Engineered Plant-Derived Nanovesicles Facilitate Tumor Therapy: Natural Bioactivity Plus Drug Controlled Release Platform

References

• Siegel RL, Miller KD, Fuchs HE, Jemal A. Cancer statistics, 2021. CA. 2021;71(1):7–33.
   Google Scholar
• Xia C, Dong X, Li H, et al. Cancer statistics in China and United States, 2022: profiles, trends, and determinants. Chin Med J. 2022;135(5):584–590.
   PubMed Web of Science ®Google Scholar
• Gulack B, Nussbaum D, Keenan J, et al. Surgical resection of the primary tumor in stage IV colorectal cancer without metastasectomy is associated with improved overall survival compared with chemotherapy/radiation therapy alone. Dis Colon Rectum. 2016;59(4):299–305.
   PubMed Web of Science ®Google Scholar
• Abraha I, Aristei C, Palumbo I, et al. Preoperative radiotherapy and curative surgery for the management of localised rectal carcinoma. Cochrane Database Syst Rev. 2018;10(10):Cd002102.
   PubMedGoogle Scholar
• Alizadeh D, Larmonier N. Chemotherapeutic targeting of cancer-induced immunosuppressive cells. Cancer Res. 2014;74(10):2663–2668.
   PubMed Web of Science ®Google Scholar
• Jenkins L, Jungwirth U, Avgustinova A, et al. Cancer-associated fibroblasts suppress CD8+ T-cell infiltration and confer resistance to immune-checkpoint blockade. Cancer Res. 2022;82(16):2904–2917.
   PubMed Web of Science ®Google Scholar
• Friedmann Angeli JP, Krysko DV, Conrad M. Ferroptosis at the crossroads of cancer-acquired drug resistance and immune evasion. Nat Rev Cancer. 2019;19(7):405–414.
   PubMed Web of Science ®Google Scholar
• Akhavan O, Ghaderi E. Graphene nanomesh promises extremely efficient in vivo photothermal therapy. Small. 2013;9(21):3593–3601.
   PubMed Web of Science ®Google Scholar
• Ouyang C, Zhang S, Xue C, et al. Precision-guided missile-like DNA nanostructure containing warhead and guidance control for aptamer-based targeted drug delivery into cancer cells in vitro and in vivo. J Am Chem Soc. 2020;142(3):1265–1277.
   PubMed Web of Science ®Google Scholar
• Dutta B, Barick KC, Hassan PA. Recent advances in active targeting of nanomaterials for anticancer drug delivery. Adv Colloid Interface Sci. 2021;296:102509.
   PubMed Web of Science ®Google Scholar
• Mitchell MJ, Billingsley MM, Haley RM, Wechsler ME, Peppas NA, Langer R. Engineering precision nanoparticles for drug delivery. Nat Rev Drug Discov. 2021;20(2):101–124.
   PubMed Web of Science ®Google Scholar
• Hou X, Zaks T, Langer R, Dong Y. Lipid nanoparticles for mRNA delivery. Nat Rev Mater. 2021;6(12):1078–1094.
   PubMed Web of Science ®Google Scholar
• He B, Sui X, Yu B, Wang S, Shen Y, Cong H. Recent advances in drug delivery systems for enhancing drug penetration into tumors. Drug Deliv. 2020;27(1):1474–1490.
   PubMed Web of Science ®Google Scholar
• Sun Y, Zheng L, Yang Y, et al. Metal-organic framework nanocarriers for drug delivery in biomedical applications. Nanomicro Lett. 2020;12(1):103.
   PubMed Web of Science ®Google Scholar
• Herrmann IK, Wood MJA, Fuhrmann G. Extracellular vesicles as a next-generation drug delivery platform. Nat Nanotechnol. 2021;16(7):748–759.
   PubMed Web of Science ®Google Scholar
• Li YJ, Wu JY, Liu J, et al. Artificial exosomes for translational nanomedicine. J Nanobiotechnology. 2021;19(1):242.
   PubMed Web of Science ®Google Scholar
• You JY, Kang SJ, Rhee WJ. Isolation of cabbage exosome-like nanovesicles and investigation of their biological activities in human cells. Bioact Mater. 2021;6(12):4321–4332.
   PubMed Web of Science ®Google Scholar
• Di Gioia S, Hossain MN, Conese M. Biological properties and therapeutic effects of plant-derived nanovesicles. Open Med. 2020;15(1):1096–1122.
   Web of Science ®Google Scholar
• Lian MQ, Chng WH, Liang J, et al. Plant-derived extracellular vesicles: recent advancements and current challenges on their use for biomedical applications. J Extracell Vesicles. 2022;11(12):e12283.
   PubMed Web of Science ®Google Scholar
• Urzì O, Raimondo S, Alessandro R. Extracellular vesicles from plants: current knowledge and open questions. Int J Mol Sci. 2021;22(10):1.
   Web of Science ®Google Scholar
• Kim SQ, Kim KH. Emergence of edible plant-derived nanovesicles as functional food components and nanocarriers for therapeutics delivery: potentials in human health and disease. Cells. 2022;11(14):1.
   Web of Science ®Google Scholar
• Ly NP, Han HS, Kim M, Park JH, Choi KY. Plant-derived nanovesicles: current understanding and applications for cancer therapy. Bioact Mater. 2023;22:365–383.
   PubMed Web of Science ®Google Scholar
• Niu W, Xiao Q, Wang X, et al. A biomimetic drug delivery system by integrating grapefruit extracellular vesicles and doxorubicin-loaded heparin-based nanoparticles for glioma therapy. Nano Lett. 2021;21(3):1484–1492.
   PubMed Web of Science ®Google Scholar
• Wang Q, Zhuang X, Mu J, et al. Delivery of therapeutic agents by nanoparticles made of grapefruit-derived lipids. Nat Commun. 2013;4:1867.
   PubMed Web of Science ®Google Scholar
• Kim K, Yoo HJ, Jung JH, et al. Cytotoxic effects of plant sap-derived extracellular vesicles on various tumor cell types. J Funct Biomater. 2020;11(2):1.
   Web of Science ®Google Scholar
• Dad HA, Gu TW, Zhu AQ, Huang LQ, Peng LH. Plant exosome-like nanovesicles: emerging therapeutics and drug delivery nanoplatforms. Mol Ther. 2021;29(1):13–31.
   PubMed Web of Science ®Google Scholar
• Cong M, Tan S, Li S, et al. Technology insight: plant-derived vesicles-How far from the clinical biotherapeutics and therapeutic drug carriers? Adv Drug Deliv Rev. 2022;182:114108.
   PubMed Web of Science ®Google Scholar
• Kim K, Jung JH, Yoo HJ, et al. Anti-metastatic effects of plant sap-derived extracellular vesicles in a 3D microfluidic cancer metastasis model. J Funct Biomater. 2020;11(3):1.
   Web of Science ®Google Scholar
• Xu XH, Yuan TJ, Dad HA, et al. Plant Exosomes As Novel Nanoplatforms for MicroRNA Transfer Stimulate Neural Differentiation of Stem Cells In Vitro and In Vivo. Nano Lett. 2021;21(19):8151–8159.
   PubMed Web of Science ®Google Scholar
• Woith E, Guerriero G, Hausman JF, et al. Plant extracellular vesicles and nanovesicles: focus on secondary metabolites, proteins and lipids with perspectives on their potential and sources. Int J Mol Sci. 2021;22(7):1.
   Web of Science ®Google Scholar
• Feng J, Xiu Q, Huang Y, Troyer Z, Li B, Zheng L. Plant-derived vesicle-like nanoparticles as promising biotherapeutic tools: present and future. Adv Mater. 2023;2023:e2207826.
   Google Scholar
• Stanly C, Alfieri M, Ambrosone A, Leone A, Fiume I, Pocsfalvi G. Grapefruit-derived micro and nanovesicles show distinct metabolome profiles and anticancer activities in the A375 human melanoma cell Line. Cells. 2020;9(12):1.
   Web of Science ®Google Scholar
• Han X, Wei Q, Lv Y, et al. Ginseng-derived nanoparticles potentiate immune checkpoint antibody efficacy by reprogramming the cold tumor microenvironment. Mol Ther. 2022;30(1):327–340.
   PubMed Web of Science ®Google Scholar
• Xiao J, Feng S, Wang X, et al. Identification of exosome-like nanoparticle-derived microRNAs from 11 edible fruits and vegetables. Peer J. 2018;6:e5186.
   PubMed Web of Science ®Google Scholar
• Yang M, Luo Q, Chen X, Chen F. Bitter melon derived extracellular vesicles enhance the therapeutic effects and reduce the drug resistance of 5-fluorouracil on oral squamous cell carcinoma. J Nanobiotechnology. 2021;19(1):259.
   PubMed Web of Science ®Google Scholar
• Wang B, Guo XJ, Cai H, et al. Momordica charantia-derived extracellular vesicles-like nanovesicles inhibited glioma proliferation, migration, and invasion by regulating the PI3K/AKT signaling pathway. J Funct Foods. 2022;90(1):104968.
   Google Scholar
• Xiao Q, Zhao W, Wu C, et al. Lemon-derived extracellular vesicles nanodrugs enable to efficiently overcome cancer multidrug resistance by endocytosis-triggered energy dissipation and energy production reduction. Adv Sci. 2022;9(20):e2105274.
   Web of Science ®Google Scholar
• Yang M, Liu X, Luo Q, Xu L, Chen F. An efficient method to isolate lemon derived extracellular vesicles for gastric cancer therapy. J Nanobiotechnology. 2020;18(1):100.
   PubMed Web of Science ®Google Scholar
• Raimondo S, Naselli F, Fontana S, et al. Citrus limon-derived nanovesicles inhibit cancer cell proliferation and suppress CML xenograft growth by inducing TRAIL-mediated cell death. Oncotarget. 2015;6(23):19514–19527.
   PubMedGoogle Scholar
• Raimondo S, Saieva L, Cristaldi M, Monteleone F, Fontana S, Alessandro R. Label-free quantitative proteomic profiling of colon cancer cells identifies acetyl-CoA carboxylase alpha as antitumor target of Citrus limon-derived nanovesicles. J Proteomics. 2018;173:1–11.
   PubMed Web of Science ®Google Scholar
• Özkan İ, Koçak P, Yıldırım M, et al. Garlic (Allium sativum)-derived SEVs inhibit cancer cell proliferation and induce caspase mediated apoptosis. Sci Rep. 2021;11(1):14773.
   PubMed Web of Science ®Google Scholar
• Wongkaewkhiaw S, Wongrakpanich A, Krobthong S, Saengsawang W, Chairoungdua A, Boonmuen N. Induction of apoptosis in human colorectal cancer cells by nanovesicles from fingerroot (Boesenbergia rotunda (L.) Mansf.). PLoS One. 2022;17(4):e0266044.
   PubMed Web of Science ®Google Scholar
• Potestà M, Roglia V, Fanelli M, et al. Effect of microvesicles from Moringa oleifera containing miRNA on proliferation and apoptosis in tumor cell lines. Cell Death Discov. 2020;6:43.
   PubMed Web of Science ®Google Scholar
• Chen Q, Li Q, Liang Y, et al. Natural exosome-like nanovesicles from edible tea flowers suppress metastatic breast cancer via ROS generation and microbiota modulation. Acta Pharm Sin B. 2022;12(2):907–923.
   PubMed Web of Science ®Google Scholar
• Zhang M, Viennois E, Prasad M, et al. Edible ginger-derived nanoparticles: a novel therapeutic approach for the prevention and treatment of inflammatory bowel disease and colitis-associated cancer. Biomaterials. 2016;101:321–340.
   PubMed Web of Science ®Google Scholar
• Cao M, Yan H, Han X, et al. Ginseng-derived nanoparticles alter macrophage polarization to inhibit melanoma growth. J Immunother Cancer. 2019;7(1):326.
   PubMed Web of Science ®Google Scholar
• Zu M, Xie D, Canup BSB, et al. ‘Green’ nanotherapeutics from tea leaves for orally targeted prevention and alleviation of colon diseases. Biomaterials. 2021;279:121178.
   PubMed Web of Science ®Google Scholar
• Kantarcıoğlu M, Yıldırım G, Akpınar Oktar P, et al. Coffee-derived exosome-like nanoparticles: are they the secret heroes? Turk J Gastroenterol. 2022;2022:1.
   Google Scholar
• Sasaki D, Kusamori K, Takayama Y, Itakura S, Todo H, Nishikawa M. Development of nanoparticles derived from corn as mass producible bionanoparticles with anticancer activity. Sci Rep. 2021;11(1):22818.
   PubMed Web of Science ®Google Scholar
• Chen T, Ma B, Lu S, et al. Cucumber-derived nanovesicles containing cucurbitacin B for non-small cell lung cancer therapy. Int J Nanomedicine. 2022;17:3583–3599.
   PubMed Web of Science ®Google Scholar
• Boccia E, Alfieri M, Belvedere R, et al. Plant hairy roots for the production of extracellular vesicles with antitumor bioactivity. Commun Biol. 2022;5(1):848.
   PubMed Web of Science ®Google Scholar
• Liu J, Xiang J, Jin C, et al. Medicinal plant-derived mtDNA via nanovesicles induces the cGAS-STING pathway to remold tumor-associated macrophages for tumor regression. J Nanobiotechnology. 2023;21(1):78.
   PubMed Web of Science ®Google Scholar
• Phan LM, Yeung SC, Lee MH. Cancer metabolic reprogramming: importance, main features, and potentials for precise targeted anti-cancer therapies. Cancer Biol Med. 2014;11(1):1–19.
   PubMedGoogle Scholar
• Hanahan D, Weinberg RA. Hallmarks of cancer: the next generation. Cell. 2011;144(5):646–674.
   PubMed Web of Science ®Google Scholar
• Hanahan D. Hallmarks of cancer: new dimensions. Cancer Discov. 2022;12(1):31–46.
   PubMed Web of Science ®Google Scholar
• Cockburn K, Annusver K, Gonzalez DG, et al. Gradual differentiation uncoupled from cell cycle exit generates heterogeneity in the epidermal stem cell layer. Nat Cell Biol. 2022;24(12):1692–1700.
   PubMed Web of Science ®Google Scholar
• Yang L, Shi P, Zhao G, et al. Targeting cancer stem cell pathways for cancer therapy. Signal Transduct Target Ther. 2020;5(1):8.
   PubMed Web of Science ®Google Scholar
• Zhang L, He F, Gao L, et al. Engineering exosome-like nanovesicles derived from asparagus cochinchinensis can inhibit the proliferation of hepatocellular carcinoma cells with better safety profile. Int J Nanomedicine. 2021;16:1575–1586.
   PubMed Web of Science ®Google Scholar
• Singh R, Letai A, Sarosiek K. Regulation of apoptosis in health and disease: the balancing act of BCL-2 family proteins. Nat Rev Mol Cell Biol. 2019;20(3):175–193.
   PubMed Web of Science ®Google Scholar
• Pistritto G, Trisciuoglio D, Ceci C, Garufi A, D’Orazi G. Apoptosis as anticancer mechanism: function and dysfunction of its modulators and targeted therapeutic strategies. Aging. 2016;8(4):603–619.
   PubMedGoogle Scholar
• Delbridge AR, Grabow S, Strasser A, Vaux DL. Thirty years of BCL-2: translating cell death discoveries into novel cancer therapies. Nat Rev Cancer. 2016;16(2):99–109.
   PubMed Web of Science ®Google Scholar
• Imran M, Aslam Gondal T, Atif M, et al. Apigenin as an anticancer agent. Phytother Res. 2020;34(8):1812–1828.
   PubMed Web of Science ®Google Scholar
• Carneiro BA, El-Deiry WS. Targeting apoptosis in cancer therapy. Nat Rev Clin Oncol. 2020;17(7):395–417.
   PubMed Web of Science ®Google Scholar
• Housman G, Byler S, Heerboth S, et al. Drug resistance in cancer: an overview. Cancers. 2014;6(3):1769–1792.
   PubMed Web of Science ®Google Scholar
• Jahangirian H, Lemraski EG, Webster TJ, Rafiee-Moghaddam R, Abdollahi Y. A review of drug delivery systems based on nanotechnology and green chemistry: green nanomedicine. Int J Nanomedicine. 2017;12:2957–2978.
   PubMed Web of Science ®Google Scholar
• Mansoori B, Mohammadi A, Davudian S, Shirjang S, Baradaran B. The different mechanisms of cancer drug resistance: a brief review. Adv Pharm Bull. 2017;7(3):339–348.
   PubMed Web of Science ®Google Scholar
• Sethy C, Kundu CN. 5-Fluorouracil (5-FU) resistance and the new strategy to enhance the sensitivity against cancer: implication of DNA repair inhibition. Biomed Pharmacother. 2021;137:111285.
   PubMed Web of Science ®Google Scholar
• Feng X, Luo Q, Zhang H, et al. The role of NLRP3 inflammasome in 5-fluorouracil resistance of oral squamous cell carcinoma. CR. 2017;36(1):81.
   Google Scholar
• Gonzalez H, Hagerling C, Werb Z. Roles of the immune system in cancer: from tumor initiation to metastatic progression. Genes Dev. 2018;32(19–20):1267–1284.
   PubMed Web of Science ®Google Scholar
• Zhao H, Wu L, Yan G, et al. Inflammation and tumor progression: signaling pathways and targeted intervention. Signal Transduct Target Ther. 2021;6(1):263.
   PubMed Web of Science ®Google Scholar
• Raimondo S, Urzì O, Meraviglia S, et al. Anti-inflammatory properties of lemon-derived extracellular vesicles are achieved through the inhibition of ERK/NF-κB signalling pathways. J Cell Mol Med. 2022;26(15):4195–4209.
   PubMed Web of Science ®Google Scholar
• Trentini M, Zanotti F, Tiengo E, et al. An apple a day keeps the doctor away: potential role of miRNA 146 on Macrophages treated with exosomes derived from apples. Biomedicines. 2022;10(2):1.
   Web of Science ®Google Scholar
• Fiori ME, Di Franco S, Villanova L, Bianca P, Stassi G, De Maria R. Cancer-associated fibroblasts as abettors of tumor progression at the crossroads of EMT and therapy resistance. Mol Cancer. 2019;18(1):70.
   PubMed Web of Science ®Google Scholar
• Li C, Teixeira AF, Zhu HJ, Ten Dijke P. Cancer associated-fibroblast-derived exosomes in cancer progression. Mol Cancer. 2021;20(1):154.
   PubMed Web of Science ®Google Scholar
• Song S, Vuai MS, Zhong M. The role of bacteria in cancer therapy - enemies in the past, but allies at present. Infect Agent Cancer. 2018;13:9.
   PubMed Web of Science ®Google Scholar
• Wong-Rolle A, Wei HK, Zhao C, Jin C. Unexpected guests in the tumor microenvironment: microbiome in cancer. Protein Cell. 2021;12(5):426–435.
   PubMed Web of Science ®Google Scholar
• Hansen LL, Nielsen ME. Plant exosomes: using an unconventional exit to prevent pathogen entry? J Exp Bot. 2017;69(1):59–68.
   PubMed Web of Science ®Google Scholar
• Regente M, Pinedo M, San Clemente H, Balliau T, Jamet E, de la Canal L. Plant extracellular vesicles are incorporated by a fungal pathogen and inhibit its growth. J Exp Bot. 2017;68(20):5485–5495.
   PubMed Web of Science ®Google Scholar
• Fu A, Yao B, Dong T, et al. Tumor-resident intracellular microbiota promotes metastatic colonization in breast cancer. Cell. 2022;185(8):1356–1372.e1326.
   PubMed Web of Science ®Google Scholar
• Liu YC, Chen WL, Kung WH, Huang HD. Plant miRNAs found in human circulating system provide evidences of cross kingdom RNAi. BMC Genom. 2017;18(Suppl 2):112.
   PubMedGoogle Scholar
• Fujita D, Arai T, Komori H, et al. Apple-derived nanoparticles modulate expression of Organic-Anion-Transporting Polypeptide (OATP) 2B1 in Caco-2 cells. Mol Pharm. 2018;15(12):5772–5780.
   PubMedGoogle Scholar
• Hatamie S, Akhavan O, Sadrnezhaad SK, Ahadian MM, Shirolkar MM, Wang HQ. Curcumin-reduced graphene oxide sheets and their effects on human breast cancer cells. Mater Sci Eng C Mater Biol Appl. 2015;55:482–489.
   PubMed Web of Science ®Google Scholar
• Song H, Chen X, Hao Y, Wang J, Xie Q, Wang X. Nanoengineering facilitating the target mission: targeted extracellular vesicles delivery systems design. J Nanobiotechnology. 2022;20(1):431.
   PubMed Web of Science ®Google Scholar
• Zhuang X, Teng Y, Samykutty A, et al. Grapefruit-derived nanovectors delivering therapeutic miR17 through an intranasal route inhibit brain tumor progression. Mol Ther. 2016;24(1):96–105.
   PubMed Web of Science ®Google Scholar
• Zeng L, Wang H, Shi W, et al. Aloe derived nanovesicle as a functional carrier for indocyanine green encapsulation and phototherapy. J Nanobiotechnology. 2021;19(1):439.
   PubMed Web of Science ®Google Scholar
• Teng Y, Ren Y, Sayed M, et al. Plant-derived exosomal MicroRNAs shape the gut microbiota. Cell Host Microbe. 2018;24(5):637–652.e638.
   PubMed Web of Science ®Google Scholar
• Abdolahad M, Janmaleki M, Mohajerzadeh S, Akhavan O, Abbasi S. Polyphenols attached graphene nanosheets for high efficiency NIR mediated photodestruction of cancer cells. Mater Sci Eng C Mater Biol Appl. 2013;33(3):1498–1505.
   PubMed Web of Science ®Google Scholar
• Zhuang X, Deng ZB, Mu J, et al. Ginger-derived nanoparticles protect against alcohol-induced liver damage. J Extracell Vesicles. 2015;4:28713.
   PubMed Web of Science ®Google Scholar
• Fan SJ, Chen JY, Tang CH, Zhao QY, Zhang JM, Qin YC. Edible plant extracellular vesicles: an emerging tool for bioactives delivery. Front Immunol. 2022;13:1028418.
   PubMed Web of Science ®Google Scholar
• Li Z, Wang H, Yin H, Bennett C, Zhang HG, Guo P. Arrowtail RNA for ligand display on ginger exosome-like nanovesicles to systemic deliver siRNA for cancer suppression. Sci Rep. 2018;8(1):14644.
   PubMedGoogle Scholar
• Tang Z, Jun Y, Lv Y, et al. Aptamer-conjugated and doxorubicin-loaded grapefruit-derived nanovectors for targeted therapy against HER2(+) breast cancer. J Drug Target. 2020;28(2):186–194.
   PubMed Web of Science ®Google Scholar
• Yan W, Tao M, Jiang B, et al. Overcoming drug resistance in colon cancer by aptamer-mediated targeted co-delivery of drug and siRNA Using grapefruit-derived nanovectors. Cell Physiol Biochem. 2018;50(1):79–91.
   PubMedGoogle Scholar
• Yi S, Wang Y, Huang Y, et al. Tea nanoparticles for immunostimulation and chemo-drug delivery in cancer treatment. J Biomed Nanotechnol. 2014;10(6):1016–1029.
   PubMed Web of Science ®Google Scholar
• Zhang M, Xiao B, Wang H, et al. Edible ginger-derived nano-lipids loaded with doxorubicin as a novel drug-delivery approach for colon cancer therapy. Mol Ther. 2016;24(10):1783–1796.
   PubMed Web of Science ®Google Scholar
• Zeng L, Shi W, Wang H, et al. Codelivery of π-π stacked dual anticancer drugs based on aloe-derived nanovesicles for breast cancer therapy. ACS Appl Mater Interfaces. 2022;14(24):27686–27702.
   PubMed Web of Science ®Google Scholar
• Del Pozo-Aceb L, López de Las Haza MC, Tomé-Carneiro J, et al. Therapeutic potential of broccoli-derived extracellular vesicles as nanocarriers of exogenous miRNAs. Pharmacol Res. 2022;185:106472.
   PubMed Web of Science ®Google Scholar
• Xia W, Tao Z, Zhu B, et al. Targeted delivery of drugs and genes using polymer nanocarriers for cancer therapy. Int J Mol Sci. 2021;22(17):1.
   Web of Science ®Google Scholar
• Wang Q, Ren Y, Mu J, et al. Grapefruit-derived nanovectors use an activated leukocyte trafficking pathway to deliver therapeutic agents to inflammatory tumor sites. Cancer Res. 2015;75(12):2520–2529.
   PubMed Web of Science ®Google Scholar
• Chen X, Li H, Song H, et al. Meet changes with constancy: defence, antagonism, recovery, and immunity roles of extracellular vesicles in confronting SARS-CoV-2. J Extracell Vesicles. 2022;11(12):e12288.
   PubMed Web of Science ®Google Scholar
• Al-Ahmady ZS, Hadjidemetriou M, Gubbins J, Kostarelos K. Formation of protein Corona in vivo affects drug release from temperature-sensitive liposomes. J Control Release. 2018;276:157–167.
   PubMed Web of Science ®Google Scholar
• Heidarzadeh M, Zarebkohan A, Rahbarghazi R, Sokullu E. Protein Corona and exosomes: new challenges and prospects. CCS. 2023;21(1):64.
   Google Scholar
• Tóth E, Turiák L, Visnovitz T, et al. Formation of a protein Corona on the surface of extracellular vesicles in blood plasma. J Extracell Vesicles. 2021;10(11):e12140.
   PubMed Web of Science ®Google Scholar
• Wu JY, Li YJ, Wang J, et al. Multifunctional exosome-mimetics for targeted anti-glioblastoma therapy by manipulating protein Corona. J Nanobiotechnology. 2021;19(1):405.
   PubMed Web of Science ®Google Scholar
• Hajipour MJ, Raheb J, Akhavan O, et al. Personalized disease-specific protein Corona influences the therapeutic impact of graphene oxide. Nanoscale. 2015;7(19):8978–8994.
   PubMed Web of Science ®Google Scholar
• Zhang M, Yang C, Yan X, Sung J, Garg P, Merlin D. Highly biocompatible functionalized layer-by-layer ginger lipid nano vectors targeting p-selectin for delivery of doxorubicin to treat colon cancer. Adv Ther. 2019;2(12):1.
   Google Scholar
• Wang B, Zhuang X, Deng ZB, et al. Targeted drug delivery to intestinal macrophages by bioactive nanovesicles released from grapefruit. Mol Ther. 2014;22(3):522–534.
   PubMed Web of Science ®Google Scholar
• Teng Y, Mu J, Hu X, et al. Grapefruit-derived nanovectors deliver miR-18a for treatment of liver metastasis of colon cancer by induction of M1 macrophages. Oncotarget. 2016;7(18):25683–25697.
   PubMedGoogle Scholar
• Sun Q, Sun X, Ma X, et al. Integration of nanoassembly functions for an effective delivery cascade for cancer drugs. Adv Mater. 2014;26(45):7615–7621.
   PubMed Web of Science ®Google Scholar
• Sultana S, Alzahrani N, Alzahrani R, et al. Stability issues and approaches to stabilised nanoparticles based drug delivery system. J Drug Target. 2020;28(5):468–486.
   PubMed Web of Science ®Google Scholar
• Adepu S, Ramakrishna S. Controlled drug delivery systems: current status and future directions. Molecules. 2021;26(19):1.
   Web of Science ®Google Scholar
• Wang QL, Zhuang X, Sriwastva MK, et al. Blood exosomes regulate the tissue distribution of grapefruit-derived nanovector via CD36 and IGFR1 pathways. Theranostics. 2018;8(18):4912–4924.
   PubMed Web of Science ®Google Scholar
• Yang K, Zhang S, Zhang G, Sun X, Lee ST, Liu Z. Graphene in mice: ultrahigh in vivo tumor uptake and efficient photothermal therapy. Nano Lett. 2010;10(9):3318–3323.
   PubMed Web of Science ®Google Scholar
• Fazaeli Y, Akhavan O, Rahighi R, Aboudzadeh MR, Karimi E, Afarideh H. In vivo SPECT imaging of tumors by 198,199 Au-labeled graphene oxide nanostructures. Mater Sci Eng C Mater Biol Appl. 2014;45:196–204.
   PubMed Web of Science ®Google Scholar
• Huang H, Yi X, Wei Q, et al. Edible and cation-free kiwi fruit derived vesicles mediated EGFR-targeted siRNA delivery to inhibit multidrug resistant lung cancer. J Nanobiotechnology. 2023;21(1):41.
   PubMed Web of Science ®Google Scholar
• Fernández M, Javaid F, Chudasama V. Advances in targeting the folate receptor in the treatment/imaging of cancers. Chem Sci. 2018;9(4):790–810.
   PubMed Web of Science ®Google Scholar
• Qi C, Wei B, Zhou W, et al. P-selectin-mediated platelet adhesion promotes tumor growth. Oncotarget. 2015;6(9):6584–6596.
   PubMed Web of Science ®Google Scholar
• Bonecchi R, Graham GJ. Atypical chemokine receptors and their roles in the resolution of the inflammatory response. Front Immunol. 2016;7:224.
   PubMed Web of Science ®Google Scholar
• Akhavan O, Ghaderi E, Aghayee S, Fereydooni Y, Talebi A. The use of a glucose-reduced graphene oxide suspension for photothermal cancer therapy. J Mater Chem. 2012;22(27):13773–13781.
   Web of Science ®Google Scholar
• Samuel M, Fonseka P, Sanwlani R, et al. Oral administration of bovine milk-derived extracellular vesicles induces senescence in the primary tumor but accelerates cancer metastasis. Nat Commun. 2021;12(1):3950.
   PubMed Web of Science ®Google Scholar
• Mu J, Zhuang X, Wang Q, et al. Interspecies communication between plant and mouse gut host cells through edible plant derived exosome-like nanoparticles. Mol Nutr Food Res. 2014;58(7):1561–1573.
   PubMed Web of Science ®Google Scholar
• Pocsfalvi G, Turiák L, Ambrosone A, et al. Protein biocargo of citrus fruit-derived vesicles reveals heterogeneous transport and extracellular vesicle populations. J Plant Physiol. 2018;229:111–121.
   PubMed Web of Science ®Google Scholar
• Woith E, Melzig MF. Extracellular vesicles from fresh and dried plants-simultaneous purification and visualization using gel electrophoresis. Int J Mol Sci. 2019;20(2):1.
   Web of Science ®Google Scholar
• Linares R, Tan S, Gounou C, Arraud N, Brisson AR. High-speed centrifugation induces aggregation of extracellular vesicles. J Extracell Vesicles. 2015;4:29509.
   PubMed Web of Science ®Google Scholar
• Kalarikkal SP, Prasad D, Kasiappan R, Chaudhari SR, Sundaram GM. A cost-effective polyethylene glycol-based method for the isolation of functional edible nanoparticles from ginger rhizomes. Sci Rep. 2020;10(1):4456.
   PubMed Web of Science ®Google Scholar
• Suresh AP, Kalarikkal SP, Pullareddy B, Sundaram GM. Low pH-based method to increase the yield of plant-derived nanoparticles from fresh ginger rhizomes. ACS omega. 2021;6(27):17635–17641.
   PubMed Web of Science ®Google Scholar
• Kim K, Park J, Sohn Y, et al. Stability of plant leaf-derived extracellular vesicles according to preservative and storage temperature. Pharmaceutics. 2022;14(2):5.
   Web of Science ®Google Scholar