Prosthetic Metals: Release, Metabolism and Toxicity

References

• Mercuri LG. Alloplastic temporomandibular joint reconstruction. Oral Surg, Oral Med Oral Pathol Oral Radiol Endod. 1998;85(6):631–637. doi:10.1016/S1079-2104(98)90028-2
   PubMed Web of Science ®Google Scholar
• Makridis KG, Karachalios T. A Brief History of Total Knee Arthroplasty. J Med Case Rep. 2015.
   Google Scholar
• Learmonth ID, Young C, Rorabeck C. The operation of the century: total Hip replacement. Lancet. 2007;370(9597):1508–1519. doi:10.1016/S0140-6736(07)60457-7
   PubMed Web of Science ®Google Scholar
• Markatos K, Savvidou OD, Foteinou A, et al. Hallmarks in the History and Development of Total Hip Arthroplasty. Surg Innov. 2020;27(6):691–694. doi:10.1177/1553350620947209
   PubMed Web of Science ®Google Scholar
• Mellon SJ, Liddle AD, Pandit H. Hip replacement: landmark surgery in modern medical history. Maturitas. 2013;75(3):221–226. doi:10.1016/j.maturitas.2013.04.011
   PubMed Web of Science ®Google Scholar
• Kovochich M, Finley BL, Novick R, et al. Understanding outcomes and toxicological aspects of second generation metal-on-metal Hip implants: a state-of-The-art review. Crit. Rev. Toxicol. 2018;48(10):853–901. doi:10.1080/10408444.2018.1563048
   PubMed Web of Science ®Google Scholar
• Ranawat CS. History of total knee replacement. J South Orthop Assoc. 2002;11(4):218–226.
   PubMedGoogle Scholar
• Rizzo TD. Chapter 61 - Total Hip Replacement**Based on a chapter in the third edition written by Juan A. Cabrera, MD and Alison L. Cabrera, MD. In: Frontera WR, Silver JK, Rizzo TD, editors. Essentials of Physical Medicine and Rehabilitation (Fourth Edition). Philadelphia: Elsevier; 2020:337–345.
   Google Scholar
• Hegde V, Stambough JB, Levine BR, Springer BD. Highlights of the 2022 American Joint Replacement Registry Annual Report. Arthroplast Today. 2023;21:101137. doi:10.1016/j.artd.2023.101137
   PubMedGoogle Scholar
• Head WC, Bauk DJ, Emerson RH. Titanium as the material of choice for cementless femoral components in total Hip arthroplasty. Clin Orthop Relat Res. 1995;311:85–90.
   PubMed Web of Science ®Google Scholar
• Kaur M, Singh K. Review on titanium and titanium based alloys as biomaterials for orthopaedic applications. Mater Sci Eng C Mater Biol Appl. 2019;102:844–862.
   PubMed Web of Science ®Google Scholar
• Chen Q, Thouas GA. Metallic implant biomaterials. Mater Sci Eng. 2015;87:1–57.
   Google Scholar
• Patel NR, Gohil PP. A review on biomaterials: scope, applications & human anatomy significance. Int J Emerging Technol Adv Eng. 2012;2(4):91–101.
   Google Scholar
• Osamu W. What are Trace Elements? J Med Case Rep. 2018. doi:10.1186/s13256-018-1703-2
   PubMedGoogle Scholar
• Berdanier CD, Dwyer JT, Feldman EB. Handbook of Nutrition and Food. CRC press; 2007.
   Google Scholar
• Trumbo P, Yates AA, Schlicker S, Poos M. Dietary reference intakes: vitamin A, vitamin K, arsenic, boron, chromium, copper, iodine, iron, manganese, molybdenum, nickel, silicon, vanadium, and zinc. J Acad Nutr Diet. 2001;101(3):294.
   Google Scholar
• Eastley R, Wilcock GK, Bucks RS. Vitamin B12 deficiency in dementia and cognitive impairment: the effects of treatment on neuropsychological function. Int j Geriatric Psychiatry. 2000;15(3):226–233. doi:10.1002/(SICI)1099-1166(200003)15:3<226::AID-GPS98>3.0.CO;2-K
   PubMed Web of Science ®Google Scholar
• Badmaev V, Prakash S, Majeed M. Vanadium: a review of its potential role in the fight against diabetes. J Altern Complementary Med. 1999;5(3):273–291. doi:10.1089/acm.1999.5.273
   PubMed Web of Science ®Google Scholar
• Beliaeva N, Gorodetskiĭ V, Tochilkin A, Golubev M, Semenova N, Kovel’man I. Vanadium compounds--a new class of therapeutic agents for the treatment of diabetes mellitus. Voprosy meditsinskoi khimii. 2000;46(4):344–360.
   PubMedGoogle Scholar
• Anderson RA. Nutritional factors influencing the glucose/insulin system: chromium. J Am Coll Nutr. 1997;16(5):404–410. doi:10.1080/07315724.1997.10718705
   PubMed Web of Science ®Google Scholar
• Kimura K. Role of essential trace elements in the disturbance of carbohydrate metabolism. Nihon rinsho Japan j clin med. 1996;54(1):79–84.
   PubMedGoogle Scholar
• Cefalu WT, Hu FB. Role of chromium in human health and in diabetes. Diabetes Care. 2004;27(11):2741–2751. doi:10.2337/diacare.27.11.2741
   PubMed Web of Science ®Google Scholar
• Chao E, Frassica F, Pritchard D, Moyer T. Metal ion release in patients with porous coated megaprostheses. Trans Orthop Res Soc. 1995;20:731.
   Google Scholar
• Buettner KM, Valentine AM. Bioinorganic chemistry of titanium. Chem. Rev. 2012;112(3):1863–1881. doi:10.1021/cr1002886
   PubMed Web of Science ®Google Scholar
• Berk L, Burchenal JH, Castle WB. Erythropoietic Effect of Cobalt in Patients with or without Anemia. N Engl J Med. 1949;240(19):754–761. doi:10.1056/NEJM194905122401903
   PubMed Web of Science ®Google Scholar
• Simonsen LO, Brown AM, Harbak H, Kristensen BI, Bennekou P. Cobalt uptake and binding in human red blood cells. Blood Cells Mol. Dis. 2011;46(4):266–276. doi:10.1016/j.bcmd.2011.02.009
   PubMed Web of Science ®Google Scholar
• Schwarz G, Mendel RR, Ribbe MW. Molybdenum cofactors, enzymes and pathways. Nature. 2009;460(7257):839–847. doi:10.1038/nature08302
   PubMed Web of Science ®Google Scholar
• Schwarz G. Molybdenum cofactor and human disease. Curr. Opin. Chem. Biol. 2016;31:179–187. doi:10.1016/j.cbpa.2016.03.016
   PubMed Web of Science ®Google Scholar
• Vincent JB. Chromium: biological Relevance. Encyclopedia Inorganic Bioinorganic Chemistry. 2011.
   Google Scholar
• Sahin K, Onderci M, Tuzcu M, et al. Effect of chromium on carbohydrate and lipid metabolism in a rat model of type 2 diabetes mellitus: the fat-fed, streptozotocin-treated rat. Metabolism. 2007;56(9):1233–1240. doi:10.1016/j.metabol.2007.04.021
   PubMed Web of Science ®Google Scholar
• Agency EP. Toxicological review of trivalent chromium. J Med. 1998.
   Google Scholar
• Ortega R, Bresson C, Fraysse A, et al. Cobalt distribution in keratinocyte cells indicates nuclear and perinuclear accumulation and interaction with magnesium and zinc homeostasis. Toxicol Lett. 2009;188(1):26–32.
   PubMed Web of Science ®Google Scholar
• Czarnek K, Terpiłowska S, Siwicki AK. Selected aspects of the action of cobalt ions in the human body. Central-Eur J Immunol. 2015;40(2):236–242.
   PubMed Web of Science ®Google Scholar
• Springer. Vanadium. Netherlands: Dordrecht: Springer; 2012.
   Google Scholar
• Malay Chatterjee SD, Chatterjeeand Kaushik Roy M. Vanadium in Biological Systems. Encyclopedia Metalloproteins. 2013.
   Google Scholar
• Niinomi M. Recent metallic materials for biomedical applications. Metall Mater Trans A. 2002;33(3):477–486. doi:10.1007/s11661-002-0109-2
   Web of Science ®Google Scholar
• Shanmuganantha L, Baharudin A, Sulong AB, Shamsudin R, Ng MH. Prospect of Metal Ceramic (Titanium-Wollastonite) Composite as Permanent Bone Implants: a Narrative Review. Materials (Basel). 2021;14(2):2. doi:10.3390/ma14020277
   Web of Science ®Google Scholar
• Oldani C, Dominguez AJRAIA. Titanium as a Biomaterial for Implants. Phys Chem Chem Phys. 2012;218:149–162.
   Google Scholar
• Metikos-Hukovic M, Kwokal A, Piljac J. The influence of niobium and vanadium on passivity of titanium-based implants in physiological solution. Biomaterials. 2003;24(21):3765–3775. doi:10.1016/S0142-9612(03)00252-7
   PubMed Web of Science ®Google Scholar
• Liao Y, Hoffman E, Wimmer M, Fischer A, Jacobs J, Marks L. CoCrMo metal-on-metal Hip replacements. Phys Chem Chem Phys. 2013;15(3):746–756. doi:10.1039/C2CP42968C
   PubMed Web of Science ®Google Scholar
• Virtanen S. Metal release mechanisms in Hip replacement. Acta orthopaedica. 2006;77(5):695–696. doi:10.1080/17453670610012854
   PubMed Web of Science ®Google Scholar
• Huber M, Reinisch G, Trettenhahn G, Zweymuller K, Lintner F. Presence of corrosion products and hypersensitivity-associated reactions in periprosthetic tissue after aseptic loosening of total Hip replacements with metal bearing surfaces. Acta Biomater. 2009;5(1):172–180. doi:10.1016/j.actbio.2008.07.032
   PubMed Web of Science ®Google Scholar
• Bijukumar DR, Salunkhe S, Zheng G, et al. Wear particles induce a new macrophage phenotype with the potential to accelerate material corrosion within total Hip replacement interfaces. Acta Biomater. 2020;101:586–597. doi:10.1016/j.actbio.2019.10.039
   PubMed Web of Science ®Google Scholar
• Gill HS, Grammatopoulos G, Adshead S, Tsialogiannis E, Tsiridis E. Molecular and immune toxicity of CoCr nanoparticles in MoM Hip arthroplasty. Trends Mol Med. 2012;18(3):145–155. doi:10.1016/j.molmed.2011.12.002
   PubMed Web of Science ®Google Scholar
• Heise G, Black CM, Smith R, Morrow BR, Mihalko WM. In vitro effects of macrophages on orthopaedic implant alloys and local release of metallic alloy components. Bone Joint j. 2020;102-B(7_Supple_B):116–121. doi:10.1302/0301-620X.102B7.BJJ-2019-1556.R1
   PubMedGoogle Scholar
• Gallo J, Goodman SB, Konttinen YT, Wimmer MA, Holinka M. Osteolysis around total knee arthroplasty: a review of pathogenetic mechanisms. Acta Biomater. 2013;9(9):8046–8058. doi:10.1016/j.actbio.2013.05.005
   PubMed Web of Science ®Google Scholar
• Hallab NJ, Jacobs JJ. Chemokines Associated with Pathologic Responses to Orthopedic Implant Debris. Front Endocrinol (Lausanne). 2017;8:5. doi:10.3389/fendo.2017.00005
   PubMed Web of Science ®Google Scholar
• Merritt K, Brown SA. Biological Effects of Corrosion Products from Metals. Corrosion and degradation of implant materials: second symposium, ASTM International; 1985.
   Google Scholar
• ALS - Clinical: aluminum, Serum. Available from: https://www.mayocliniclabs.com/test-catalog/Clinical+and+Interpretive/8373. Accessed May 20, 2024.
   Google Scholar
• TIS - Clinical: titanium, Serum. Available from: https://www.mayocliniclabs.com/test-catalog/Clinical+and+Interpretive/89367. Accessed May 20, 2024.
   Google Scholar
• CRS - Clinical: chromium, Serum. Available from: https://www.mayocliniclabs.com/test-catalog/Clinical+and+Interpretive/8638. Accessed May 20, 2024.
   Google Scholar
• COS - Clinical: cobalt, Serum. Available from: https://www.mayocliniclabs.com/test-catalog/Clinical+and+Interpretive/80084. Accessed May 20, 2024.
   Google Scholar
• MOWB - Clinical: molybdenum, Blood. Available from: https://www.mayocliniclabs.com/test-catalog/Clinical+and+Interpretive/64272. Accessed May 20, 2024.
   Google Scholar
• CRWB - Clinical: chromium, Blood. Available from: https://www.mayocliniclabs.com/test-catalog/Clinical+and+Interpretive/65601. Accessed May 20, 2024.
   Google Scholar
• COWB - Clinical: cobalt, Blood. Available from: https://www.mayocliniclabs.com/test-catalog/Clinical+and+Interpretive/60355. Accessed May 20, 2024.
   Google Scholar
• MOS - Clinical: molybdenum, Serum. Available from: https://www.mayocliniclabs.com/test-catalog/Clinical+and+Interpretive/89270. Accessed May 20, 2024.
   Google Scholar
• VS - Clinical: vanadium, Serum. Available from: https://ltig.lhsc.on.ca/?action=view_rec&test=Vanadium%2C%20Plasma. Accessed May 20, 2024.
   Google Scholar
• VWB - Clinical: vanadium, Blood. Available from: https://ltig.lhsc.on.ca/?action=view_rec&test=Vanadium%2CWhole%20Blood. Accessed May 20, 2024.
   Google Scholar
• ALWB - Clinical: aluminum, Blood. Available from: https://ltig.lhsc.on.ca/?action=view_rec&test=Aluminum%2C%20Whole%20Blood. Accessed May 20, 2024.
   Google Scholar
• TIWB - Clinical: titanium, Blood. Available from: https://ltig.lhsc.on.ca/?action=view_rec&test=Titanium%2C%20Whole%20Blood. Accessed May 20, 2024.
   Google Scholar
• Control, C. f. D. Prevention, Guidelines for Collecting and Handling Blood Lead Samples [Video]; 2004.
   Google Scholar
• Smolders JM, Hol A, Rijnberg WJ, van Susante JL. Metal ion levels and functional results after either resurfacing Hip arthroplasty or conventional metal-on-metal Hip arthroplasty. Acta orthopaedica. 2011;82(5):559–566. doi:10.3109/17453674.2011.625533
   PubMedGoogle Scholar
• Moroni A, Nocco E, Hoque M, et al. Cushion bearings versus large diameter head metal-on-metal bearings in total Hip arthroplasty: a short-term metal ion study. Arch Orthopaedic Trauma Surgery. 2012;132(1):123–129. doi:10.1007/s00402-011-1364-8
   PubMed Web of Science ®Google Scholar
• Schouten R, Malone AA, Frampton CM, Tiffen C, Hooper G. Five-year follow-up of a prospective randomised trial comparing ceramic-on-metal and metal-on-metal bearing surfaces in total Hip arthroplasty. Bone Joint j. 2017;99-b(10):1298–1303. doi:10.1302/0301-620X.99B10.BJJ-2016-0905.R1
   PubMedGoogle Scholar
• Cadossi M, Mazzotti A, Baldini N, Giannini S, Savarino L. New couplings, old problems: is there a role for ceramic-on-metal Hip arthroplasty? J Biomed Mater Res Part B. 2016;104(1):204–209. doi:10.1002/jbm.b.33383
   PubMed Web of Science ®Google Scholar
• Engh CA, MacDonald SJ, Sritulanondha S, Korczak A, Naudie D, Engh C. Metal ion levels after metal-on-metal total Hip arthroplasty: a five-year, prospective randomized trial. J Bone Joint Surg Am Vol. 2014;96(6):448–455. doi:10.2106/JBJS.M.00164
   PubMedGoogle Scholar
• Hailer NP, Blaheta RA, Dahlstrand H, Stark A. Elevation of circulating HLA DR(+) CD8(+) T-cells and correlation with chromium and cobalt concentrations 6 years after metal-on-metal Hip arthroplasty. Acta orthopaedica. 2011;82(1):6–12. doi:10.3109/17453674.2010.548028
   PubMed Web of Science ®Google Scholar
• Zijlstra WP, van der Veen HC, van den Akker-Scheek I, Zee MJ, Bulstra SK, van Raay JJ. Acetabular bone density and metal ions after metal-on-metal versus metal-on-polyethylene total Hip arthroplasty; short-term results. Hip International. 2014;24(2):136–143. doi:10.5301/hipint.5000087
   PubMed Web of Science ®Google Scholar
• Vendittoli PA, Rivière C, Roy AG, Barry J, Lusignan D, Lavigne M. Metal-on-metal Hip resurfacing compared with 28-mm diameter metal-on-metal total Hip replacement: a randomised study with six to nine years’ follow-up. Bone Joint j. 2013;95-b(11):1464–1473. doi:10.1302/0301-620X.95B11.31604
   PubMed Web of Science ®Google Scholar
• Smolders JM, Bisseling P, Hol A, Van Der Straeten C, Schreurs BW, van Susante JL. Metal ion interpretation in resurfacing versus conventional Hip arthroplasty and in whole blood versus serum. How should we interpret metal ion data. Hip International. 2011;21(5):587–595. doi:10.5301/HIP.2011.8643
   PubMed Web of Science ®Google Scholar
• Bisseling P, Smolders JM, Hol A, van Susante JL. Metal ion levels and functional results following resurfacing Hip arthroplasty versus conventional small-diameter metal-on-metal total Hip arthroplasty; a 3 to 5 year follow-up of a randomized controlled trial. J Arthroplasty. 2015;30(1):61–67. doi:10.1016/j.arth.2014.07.036
   PubMed Web of Science ®Google Scholar
• Smolders JM, Hol A, van Susante JL. Metal ion trend may be more predictive for malfunctioning metal-on-metal implants than a single measurement. Hip International. 2013;23(5):434–440. doi:10.5301/hipint.5000066
   PubMed Web of Science ®Google Scholar
• Ando W, Yasui H, Yamamoto K, et al. A comparison of the effect of large and small metal-on-metal bearings in total Hip arthroplasty on metal ion levels and the incidence of pseudotumour: a five-year follow-up of a previous report. Bone Joint j. 2018;100-b(8):1018–1024. doi:10.1302/0301-620X.100B8.BJJ-2018-0414.R1
   PubMedGoogle Scholar
• Briggs TW, Hanna SA, Kayani B, et al. Metal-on-polyethylene versus metal-on-metal bearing surfaces in total Hip arthroplasty: a prospective randomised study investigating metal ion levels and chromosomal aberrations in peripheral lymphocytes. Bone Joint j. 2015;97-b(9):1183–1191. doi:10.1302/0301-620X.97B9.34824
   PubMed Web of Science ®Google Scholar
• Malviya A, Ramaskandhan JR, Bowman R, et al. What advantage is there to be gained using large modular metal-on-metal bearings in routine primary Hip replacement? A preliminary report of a prospective randomised controlled trial. J Bone Joint Surg Br Vol. 2011;93(12):1602–1609. doi:10.1302/0301-620X.93B12.27533
   PubMedGoogle Scholar
• Hutt J, Lavigne M, Lungu E, Belzile E, Morin F, Vendittoli PA. Comparison of Whole-Blood Metal Ion Levels Among Four Types of Large-Head, Metal-on-Metal Total Hip Arthroplasty Implants: a Concise Follow-up, at Five Years, of a Previous Report. J Bone Joint Surg Am Vol. 2016;98(4):257–266. doi:10.2106/JBJS.O.00201
   PubMed Web of Science ®Google Scholar
• Lützner J, Hartmann A, Dinnebier G, Spornraft-Ragaller P, Hamann C, Kirschner S. Metal hypersensitivity and metal ion levels in patients with coated or uncoated total knee arthroplasty: a randomised controlled study. International Orthopaedics. 2013;37(10):1925–1931. doi:10.1007/s00264-013-2010-6
   PubMed Web of Science ®Google Scholar
• Postler A, Beyer F, Lützner C, Tille E, Lützner J. Similar outcome during short-term follow-up after coated and uncoated total knee arthroplasty: a randomized controlled study. Knee Surg Sports Traumatol Arthrosc. 2018;26(11):3459–3467. doi:10.1007/s00167-018-4928-0
   PubMed Web of Science ®Google Scholar
• Bistolfi A, Cimino A, Lee GC, et al. Does metal porosity affect metal ion release in blood and urine following total Hip arthroplasty? A short term study. Hip International. 2018;28(5):522–530. doi:10.1177/1120700018762167
   PubMed Web of Science ®Google Scholar
• Jantzen C, Jorgensen HL, Duus BR, Sporring SL, Lauritzen JB. Chromium and cobalt ion concentrations in blood and serum following various types of metal-on-metal Hip arthroplasties: a literature overview. Acta orthopaedica. 2013;84(3):229–236. doi:10.3109/17453674.2013.792034
   PubMed Web of Science ®Google Scholar
• Cui P, Jiang W, Fan M, Wan Y. Detection and influence factor of serum metal ions concentration level after resurfacing arthroplasty of the Hip. Chin J Reparative Reconst Surg. 2017;31(4):404–409. doi:10.7507/1002-1892.201608018
   Google Scholar
• Lainiala O, Reito A, Jamsa P, Eskelinen A. Mild or moderate renal insufficiency does not increase circulating levels of cobalt and chromium in patients with metal-on-metal Hip arthroplasty. Bone Joint j. 2017;99-B(9):1147–1152. doi:10.1302/0301-620X.99B9.BJJ-2016-0773.R2
   PubMedGoogle Scholar
• Manninen E, Lainiala O, Karsikas M, Reito A, Jamsa P, Eskelinen A. Do cobalt or chromium accumulate in metal-on-metal Hip arthroplasty patients who have mild, moderate, or severe renal insufficiency? Bone Joint j. 2021;103-B(7):1231–1237. doi:10.1302/0301-620X.103B7.BJJ-2020-0836.R2
   PubMedGoogle Scholar
• Hartmann A, Hannemann F, Lutzner J, et al. Metal ion concentrations in body fluids after implantation of Hip replacements with metal-on-metal bearing--systematic review of clinical and epidemiological studies. PLoS One. 2013;8(8):e70359. doi:10.1371/journal.pone.0070359
   PubMed Web of Science ®Google Scholar
• Friesenbichler J, Maurer-Ertl W, Sadoghi P, Lovse T, Windhager R, Leithner A. Serum metal ion levels after rotating-hinge knee arthroplasty: comparison between a standard device and a megaprosthesis. Int Orthop. 2012;36(3):539–544. doi:10.1007/s00264-011-1317-4
   PubMed Web of Science ®Google Scholar
• Reiner T, Sorbi R, Muller M, et al. Blood Metal Ion Release After Primary Total Knee Arthroplasty: a Prospective Study. Orthop Surg. 2020;12(2):396–403. doi:10.1111/os.12591
   PubMed Web of Science ®Google Scholar
• Nuevo-Ordonez Y, Montes-Bayon M, Blanco-Gonzalez E, et al. Titanium release in serum of patients with different bone fixation implants and its interaction with serum biomolecules at physiological levels. Anal Bioanal Chem. 2011;401(9):2747–2754. doi:10.1007/s00216-011-5232-8
   PubMed Web of Science ®Google Scholar
• Alfrey AC. Aluminum metabolism. Kidney Int Suppl. 1986;18:S8–11.
   PubMedGoogle Scholar
• Riihimaki V, Aitio A. Occupational exposure to aluminum and its biomonitoring in perspective. Crit. Rev. Toxicol. 2012;42(10):827–853. doi:10.3109/10408444.2012.725027
   PubMed Web of Science ®Google Scholar
• Barceloux DG. Vanadium. J Toxicol. 1999;37(2):265–278. doi:10.1081/clt-100102425
   PubMed Web of Science ®Google Scholar
• Rehder D. Vanadium. Its role for humans. Metal Ions Life Sci. 2013;13:139–169.
   PubMedGoogle Scholar
• Dahlstrand H, Stark A, Wick MC, Anissian L, Hailer NP, Weiss RJ. Comparison of metal ion concentrations and implant survival after total Hip arthroplasty with metal-on-metal versus metal-on-polyethylene articulations. Acta orthopaedica. 2017;88(5):490–495. doi:10.1080/17453674.2017.1350370
   PubMed Web of Science ®Google Scholar
• Bosker BH, Ettema HB, Boomsma MF, Kollen BJ, Maas M, Verheyen CC. High incidence of pseudotumour formation after large-diameter metal-on-metal total Hip replacement: a prospective cohort study. J Bone Joint Surg Br Vol. 2012;94(6):755–761. doi:10.1302/0301-620X.94B6.28373
   PubMedGoogle Scholar
• Omlor GW, Kretzer JP, Reinders J, et al. In vivo serum titanium ion levels following modular neck total Hip arthroplasty--10 year results in 67 patients. Acta Biomater. 2013;9(4):6278–6282. doi:10.1016/j.actbio.2012.12.001
   PubMed Web of Science ®Google Scholar
• Hahn M, Busse B, Procop M, Zustin J, Amling M, Katzer A. Cobalt deposition in mineralized bone tissue after metal-on-metal Hip resurfacing: quantitative mu-X-ray-fluorescence analysis of implant material incorporation in periprosthetic tissue. J Biomed Mater Res Part B. 2017;105(7):1855–1862. doi:10.1002/jbm.b.33667
   PubMed Web of Science ®Google Scholar
• Simonsen LO, Harbak H, Bennekou P. Cobalt metabolism and toxicology--a brief update. Sci Total Environ. 2012;432:210–215. doi:10.1016/j.scitotenv.2012.06.009
   PubMed Web of Science ®Google Scholar
• Katz SA, Salem H. The toxicology of chromium with respect to its chemical speciation: a review. J Appl Toxicol. 1993;13(3):217–224. doi:10.1002/jat.2550130314
   PubMed Web of Science ®Google Scholar
• Merritt K, Brown SA. Distribution of titanium and vanadium following repeated injection of high-dose salts. J Biomed Mater Res. 1995;29(10):1175–1178. doi:10.1002/jbm.820291003
   PubMed Web of Science ®Google Scholar
• Krewski D, Yokel RA, Nieboer E, et al. Human health risk assessment for aluminium, aluminium oxide, and aluminium hydroxide. J Toxicol Environ Health B Crit Rev. 2007;10 Suppl 1:1–269. doi:10.1080/10937400701597766
   PubMed Web of Science ®Google Scholar
• Peto MV. Aluminium and iron in humans: bioaccumulation, pathology, and removal. Rejuvenation Res. 2010;13(5):589–598. doi:10.1089/rej.2009.0995
   PubMed Web of Science ®Google Scholar
• Trevino S, Diaz A, Sanchez-Lara E, Sanchez-Gaytan BL, Perez-Aguilar JM, Gonzalez-Vergara E. Vanadium in Biological Action: chemical, Pharmacological Aspects, and Metabolic Implications in Diabetes Mellitus. Biol. Trace Elem. Res. 2019;188(1):68–98. doi:10.1007/s12011-018-1540-6
   PubMed Web of Science ®Google Scholar
• Dobbs HS, Minski MJ. Metal ion release after total Hip replacement. Biomaterials. 1980;1(4):193–198. doi:10.1016/0142-9612(80)90016-2
   PubMed Web of Science ®Google Scholar
• Jakobsen SS, Danscher G, Stoltenberg M, et al. Cobalt-chromium-molybdenum alloy causes metal accumulation and metallothionein up-regulation in rat liver and kidney. Basic Clin Pharmacol Toxicol. 2007;101(6):441–446. doi:10.1111/j.1742-7843.2007.00137.x
   PubMed Web of Science ®Google Scholar
• Rubio JC, Garcia-Alonso MC, Alonso C, et al. Determination of metallic traces in kidneys, livers, lungs and spleens of rats with metallic implants after a long implantation time. J Mater Sci Mater Med. 2008;19(1):369–375. doi:10.1007/s10856-007-3002-0
   PubMed Web of Science ®Google Scholar
• Golasik M, Herman M, Piekoszewski W. Toxicological aspects of soluble titanium - a review of in vitro and in vivo studies. Metallomics. 2016;8(12):1227–1242. doi:10.1039/C6MT00110F
   PubMed Web of Science ®Google Scholar
• Mukherjee B, Patra B, Mahapatra S, Banerjee P, Tiwari A, Chatterjee M. Vanadium--an element of atypical biological significance. Toxicol Lett. 2004;150(2):135–143. doi:10.1016/j.toxlet.2004.01.009
   PubMed Web of Science ®Google Scholar
• Hong F, Mu X, Ze Y, Li W, Zhou Y, Ji J. Damage to the Blood Brain Barrier Structure and Function from Nano Titanium Dioxide Exposure Involves the Destruction of Key Tight Junction Proteins in the Mouse Brain. J biomedical nanotechnol. 2021;17(6):1068–1078. doi:10.1166/jbn.2021.3083
   PubMed Web of Science ®Google Scholar
• Shelly S, Liraz Zaltsman S, Ben-Gal O, et al. Potential neurotoxicity of titanium implants: prospective, in-vivo and in-vitro study. Biomaterials. 2021;276:121039. doi:10.1016/j.biomaterials.2021.121039
   PubMed Web of Science ®Google Scholar
• Shi H, Magaye R, Castranova V, Zhao J. Titanium dioxide nanoparticles: a review of current toxicological data. Part Fibre Toxicol. 2013;10(1):15. doi:10.1186/1743-8977-10-15
   PubMedGoogle Scholar
• Sun L, Wang K, Li Y, Fan Q, Zheng W, Li H. Vanadium exposure-induced striatal learning and memory alterations in rats. Neurotoxicology. 2017;62:124–129. doi:10.1016/j.neuro.2017.06.008
   PubMed Web of Science ®Google Scholar
• Fatola OI, Olaolorun FA, Olopade FE, Olopade JO. Trends in vanadium neurotoxicity. Brain Res Bull. 2019;145:75–80. doi:10.1016/j.brainresbull.2018.03.010
   PubMed Web of Science ®Google Scholar
• Harrison-Brown M, Scholes C, Field C, et al. Limited penetration of cobalt and chromium ions into the cerebrospinal fluid following metal on metal arthroplasty: a cross-sectional analysis. Clin toxicol. 2020;58(4):233–240. doi:10.1080/15563650.2019.1636993
   PubMed Web of Science ®Google Scholar
• Gomez-Arnaiz S, Tate RJ, Grant MH. Cobalt Neurotoxicity: transcriptional Effect of Elevated Cobalt Blood Levels in the Rodent Brain. Toxics. 2022;10(2):2. doi:10.3390/toxics10020059
   Web of Science ®Google Scholar
• Salama A, Hegazy R, Hassan A. Intranasal Chromium Induces Acute Brain and Lung Injuries in Rats: assessment of Different Potential Hazardous Effects of Environmental and Occupational Exposure to Chromium and Introduction of a Novel Pharmacological and Toxicological Animal Model. PLoS One. 2016;11(12):e0168688. doi:10.1371/journal.pone.0168688
   PubMed Web of Science ®Google Scholar
• Woodman JL, Jacobs JJ, Galante JO, Urban RM. Metal ion release from titanium-based prosthetic segmental replacements of long bones in baboons: a long-term study. J Orthop Res. 1984;1(4):421–430. doi:10.1002/jor.1100010411
   PubMedGoogle Scholar
• Afolaranmi GA, Akbar M, Brewer J, Grant MH. Distribution of metal released from cobalt-chromium alloy orthopaedic wear particles implanted into air pouches in mice. J Biomed Mater Res Part A. 2012;100(6):1529–1538. doi:10.1002/jbm.a.34091
   PubMedGoogle Scholar
• Urban RM, Jacobs JJ, Tomlinson MJ, Gavrilovic J, Black J, Peoc’h M. Dissemination of wear particles to the liver, spleen, and abdominal lymph nodes of patients with Hip or knee replacement. J Bone Joint Surg Am Vol. 2000;82(4):457–476. doi:10.2106/00004623-200004000-00002
   PubMed Web of Science ®Google Scholar
• Urban RM, Tomlinson MJ, Hall DJ, Jacobs JJ. Accumulation in liver and spleen of metal particles generated at nonbearing surfaces in Hip arthroplasty. J Arthroplasty. 2004;19(8 Suppl 3):94–101. doi:10.1016/j.arth.2004.09.013
   PubMed Web of Science ®Google Scholar
• Hethey C, Hartung N, Wangorsch G, Weisser K, Huisinga W. Physiology-based toxicokinetic modelling of aluminium in rat and man. Arch Toxicol. 2021;95(9):2977–3000. doi:10.1007/s00204-021-03107-y
   PubMed Web of Science ®Google Scholar
• Hernandez-Vaquero D, Rodriguez de la Flor M, Fernandez-Carreira JM, Sariego-Muniz C. Detection of metal ions in hair after metal-metal Hip arthroplasty. Revista espanola de cirugia ortopedica y traumatologia. 2014;58(5):267–273. doi:10.1016/j.recot.2014.01.008
   PubMedGoogle Scholar
• Rodriguez de la Flor M, Hernandez-Vaquero D, Fernandez-Carreira JM. Metal presence in hair after metal-on-metal resurfacing arthroplasty. J Orthop Res. 2013;31(12):2025–2031. doi:10.1002/jor.22450
   PubMed Web of Science ®Google Scholar
• Zywiel MG, Brandt JM, Overgaard CB, Cheung AC, Turgeon TR, Syed KA. Fatal cardiomyopathy after revision total Hip replacement for fracture of a ceramic liner. Bone Joint j. 2013;95-B(1):31–37. doi:10.1302/0301-620X.95B1.30060
   PubMedGoogle Scholar
• Matusiewicz H. Potential release of in vivo trace metals from metallic medical implants in the human body: from ions to nanoparticles--a systematic analytical review. Acta Biomater. 2014;10(6):2379–2403. doi:10.1016/j.actbio.2014.02.027
   PubMed Web of Science ®Google Scholar
• Zeiner M, Zenz P, Lintner F, Schuster E, Schwagerl W, Steffan I. Influence on elemental status by Hip-endoprostheses. Microchem J. 2007;85(1):145–148. doi:10.1016/j.microc.2006.04.019
   Web of Science ®Google Scholar
• Mertz W. Chromium occurrence and function in biological systems. Physiol Rev. 1969;49(2):163–239. doi:10.1152/physrev.1969.49.2.163
   PubMed Web of Science ®Google Scholar
• Turnlund JR, Keyes WR, Peiffer GL, Chiang G. Molybdenum absorption, excretion, and retention studied with stable isotopes in young men during depletion and repletion. The American Journal of Clinical Nutrition. 1995;61(5):1102–1109. doi:10.1093/ajcn/61.5.1102
   PubMed Web of Science ®Google Scholar
• Rodushkin I, Engstrom E, Stenberg A, Baxter DC. Determination of low-abundance elements at ultra-trace levels in urine and serum by inductively coupled plasma-sector field mass spectrometry. Anal Bioanal Chem. 2004;380(2):247–257. doi:10.1007/s00216-004-2742-7
   PubMed Web of Science ®Google Scholar
• Catalani S, Stea S, Beraudi A, et al. Vanadium release in whole blood, serum and urine of patients implanted with a titanium alloy Hip prosthesis. Clin toxicol. 2013;51(7):550–556. doi:10.3109/15563650.2013.818682
   Web of Science ®Google Scholar
• Sarmiento-González A, Marchante-Gayón JM, Tejerina-Lobo JM. High-resolution ICP-MS determination of Ti, V, Cr, Co, Ni, and Mo in human blood and urine of patients implanted with a Hip or knee prosthesis. Anal Bioanal Chem. 2008;391(7):2583–2589. doi:10.1007/s00216-008-2188-4
   PubMed Web of Science ®Google Scholar
• Takai S, Yoshino N, Kusaka Y, Watanabe Y, Hirasawa Y. Dissemination of metals from a failed patellar component made of titanium-base alloy. J Arthroplasty. 2003;18(7):931–935. doi:10.1016/S0883-5403(03)00277-8
   PubMed Web of Science ®Google Scholar
• La Barbera L, D’Apolito R, Peretti GM, Piergiovanni M, Banfi G, Zagra L; Xix Congresso Nazionale S.I.C.O.O.P. Societa’ Italiana Chirurghi Ortopedici Dell’Ospedalita’ Privata, A. Modular implant design affects metal ion release following metal-on-metal Hip arthroplasty: a retrospective study on 75 cases. J Biol Regul Homeost Agents. 2019;33(2 Suppl. 1):79–88.
   PubMed Web of Science ®Google Scholar
• Reiner T, Bader N, Panzram B, et al. In vivo blood metal ion levels in patients after total shoulder arthroplasty. J Shoulder Elbow Surgery. 2019;28(3):539–546. doi:10.1016/j.jse.2018.08.027
   PubMed Web of Science ®Google Scholar
• Pernaa K, Saltychev M, Makela K. Relationship between Pelvic Incidence Angle and Blood Concentration of Chromium and Cobalt Ions after Metal-on-Metal Hip Replacement: a Brief Report. Scand J Surg. 2018;107(1):91–94. doi:10.1177/1457496917731182
   PubMed Web of Science ®Google Scholar
• Kasparek MF, Renner L, Faschingbauer M, Waldstein W, Weber M, Boettner F. Predictive factors for metal ion levels in metal-on-metal total Hip arthroplasty. Arch Orthopaedic Trauma Surgery. 2018;138(2):281–286. doi:10.1007/s00402-017-2856-y
   PubMed Web of Science ®Google Scholar
• Wyles CC, Wright TC, Bois MC, et al. Myocardial Cobalt Levels Are Elevated in the Setting of Total Hip Arthroplasty. J Bone Joint Surg Am Vol. 2017;99(22):e118. doi:10.2106/JBJS.17.00159
   PubMed Web of Science ®Google Scholar
• Ohtsuru T, Morita Y, Murata Y, Shimamoto S, Munakata Y, Kato Y. Blood metal ion concentrations in metal-on-metal total Hip arthroplasty. Eurn J of Orthop Surg and Traumatol. 2017;27(4):527–532. doi:10.1007/s00590-017-1931-y
   PubMedGoogle Scholar
• Nam D, Salih R, Brown KM, Nunley RM, Barrack RL. Metal Ion Levels in Young, Active Patients Receiving a Modular, Dual Mobility Total Hip Arthroplasty. J Arthroplasty. 2017;32(5):1581–1585. doi:10.1016/j.arth.2016.12.012
   PubMed Web of Science ®Google Scholar
• Milosev I, Levasic V, Vidmar J, Kovac S, Trebse R. pH and metal concentration of synovial fluid of osteoarthritic joints and joints with metal replacements. J Biomed Mater Res Part B. 2017;105(8):2507–2515. doi:10.1002/jbm.b.33793
   PubMed Web of Science ®Google Scholar
• Lehtovirta L, Reito A, Parkkinen J, et al. Analysis of bearing wear, whole blood and synovial fluid metal ion concentrations and histopathological findings in patients with failed ASR Hip resurfacings. BMC Musculoskeletal Disorders. 2017;18(1):523. doi:10.1186/s12891-017-1894-5
   PubMedGoogle Scholar
• Smith T, Edmonds CJ, Barnaby CF. Absorption and retention of cobalt in man by whole-body counting. Health Phys. 1972;22(4):359–367. doi:10.1097/00004032-197204000-00007
   PubMed Web of Science ®Google Scholar
• Clark NA, Teschke K, Rideout K, Copes R. Trace element levels in adults from the west coast of Canada and associations with age, gender, diet, activities, and levels of other trace elements. Chemosphere. 2007;70(1):155–164. doi:10.1016/j.chemosphere.2007.06.038
   PubMed Web of Science ®Google Scholar
• Barceloux DG. Molybdenum. J Toxicol. 1999;37(2):231–237. doi:10.1081/clt-100102422
   PubMed Web of Science ®Google Scholar
• Barceloux DG. Chromium. J Toxicol. 1999;37(2):173–194. doi:10.1081/clt-100102418
   PubMed Web of Science ®Google Scholar
• Tripathi D, Mani V, Pal RP. Vanadium in Biosphere and Its Role in Biological Processes. Biol. Trace Elem. Res. 2018;186(1):52–67. doi:10.1007/s12011-018-1289-y
   PubMed Web of Science ®Google Scholar
• Leggett RW. The biokinetics of inorganic cobalt in the human body. Sci Total Environ. 2008;389(2–3):259–269. doi:10.1016/j.scitotenv.2007.08.054
   PubMed Web of Science ®Google Scholar
• Hong F, Yu X, Wu N, Zhang YQ. Progress of in vivo studies on the systemic toxicities induced by titanium dioxide nanoparticles. Toxicol Res (Camb). 2017;6(2):115–133. doi:10.1039/C6TX00338A
   PubMed Web of Science ®Google Scholar
• Aguilar F, Autrup H, Barlow S, et al. Safety of aluminium from dietary intake scientific opinion of the panel on food additives, flavourings, processing aids and food contact materials (AFC). J Med. 2008;754:1–34.
   Google Scholar
• Fleshman DG, Silva AJ, Shore B. The metabolism of tantalum in the rat. Health Phys. 1971;21(3):385–392. doi:10.1097/00004032-197109000-00004
   PubMed Web of Science ®Google Scholar
• Ho JH, Leikin JB, Dargan PI, Archer JRH, Wood DM, Brent J. Metal-on-Metal Hip Joint Prostheses: a Retrospective Case Series Investigating the Association of Systemic Toxicity with Serum Cobalt and Chromium Concentrations. J Med Toxicol. 2017;13(4):321–328. doi:10.1007/s13181-017-0629-1
   PubMedGoogle Scholar
• Ikeda T, Takahashi K, Kabata T, Sakagoshi D, Tomita K, Yamada M. Polyneuropathy caused by cobalt-chromium metallosis after total Hip replacement. Muscle and Nerve. 2010;42(1):140–143. doi:10.1002/mus.21638
   PubMed Web of Science ®Google Scholar
• Gilbert CJ, Cheung A, Butany J, et al. Hip pain and heart failure: the missing link. Can J Cardiol. 2013;29(5):639 e1–2. doi:10.1016/j.cjca.2012.10.015
   PubMed Web of Science ®Google Scholar
• Bradberry SM, Wilkinson JM, Ferner RE. Systemic toxicity related to metal Hip prostheses. Clin toxicol. 2014;52(8):837–847. doi:10.3109/15563650.2014.944977
   PubMed Web of Science ®Google Scholar
• Kavanagh KT, Kraman SS, Kavanagh SP. An Analysis of the FDA MAUDE Database and the Search for Cobalt Toxicity in Class 3 Johnson & Johnson/DePuy Metal-on-Metal Hip Implants. J Patient Saf. 2018;14(4):e89–e96. doi:10.1097/PTS.0000000000000534
   PubMed Web of Science ®Google Scholar
• Peters K, Unger RE, Barth S, Gerdes T, Kirkpatrick CJ. Induction of apoptosis in human microvascular endothelial cells by divalent cobalt ions. Evidence for integrin-mediated signaling via the cytoskeleton. J Mater Sci Mater Med. 2001;12(10–12):955–958. doi:10.1023/A:1012852814570
   PubMed Web of Science ®Google Scholar
• Prescott E, Netterstrom B, Faber J, Hegedus L, Suadicani P, Christensen JM. Effect of occupational exposure to cobalt blue dyes on the thyroid volume and function of female plate painters. Scand J Work Environ Health. 1992;18(2):101–104. doi:10.5271/sjweh.1605
   PubMed Web of Science ®Google Scholar
• Holly RG. Studies on iron and cobalt metabolism. Journal of the American Medical Association. 1955;158(15):1349–1352. doi:10.1001/jama.1955.02960150019005
   PubMed Web of Science ®Google Scholar
• Barceloux DG. Cobalt. J Toxicol. 1999;37(2):201–206. doi:10.1081/clt-100102420
   PubMed Web of Science ®Google Scholar
• Parkinson I, Ward M, Kerr D. Dialysis encephalopathy, bone disease and anaemia: the aluminum intoxication syndrome during regular haemodialysis. J Clin Pathol. 1981;34(11):1285. doi:10.1136/jcp.34.11.1285
   PubMed Web of Science ®Google Scholar
• Willhite CC, Karyakina NA, Yokel RA, et al. Systematic review of potential health risks posed by pharmaceutical, occupational and consumer exposures to metallic and nanoscale aluminum, aluminum oxides, aluminum hydroxide and its soluble salts. Crit. Rev. Toxicol. 2014;44 Suppl 4(Suppl 4):1–80. doi:10.3109/10408444.2014.934439
   PubMedGoogle Scholar
• Domingo JL. Vanadium: a review of the reproductive and developmental toxicity. Reprod Toxicol. 1996;10(3):175–182. doi:10.1016/0890-6238(96)00019-6
   PubMed Web of Science ®Google Scholar
• Peat F, Coomber R, Rana A, Vince A. Vanadium allergy following total knee arthroplasty. BMJ Case Rep. 2018;2018:548.
   Google Scholar
• Granchi D, Cenni E, Tigani D, Trisolino G, Baldini N, Giunti A. Sensitivity to implant materials in patients with total knee arthroplasties. Biomaterials. 2008;29(10):1494–1500. doi:10.1016/j.biomaterials.2007.11.038
   PubMed Web of Science ®Google Scholar
• Moretti B, Pesce V, Maccagnano G, et al. Peripheral neuropathy after Hip replacement failure: is vanadium the culprit? Lancet. 2012;379(9826):1676. doi:10.1016/S0140-6736(12)60273-6
   PubMed Web of Science ®Google Scholar
• Cancilleri F, De Giorgis P, Verdoia C, Parrini L, Lodi A, Crosti C. Allergy to components of total Hip arthroplasty before and after surgery. Ital J Orthop Traumatol. 1992;18(3):407–410.
   PubMedGoogle Scholar
• Smith D, Pickering R. A systematic review of vanadium oral supplements for glycaemic control in type 2 diabetes mellitus. QJM. 2008;101(5):351–358. doi:10.1093/qjmed/hcn003
   PubMed Web of Science ®Google Scholar
• Barceloux DG, Barceloux D. Vanadium. J Toxicol. 1999;37(2):265–278.
   PubMed Web of Science ®Google Scholar
• Vyskočil A, Viau C. Assessment of molybdenum toxicity in humans. J Appl Toxicol. 1999;19(3):185–192. doi:10.1002/(SICI)1099-1263(199905/06)19:3<185::AID-JAT555>3.0.CO;2-Z
   PubMed Web of Science ®Google Scholar
• Lewis RC, Johns LE, Meeker JD. Exploratory analysis of the potential relationship between urinary molybdenum and bone mineral density among adult men and women from NHANES 2007–2010. Chemosphere. 2016;164:677–682. doi:10.1016/j.chemosphere.2016.08.142
   PubMed Web of Science ®Google Scholar
• Parry NM, Phillippo M, Reid MD, McGaw BA, Flint DJ, Loveridge N. Molybdenum-induced changes in the epiphyseal growth plate. Calcified Tissue Int. 1993;53(3):180–186. doi:10.1007/BF01321835
   PubMed Web of Science ®Google Scholar
• Meeker JD, Rossano MG, Protas B, et al. Cadmium, lead, and other metals in relation to semen quality: human evidence for molybdenum as a male reproductive toxicant. Environ. Health Perspect. 2008;116(11):1473–1479. doi:10.1289/ehp.11490
   PubMed Web of Science ®Google Scholar
• Meeker JD, Rossano MG, Protas B, et al. Environmental exposure to metals and male reproductive hormones: circulating testosterone is inversely associated with blood molybdenum. Fertil Sterility. 2010;93(1):130–140. doi:10.1016/j.fertnstert.2008.09.044
   PubMed Web of Science ®Google Scholar
• Ribeiro AM, Flores-Sahagun THS, Paredes RC. A perspective on molybdenum biocompatibility and antimicrobial activity for applications in implants. J Mater Sci. 2015;51(6):2806–2816. doi:10.1007/s10853-015-9664-y
   Web of Science ®Google Scholar
• Thomas WC, Prieto HA. Total Hip replacement failure due to adverse local tissue reaction from both ceramic abrasive wear and trunnion corrosion. Arthroplast Today. 2019;5(4):384–388.
   PubMedGoogle Scholar
• Cadossi M, Chiarello E, Savarino L, et al. Fast growing pseudotumour in a hairdresser after metal-on-metal Hip resurfacing: a case report. Eur. Rev. Med. Pharmacol. Sci. 2014;18(1 Suppl):29–33.
   PubMedGoogle Scholar
• Grote CW, Cowan PC, Anderson DW, Templeton KJ. Pseudotumor from Metal-on-Metal Total Hip Arthroplasty Causing Unilateral Leg Edema: case Presentation and Literature Review. Biores Open Access. 2018;7(1):33–38. doi:10.1089/biores.2017.0035
   PubMedGoogle Scholar
• Lainiala O, Eskelinen A, Elo P, Puolakka T, Korhonen J, Moilanen T. Adverse reaction to metal debris is more common in patients following MoM total Hip replacement with a 36 mm femoral head than previously thought: results from a modern MoM follow-up programme. Bone Joint j. 2014;96-B(12):1610–1617. doi:10.1302/0301-620X.96B12.33742
   PubMed Web of Science ®Google Scholar
• Czajka M, Sawicki K, Sikorska K, Popek S, Kruszewski M, Kapka-Skrzypczak L. Toxicity of titanium dioxide nanoparticles in central nervous system. Toxicol in vitro. 2015;29(5):1042–1052. doi:10.1016/j.tiv.2015.04.004
   PubMed Web of Science ®Google Scholar
• Hou J, Wang L, Wang C, et al. Toxicity and mechanisms of action of titanium dioxide nanoparticles in living organisms. J Environ Sci (China). 2019;75:40–53. doi:10.1016/j.jes.2018.06.010
   PubMed Web of Science ®Google Scholar
• Miller RA, Ro JY, Schwartz MR. Adverse tissue reactions after total Hip arthroplasty. Ann Diagn Pathol. 2017;27:83–87. doi:10.1016/j.anndiagpath.2016.07.006
   PubMed Web of Science ®Google Scholar
• Wu D, Bhalekar RM, Marsh JS, Langton DJ, Stewart AJ. Periarticular metal hypersensitivity complications of Hip bearings containing cobalt-chromium. EFORT Open Rev. 2022;7(11):758–771. doi:10.1530/EOR-22-0036
   PubMed Web of Science ®Google Scholar
• Rajamaki A, Lehtovirta L, Niemelainen M, et al. Mild aseptic lymphocyte-dominated vasculitis-associated lesion (ALVAL)-type reactions also present in patients with failed knee prostheses. Bone Joint Res. 2024;13(4):149–156. doi:10.1302/2046-3758.134.BJR-2023-0255.R1
   PubMed Web of Science ®Google Scholar
• Cohen MD, Kargacin B, Klein CB, Costa M. Mechanisms of chromium carcinogenicity and toxicity. Crit. Rev. Toxicol. 1993;23(3):255–281. doi:10.3109/10408449309105012
   PubMed Web of Science ®Google Scholar
• Gad SC. Acute and chronic systemic chromium toxicity. Sci Total Environ. 1989;86(1–2):149–157. doi:10.1016/0048-9697(89)90201-5
   PubMed Web of Science ®Google Scholar
• Pavesi T, Moreira JC. Mechanisms and individuality in chromium toxicity in humans. J Appl Toxicol. 2020;40(9):1183–1197. doi:10.1002/jat.3965
   PubMed Web of Science ®Google Scholar
• Wang Y, Su H, Gu Y, Song X, Zhao J. Carcinogenicity of chromium and chemoprevention: a brief update. Onco Targets Ther. 2017;10:4065–4079. doi:10.2147/OTT.S139262
   PubMed Web of Science ®Google Scholar
• Chen QY, DesMarais T, Costa M. Metals and Mechanisms of Carcinogenesis. Annu Rev Pharmacol Toxicol. 2019;59(1):537–554. doi:10.1146/annurev-pharmtox-010818-021031
   PubMedGoogle Scholar
• Gomes CC, Moreira LM, Santos VJ, et al. Assessment of the genetic risks of a metallic alloy used in medical implants. Genetics Mol Biol. 2011;34(1):116–121. doi:10.1590/S1415-47572010005000118
   PubMed Web of Science ®Google Scholar
• Huang C, Sun M, Yang Y, et al. Titanium dioxide nanoparticles prime a specific activation state of macrophages. Nanotoxicology. 2017;11(6):737–750. doi:10.1080/17435390.2017.1349202
   PubMed Web of Science ®Google Scholar
• Santos Filho RD, Vicari T, Santos SA, et al. Genotoxicity of titanium dioxide nanoparticles and triggering of defense mechanisms in Allium cepa. Genet Mol Biol. 2019;42(2):425–435. doi:10.1590/1678-4685-gmb-2018-0205
   PubMed Web of Science ®Google Scholar
• Wakeman TP, Yang A, Dalal NS, et al. DNA mismatch repair protein Mlh1 is required for tetravalent chromium intermediate-induced DNA damage. Oncotarget. 2017;8(48):83975–83985. doi:10.18632/oncotarget.20150
   PubMedGoogle Scholar
• Papis E, Gornati R, Prati M, Ponti J, Sabbioni E, Bernardini G. Gene expression in nanotoxicology research: analysis by differential display in BALB3T3 fibroblasts exposed to cobalt particles and ions. Toxicol Lett. 2007;170(3):185–192. doi:10.1016/j.toxlet.2007.03.005
   PubMed Web of Science ®Google Scholar
• Lison D, De Boeck M, Verougstraete V, Kirsch-Volders M. Update on the genotoxicity and carcinogenicity of cobalt compounds. Occup Environ Med. 2001;58(10):619–625. doi:10.1136/oem.58.10.619
   PubMed Web of Science ®Google Scholar
• De Boeck M, Kirsch-Volders M, Lison D. Cobalt and antimony: genotoxicity and carcinogenicity. Mutat Res. 2003;533(1–2):135–152. doi:10.1016/j.mrfmmm.2003.07.012
   PubMed Web of Science ®Google Scholar
• Magaye R, Zhao J, Bowman L, Ding M. Genotoxicity and carcinogenicity of cobalt-, nickel- and copper-based nanoparticles. Exp Ther Med. 2012;4(4):551–561. doi:10.3892/etm.2012.656
   PubMed Web of Science ®Google Scholar
• Behl M, Stout MD, Herbert RA, et al. Comparative toxicity and carcinogenicity of soluble and insoluble cobalt compounds. Toxicology. 2015;333:195–205. doi:10.1016/j.tox.2015.04.008
   PubMed Web of Science ®Google Scholar
• Savarino L, Fotia C, Roncuzzi L, et al. Does chronic raise of metal ion levels induce oxidative DNA damage and hypoxia-like response in patients with metal-on-metal Hip resurfacing? J Biomed Mater Res Part B. 2017;105(2):460–466. doi:10.1002/jbm.b.33555
   PubMed Web of Science ®Google Scholar
• Christian WV, Oliver LD, Paustenbach DJ, Kreider ML, Finley BL. Toxicology-based cancer causation analysis of CoCr-containing Hip implants: a quantitative assessment of genotoxicity and tumorigenicity studies. J Appl Toxicol. 2014;34(9):939–967. doi:10.1002/jat.3039
   PubMed Web of Science ®Google Scholar
• Ollivere B, Wimhurst JA, Clark IM, Donell ST. Current concepts in osteolysis. J Bone Joint Surg Br Vol. 2012;94(1):10–15. doi:10.1302/0301-620X.94B1.28047
   PubMed Web of Science ®Google Scholar
• Purdue PE, Koulouvaris P, Nestor BJ, Sculco TP. The central role of wear debris in periprosthetic osteolysis. HSS J. 2006;2(2):102–113. doi:10.1007/s11420-006-9003-6
   PubMedGoogle Scholar
• Sansone V, Pagani D, Melato M. The effects on bone cells of metal ions released from orthopaedic implants. A review. Clin Cases Miner Bone Metab. 2013;10(1):34–40. doi:10.11138/ccmbm/2013.10.1.034
   PubMedGoogle Scholar
• Kudo O, Sabokbar A, Pocock A, Itonaga I, Fujikawa Y, Athanasou NA. Interleukin-6 and interleukin-11 support human osteoclast formation by a RANKL-independent mechanism. Bone. 2003;32(1):1–7. doi:10.1016/S8756-3282(02)00915-8
   PubMed Web of Science ®Google Scholar
• Niki Y, Matsumoto H, Suda Y, et al. Metal ions induce bone-resorbing cytokine production through the redox pathway in synoviocytes and bone marrow macrophages. Biomaterials. 2003;24(8):1447–1457. doi:10.1016/S0142-9612(02)00531-8
   PubMed Web of Science ®Google Scholar
• Cadosch D, Al-Mushaiqri MS, Gautschi OP, Meagher J, Simmen HP, Filgueira L. Biocorrosion and uptake of titanium by human osteoclasts. J Biomed Mater Res Part A. 2010;95(4):1004–1010. doi:10.1002/jbm.a.32914
   PubMedGoogle Scholar
• Kim BJ, Koh JM. Coupling factors involved in preserving bone balance. Cell Mol Life Sci. 2019;76(7):1243–1253. doi:10.1007/s00018-018-2981-y
   PubMed Web of Science ®Google Scholar
• Vermes C, Glant TT, Hallab NJ, Fritz EA, Roebuck KA, Jacobs JJ. The potential role of the osteoblast in the development of periprosthetic osteolysis: review of in vitro osteoblast responses to wear debris, corrosion products, and cytokines and growth factors. J Arthroplasty. 2001;16(8 Suppl 1):95–100. doi:10.1054/arth.2001.28719
   PubMed Web of Science ®Google Scholar
• Hallab NJ. Concentration- and composition-dependent effects of metal ions on human MG-63 osteoblasts. J Biomed Mater Res. 2002;60(3):420–433. doi:10.1002/jbm.10106
   PubMed Web of Science ®Google Scholar
• Vermes C, Chandrasekaran R, Jacobs JJ, Galante JO, Roebuck KA, Glant TT. The effects of particulate wear debris, cytokines, and growth factors on the functions of MG-63 osteoblasts. J Bone Joint Surg Am Vol. 2001;83(2):201–211. doi:10.2106/00004623-200102000-00007
   PubMedGoogle Scholar
• Rakow A, Schoon J, Dienelt A, et al. Influence of particulate and dissociated metal-on-metal Hip endoprosthesis wear on mesenchymal stromal cells in vivo and in vitro. Biomaterials. 2016;98:31–40. doi:10.1016/j.biomaterials.2016.04.023
   PubMed Web of Science ®Google Scholar
• Roebuck KA, Vermes C, Carpenter LR, Fritz EA, Narayanan R, Glant TT. Down-regulation of procollagen alpha1[I]] messenger RNA by titanium particles correlates with nuclear factor kappaB (NF-kappaB) activation and increased rel A and NF-kappaB1 binding to the collagen promoter. J Bone Miner Res. 2001;16(3):501–510. doi:10.1359/jbmr.2001.16.3.501
   PubMed Web of Science ®Google Scholar
• Vermes C, Roebuck KA, Chandrasekaran R, Dobai JG, Jacobs JJ, Glant TT. Particulate wear debris activates protein tyrosine kinases and nuclear factor kappaB, which down-regulates type I collagen synthesis in human osteoblasts. J Bone Miner Res. 2000;15(9):1756–1765. doi:10.1359/jbmr.2000.15.9.1756
   PubMed Web of Science ®Google Scholar
• Ormsby RT, Solomon LB, Yang D, et al. Osteocytes respond to particles of clinically-relevant conventional and cross-linked polyethylene and metal alloys by up-regulation of resorptive and inflammatory pathways. Acta Biomater. 2019;87:296–306. doi:10.1016/j.actbio.2019.01.047
   PubMed Web of Science ®Google Scholar
• Minematsu H, Shin MJ, Celil AA, et al. Orthopedic implant particle-induced tumor necrosis factor-alpha production in macrophage-monocyte lineage cells is mediated by nuclear factor of activated T cells. Ann N Y Acad Sci. 2007;1117:143–150. doi:10.1196/annals.1402.026
   PubMed Web of Science ®Google Scholar
• Orhue V, Kanaji A, Caicedo MS, et al. Calcineurin/nuclear factor of activated T cells (NFAT) signaling in cobalt-chromium-molybdenum (CoCrMo) particles-induced tumor necrosis factor-alpha (TNFalpha) secretion in MLO-Y4 osteocytes. J Orthop Res. 2011;29(12):1867–1873. doi:10.1002/jor.21458
   PubMed Web of Science ®Google Scholar
• Kanaji A, Caicedo MS, Virdi AS, Sumner DR, Hallab NJ, Sena K. Co-Cr-Mo alloy particles induce tumor necrosis factor alpha production in MLO-Y4 osteocytes: a role for osteocytes in particle-induced inflammation. Bone. 2009;45(3):528–533. doi:10.1016/j.bone.2009.05.020
   PubMed Web of Science ®Google Scholar
• Ingham E, Fisher J. The role of macrophages in osteolysis of total joint replacement. Biomaterials. 2005;26(11):1271–1286. doi:10.1016/j.biomaterials.2004.04.035
   PubMed Web of Science ®Google Scholar
• Sun L, Blair HC, Peng Y, et al. Calcineurin regulates bone formation by the osteoblast. Proc Natl Acad Sci USA. 2005;102(47):17130–17135. doi:10.1073/pnas.0508480102
   PubMed Web of Science ®Google Scholar
• Winslow MM, Pan M, Starbuck M, et al. Calcineurin/NFAT signaling in osteoblasts regulates bone mass. Dev Cell. 2006;10(6):771–782. doi:10.1016/j.devcel.2006.04.006
   PubMed Web of Science ®Google Scholar
• Yamanaka Y, Abu-Amer W, Foglia D, Otero J, Clohisy JC, Abu-Amer Y. NFAT2 is an essential mediator of orthopedic particle-induced osteoclastogenesis. J Orthop Res. 2008;26(12):1577–1584. doi:10.1002/jor.20714
   PubMed Web of Science ®Google Scholar
• Celil AA, Minematsu H, Gardner TR, Kim KO, Ahn JM, Lee FY. Nuclear factor of activated T cells mediates fluid shear stress- and tensile strain-induced Cox2 in human and murine bone cells. Bone. 2010;46(1):167–175. doi:10.1016/j.bone.2009.08.061
   PubMed Web of Science ®Google Scholar
• Magone K, Luckenbill D, Goswami T. Metal ions as inflammatory initiators of osteolysis. Arch Orthopaedic Trauma Surgery. 2015;135(5):683–695. doi:10.1007/s00402-015-2196-8
   PubMed Web of Science ®Google Scholar
• Gallo J, Slouf M, Goodman SB. The relationship of polyethylene wear to particle size, distribution, and number: a possible factor explaining the risk of osteolysis after Hip arthroplasty. J Biomed Mater Res Part B. 2010;94(1):171–177. doi:10.1002/jbm.b.31638
   PubMedGoogle Scholar
• Gallo J, Raska M, Mrazek F, Petrek M. Bone remodeling, particle disease and individual susceptibility to periprosthetic osteolysis. Physiol Res. 2008;57(3):339–349. doi:10.33549/physiolres.931140
   PubMed Web of Science ®Google Scholar
• Goodman SB, Ma T. Cellular chemotaxis induced by wear particles from joint replacements. Biomaterials. 2010;31(19):5045–5050. doi:10.1016/j.biomaterials.2010.03.046
   PubMed Web of Science ®Google Scholar
• Gallo J, Kaminek P, Ticha V, Rihakova P, Ditmar R. Particle disease. A comprehensive theory of periprosthetic osteolysis: a review. Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2002;146(2):21–28. doi:10.5507/bp.2002.004
   PubMedGoogle Scholar
• Merkel KD, Erdmann JM, McHugh KP, Abu-Amer Y, Ross FP, Teitelbaum SL. Tumor necrosis factor-alpha mediates orthopedic implant osteolysis. Am J Pathol. 1999;154(1):203–210. doi:10.1016/S0002-9440(10)65266-2
   PubMed Web of Science ®Google Scholar
• Catelas I, Petit A, Zukor DJ, Antoniou J, Huk OL. TNF-alpha secretion and macrophage mortality induced by cobalt and chromium ions in vitro-qualitative analysis of apoptosis. Biomaterials. 2003;24(3):383–391. doi:10.1016/S0142-9612(02)00351-4
   PubMed Web of Science ®Google Scholar
• Queally JM, Devitt BM, Butler JS, et al. Cobalt ions induce chemokine secretion in primary human osteoblasts. J Orthop Res. 2009;27(7):855–864. doi:10.1002/jor.20837
   PubMed Web of Science ®Google Scholar
• Eltit F, Noble J, Sharma M, et al. Cobalt ions induce metabolic stress in synovial fibroblasts and secretion of cytokines/chemokines that may be diagnostic markers for adverse local tissue reactions to Hip implants. Acta Biomater. 2021;131:581–594. doi:10.1016/j.actbio.2021.06.039
   PubMed Web of Science ®Google Scholar
• Liu G, Wang X, Zhou X, et al. Modulating the cobalt dose range to manipulate multisystem cooperation in bone environment: a strategy to resolve the controversies about cobalt use for orthopedic applications. Theranostics. 2020;10(3):1074–1089. doi:10.7150/thno.37931
   PubMed Web of Science ®Google Scholar
• Baskey SJ, Lehoux EA, Catelas I. Effects of cobalt and chromium ions on lymphocyte migration. J Orthop Res. 2017;35(4):916–924. doi:10.1002/jor.23336
   PubMed Web of Science ®Google Scholar
• Caicedo MS, Pennekamp PH, McAllister K, Jacobs JJ, Hallab NJ. Soluble ions more than particulate cobalt-alloy implant debris induce monocyte costimulatory molecule expression and release of proinflammatory cytokines critical to metal-induced lymphocyte reactivity. J Biomed Mater Res Part A. 2010;93(4):1312–1321. doi:10.1002/jbm.a.32627
   PubMedGoogle Scholar
• Schwab LP, Marlar J, Hasty KA, Smith RA. Macrophage response to high number of titanium particles is cytotoxic and COX-2 mediated and it is not affected by the particle’s endotoxin content or the cleaning treatment. J Biomed Mater Res Part A. 2011;99(4):630–637. doi:10.1002/jbm.a.33222
   PubMedGoogle Scholar
• Hotchkiss KM, Reddy GB, Hyzy SL, Schwartz Z, Boyan BD, Olivares-Navarrete R. Titanium surface characteristics, including topography and wettability, alter macrophage activation. Acta Biomater. 2016;31:425–434. doi:10.1016/j.actbio.2015.12.003
   PubMed Web of Science ®Google Scholar
• Rader CP, Sterner T, Jakob F, Schutze N, Eulert J. Cytokine response of human macrophage-like cells after contact with polyethylene and pure titanium particles. J Arthroplasty. 1999;14(7):840–848. doi:10.1016/S0883-5403(99)90035-9
   PubMed Web of Science ®Google Scholar
• Valles G, Gil-Garay E, Munuera L, Vilaboa N. Modulation of the cross-talk between macrophages and osteoblasts by titanium-based particles. Biomaterials. 2008;29(15):2326–2335. doi:10.1016/j.biomaterials.2008.02.011
   PubMed Web of Science ®Google Scholar
• Carter JD, Ghio AJ, Samet JM, Devlin RB. Cytokine production by human airway epithelial cells after exposure to an air pollution particle is metal-dependent. Toxicol Appl Pharmacol. 1997;146(2):180–188. doi:10.1006/taap.1997.8254
   PubMed Web of Science ®Google Scholar
• Ye J, Ding M, Zhang X, et al. Induction of TNFalpha in macrophages by vanadate is dependent on activation of transcription factor NF-kappaB and free radical reactions. Mol Cell Biochem. 1999;198(1–2):193–200. doi:10.1023/A:1006969008056
   PubMed Web of Science ®Google Scholar
• Tsave O, Petanidis S, Kioseoglou E, et al. Role of Vanadium in Cellular and Molecular Immunology: association with Immune-Related Inflammation and Pharmacotoxicology Mechanisms. Oxid Med Cell Longev. 2016;2016:4013639. doi:10.1155/2016/4013639
   PubMed Web of Science ®Google Scholar
• Zwolak I. Vanadium carcinogenic, immunotoxic and neurotoxic effects: a review of in vitro studies. Toxicol Mech Methods. 2014;24(1):1–12. doi:10.3109/15376516.2013.843110
   PubMed Web of Science ®Google Scholar
• Pineton de Chambrun G, Body-Malapel M, Frey-Wagner I, et al. Aluminum enhances inflammation and decreases mucosal healing in experimental colitis in mice. Mucosal Immunol. 2014;7(3):589–601. doi:10.1038/mi.2013.78
   PubMed Web of Science ®Google Scholar
• Johnson VJ, Sharma RP. Aluminum disrupts the pro-inflammatory cytokine/neurotrophin balance in primary brain rotation-mediated aggregate cultures: possible role in neurodegeneration. Neurotoxicology. 2003;24(2):261–268. doi:10.1016/S0161-813X(02)00194-8
   PubMed Web of Science ®Google Scholar
• Drynda A, Drynda S, Kekow J, Lohmann CH, Bertrand J. Differential Effect of Cobalt and Chromium Ions as Well as CoCr Particles on the Expression of Osteogenic Markers and Osteoblast Function. Int J Mol Sci. 2018;19(10):10. doi:10.3390/ijms19103034
   Web of Science ®Google Scholar
• Wang JY, Wicklund BH, Gustilo RB, Tsukayama DT. Titanium, chromium and cobalt ions modulate the release of bone-associated cytokines by human monocytes/macrophages in vitro. Biomaterials. 1996;17(23):2233–2240. doi:10.1016/0142-9612(96)00072-5
   PubMed Web of Science ®Google Scholar
• Lee YW, Cherng YG, Yang ST, Liu SH, Chen TL, Chen RM. Hypoxia Induced by Cobalt Chloride Triggers Autophagic Apoptosis of Human and Mouse Drug-Resistant Glioblastoma Cells through Targeting the PI3K-AKT-mTOR Signaling Pathway. Oxid Med Cell Longev. 2021;2021:5558618. doi:10.1155/2021/5558618
   PubMed Web of Science ®Google Scholar
• Zhang C, Chen M, Tao Q, Chi Z. Cobalt chloride-stimulated hypoxia promotes the proliferation of cholesteatoma keratinocytes via the PI3K/Akt signaling pathway. Int J Med Sci. 2021;18(15):3403–3411. doi:10.7150/ijms.60617
   PubMed Web of Science ®Google Scholar
• Xu J, Yang J, Nyga A, et al. Cobalt (II) ions and nanoparticles induce macrophage retention by ROS-mediated down-regulation of RhoA expression. Acta Biomater. 2018;72:434–446. doi:10.1016/j.actbio.2018.03.054
   PubMed Web of Science ®Google Scholar
• Zhang X, Wang Y, Chen M, Zeng M. Hexavalent chromium-induced apoptosis in Hep3B cells is accompanied by calcium overload, mitochondrial damage, and AIF translocation. Ecotoxicol Environ Saf. 2021;208:111391. doi:10.1016/j.ecoenv.2020.111391
   PubMed Web of Science ®Google Scholar
• Ganapathy S, Li P, Lafontant J, et al. Chromium IV exposure, via Src/Ras signaling, promotes cell transformation. Mol, Carcinog. 2017;56(7):1808–1815. doi:10.1002/mc.22639
   PubMed Web of Science ®Google Scholar
• Yang Q, Han B, Xue J, et al. Hexavalent chromium induces mitochondrial dynamics disorder in rat liver by inhibiting AMPK/PGC-1alpha signaling pathway. Environ Pollut. 2020;265(Pt A):114855. doi:10.1016/j.envpol.2020.114855
   PubMed Web of Science ®Google Scholar
• Bozinovic K, Nestic D, Centa UG, et al. In-vitro toxicity of molybdenum trioxide nanoparticles on human keratinocytes. Toxicology. 2020;444:152564. doi:10.1016/j.tox.2020.152564
   PubMed Web of Science ®Google Scholar
• Yang TY, Yen CC, Lee KI, et al. Molybdenum induces pancreatic beta-cell dysfunction and apoptosis via interdependent of JNK and AMPK activation-regulated mitochondria-dependent and ER stress-triggered pathways. Toxicol Appl Pharmacol. 2016;294:54–64. doi:10.1016/j.taap.2016.01.013
   PubMed Web of Science ®Google Scholar
• Gholinejad Z, Khadem Ansari MH, Rasmi Y. Titanium dioxide nanoparticles induce endothelial cell apoptosis via cell membrane oxidative damage and p38, PI3K/Akt, NF-kappaB signaling pathways modulation. J Trace Elem Med Biol. 2019;54:27–35. doi:10.1016/j.jtemb.2019.03.008
   PubMed Web of Science ®Google Scholar
• Xian G, Chen W, Gu M, et al. Titanium particles induce apoptosis by promoting autophagy in macrophages via the PI3K/Akt signaling pathway. J Biomed Mater Res Part A. 2020;108(9):1792–1805. doi:10.1002/jbm.a.36938
   PubMed Web of Science ®Google Scholar
• Yu X, Hong F, Zhang YQ. Cardiac inflammation involving in PKCepsilon or ERK1/2-activated NF-kappaB signalling pathway in mice following exposure to titanium dioxide nanoparticles. J Hazard Mater. 2016;313:68–77. doi:10.1016/j.jhazmat.2016.03.088
   PubMed Web of Science ®Google Scholar
• Gu Y, Wang Z, Shi J, et al. Titanium particle-induced osteogenic inhibition and bone destruction are mediated by the GSK-3beta/beta-catenin signal pathway. Cell Death Dis. 2017;8(6):e2878. doi:10.1038/cddis.2017.275
   PubMedGoogle Scholar
• Zhu WQ, Ming PP, Zhang SM, Qiu J. Role of MAPK/JNK signaling pathway on the regulation of biological behaviors of MC3T3E1 osteoblasts under titanium ion exposure. Mol Med Rep. 2020;22(6):4792–4800. doi:10.3892/mmr.2020.11575
   PubMed Web of Science ®Google Scholar
• Zhu WQ, Ming PP, Qiu J, et al. Effect of titanium ions on the Hippo/YAP signaling pathway in regulating biological behaviors of MC3T3-E1 osteoblasts. J Appl Toxicol. 2018;38(6):824–833. doi:10.1002/jat.3590
   PubMed Web of Science ®Google Scholar
• Diaz D, Bartolo R, Delgadillo DM, Higueldo F, Gomora JC. Contrasting effects of Cd2+ and Co2+ on the blocking/unblocking of human Cav3 channels. J Membr Biol. 2005;207(2):91–105. doi:10.1007/s00232-005-0804-1
   PubMed Web of Science ®Google Scholar
• Li X, Han Y, Guan Y, Zhang L, Bai C, Li Y. Aluminum induces osteoblast apoptosis through the oxidative stress-mediated JNK signaling pathway. Biol. Trace Elem. Res. 2012;150(1–3):502–508. doi:10.1007/s12011-012-9523-5
   PubMed Web of Science ®Google Scholar
• Cao Z, Liu D, Zhang Q, Sun X, Li Y. Aluminum Chloride Induces Osteoblasts Apoptosis via Disrupting Calcium Homeostasis and Activating Ca(2+)/CaMKII Signal Pathway. Biol. Trace Elem. Res. 2016;169(2):247–253. doi:10.1007/s12011-015-0417-1
   PubMed Web of Science ®Google Scholar
• Sun X, Cao Z, Zhang Q, et al. Aluminum trichloride impairs bone and downregulates Wnt/beta-catenin signaling pathway in young growing rats. Food Chem Toxicol. 2015;86:154–162. doi:10.1016/j.fct.2015.10.005
   PubMed Web of Science ®Google Scholar
• Persson B, Carlenor E, Clyne N, et al. Binding of dietary cobalt to sarcoplasmic reticulum proteins. Scand J Clin Lab Invest. 1992;52(2):137–140. doi:10.3109/00365519209088777
   PubMed Web of Science ®Google Scholar
• Karovic O, Tonazzini I, Rebola N, et al. Toxic effects of cobalt in primary cultures of mouse astrocytes. Similarities with hypoxia and role of HIF-1alpha. Biochem Pharmacol. 2007;73(5):694–708. doi:10.1016/j.bcp.2006.11.008
   PubMed Web of Science ®Google Scholar
• Assem FL, Levy LS. A review of current toxicological concerns on vanadium pentoxide and other vanadium compounds: gaps in knowledge and directions for future research. J Toxicol Environ Health B Crit Rev. 2009;12(4):289–306. doi:10.1080/10937400903094166
   PubMed Web of Science ®Google Scholar
• Hao W, Hao C, Wu C, et al. Aluminum impairs cognitive function by activating DDX3X-NLRP3-mediated pyroptosis signaling pathway. Food Chem Toxicol. 2021;157:112591. doi:10.1016/j.fct.2021.112591
   PubMed Web of Science ®Google Scholar
• Li H, Xue X, Li Z, Pan B, Hao Y, Niu Q. Aluminium-induced synaptic plasticity injury via the PHF8-H3K9me2-BDNF signalling pathway. Chemosphere. 2020;244:125445. doi:10.1016/j.chemosphere.2019.125445
   PubMed Web of Science ®Google Scholar
• Korbecki J, Baranowska-Bosiacka I, Gutowska I, Chlubek D. Vanadium Compounds as Pro-Inflammatory Agents: effects on Cyclooxygenases. Int J Mol Sci. 2015;16(6):12648–12668. doi:10.3390/ijms160612648
   PubMed Web of Science ®Google Scholar
• Gajski G, Jelcic Z, Orescanin V, Geric M, Kollar R, Garaj-Vrhovac V. Physico-chemical characterization and the in vitro genotoxicity of medical implants metal alloy (TiAlV and CoCrMo) and polyethylene particles in human lymphocytes. Biochim Biophys Acta. 2014;1840(1):565–576. doi:10.1016/j.bbagen.2013.10.015
   PubMed Web of Science ®Google Scholar
• Chen F, Shi X. Intracellular signal transduction of cells in response to carcinogenic metals. Crit Rev Oncol Hematol. 2002;42(1):105–121. doi:10.1016/S1040-8428(01)00211-6
   PubMed Web of Science ®Google Scholar
• Gulati K, Scimeca JC, Ivanovski S, Verron E. Double-edged sword: therapeutic efficacy versus toxicity evaluations of doped titanium implants. Drug Discov Today. 2021;26(11):2734–2742. doi:10.1016/j.drudis.2021.07.004
   PubMed Web of Science ®Google Scholar
• Hartwig A. Zinc finger proteins as potential targets for toxic metal ions: differential effects on structure and function. Antioxid Redox Signal. 2001;3(4):625–634. doi:10.1089/15230860152542970
   PubMed Web of Science ®Google Scholar
• Baldwin EL, Byl JA, Osheroff N. Cobalt enhances DNA cleavage mediated by human topoisomerase II alpha in vitro and in cultured cells. Biochemistry. 2004;43(3):728–735. doi:10.1021/bi035472f
   PubMed Web of Science ®Google Scholar
• Lloyd DR, Carmichael PL, Phillips DH. Comparison of the formation of 8-hydroxy-2’-deoxyguanosine and single- and double-strand breaks in DNA mediated by Fenton reactions. Chem Res Toxicol. 1998;11(5):420–427. doi:10.1021/tx970156l
   PubMed Web of Science ®Google Scholar
• Beyersmann D, Hartwig A. The genetic toxicology of cobalt. Toxicol Appl Pharmacol. 1992;115(1):137–145. doi:10.1016/0041-008X(92)90377-5
   PubMed Web of Science ®Google Scholar
• Paustenbach DJ, Tvermoes BE, Unice KM, Finley BL, Kerger BD. A review of the health hazards posed by cobalt. Crit. Rev. Toxicol. 2013;43(4):316–362. doi:10.3109/10408444.2013.779633
   PubMed Web of Science ®Google Scholar
• Lison D, van den Brule S, Van Maele-Fabry G. Cobalt and its compounds: update on genotoxic and carcinogenic activities. Crit. Rev. Toxicol. 2018;48(7):522–539. doi:10.1080/10408444.2018.1491023
   PubMed Web of Science ®Google Scholar
• Wang J, Stieglitz KA, Kantrowitz ER. Metal specificity is correlated with two crucial active site residues in Escherichia coli alkaline phosphatase. Biochemistry. 2005;44(23):8378–8386. doi:10.1021/bi050155p
   PubMed Web of Science ®Google Scholar
• Snow ET. Effects of chromium on DNA replication in vitro. Environ Health Perspect. 1994;102(Suppl 3):41–44. doi:10.1289/ehp.94102s341
   PubMedGoogle Scholar
• Bijukumar DR, Segu A, Souza J, et al. Systemic and local toxicity of metal debris released from Hip prostheses: a review of experimental approaches. Nanomedicine. 2018;14(3):951–963. doi:10.1016/j.nano.2018.01.001
   PubMed Web of Science ®Google Scholar
• Chen L, Zhang J, Zhu Y, Zhang Y. Interaction of chromium(III) or chromium(VI) with catalase and its effect on the structure and function of catalase: an in vitro study. Food Chem. 2018;244:378–385. doi:10.1016/j.foodchem.2017.10.062
   PubMed Web of Science ®Google Scholar
• Aureliano M. Recent perspectives into biochemistry of decavanadate. World J Biol Chem. 2011;2(10):215–225. doi:10.4331/wjbc.v2.i10.215
   PubMedGoogle Scholar
• Valko M, Rhodes CJ, Moncol J, Izakovic M, Mazur M. Free radicals, metals and antioxidants in oxidative stress-induced cancer. Chem Biol Interact. 2006;160(1):1–40. doi:10.1016/j.cbi.2005.12.009
   PubMed Web of Science ®Google Scholar
• Terpilowska S, Siwicki AK. Interactions between chromium(III) and iron(III), molybdenum(III) or nickel(II): cytotoxicity, genotoxicity and mutagenicity studies. Chemosphere. 2018;201:780–789. doi:10.1016/j.chemosphere.2018.03.062
   PubMed Web of Science ®Google Scholar
• Ducros V. Chromium metabolism. A literature review. Biol. Trace Elem. Res. 1992;32(1–3):65–77. doi:10.1007/BF02784589
   PubMed Web of Science ®Google Scholar
• Merritt K, Brown SA. Release of hexavalent chromium from corrosion of stainless steel and cobalt-chromium alloys. J Biomed Mater Res. 1995;29(5):627–633. doi:10.1002/jbm.820290510
   PubMed Web of Science ®Google Scholar
• Braakhuis HM, Gosens I, Heringa MB, et al. Mechanism of Action of TiO 2: recommendations to Reduce Uncertainties Related to Carcinogenic Potential. Annu Rev Pharmacol Toxicol. 2021;61(1):203–223. doi:10.1146/annurev-pharmtox-101419-100049
   PubMedGoogle Scholar
• Shukla RK, Sharma V, Pandey AK, Singh S, Sultana S, Dhawan A. ROS-mediated genotoxicity induced by titanium dioxide nanoparticles in human epidermal cells. Toxicol In Vitro. 2011;25(1):231–241. doi:10.1016/j.tiv.2010.11.008
   PubMed Web of Science ®Google Scholar
• Liu M, Wu X, Cui Y, et al. Mitophagy and apoptosis mediated by ROS participate in AlCl3-induced MC3T3-E1 cell dysfunction. Food Chem Toxicol. 2021;155:112388. doi:10.1016/j.fct.2021.112388
   PubMed Web of Science ®Google Scholar
• Mandriota SJ, Tenan M, Nicolle A, et al. Genomic Instability Is an Early Event in Aluminium-Induced Tumorigenesis. Int J Mol Sci. 2020;21:23. doi:10.3390/ijms21239332
   Web of Science ®Google Scholar
• Rojas E, Valverde M, Herrera LA, Altamirano-Lozano M, Ostrosky-Wegman P. Genotoxicity of vanadium pentoxide evaluate by the single cell gel electrophoresis assay in human lymphocytes. Mutat Res. 1996;359(2):77–84. doi:10.1016/S0165-1161(96)90254-X
   PubMed Web of Science ®Google Scholar
• Ivancsits S, Pilger A, Diem E, Schaffer A, Rudiger HW. Vanadate induces DNA strand breaks in cultured human fibroblasts at doses relevant to occupational exposure. Mutat Res. 2002;519(1–2):25–35. doi:10.1016/S1383-5718(02)00138-9
   PubMed Web of Science ®Google Scholar
• Rodriguez-Mercado JJ, Mateos-Nava RA, Altamirano-Lozano MA. DNA damage induction in human cells exposed to vanadium oxides in vitro. Toxicol in vitro. 2011;25(8):1996–2002. doi:10.1016/j.tiv.2011.07.009
   PubMed Web of Science ®Google Scholar
• Shi X, Jiang H, Mao Y, Ye J, Saffiotti U. Vanadium(IV)-mediated free radical generation and related 2’-deoxyguanosine hydroxylation and DNA damage. Toxicology. 1996;106(1–3):27–38. doi:10.1016/0300-483X(95)03151-5
   PubMed Web of Science ®Google Scholar
• Tang H, Sun Y, Xiu Q, Lu H, Han H. Cyclooxygenase-2 induction requires activation of nuclear factor of activated T-cells in Beas-2B cells after vanadium exposure and plays an anti-apoptotic role. Arch Biochem Biophys. 2007;468(1):92–99. doi:10.1016/j.abb.2007.09.016
   PubMed Web of Science ®Google Scholar
• Zhang Z, Huang C, Li J, Shi X. Vanadate-induced cell growth arrest is p53-dependent through activation of p21 in C141 cells. J Inorg Biochem. 2002;89(1–2):142–148. doi:10.1016/S0162-0134(01)00409-3
   PubMed Web of Science ®Google Scholar
• Zhang Z, Huang C, Li J, et al. Vanadate-induced cell growth regulation and the role of reactive oxygen species. Arch Biochem Biophys. 2001;392(2):311–320. doi:10.1006/abbi.2001.2464
   PubMed Web of Science ®Google Scholar
• Rodriguez-Mercado JJ, Roldan-Reyes E, Altamirano-Lozano M. Genotoxic effects of vanadium(IV) in human peripheral blood cells. Toxicol Lett. 2003;144(3):359–369. doi:10.1016/S0378-4274(03)00255-8
   PubMed Web of Science ®Google Scholar
• Geyikoglu F, Turkez H. Boron compounds reduce vanadium tetraoxide genotoxicity in human lymphocytes. Environ Toxicol Pharmacol. 2008;26(3):342–347. doi:10.1016/j.etap.2008.07.002
   PubMed Web of Science ®Google Scholar
• Ramirez P, Eastmond DA, Laclette JP, Ostrosky-Wegman P. Disruption of microtubule assembly and spindle formation as a mechanism for the induction of aneuploid cells by sodium arsenite and vanadium pentoxide. Mutat Res. 1997;386(3):291–298. doi:10.1016/S1383-5742(97)00018-5
   PubMed Web of Science ®Google Scholar