Ultrasound-Targeted Microbubble Disruption with Key Nanodroplets for Effective Ferroptosis in Triple-Negative Breast Cancer Using Animal Model

References

• Foulkes WD, Reis-Filho JS, Reis-Filho JS. Triple-negative breast cancer. N Engl J Med. 2010;363:1938–1948. doi:10.1056/NEJMra1001389
   PubMed Web of Science ®Google Scholar
• Yu H, Yang C, Jian L, et al. Sulfasalazine‑induced ferroptosis in breast cancer cells is reduced by the inhibitory effect of estrogen receptor on the transferrin receptor. Oncol Rep. 2019. doi:10.3892/or.2019.7189
   Web of Science ®Google Scholar
• Denkert C, Liedtke C, Tutt A, von Minckwitz G. Molecular alterations in triple-negative breast cancer—the road to new treatment strategies. Lancet. 2017;389(10087):2430–2442. doi:10.1016/S0140-6736(16)32454-0
   PubMed Web of Science ®Google Scholar
• Mou Y, Wang J, Wu J, et al. Ferroptosis, a new form of cell death: opportunities and challenges in cancer. J Hematol Oncol. 2019;12(1):34. doi:10.1186/s13045-019-0720-y
   PubMed Web of Science ®Google Scholar
• Doll S, Proneth B, Tyurina YY, et al. ACSL4 dictates ferroptosis sensitivity by shaping cellular lipid composition. Nat Chem Biol. 2017;13(1):91–98. doi:10.1038/nchembio.2239
   PubMed Web of Science ®Google Scholar
• Ding Y, Chen X, Liu C, et al. Identification of a small molecule as inducer of ferroptosis and apoptosis through ubiquitination of GPX4 in triple negative breast cancer cells. J Hematol Oncol. 2021;14(1):19. doi:10.1186/s13045-020-01016-8
   PubMed Web of Science ®Google Scholar
• Zhu J, Dai P, Liu F, et al. Upconverting nanocarriers enable triggered microtubule inhibition and concurrent ferroptosis induction for selective treatment of triple-negative breast cancer. Nano Lett. 2020;20(9):6235–6245. doi:10.1021/acs.nanolett.0c00502
   PubMed Web of Science ®Google Scholar
• Hou L, Pu L, Chen Y, et al. Targeted intervention of NF2–YAP signaling axis in CD24-overexpressing cells contributes to encouraging therapeutic effects in TNBC. ACS Nano. 2022;16(4):5807–5819. doi:10.1021/acsnano.1c10921
   PubMed Web of Science ®Google Scholar
• Chen X, Kang R, Kroemer G, Tang D. Broadening horizons: the role of ferroptosis in cancer. Nat Rev Clin Oncol. 2021;18(5):280–296. doi:10.1038/s41571-020-00462-0
   PubMed Web of Science ®Google Scholar
• Dixon SJ, Lemberg KM, Lamprecht MR, et al. Ferroptosis: an iron-dependent form of nonapoptotic cell death. Cell. 2012;149(5):1060–1072. doi:10.1016/j.cell.2012.03.042
   PubMed Web of Science ®Google Scholar
• Yang WS, SriRamaratnam R, Welsch ME, et al. Regulation of ferroptotic cancer cell death by GPX4. Cell. 2014;156(1–2):317–331. doi:10.1016/j.cell.2013.12.010
   PubMed Web of Science ®Google Scholar
• Zhang X, Sui S, Wang L, et al. Inhibition of tumor propellant glutathione peroxidase 4 induces ferroptosis in cancer cells and enhances anticancer effect of cisplatin. J Cell Physiol. 2020;235(4):3425–3437. doi:10.1002/jcp.29232
   PubMed Web of Science ®Google Scholar
• Bjarnadottir O, Romero Q, Bendahl PO, et al. Targeting HMG-CoA reductase with statins in a window-of-opportunity breast cancer trial. Breast Cancer Res Treat. 2013;138(2):499–508. doi:10.1007/s10549-013-2473-6
   PubMed Web of Science ®Google Scholar
• Sondergaard T, Pedersen P, Andersen T, et al. A Phase II clinical trial does not show that high dose simvastatin has beneficial effect on markers of bone turnover in multiple myeloma. Hematol Oncol. 2009;27(1):17–22. doi:10.1002/hon.869
   PubMed Web of Science ®Google Scholar
• Li J, Cao F, Liang YH, et al. Ferroptosis: past, present and future. Cell Death Dis. 2020;11(2):88. doi:10.1038/s41419-020-2298-2
   PubMed Web of Science ®Google Scholar
• Petyaev IM. State of the art paper improvement of hepatic bioavailability as a new step for the future of statin. aoms. 2015;2:406–410. doi:10.5114/aoms.2015.50972
   Google Scholar
• Schachter M. Chemical, pharmacokinetic and pharmacodynamic properties of statins: an update. Fundam Clin Pharmacol. 2005;19(1):117–125. doi:10.1111/j.1472-8206.2004.00299.x
   PubMed Web of Science ®Google Scholar
• Preiss D. Risk of incident diabetes with intensive-dose compared with moderate-dose statin therapy: a meta-analysis. JAMA. 2011;305(24):2556. doi:10.1001/jama.2011.860
   PubMed Web of Science ®Google Scholar
• Rosenson RS, Baker SK, Jacobson TA, Kopecky SL, Parker BA. An assessment by the Statin Muscle safety task force: 2014 update. J Clin Lipidol. 2014;8(3):S58–S71. doi:10.1016/j.jacl.2014.03.004
   PubMed Web of Science ®Google Scholar
• Li K, Lin C, Li M, et al. Multienzyme-like reactivity cooperatively impairs glutathione peroxidase 4 and ferroptosis suppressor protein 1 pathways in triple-negative breast cancer for sensitized ferroptosis therapy. ACS Nano. 2022;16(2):2381–2398. doi:10.1021/acsnano.1c08664
   PubMed Web of Science ®Google Scholar
• Gai C, Liu C, Wu X, et al. MT1DP loaded by folate-modified liposomes sensitizes erastin-induced ferroptosis via regulating miR-365a-3p/NRF2 axis in non-small cell lung cancer cells. Cell Death Dis. 2020;11(9):751. doi:10.1038/s41419-020-02939-3
   PubMed Web of Science ®Google Scholar
• Tao W, Wang N, Ruan J, et al. Enhanced ROS-boosted phototherapy against pancreatic cancer via Nrf2-mediated stress-defense pathway suppression and ferroptosis induction. ACS Appl Mater Interfaces. 2022;14(5):6404–6416. doi:10.1021/acsami.1c22861
   PubMed Web of Science ®Google Scholar
• Degors IMS, Wang C, Rehman ZU, Zuhorn IS. Carriers break barriers in drug delivery: endocytosis and endosomal escape of gene delivery vectors. Acc Chem Res. 2019;52(7):1750–1760. doi:10.1021/acs.accounts.9b00177
   PubMed Web of Science ®Google Scholar
• Shafi AS, McClements J, Albaijan I, Abou-Saleh RH, Moran C, Koutsos V. Probing phospholipid microbubbles by atomic force microscopy to quantify bubble mechanics and nanostructural shell properties. Colloids Surf B Biointerfaces. 2019;181:506–515. doi:10.1016/j.colsurfb.2019.04.062
   PubMed Web of Science ®Google Scholar
• Shang M, Sun X, Guo L, et al. pH- and ultrasound-responsive paclitaxel-loaded carboxymethyl chitosan nanodroplets for combined imaging and synergistic chemoradiotherapy. IJN. 2020;15:537–552. doi:10.2147/IJN.S233669
   Google Scholar
• Sun W, Li Z, Zhou X, Yang G, Yuan L. Efficient exosome delivery in refractory tissues assisted by ultrasound-targeted microbubble destruction. Drug Deliv. 2019;26(1):45–50. doi:10.1080/10717544.2018.1534898
   PubMed Web of Science ®Google Scholar
• Shi D, Guo L, Sun X, et al. UTMD inhibit EMT of breast cancer through the ROS/miR-200c/ZEB1 axis. Sci Rep. 2020;10(1):6657. doi:10.1038/s41598-020-63653-w
   PubMed Web of Science ®Google Scholar
• Xu Q, Zhan G, Zhang Z, Yong T, Yang X, Gan L. Manganese porphyrin-based metal-organic framework for synergistic sonodynamic therapy and ferroptosis in hypoxic tumors. Theranostics. 2021;11(4):1937–1952. doi:10.7150/thno.45511
   PubMed Web of Science ®Google Scholar
• Meng D, Guo L, Shi D, et al. Charge-conversion and ultrasound-responsive O-carboxymethyl chitosan nanodroplets for controlled drug delivery. Nanomedicine. 2019;14(19):2549–2565. doi:10.2217/nnm-2019-0217
   PubMed Web of Science ®Google Scholar
• Singh R, Lillard JW. Nanoparticle-based targeted drug delivery. Exp Mol Pathol. 2009;86(3):215–223. doi:10.1016/j.yexmp.2008.12.004
   PubMed Web of Science ®Google Scholar
• Gujarathi NA, Rane BR, Patel JK. pH sensitive polyelectrolyte complex of O-carboxymethyl chitosan and poly (acrylic acid) cross-linked with calcium for sustained delivery of acid susceptible drugs. Int J Pharm. 2012;436(1–2):418–425. doi:10.1016/j.ijpharm.2012.07.016
   PubMedGoogle Scholar
• Kalliola S, Repo E, Srivastava V, et al. The pH sensitive properties of carboxymethyl chitosan nanoparticles cross-linked with calcium ions. Colloids Surf B Biointerfaces. 2017;153:229–236. doi:10.1016/j.colsurfb.2017.02.025
   PubMed Web of Science ®Google Scholar
• Lee JY, Carugo D, Crake C, et al. Nanoparticle-loaded protein-polymer nanodroplets for improved stability and conversion efficiency in ultrasound imaging and drug delivery. Adv Mater. 2015;27(37):5484–5492. doi:10.1002/adma.201502022
   PubMed Web of Science ®Google Scholar
• Chowdhury SM, Abou-Elkacem L, Lee T, Dahl J, Lutz AM. Ultrasound and microbubble mediated therapeutic delivery: underlying mechanisms and future outlook. J Control Release. 2020;326:75–90. doi:10.1016/j.jconrel.2020.06.008
   PubMed Web of Science ®Google Scholar
• Yan B, Ai Y, Sun Q, et al. Membrane damage during ferroptosis is caused by oxidation of phospholipids catalyzed by the oxidoreductases POR and CYB5R1. Mol Cell. 2021;81(2):355–369.e10. doi:10.1016/j.molcel.2020.11.024
   PubMed Web of Science ®Google Scholar
• Qu F, Wang P, Zhang K, et al. Manipulation of Mitophagy by “All-in-One” nanosensitizer augments sonodynamic glioma therapy. Autophagy. 2020;16(8):1413–1435. doi:10.1080/15548627.2019.1687210
   PubMed Web of Science ®Google Scholar
• He C, Zhang X, Yan R, et al. Enhancement of cisplatin efficacy by lipid–CaO 2 nanocarrier-mediated comprehensive modulation of the tumor microenvironment. Biomater Sci. 2019;7(10):4260–4272. doi:10.1039/C9BM00797K
   PubMed Web of Science ®Google Scholar
• Wei G, Huang L, Jiang Y, et al. Lenvatinib-zinc phthalocyanine conjugates as potential agents for enhancing synergistic therapy of multidrug-resistant cancer by glutathione depletion. Eur J Med Chem. 2019;169:53–64. doi:10.1016/j.ejmech.2019.02.065
   PubMed Web of Science ®Google Scholar
• Dorsch M, Kowalczyk M, Planque M, et al. Statins affect cancer cell plasticity with distinct consequences for tumor progression and metastasis. Cell Rep. 2021;37(8):110056. doi:10.1016/j.celrep.2021.110056
   PubMed Web of Science ®Google Scholar
• Jiang W, Hu JW, He XR, Jin WL, He XY. Statins: a repurposed drug to fight cancer. J Exp Clin Cancer Res. 2021;40(1):241. doi:10.1186/s13046-021-02041-2
   PubMed Web of Science ®Google Scholar
• Wei R, Zhao Y, Wang J, et al. Tagitinin C induces ferroptosis through PERK-Nrf2-HO-1 signaling pathway in colorectal cancer cells. Int J Biol Sci. 2021;17(11):2703–2717. doi:10.7150/ijbs.59404
   PubMed Web of Science ®Google Scholar
• Guan D, Zhou W, Wei H, et al. Ferritinophagy-mediated ferroptosis and activation of Keap1/Nrf2/HO-1 pathway were conducive to EMT inhibition of gastric cancer cells in action of 2,2-di-pyridineketone hydrazone dithiocarbamate butyric acid ester. Oxid Med Cell Longev. 2022;2022:1–15. doi:10.1155/2022/3920664
   Web of Science ®Google Scholar
• Wang X, Shang M, Sun X, et al. Dual-responsive nanodroplets combined with ultrasound-targeted microbubble destruction suppress tumor growth and metastasis via autophagy blockade. J Control Release. 2022;343:66–77. doi:10.1016/j.jconrel.2022.01.009
   PubMed Web of Science ®Google Scholar
• Lowe KC. Perfluorinated blood substitutes and artificial oxygen carriers. Blood Rev. 1999;13(3):171–184. doi:10.1054/blre.1999.0113
   PubMed Web of Science ®Google Scholar
• Tian F, Wang S, Shi K, et al. Dual‐depletion of intratumoral lactate and ATP with radicals generation for cascade metabolic‐chemodynamic therapy. Adv Sci. 2021;8(24):2102595. doi:10.1002/advs.202102595
   Web of Science ®Google Scholar
• Gosens I, Post JA, de la Fonteyne LJ, et al. Impact of agglomeration state of nano- and submicron sized gold particles on pulmonary inflammation. Part Fibre Toxicol. 2010;7(1):37. doi:10.1186/1743-8977-7-37
   PubMedGoogle Scholar
• Xu Y, Liu S, Zeng L, et al. An enzyme‐engineered nonporous copper (I) coordination polymer nanoplatform for cuproptosis‐based synergistic cancer therapy. Adv Mater. 2022;34(43):2204733. doi:10.1002/adma.202204733
   Web of Science ®Google Scholar