10.1126/science.167.3916.279
   PubMed Web of Science ®Google Scholar
• Liu X, Ding C, Chu PK. Mechanism of apatite formation on wollastonite coatings in simulated body fluids. Biomaterials. 2004;25(10):1755–1761. doi:10.1016/j.biomaterials.2003.08.024
   PubMed Web of Science ®Google Scholar
• Pei P, Qi X, Du X, Zhu M, Zhao S, Zhu Y. Three-dimensional printing of tricalcium silicate/mesoporous bioactive glass cement scaffolds for bone regeneration. J Mater Chem B. 2016;4(46):7452–7463. doi:10.1039/c6tb02055k
   PubMed Web of Science ®Google Scholar
• Zhai W, Lu H, Wu C, et al. Stimulatory effects of the ionic products from Ca-Mg-Si bioceramics on both osteogenesis and angiogenesis in vitro. Acta Biomater. 2013;9(8):8004–8014. doi:10.1016/j.actbio.2013.04.024
   PubMed Web of Science ®Google Scholar
• Li T, Peng M, Yang Z, et al. 3D-printed IFN-γ-loading calcium silicate-β-tricalcium phosphate scaffold sequentially activates M1 and M2 polarization of macrophages to promote vascularization of tissue engineering bone. Acta Biomater. 2018;71:96–107. doi:10.1016/j.actbio.2018.03.012
   PubMed Web of Science ®Google Scholar
• Bai X, Liu W, Xu L, et al. Sequential macrophage transition facilitates endogenous bone regeneration induced by Zn-doped porous microcrystalline bioactive glass. J Mater Chem B. 2021;9(12):2885–2898. doi:10.1039/d0tb02884c
   PubMed Web of Science ®Google Scholar
• Chen Z, Bachhuka A, Han S, et al. Tuning chemistry and topography of nanoengineered surfaces to manipulate immune response for bone regeneration applications. ACS Nano. 2017;11(5):4494–4506. doi:10.1021/acsnano.6b07808
   PubMed Web of Science ®Google Scholar
• Zhang R, Elkhooly TA, Huang Q, et al. Effects of the hierarchical macro/mesoporous structure on the osteoblast-like cell response. J Biomed Mater Res A. 2018;106(7):1896–1902. doi:10.1002/jbm.a.36387
   PubMed Web of Science ®Google Scholar
• Murphy CM, Haugh MG, O’Brien FJ. The effect of mean pore size on cell attachment, proliferation and migration in collagen-glycosaminoglycan scaffolds for bone tissue engineering. Biomaterials. 2010;31(3):461–466. doi:10.1016/j.biomaterials.2009.09.063
   PubMed Web of Science ®Google Scholar
• Chen L, Deng C, Li J, et al. 3D printing of a lithium-calcium-silicate crystal bioscaffold with dual bioactivities for osteochondral interface reconstruction. Biomaterials. 2019;196:138–150. doi:10.1016/j.biomaterials.2018.04.005
   PubMed Web of Science ®Google Scholar