Advances in the Study of Bioactive Nanoparticles for the Treatment of HCC and Its Postoperative Residual Cancer

References

• Lu SD, Li L, Liang XM, et al. Updates and advancements in the management of hepatocellular carcinoma patients after hepatectomy. Expert Rev Gastroenterol Hepatol. 2019;13(11):1077–1088. doi:10.1080/17474124.2019.1684898
   PubMed Web of Science ®Google Scholar
• Valery PC, Laversanne M, Clark PJ, Petrick JL, McGlynn KA, Bray F. Projections of primary liver cancer to 2030 in 30 countries worldwide. Hepatology. 2018;67(2):600–611. doi:10.1002/hep.29498
   PubMed Web of Science ®Google Scholar
• El-Serag HB, Kanwal F. Epidemiology of hepatocellular carcinoma in the United States: where are we? Where do we go? Hepatology. 2014;60(5):1767–1775. doi:10.1002/hep.27222
   PubMed Web of Science ®Google Scholar
• D’Souza S, Lau KC, Coffin CS, Patel TR. Molecular mechanisms of viral hepatitis induced hepatocellular carcinoma. World J Gastroenterol. 2020;26(38):5759–5783. doi:10.3748/wjg.v26.i38.5759
   PubMed Web of Science ®Google Scholar
• Rushing BR, Selim MI. Aflatoxin B1: a review on metabolism, toxicity, occurrence in food, occupational exposure, and detoxification methods. Food Chem Toxicol. 2019;124:81–100. doi:10.1016/j.fct.2018.11.047
   PubMed Web of Science ®Google Scholar
• Huang DQ, Mathurin P, Cortez-Pinto H, Loomba R. Global epidemiology of alcohol-associated cirrhosis and HCC: trends, projections and risk factors. Nat Rev Gastroenterol Hepatol. 2023;20(1):37–49. doi:10.1038/s41575-022-00688-6
   PubMed Web of Science ®Google Scholar
• Marengo A, Rosso C, Bugianesi E. Liver cancer: connections with obesity, fatty liver, and cirrhosis. Annu Rev Med. 2016;67:103–117. doi:10.1146/annurev-med-090514-013832
   PubMed Web of Science ®Google Scholar
• Plaz Torres MC, Jaffe A, Perry R, Marabotto E, Strazzabosco M, Giannini EG. Diabetes medications and risk of HCC. Hepatology. 2022;76(6):1880–1897. doi:10.1002/hep.32439
   PubMed Web of Science ®Google Scholar
• Affo S, Yu LX, Schwabe RF. The role of cancer-associated fibroblasts and fibrosis in liver cancer. Annu Rev Pathol. 2017;12:153–186. doi:10.1146/annurev-pathol-052016-100322
   PubMed Web of Science ®Google Scholar
• Yarchoan M, Agarwal P, Villanueva A, et al. Correction: recent developments and therapeutic strategies against hepatocellular carcinoma. Cancer Res. 2019;79(22):5897. doi:10.1158/0008-5472.CAN-19-2958
   PubMed Web of Science ®Google Scholar
• Llovet JM, Zucman-Rossi J, Pikarsky E, et al. Hepatocellular carcinoma. Nat Rev Dis Primers. 2016;2:16018. doi:10.1038/nrdp.2016.18
   PubMed Web of Science ®Google Scholar
• Soydal C, Araz M, Nak D, et al. Analysis of prognostic factors in patients receiving transarterial radioembolization for unresectable hepatocellular carcinoma. Nucl Med Commun. 2020;41(1):73–77. doi:10.1097/MNM.0000000000001122
   PubMed Web of Science ®Google Scholar
• Mouli SK, Goff LW. Local arterial therapies in the management of unresectable hepatocellular carcinoma. Curr Treat Options Oncol. 2017;18(11):67. doi:10.1007/s11864-017-0509-6
   PubMed Web of Science ®Google Scholar
• Affonso BB, Galastri FL, da Motta Leal Filho JM, et al. Long-term outcomes of hepatocellular carcinoma that underwent chemoembolization for bridging or downstaging. World J Gastroenterol. 2019;25(37):5687–5701. doi:10.3748/wjg.v25.i37.5687
   PubMed Web of Science ®Google Scholar
• Kishan A, Cosgriff-Hernandez E. Recent advancements in electrospinning design for tissue engineering applications: a review. J Biomed Mater Res A. 2017;105(10):2892–2905. doi:10.1002/jbm.a.36124
   PubMed Web of Science ®Google Scholar
• Babitha S, Rachita L, Karthikeyan K, et al. Electrospun protein nanofibers in healthcare: a review. Int J Pharm. 2017;523(1):52–90. doi:10.1016/j.ijpharm.2017.03.013
   PubMed Web of Science ®Google Scholar
• Kenawy E-R, Bowlin GL, Mansfield K, et al. Release of tetracycline hydrochloride from electrospun poly(ethylene-co-vinylacetate), poly(lactic acid), and a blend. J Control Release. 2002;81(1):57–64. doi:10.1016/S0168-3659(02)00041-X
   PubMed Web of Science ®Google Scholar
• Katti DS, Robinson KW, Ko FK, Laurencin CT. Bioresorbable nanofiber-based systems for wound healing and drug delivery: optimization of fabrication parameters. J Biomed Mater Res B Appl Biomater. 2004;70(2):286–296. doi:10.1002/jbm.b.30041
   PubMed Web of Science ®Google Scholar
• Bian Y, Guo D. Targeted therapy for hepatocellular carcinoma: co-delivery of sorafenib and curcumin using lactosylated pH-responsive nanoparticles. Drug Des Devel Ther. 2020;14:647–659. doi:10.2147/DDDT.S238955
   PubMed Web of Science ®Google Scholar
• Anwanwan D, Singh SK, Singh S, Saikam V, Singh R. Challenges in liver cancer and possible treatment approaches. Biochim Biophys Acta Rev Cancer. 2020;1873(1):188314. doi:10.1016/j.bbcan.2019.188314
   PubMed Web of Science ®Google Scholar
• Zhou F, Teng F, Deng P, Meng N, Song Z, Feng R. Recent progress of nano-drug delivery system for liver cancer treatment. Anticancer Agents Med Chem. 2018;17(14):1884–1897. doi:10.2174/1871520617666170713151149
   PubMed Web of Science ®Google Scholar
• El Fawal G, Hong H, Song X, et al. Polyvinyl alcohol/hydroxyethylcellulose containing ethosomes as a scaffold for transdermal drug delivery applications. Appl Biochem Biotechnol. 2020;191(4):1624–1637. doi:10.1007/s12010-020-03282-1
   PubMed Web of Science ®Google Scholar
• Li B, Yang X. Rutin-loaded cellulose acetate/poly(ethylene oxide) fiber membrane fabricated by electrospinning: a bioactive material. Mater Sci Eng C Mater Biol Appl. 2020;109:110601. doi:10.1016/j.msec.2019.110601
   PubMed Web of Science ®Google Scholar
• Najlah M, Ahmed Z, Iqbal M, et al. Development and characterisation of disulfiram-loaded PLGA nanoparticles for the treatment of non-small cell lung cancer. Eur J Pharm Biopharm. 2017;112:224–233. doi:10.1016/j.ejpb.2016.11.032
   PubMed Web of Science ®Google Scholar
• Zhuang Y, Lin K, Yu H. Advance of nano-composite electrospun fibers in periodontal regeneration. Front Chem. 2019;7:495. doi:10.3389/fchem.2019.00495
   PubMed Web of Science ®Google Scholar
• Campiglio CE, Marcolin C, Draghi L. Electrospun ECM macromolecules as biomimetic scaffold for regenerative medicine: challenges for preserving conformation and bioactivity. AIMS Mater Sci. 2017;4(3):638–669. doi:10.3934/matersci.2017.3.638
   Google Scholar
• Qasim SB, Najeeb S, Delaine-Smith RM, Rawlinson A, Ur Rehman I. Potential of electrospun chitosan fibers as a surface layer in functionally graded GTR membrane for periodontal regeneration. Dent Mater. 2017;33(1):71–83. doi:10.1016/j.dental.2016.10.003
   PubMed Web of Science ®Google Scholar
• Eskitoros-Togay ŞM, Bulbul YE, Tort S, Demirtaş Korkmaz F, Acartürk F, Dilsiz N. Fabrication of doxycycline-loaded electrospun PCL/PEO membranes for a potential drug delivery system. Int J Pharm. 2019;565:83–94. doi:10.1016/j.ijpharm.2019.04.073
   PubMed Web of Science ®Google Scholar
• Huang ZM, He CL, Yang A, et al. Encapsulating drugs in biodegradable ultrafine fibers through co-axial electrospinning. J Biomed Mater Res A. 2006;77(1):169–179. doi:10.1002/jbm.a.30564
   PubMedGoogle Scholar
• Kim K, Luu YK, Chang C, et al. Incorporation and controlled release of a hydrophilic antibiotic using poly(lactide-co-glycolide)-based electrospun nanofibrous scaffolds. J Control Release. 2004;98(1):47–56. doi:10.1016/j.jconrel.2004.04.009
   PubMed Web of Science ®Google Scholar
• Ulery BD, Kumar D, Ramer-Tait AE, Metzger DW, Wannemuehler MJ, Narasimhan B. Design of a protective single-dose intranasal nanoparticle-based vaccine platform for respiratory infectious diseases. PLoS One. 2011;6(3):e17642. doi:10.1371/journal.pone.0017642
   PubMed Web of Science ®Google Scholar
• Jiang H, Fang D, Hsiao B, Chu B, Chen W. Preparation and characterization of ibuprofen-loaded poly(lactide-co-glycolide)/poly(ethylene glycol)-g-chitosan electrospun membranes. J Biomater Sci Polym Ed. 2004;15(3):279–296. doi:10.1163/156856204322977184
   PubMed Web of Science ®Google Scholar
• Chang YS, Adnane J, Trail PA, et al. Sorafenib (BAY 43-9006) inhibits tumor growth and vascularization and induces tumor apoptosis and hypoxia in RCC xenograft models. Cancer Chemother Pharmacol. 2007;59(5):561–574. doi:10.1007/s00280-006-0393-4
   PubMed Web of Science ®Google Scholar
• Liu X, Zhu X, Qi X, Meng X, Xu K. Co-Administration of iRGD with sorafenib-loaded iron-based metal-organic framework as a targeted ferroptosis agent for liver cancer therapy. Int J Nanomedicine. 2021;16:1037–1050. doi:10.2147/IJN.S292528
   PubMed Web of Science ®Google Scholar
• Munoz-Gamez JA, Lopez Viota J, Barrientos A, et al. Synergistic cytotoxicity of the poly (ADP-ribose) polymerase inhibitor ABT-888 and temozolomide in dual-drug targeted magnetic nanoparticles. Liver Int. 2015;35(4):1430–1441. doi:10.1111/liv.12586
   PubMed Web of Science ®Google Scholar
• Taha H, Elfar N, Haffez H, Hassan ZA. Raptinal silver nanoparticles: new therapeutic advances in hepatocellular carcinoma mouse model. Naunyn Schmiedebergs Arch Pharmacol. 2021;394(2):279–289. doi:10.1007/s00210-020-01973-4
   PubMed Web of Science ®Google Scholar
• Shoshan MS, Vonderach T, Hattendorf B, Wennemers H. Peptide-coated platinum nanoparticles with selective toxicity against liver cancer cells. Angew Chem. 2019;58(15):4901–4905. doi:10.1002/anie.201813149
   Google Scholar
• Wang ZY, Chen Z. Acute promyelocytic leukemia: from highly fatal to highly curable. Blood. 2008;111(5):2505–2515. doi:10.1182/blood-2007-07-102798
   PubMed Web of Science ®Google Scholar
• Huang Y, Zhou B, Luo H, et al. ZnAs@SiO2 nanoparticles as a potential anti-tumor drug for targeting stemness and epithelial-mesenchymal transition in hepatocellular carcinoma via SHP-1/JAK2/STAT3 signaling. Theranostics. 2019;9(15):4391–4408. doi:10.7150/thno.32462
   PubMed Web of Science ®Google Scholar
• Hu J, Dong Y, Ding L, et al. Local delivery of arsenic trioxide nanoparticles for hepatocellular carcinoma treatment. Signal Transduct Target Ther. 2019;4:28. doi:10.1038/s41392-019-0062-9
   PubMed Web of Science ®Google Scholar
• Qi L, Xu Z, Chen M. In vitro and in vivo suppression of hepatocellular carcinoma growth by chitosan nanoparticles. Eur J Cancer. 2007;43(1):184–193. doi:10.1016/j.ejca.2006.08.029
   PubMed Web of Science ®Google Scholar
• Jiang H-L, Kim Y-K, Arote R, et al. Mannosylated chitosan-graft-polyethylenimine as a gene carrier for Raw 264.7 cell targeting. Int J Pharm. 2009;375(1):133–139. doi:10.1016/j.ijpharm.2009.03.033
   PubMedGoogle Scholar
• Gali-Muhtasib H, Hmadi R, Kareh M, Tohme R, Darwiche N. Cell death mechanisms of plant-derived anticancer drugs: beyond apoptosis. Apoptosis. 2015;20(12):1531–1562. doi:10.1007/s10495-015-1169-2
   PubMed Web of Science ®Google Scholar
• Zhang YQ, Shen Y, Liao MM, et al. Galactosylated chitosan triptolide nanoparticles for overcoming hepatocellular carcinoma: enhanced therapeutic efficacy, low toxicity, and validated network regulatory mechanisms. Nanomedicine. 2019;15(1):86–97. doi:10.1016/j.nano.2018.09.002
   PubMed Web of Science ®Google Scholar
• Anirudhan TS. Binusreejayan. Dextran based nanosized carrier for the controlled and targeted delivery of curcumin to liver cancer cells. Int J Biol Macromol. 2016;88:222–235. doi:10.1016/j.ijbiomac.2016.03.040
   PubMed Web of Science ®Google Scholar
• Pan X, Liu S, Ju L, et al. Preparation, evaluation, and in vitro cytotoxicity studies of artesunate-loaded glycyrrhetinic acid decorated PEG-PLGA nanoparticles. Drug Dev Ind Pharm. 2020;46(11):1889–1897. doi:10.1080/03639045.2020.1825475
   PubMed Web of Science ®Google Scholar
• Zhang Y, Peng L, Chu J, et al. pH and redox dual-responsive copolymer micelles with surface charge reversal for co-delivery of all-trans-retinoic acid and paclitaxel for cancer combination chemotherapy. Int J Nanomedicine. 2018;13:6499–6515. doi:10.2147/IJN.S179046
   PubMed Web of Science ®Google Scholar
• Fang XB, Xu YQ, Chan HF, et al. A Redox-Sensitive and RAGE-targeting nanocarrier for hepatocellular carcinoma therapy. Mol Pharm. 2016;13(11):3613–3625. doi:10.1021/acs.molpharmaceut.6b00116
   PubMedGoogle Scholar
• Zhi D, Yang T, O’Hagan J, Zhang S, Donnelly RF. Photothermal therapy. J Control Release. 2020;325:52–71. doi:10.1016/j.jconrel.2020.06.032
   PubMed Web of Science ®Google Scholar
• Chen L, Hong W, Duan S, Li Y, Wang J, Zhu J. Graphene quantum dots mediated magnetic chitosan drug delivery nanosystems for targeting synergistic photothermal-chemotherapy of hepatocellular carcinoma. Cancer Biol Ther. 2022;23(1):281–293. doi:10.1080/15384047.2022.2054249
   PubMed Web of Science ®Google Scholar
• Tian G, Pan R, Zhang B, et al. Liver-targeted combination therapy basing on glycyrrhizic acid-modified DSPE-PEG-PEI nanoparticles for co-delivery of doxorubicin and Bcl-2 siRNA. Front Pharmacol. 2019;10:4. doi:10.3389/fphar.2019.00004
   PubMed Web of Science ®Google Scholar
• Mezghrani O, Tang Y, Ke X, et al. Hepatocellular carcinoma dually-targeted nanoparticles for reduction triggered intracellular delivery of doxorubicin. Int J Pharm. 2015;478(2):553–568. doi:10.1016/j.ijpharm.2014.10.041
   PubMedGoogle Scholar
• Kandasamy G, Sudame A, Luthra T, Saini K, Maity D. Functionalized hydrophilic superparamagnetic iron oxide nanoparticles for magnetic fluid hyperthermia application in liver cancer treatment. ACS Omega. 2018;3(4):3991–4005. doi:10.1021/acsomega.8b00207
   PubMed Web of Science ®Google Scholar
• Zhao J, Vykoukal J, Abdelsalam M, et al. Stem cell-mediated delivery of SPIO-loaded gold nanoparticles for the theranosis of liver injury and hepatocellular carcinoma. Nanotechnology. 2014;25(40):405101. doi:10.1088/0957-4484/25/40/405101
   PubMed Web of Science ®Google Scholar
• Shen JM, Li XX, Fan LL, et al. Heterogeneous dimer peptide-conjugated polylysine dendrimer-Fe(3)O(4) composite as a novel nanoscale molecular probe for early diagnosis and therapy in hepatocellular carcinoma. Int J Nanomedicine. 2017;12:1183–1200. doi:10.2147/IJN.S126887
   PubMed Web of Science ®Google Scholar
• Massaguer A, González-Cantó A, Escribano E, et al. Integrin-targeted delivery into cancer cells of a Pt(IV) pro-drug through conjugation to RGD-containing peptides. Dalton Trans. 2015;44(1):202–212. doi:10.1039/C4DT02710H
   PubMed Web of Science ®Google Scholar
• Zheng Y, Ji S, Czerwinski A, Valenzuela F, Pennington M, Liu S. FITC-conjugated cyclic RGD peptides as fluorescent probes for staining integrin αvβ3/αvβ5 in tumor tissues. Bioconjug Chem. 2014;25(11):1925–1941. doi:10.1021/bc500452y
   PubMed Web of Science ®Google Scholar
• Mo Y, He L, Lai Z, et al. Gold nano-particles (AuNPs) carrying miR-326 targets PDK1/AKT/c-myc axis in hepatocellular carcinoma. Artif Cells Nanomed Biotechnol. 2019;47(1):2830–2837. doi:10.1080/21691401.2018.1489266
   PubMed Web of Science ®Google Scholar
• Nandhini JT, Ezhilarasan D, Rajeshkumar S. An ecofriendly synthesized gold nanoparticles induces cytotoxicity via apoptosis in HepG2 cells. Environ Toxicol. 2020;36(1):24–32. doi:10.1002/tox.23007
   PubMed Web of Science ®Google Scholar
• Li T, Chen X, Liu Y, et al. pH-Sensitive mesoporous silica nanoparticles anticancer prodrugs for sustained release of ursolic acid and the enhanced anti-cancer efficacy for hepatocellular carcinoma cancer. Eur J Pharm Sci. 2017;96:456–463. doi:10.1016/j.ejps.2016.10.019
   PubMed Web of Science ®Google Scholar
• Xue H, Yu Z, Liu Y, et al. Delivery of miR-375 and doxorubicin hydrochloride by lipid-coated hollow mesoporous silica nanoparticles to overcome multiple drug resistance in hepatocellular carcinoma. Int J Nanomedicine. 2017;12:5271–5287. doi:10.2147/IJN.S135306
   PubMed Web of Science ®Google Scholar
• Lai C, Yu X, Zhuo H, et al. Anti-tumor immune response of folate-conjugated chitosan nanoparticles containing the IP-10 gene in mice with hepatocellular carcinoma. J Biomed Nanotechnol. 2014;10(12):3576–3589. doi:10.1166/jbn.2014.2051
   PubMed Web of Science ®Google Scholar
• Xue WJ, Feng Y, Wang F, et al. Asialoglycoprotein receptor-magnetic dual targeting nanoparticles for delivery of RASSF1A to hepatocellular carcinoma. Sci Rep. 2016;6:22149. doi:10.1038/srep22149
   PubMed Web of Science ®Google Scholar
• Abu-Serie MM. Evaluation of the selective toxic effect of the charge switchable diethyldithiocarbamate-loaded nanoparticles between hepatic normal and cancerous cells. Sci Rep. 2018;8(1):4617. doi:10.1038/s41598-018-22915-4
   PubMedGoogle Scholar
• Cheng YJ, Qin SY, Ma YH, Chen XS, Zhang AQ, Zhang XZ. Super-pH-sensitive mesoporous silica nanoparticle-based drug delivery system for effective combination cancer therapy. ACS Biomater Sci. 2019;5(4):1878–1886. doi:10.1021/acsbiomaterials.9b00099
   PubMed Web of Science ®Google Scholar
• Wang J, Zhang Y, Liu L, et al. Combined chemo/photothermal therapy based on mesoporous silica-Au core-shell nanoparticles for hepatocellular carcinoma treatment. Drug Dev Ind Pharm. 2019;45(9):1487–1495. doi:10.1080/03639045.2019.1629688
   PubMed Web of Science ®Google Scholar
• Yang H, Liu HS, Hou W, et al. An NIR-responsive mesoporous silica nanosystem for synergetic photothermal-immunoenhancement therapy of hepatocellular carcinoma. J Mater Chem B. 2020;8(2):251–259. doi:10.1039/C9TB01891C
   PubMed Web of Science ®Google Scholar
• Zheng G, Zhao R, Xu A, Shen Z, Chen X, Shao J. Co-delivery of sorafenib and siVEGF based on mesoporous silica nanoparticles for ASGPR mediated targeted HCC therapy. Eur J Pharm Sci. 2018;111:492–502. doi:10.1016/j.ejps.2017.10.036
   PubMed Web of Science ®Google Scholar
• Zhang BC, Luo BY, Zou JJ, et al. Co-delivery of Sorafenib and CRISPR/Cas9 based on targeted core-shell hollow mesoporous organosilica nanoparticles for synergistic HCC therapy. ACS Appl Mater Interfaces. 2020;12(51):57362–57372. doi:10.1021/acsami.0c17660
   PubMed Web of Science ®Google Scholar
• Wang Z, Chang Z, Lu M, et al. Shape-controlled magnetic mesoporous silica nanoparticles for magnetically-mediated suicide gene therapy of hepatocellular carcinoma. Biomaterials. 2018;154:147–157. doi:10.1016/j.biomaterials.2017.10.047
   PubMed Web of Science ®Google Scholar
• Ning Q, Liu YF, Ye PJ, et al. Delivery of Liver-Specific miRNA-122 using a targeted macromolecular prodrug toward synergistic therapy for hepatocellular carcinoma. ACS Appl Mater Interfaces. 2019;11(11):10578–10588. doi:10.1021/acsami.9b00634
   PubMed Web of Science ®Google Scholar
• Aoki M, Fujishita T. Oncogenic Roles of the PI3K/AKT/mTOR Axis. Curr Top Microbiol Immunol. 2017;407:153–189. doi:10.1007/82_2017_6
   PubMed Web of Science ®Google Scholar
• Zheng N, Liu W, Li B, et al. Co-delivery of sorafenib and metapristone encapsulated by CXCR4-targeted PLGA-PEG nanoparticles overcomes hepatocellular carcinoma resistance to sorafenib. J Exp Clin Cancer Res. 2019;38(1):232. doi:10.1186/s13046-019-1216-x
   PubMedGoogle Scholar
• Wang SB, Ma YY, Chen XY, Zhao YY, Mou XZ. Ceramide-graphene oxide nanoparticles enhance cytotoxicity and decrease HCC xenograft development: a novel approach for targeted cancer therapy. Front Pharmacol. 2019;10:69. doi:10.3389/fphar.2019.00069
   PubMed Web of Science ®Google Scholar
• Gao Y, Hu L, Liu Y, Xu X, Wu C. Targeted delivery of paclitaxel in liver cancer using hyaluronic acid functionalized mesoporous hollow alumina nanoparticles. Biomed Res Int. 2019;2019:2928507. doi:10.1155/2019/2928507
   PubMed Web of Science ®Google Scholar
• Zhang J, Yu C, Jiang G. Synthesis of cholic-acid-carrying polymer and in-vitro evaluation of hepatoma-targeting nanoparticles decorated with the polymer. J Biomater Sci Polym Ed. 2016;27(9):865–879. doi:10.1080/09205063.2016.1168764
   PubMed Web of Science ®Google Scholar
• Ali D, Alarifi S, Alkahtani S, Almeer RS. Silver-doped graphene oxide nanocomposite triggers cytotoxicity and apoptosis in human hepatic normal and carcinoma cells. Int J Nanomedicine. 2018;13:5685–5699. doi:10.2147/IJN.S165448
   PubMed Web of Science ®Google Scholar
• Shapiro J, Jersky J, Katzav S, Feldman M, Segal S. Anesthetic drugs accelerate the progression of postoperative metastases of mouse tumors. J Clin Invest. 1981;68(3):678–685. doi:10.1172/JCI110303
   PubMed Web of Science ®Google Scholar
• Lange PH, Hekmat K, Bosl G, Kennedy BJ, Fraley EE. Accelerated growth of testicular cancer after cytoreductive surgery. Cancer. 1980;45(6):1498–1506. doi:10.1002/1097-0142(19800315)45:6<1498::AID-CNCR2820450633>3.0.CO;2-7
   PubMed Web of Science ®Google Scholar
• deVere White R, Deitch AD, Hong WK, Olsson CA. The influence of cytoreductive surgery on the response to chemotherapy of a rat renal cancer. Urol Res. 1985;13(1):35–38. doi:10.1007/BF00571754
   PubMedGoogle Scholar
• O’Reilly MS, Boehm T, Shing Y, et al. Endostatin: an endogenous inhibitor of angiogenesis and tumor growth. Cell. 1997;88(2):277–285. doi:10.1016/S0092-8674(00)81848-6
   PubMed Web of Science ®Google Scholar
• Tohme S, Simmons RL, Tsung A. Surgery for Cancer: a Trigger for Metastases. Cancer Res. 2017;77(7):1548–1552. doi:10.1158/0008-5472.CAN-16-1536
   PubMed Web of Science ®Google Scholar
• Shi M, Guo RP, Lin XJ, et al. Partial hepatectomy with wide versus narrow resection margin for solitary hepatocellular carcinoma: a prospective randomized trial. Ann Surg. 2007;245(1):36–43. doi:10.1097/01.sla.0000231758.07868.71
   PubMed Web of Science ®Google Scholar
• Ceelen W, Pattyn P, Mareel M. Surgery, wound healing, and metastasis: recent insights and clinical implications. Crit Rev Oncol Hematol. 2014;89(1):16–26. doi:10.1016/j.critrevonc.2013.07.008
   PubMed Web of Science ®Google Scholar
• Govaert KM, Emmink BL, Nijkamp MW, et al. Hypoxia after liver surgery imposes an aggressive cancer stem cell phenotype on residual tumor cells. Ann Surg. 2014;259(4):750–759. doi:10.1097/SLA.0b013e318295c160
   PubMed Web of Science ®Google Scholar
• Wang XM, Yu DM, McCaughan GW, Gorrell MD. Fibroblast activation protein increases apoptosis, cell adhesion, and migration by the LX-2 human stellate cell line. Hepatology. 2005;42(4):935–945. doi:10.1002/hep.20853
   PubMed Web of Science ®Google Scholar
• Nakamura T, Sakai K, Nakamura T, Matsumoto K. Hepatocyte growth factor twenty years on: much more than a growth factor. J Gastroenterol Hepatol. 2011;26(Suppl 1):188–202. doi:10.1111/j.1440-1746.2010.06549.x
   PubMed Web of Science ®Google Scholar
• Deng H, Wang HF, Gao YB, Jin XL, Xiao JC. Hepatic progenitor cell represents a transitioning cell population between liver epithelium and stroma. Med Hypotheses. 2011;76(6):809–812. doi:10.1016/j.mehy.2011.02.024
   PubMed Web of Science ®Google Scholar
• Zhao H, Feng Y, Wang Y, Yang B, Xing Z. Comparison of different loading dose of celecoxib on postoperative anti-inflammation and analgesia in patients undergoing endoscopic nasal surgery-200 mg is equivalent to 400 mg. Pain Med. 2011;12(8):1267–1275. doi:10.1111/j.1526-4637.2011.01196.x
   PubMed Web of Science ®Google Scholar
• Ruan D, So SP. Prostaglandin E2 produced by inducible COX-2 and mPGES-1 promoting cancer cell proliferation in vitro and in vivo. Life Sci. 2014;116(1):43–50. doi:10.1016/j.lfs.2014.07.042
   PubMed Web of Science ®Google Scholar
• Wang D, Dubois RN. Eicosanoids and cancer. Nat Rev Cancer. 2010;10(3):181–193. doi:10.1038/nrc2809
   PubMed Web of Science ®Google Scholar
• Swartz MA, Lund AW. Lymphatic and interstitial flow in the tumour microenvironment: linking mechanobiology with immunity. Nat Rev Cancer. 2012;12(3):210–219. doi:10.1038/nrc3186
   PubMed Web of Science ®Google Scholar
• Le CP, Nowell CJ, Kim-Fuchs C, et al. Chronic stress in mice remodels lymph vasculature to promote tumour cell dissemination. Nat Commun. 2016;7:10634. doi:10.1038/ncomms10634
   PubMed Web of Science ®Google Scholar
• Sloan EK, Priceman SJ, Cox BF, et al. The sympathetic nervous system induces a metastatic switch in primary breast cancer. Cancer Res. 2010;70(18):7042–7052. doi:10.1158/0008-5472.CAN-10-0522
   PubMed Web of Science ®Google Scholar
• Abramovitch R, Marikovsky M, Meir G, Neeman M. Stimulation of tumour growth by wound-derived growth factors. Br J Cancer. 1999;79(9–10):1392–1398. doi:10.1038/sj.bjc.6690223
   PubMed Web of Science ®Google Scholar
• Sánchez A, Alvarez AM, Pagan R, et al. Fibronectin regulates morphology, cell organization and gene expression of rat fetal hepatocytes in primary culture. J Hepatol. 2000;32(2):242–250. doi:10.1016/S0168-8278(00)80069-0
   PubMed Web of Science ®Google Scholar
• Kim SH, Turnbull J, Guimond S. Extracellular matrix and cell signalling: the dynamic cooperation of integrin, proteoglycan and growth factor receptor. J Endocrinol. 2011;209(2):139–151. doi:10.1530/JOE-10-0377
   PubMed Web of Science ®Google Scholar
• Li L, Xie T. Stem cell niche: structure and function. Annu Rev Cell Dev Biol. 2005;21:605–631. doi:10.1146/annurev.cellbio.21.012704.131525
   PubMed Web of Science ®Google Scholar
• Fan ST, Yang ZF, Ho DW, Ng MN, Yu WC, Wong J. Prediction of posthepatectomy recurrence of hepatocellular carcinoma by circulating cancer stem cells: a prospective study. Ann Surg. 2011;254(4):569–576. doi:10.1097/SLA.0b013e3182300a1d
   PubMed Web of Science ®Google Scholar
• Coffey JC, Wang JH, Smith MJ, Bouchier-Hayes D, Cotter TG, Redmond HP. Excisional surgery for cancer cure: therapy at a cost. Lancet Oncol. 2003;4(12):760–768. doi:10.1016/S1470-2045(03)01282-8
   PubMed Web of Science ®Google Scholar
• Demicheli R, Retsky MW, Hrushesky WJ, Baum M, Gukas ID. The effects of surgery on tumor growth: a century of investigations. Ann Oncol. 2008;19(11):1821–1828. doi:10.1093/annonc/mdn386
   PubMed Web of Science ®Google Scholar
• Wang B, Xia CY, Lau WY, et al. Determination of clonal origin of recurrent hepatocellular carcinoma for personalized therapy and outcomes evaluation: a new strategy for hepatic surgery. J Am Coll Surg. 2013;217(6):1054–1062. doi:10.1016/j.jamcollsurg.2013.07.402
   PubMed Web of Science ®Google Scholar
• Wu HH, Huang CC, Chang CP, Lin MT, Niu KC, Tian YF. Heat shock protein 70 (HSP70) reduces hepatic inflammatory and oxidative damage in a rat model of liver ischemia/reperfusion injury with hyperbaric oxygen preconditioning. Med Sci Monit. 2018;24:8096–8104. doi:10.12659/MSM.911641
   PubMed Web of Science ®Google Scholar
• Schumacher N, Rose-John S. ADAM17 Activity and IL-6 Trans-signaling in inflammation and cancer. Cancers. 2019;11:11. doi:10.3390/cancers11111736
   Web of Science ®Google Scholar
• Sun X, Hu F, Hou Z, et al. SIX4 activates Akt and promotes tumor angiogenesis. Exp Cell Res. 2019;383(1):111495. doi:10.1016/j.yexcr.2019.111495
   PubMed Web of Science ®Google Scholar
• Zhai XF, Liu XL, Shen F, Fan J, Ling CQ. Traditional herbal medicine prevents postoperative recurrence of small hepatocellular carcinoma: a randomized controlled study. Cancer. 2018;124(10):2161–2168. doi:10.1002/cncr.30915
   PubMed Web of Science ®Google Scholar
• Khalid AD, Ur-Rehman N, Tariq GH, et al. Functional bioinspired nanocomposites for anticancer activity with generation of reactive oxygen species. Chemosphere. 2023;310:136885. doi:10.1016/j.chemosphere.2022.136885
   PubMed Web of Science ®Google Scholar
• Long BA, Lau CY, Rodriguez DJ, Tang SA, Anderson SL. Sublimation kinetics for individual graphite and graphene nanoparticles (NPs): NP-to-NP variations and evolving structure-kinetics and structure-emissivity relationships. J Am Chem Soc. 2020;142(33):14090–14101. doi:10.1021/jacs.0c01720
   PubMed Web of Science ®Google Scholar
• Tran S, DeGiovanni PJ, Piel B, Rai P. Cancer nanomedicine: a review of recent success in drug delivery. Clin Transl Med. 2017;6(1):44. doi:10.1186/s40169-017-0175-0
   PubMed Web of Science ®Google Scholar
• Fong ELS, Toh TB, Lin QXX, et al. Generation of matched patient-derived xenograft in vitro-in vivo models using 3D macroporous hydrogels for the study of liver cancer. Biomaterials. 2018;159:229–240. doi:10.1016/j.biomaterials.2017.12.026
   PubMed Web of Science ®Google Scholar
• Kolesky DB, Truby RL, Gladman AS, Busbee TA, Homan KA, Lewis JA. 3D bioprinting of vascularized, heterogeneous cell-laden tissue constructs. Adv Mater. 2014;26(19):3124–3130. doi:10.1002/adma.201305506
   PubMed Web of Science ®Google Scholar
• Ruan S, Zhou Y, Jiang X, Gao H. Rethinking CRITID procedure of brain targeting drug delivery: circulation, blood brain barrier recognition, intracellular transport, diseased cell targeting, internalization, and drug release. Adv Sci. 2021;8(9):2004025. doi:10.1002/advs.202004025
   Web of Science ®Google Scholar
• Baboci L, Capolla S, Di Cintio F, et al. The dual role of the liver in nanomedicine as an actor in the elimination of nanostructures or a therapeutic target. J Oncol. 2020;2020:4638192. doi:10.1155/2020/4638192
   PubMed Web of Science ®Google Scholar
• Habek D, Cerovac A, Kamerić L, Nevačinović E, Šerak A. Balneogynaecology in the 21st century: increasingly recommended primary and complementary treatment of chronic gynaecological diseases. Med Glas (Zenica). 2021;18(1):1–6. doi:10.17392/1263-21
   PubMedGoogle Scholar
• De Falco L, Troiano E, Cesar M, et al. Intra-operative local plus systemic tranexamic acid significantly decreases post-operative bleeding and the need for allogeneic blood transfusion in total knee arthroplasty. Med Glas (Zenica). 2021;18(1):267–272. doi:10.17392/1327-21
   PubMedGoogle Scholar
• Iftikhar M, Noureen A, Jabeen F, et al. Bioinspired engineered nickel nanoparticles with multifunctional attributes for reproductive toxicity. Chemosphere. 2023;311(Pt 1):136927. doi:10.1016/j.chemosphere.2022.136927
   PubMedGoogle Scholar
• Ferlay J, Colombet M, Soerjomataram I, et al. Estimating the global cancer incidence and mortality in 2018: GLOBOCAN sources and methods. Int J Cancer. 2019;144(8):1941–1953. doi:10.1002/ijc.31937
   PubMed Web of Science ®Google Scholar