691
Views
114
CrossRef citations to date
0
Altmetric
Review

Polymeric nanoparticles for targeted treatment in oncology: current insights

, &
Pages 1001-1018 | Published online: 02 Feb 2015

References

  • HaleyBFrenkelENanoparticles for drug delivery in cancer treatmentUrol Oncol2008261576418190833
  • ChoKWangXNieSChenZGShinDMTherapeutic nanoparticles for drug delivery in cancerClin Cancer Res20081451310131618316549
  • SinhaRKimGJNieSShinDMNanotechnology in cancer therapeutics: bioconjugated nanoparticles for drug deliveryMol Cancer Ther2006581909191716928810
  • GuFXKarnikRWangAZTargeted nanoparticles for cancer therapyNano Today2007231421
  • ByrneJDBetancourtTBrannon-PeppasLActive targeting schemes for nanoparticle systems in cancer therapeuticsAdv Drug Deliv Rev200860151615162618840489
  • AlexisFPridgenEMolnarLKFarokhzadOCFactors affecting the clearance and biodistribution of polymeric nanoparticlesMol Pharm20085450551518672949
  • MaedaHThe enhanced permeability and retention (EPR) effect in tumor vasculature: the key role of tumor-selective macromolecular drug targetingAdv Enzyme Regul20014118920711384745
  • CarmelietPJainRKAngiogenesis in cancer and other diseasesNature2000407680124925711001068
  • PelicanoHMartinDSXuRHHuangPGlycolysis inhibition for anticancer treatmentOncogene200625344633464616892078
  • YatvinMBKreutzWHorwitzBAShinitzkyMpH-sensitive liposomes: possible clinical implicationsScience19802104475125312557434025
  • BrewerEColemanJLowmanAEmerging technologies of polymeric nanoparticles in cancer drug deliveryJ Nanomater2011201111021808638
  • ChengFYSuCHWuPCYehCSMultifunctional polymeric nanoparticles for combined chemotherapeutic and near-infrared photothermal cancer therapy in vitro and in vivoChem Commun (Camb)201046183167316920424762
  • DeryuginaEIQuigleyJPMatrix metalloproteinases and tumor metastasisCancer Metastasis Rev200625193416680569
  • MansourAMDrevsJEsserNA new approach for the treatment of malignant melanoma: enhanced antitumor efficacy of an albumin-binding doxorubicin prodrug that is cleaved by matrix metalloproteinase 2Cancer Res200363144062406612874007
  • JamesAMAmbroseEJLowickJHDifferences between the electrical charge carried by normal and homologous tumour cellsNature1956177450857657713321908
  • RanSDownesAThorpePEIncreased exposure of anionic phospholipids on the surface of tumor blood vesselsCancer Res200262216132614012414638
  • KrasniciSWernerAEichhornMEEffect of the surface charge of liposomes on their uptake by angiogenic tumor vesselsInt J Cancer2003105456156712712451
  • AsatiASantraSKaittanisCPerezJMSurface-charge-dependent cell localization and cytotoxicity of cerium oxide nanoparticlesACS Nano2010495321533120690607
  • BoyerCTeoJPhillipsPEffective delivery of siRNA into cancer cells and tumors using well-defined biodegradable cationic star polymersMol Pharm20131062435244423611705
  • BehCWSeowWYWangYEfficient delivery of Bcl-2-targeted siRNA using cationic polymer nanoparticles: downregulating mRNA expression level and sensitizing cancer cells to anticancer drugBiomacromolecules2009101414819072631
  • DanhierFFeronOPréatVTo exploit the tumor microenvironment: passive and active tumor targeting of nanocarriers for anti-cancer drug deliveryJ Control Release2010148213514620797419
  • PeerDKarpJMHongSFarokhzadOCMargalitRLangerRNanocarriers as an emerging platform for cancer therapyNat Nanotechnol200721275176018654426
  • KirpotinDBDrummondDCShaoYAntibody targeting of long-circulating lipidic nanoparticles does not increase tumor localization but does increase internalization in animal modelsCancer Res200666136732674016818648
  • DrummondDCHongKParkJWBenzCCKirpotinDBLiposome targeting to tumors using vitamin and growth factor receptorsVitam Horm20006028533211037627
  • IinumaHMaruyamaKOkinagaKIntracellular targeting therapy of cisplatin-encapsulated transferrin-polyethylene glycol liposome on peritoneal dissemination of gastric cancerInt J Cancer200299113013711948504
  • KobayashiTIshidaTOkadaYIseSHarashimaHKiwadaHEffect of transferrin receptor-targeted liposomal doxorubicin in P-glycoprotein-mediated drug resistant tumor cellsInt J Pharm20073291–29410216997518
  • Lopes de MenezesDEPilarskiLMAllenTMIn vitro and in vivo targeting of immunoliposomal doxorubicin to human B-cell lymphomaCancer Res19985815332033309699662
  • PastorinoFBrignoleCDi PaoloDTargeting liposomal chemotherapy via both tumor cell-specific and tumor vasculature-specific ligands potentiates therapeutic efficacyCancer Res20066620100731008217047071
  • DanielsTRDelgadoTHelgueraGPenichetMLThe transferrin receptor part II: targeted delivery of therapeutic agents into cancer cellsClin Immunol2006121215917616920030
  • LowPSKularatneSAFolate-targeted therapeutic and imaging agents for cancerCurr Opin Chem Biol200913325626219419901
  • SudimackJLeeRJTargeted drug delivery via the folate receptorAdv Drug Deliv Rev200041214716210699311
  • LowPSAntonyACFolate receptor-targeted drugs for cancer and inflammatory diseasesAdv Drug Deliv Rev20045681055105815094205
  • LaskinJJSandlerABEpidermal growth factor receptor: a promising target in solid tumoursCancer Treat Rev200430111714766123
  • AcharyaSDilnawazFSahooSKTargeted epidermal growth factor receptor nanoparticle bioconjugates for breast cancer therapyBiomaterials200930295737575019631377
  • ScaltritiMBaselgaJThe epidermal growth factor receptor pathway: a model for targeted therapyClin Cancer Res200612185268527217000658
  • LurjeGLenzHJEGFR signaling and drug discoveryOncology200977640041020130423
  • MinkoTDrug targeting to the colon with lectins and neoglycoconjugatesAdv Drug Deliv Rev200456449150914969755
  • LammersTHenninkWEStormGTumour-targeted nanomedicines: principles and practiceBr J Cancer200899339239718648371
  • DavisDWHerbstRAbbruzzeseJLAntiangiogenic Cancer TherapyBoca RatonCRC Press2008
  • KumarSLiCTargeting of vasculature in cancer and other angiogenic diseasesTrends Immunol200122312911334027
  • ShadidiMSioudMSelective targeting of cancer cells using synthetic peptidesDrug Resist Updat20036636337114744500
  • CarmelietPVEGF as a key mediator of angiogenesis in cancerOncology200569suppl 341016301830
  • DesgrosellierJSChereshDAIntegrins in cancer: biological implications and therapeutic opportunitiesNat Rev Cancer201010192220029421
  • DienstAGrunowAUnruhMSpecific occlusion of murine and human tumor vasculature by VCAM-1-targeted recombinant fusion proteinsJ Natl Cancer Inst2005971073374715900043
  • OsbornLHessionCTizardRDirect expression cloning of vascular cell adhesion molecule 1, a cytokine induced endothelial protein that binds to lymphocytesCell1989596120312112688898
  • GenísLGálvezBGGonzaloPArroyoAGMT1-MMP: universal or particular player in angiogenesis?Cancer Metastasis Rev2006251778616680574
  • VihinenPAla-ahoRKähäriVMMatrix metalloproteinases as therapeutic targets in cancerCurr Cancer Drug Targets20055320322015892620
  • ChanJMValenciaPMZhangLLangerRFarokhzadOCPolymeric nanoparticles for drug deliveryMethods Mol Biol201062416317520217595
  • ParveenSSahooSKPolymeric nanoparticles for cancer therapyJ Drug Target200816210812318274932
  • LetchfordKBurtHA review of the formation and classification of amphiphilic block copolymer nanoparticulate structures: micelles, nanospheres, nanocapsules and polymersomesEur J Pharm Biopharm200765325926917196803
  • DanhierFLecouturierNVromanBPaclitaxel-loaded PEGylated PLGA-based nanoparticles: in vitro and in vivo evaluationJ Control Release20091331111718950666
  • MorenoDde IlarduyaCTBandrésECharacterization of cisplatin cytotoxicity delivered from PLGA-systemsEur J Pharm Biopharm200868350351217881198
  • MorenoDZalbaSNavarroITros de IlarduyaCGarridoMJPharmacodynamics of cisplatin-loaded PLGA nanoparticles administered to tumor-bearing miceEur J Pharm Biopharm201074226527419883755
  • NairKLJagadeeshanSNairSAKumarGSBiological evaluation of 5-fluorouracil nanoparticles for cancer chemotherapy and its dependence on the carrier, PLGAInt J Nanomed2011616851697
  • BetancourtTBrownBBrannon-PeppasLDoxorubicin-loaded PLGA nanoparticles by nanoprecipitation: preparation, characterization and in vitro evaluationNanomedicine (Lond)20072221923217716122
  • ParkHYangJLeeJHaamSChoiIHYooKHMultifunctional nanoparticles for combined doxorubicin and photothermal treatmentsACS Nano20093102919292619772302
  • AmjadiIRabieeMHosseiniMSMozafariMSynthesis and characterization of doxorubicin-loaded poly(lactide-co-glycolide) nanoparticles as a sustained release anticancer drug delivery systemAppl Biochem Biotechnol201216861434144722976852
  • JainAKSwarnakarNKGoduguCSinghRPJainSThe effect of the oral administration of polymeric nanoparticles on the efficacy and toxicity of tamoxifenBiomaterials201132250351520934747
  • RenoirJMStellaBAmellerTConnaultEOpolonPMarsaudVImproved anti-tumoral capacity of mixed and pure anti-oestrogens in breast cancer cell xenografts after their administration by entrapment in colloidal nanosystemsJ Steroid Biochem Mol Biol20061021–511412717056251
  • PapaALBasuSSenguptaPBanerjeeDSenguptaSHarfoucheRMechanistic studies of gemcitabine-loaded nanoplatforms in resistant pancreatic cancer cellsBMC Cancer20121241922998550
  • GryparisECHatziapostolouMPapadimitriouEAvgoustakisKAnticancer activity of cisplatin-loaded PLGA-mPEG nanoparticles on LNCaP prostate cancer cellsEur J Pharm Biopharm20076711817303395
  • ChengLJinCLvWDingQHanXDeveloping a highly stable PLGA-mPEG nanoparticle loaded with cisplatin for chemotherapy of ovarian cancerPLoS One201169e2543321966528
  • ChengMRLiQWanTGalactosylated chitosan/5-fluorouracil nanoparticles inhibit mouse hepatic cancer growth and its side effectsWorld J Gastroenterol201218426076608723155336
  • ChengMHeBWanT5-Fluorouracil nanoparticles inhibit hepatocellular carcinoma via activation of the p53 pathway in the orthotopic transplant mouse modelPLoS One2012710e4711523077553
  • YadavAKAgarwalARaiGDevelopment and characterization of hyaluronic acid decorated PLGA nanoparticles for delivery of 5-fluorouracilDrug Deliv201017856157220738221
  • LiSWangAJiangWGuanZPharmacokinetic characteristics and anticancer effects of 5-fluorouracil loaded nanoparticlesBMC Cancer2008810318412945
  • ChangLDengLWangWPoly(ethyleneglycol)-b-poly(ε-caprolactone-co-γ-hydroxyl- ε -caprolactone) bearing pendant hydroxyl groups as nanocarriers for doxorubicin deliveryBiomacromolecules201213103301331022931197
  • WohlfartSKhalanskyASGelperinaSEfficient chemotherapy of rat glioblastoma using doxorubicin loaded PLGA nanoparticles with different stabilizersPLoS One201165e1912121573151
  • PérezEBenitoMTeijónCOlmoRTeijónJMBlancoMDTamoxifen-loaded nanoparticles based on a novel mixture of biodegradable polyesters: characterization and in vitro evaluation as sustained release systemsJ Microencapsul201229430932222251238
  • CavalliRBisazzaABussanoRPoly(amidoamine)-cholesterol conjugate nanoparticles obtained by electrospraying as novel tamoxifen delivery systemJ Drug Deliv2011201158760421785731
  • DevalapallyHDuanZSeidenMVAmijiMMModulation of drug resistance in ovarian adenocarcinoma by enhancing intracellular ceramide using tamoxifen-loaded biodegradable polymeric nanoparticlesClin Cancer Res200814103193320318483388
  • JiaLZhengJJJiangSMHuangKHPreparation, physicochemical characterization and cytotoxicity in vitro of gemcitabine-loaded PEG-PDLLA nanovesiclesWorld J Gastroenterol20101681008101320180242
  • YordanovGSkrobanskaREvangelatovAEntrapment of epirubicin in poly(butyl cyanoacrylate) colloidal nanospheres by nanoprecipitation: formulation development and in vitro studies on cancer cell linesColloids Surf B Biointerfaces2012929810522154011
  • ChittasuphoCXieSXBaoumAYakovlevaTSiahaanTJBerklandCJICAM-1 targeting of doxorubicin-loaded PLGA nanoparticles to lung epithelial cellsEur J Pharm Sci200937214115019429421
  • AggarwalSYadavSGuptaSEGFR targeted PLGA nanoparticles using gemcitabine for treatment of pancreatic cancerJ Biomed Nanotechnol20117113713821485840
  • ChengJTeplyBASherifiIFormulation of functionalized PLGA-PEG nanoparticles for in vivo targeted drug deliveryBiomaterials200728586987617055572
  • FarokhzadOCChengJTeplyBATargeted nanoparticle-aptamer bioconjugates for cancer chemotherapy in vivoProc Natl Acad Sci U S A2006103166315632016606824
  • DharSGuFXLangerRFarokhzadOCLippardSJTargeted delivery of cisplatin to prostate cancer cells by aptamer functionalized Pt(IV) prodrug-PLGA-PEG nanoparticlesProc Natl Acad Sci U S A200810545173561736118978032
  • DharSKolishettiNLippardSJFarokhzadOCTargeted delivery of a cisplatin prodrug for safer and more effective prostate cancer therapy in vivoProc Natl Acad Sci U S A201110851850185521233423
  • GrafNBielenbergDRKolishettiNα(V)β(3) integrin-targeted PLGA-PEG nanoparticles for enhanced anti-tumor efficacy of a Pt(IV) prodrugACS Nano2012654530453922584163
  • LiuCWLinWJPolymeric nanoparticles conjugate a novel heptapeptide as an epidermal growth factor receptor-active targeting ligand for doxorubicinInt J Nanomedicine201274749476722973097
  • HouZZhanCJiangQBoth FA- and mPEG-conjugated chitosan nanoparticles for targeted cellular uptake and enhanced tumor tissue distributionNanoscale Res Lett20116156322027239
  • ZhangHZLiXMGaoFPLiuLRZhouZMZhangQQPreparation of folate-modified pullulan acetate nanoparticles for tumor-targeted drug deliveryDrug Deliv2010171485722747075
  • SuttonDNasongklaNBlancoEGaoJFunctionalized micellar systems for cancer targeted drug deliveryPharm Res20072461029104617385025
  • OerlemansCBultWBosMStormGNijsenJFHenninkWEPolymeric micelles in anticancer therapy: targeting, imaging and triggered releasePharm Res201027122569258920725771
  • BishtSFeldmannGSoniSPolymeric nanoparticle-encapsulated curcumin (“nanocurcumin”): a novel strategy for human cancer therapyJ Nanobiotechnology20075317439648
  • JinXMoRDingYZhengWZhangCPaclitaxel-loaded N-octyl-O-sulfate chitosan micelles for superior cancer therapeutic efficacy and overcoming drug resistanceMol Pharm201411114515724261922
  • JeongYIKim doHChungCWDoxorubicin-incorporated polymeric micelles composed of dextran-b-poly(dl-lactide-co-glycolide) copolymerInt J Nanomedicine201161415142721796244
  • NishiyamaNOkazakiSCabralHNovel cisplatin-incorporated polymeric micelles can eradicate solid tumors in miceCancer Res200363248977898314695216
  • VegaJKeSFanZWallaceSCharsangavejCLiCTargeting doxorubicin to epidermal growth factor receptors by site-specific conjugation of C225 to poly(l-glutamic acid) through a polyethylene glycol spacerPharm Res200320582683212751641
  • TorchilinVPLukyanovANGaoZPapahadjopoulos-SternbergBImmunomicelles: targeted pharmaceutical carriers for poorly soluble drugsProc Natl Acad Sci U S A2003100106039604412716967
  • NasongklaNShuaiXAiHcRGD-functionalized polymer micelles for targeted doxorubicin deliveryAngew Chem Int Ed Engl200443466323632715558662
  • YooHSParkTGFolate receptor targeted biodegradable polymeric doxorubicin micellesJ Control Release200496227328315081218
  • ParkEKLeeSBLeeYMPreparation and characterization of methoxy poly(ethylene glycol)/poly(epsilon-caprolactone) amphiphilic block copolymeric nanospheres for tumor-specific folate-mediated targeting of anticancer drugsBiomaterials20052691053106115369694
  • HanXLiuJLiuM9-NC-loaded folate-conjugated polymer micelles as tumor targeted drug delivery system: preparation and evaluation in vitroInt J Pharm20093721–212513119166923
  • WangYYuLHanLShaXFangXDifunctional pluronic copolymer micelles for paclitaxel delivery: synergistic effect of folate-mediated targeting and pluronic-mediated overcoming multidrug resistance in tumor cell linesInt J Pharm20073371–2637317289311
  • JeongYISeoSJParkIKCellular recognition of paclitaxel-loaded polymeric nanoparticles composed of poly(gamma-benzyl l-glutamate) and poly(ethylene glycol) diblock copolymer endcapped with galactose moietyInt J Pharm20052961–215116115885467
  • FarokhzadOCJonSKhademhosseiniATranTNLavanDALangerRNanoparticle-aptamer bioconjugates: a new approach for targeting prostate cancer cellsCancer Res200464217668767215520166
  • BharaliDJKhalilMGurbuzMSimoneTMMousaSANanoparticles and cancer therapy: a concise review with emphasis on dendrimersInt J Nanomedicine200941719421366
  • MorganMTCarnahanMAImmoosCEDendritic molecular capsules for hydrophobic compoundsJ Am Chem Soc200312550154851548914664594
  • MorganMTCarnahanMAFinkelsteinSDendritic supramolecular assemblies for drug deliveryChem Commun (Camb)2005344309431116113731
  • MorganMTNakanishiYKrollDJDendrimer-encapsulated camptothecins: increased solubility, cellular uptake, and cellular retention affords enhanced anticancer activity in vitroCancer Res20066624119131192117178889
  • WangFBronichTKKabanovAVRauhRDRooversJSynthesis and evaluation of a star amphiphilic block copolymer from poly(epsilon-caprolactone) and poly(ethylene glycol) as a potential drug delivery carrierBioconjug Chem200516239740515769095
  • NeermanMFChenHTParrishARSimanekEEReduction of drug toxicity using dendrimers based on melamineMol Pharm20041539039316026011
  • Padilla De JesúsOLIhreHRGagneLFréchetJMSzokaFCJrPolyester dendritic systems for drug delivery applications: in vitro and in vivo evaluationBioconjug Chem200213345346112009933
  • MalikNEvagorouEGDuncanRDendrimer-platinate: a novel approach to cancer chemotherapyAnticancer Drugs199910876777610573209
  • PatriAKKukowska-LatalloJFBakerJRJrTargeted drug delivery with dendrimers: comparison of the release kinetics of covalently conjugated drug and non-covalent drug inclusion complexAdv Drug Deliv Rev200557152203221416290254
  • MajorosIJMycAThomasTMehtaCBBakerJRJrPAMAM dendrimer-based multifunctional conjugate for cancer therapy: synthesis, characterization, and functionalityBiomacromolecules20067257257916471932
  • LevineDHGhoroghchianPPFreudenbergJPolymersomes: a new multi-functional tool for cancer diagnosis and therapyMethods2008461253218572025
  • XuJZhaoQJinYQiuLHigh loading of hydrophilic/hydrophobic doxorubicin into polyphosphazene polymersome for breast cancer therapyNanomedicine201410234935823969103
  • LiSByrneBWelshJPalmerAFSelf-assembled poly(butadiene)-b-poly(ethyleneoxide) polymersomes as paclitaxel carriersBiotechnol Prog200723127828517269699
  • AhmedFPakunluRIBrannanABatesFMinkoTDischerDEBiodegradable polymersomes loaded with both paclitaxel and doxorubicin permeate and shrink tumors, inducing apoptosis in proportion to accumulated drugJ Control Release2006116215015816942814
  • AhmedFPakunluRISrinivasGShrinkage of a rapidly growing tumor by drug-loaded polymersomes: pH-triggered release through copolymer degradationMol Pharm20063334035016749866
  • PetersenMAHillmyerMAKokkoliEBioresorbable polymersomes for targeted delivery of cisplatinBioconjug Chem201324453354323521104
  • UpadhyayKKMishraAKChuttaniKThe in vivo behavior and antitumor activity of doxorubicin-loaded poly(γ-benzyl l-glutamate)-block-hyaluronan polymersomes in Ehrlich ascites tumor-bearing BalB/c miceNanomedicine201281718021703363
  • DemirgözDPangburnTODavisKPLeeSBatesFSKokkoliEPR_b-targeted delivery of tumor necrosis factor-α by polymersomes for the treatment of prostate cancerSoft Matter2009520112019
  • ChristieRJNishiyamaNKataokaKDelivering the code: polyplex carriers for deoxyribonucleic acid and ribonucleic acid interference therapiesEndocrinology2010151246647320032060
  • ZhaoGXTanakaHKimCWHistidinylated poly-l-lysine-based vectors for cancer-specific gene expression via enhancing the endosomal escapeJ Biomater Sci Polym Ed201425551953424460548
  • ChenLWangHZhangYWangYHuQJiJBioinspired phosphorylcholine-modified polyplexes as an effective strategy for selective uptake and transfection of cancer cellsColloids Surf B Biointerfaces201311129730523838196
  • NieYSchaffertDRödlWOgrisMWagnerEGüntherMDual-targeted polyplexes: one step towards a synthetic virus for cancer gene therapyJ Control Release2011152112713421392549
  • van SteenisJHvan MaarseveenEMVerbaanFJPreparation and characterization of folate-targeted PEG-coated pDMAEMA-based polyplexesJ Control Release2003871–316717612618033
  • WangJLTangGPShenJA gene nanocomplex conjugated with monoclonal antibodies for targeted therapy of hepatocellular carcinomaBiomaterials201233184597460722469295
  • HanLTangCYinCEffect of binding affinity for siRNA on the in vivo antitumor efficacy of polyplexesBiomaterials201334215317532723591392
  • DohmenCEdingerDFröhlichTNanosized multifunctional polyplexes for receptor-mediated siRNA deliveryACS Nano2012665198520822646997
  • KimSHLeeSHTianHChenXParkTGProstate cancer cell-specific VEGF siRNA delivery system using cell targeting peptide conjugated polyplexesJ Drug Target200917431131719242850
  • ZhangLChanJMGuFXSelf-assembled lipid-polymer hybrid nanoparticles: a robust drug delivery platformACS Nano2008281696170219206374
  • WongHLRauthAMBendayanRA new polymer-lipid hybrid nanoparticle system increases cytotoxicity of doxorubicin against multidrug-resistant human breast cancer cellsPharm Res20062371574158516786442
  • WongHLBendayanRRauthAMXueHYBabakhanianKWuXYA mechanistic study of enhanced doxorubicin uptake and retention in multidrug resistant breast cancer cells using a polymer-lipid hybrid nanoparticle systemJ Pharmacol Exp Ther200631731372138116547167
  • WongHLRauthAMBendayanRWuXYIn vivo evaluation of a new polymer-lipid hybrid nanoparticle (PLN) formulation of doxoru-bicin in a murine solid tumor modelEur J Pharm Biopharm200765330030817156986
  • HuCMKaushalSTran CaoHSHalf-antibody functionalized lipid-polymer hybrid nanoparticles for targeted drug delivery to carcinoembryonic antigen presenting pancreatic cancer cellsMol Pharm20107391492020394436
  • LiuYLiKPanJLiuBFengSSFolic acid conjugated nanoparticles of mixed lipid monolayer shell and biodegradable polymer core for targeted delivery of docetaxelBiomaterials201031233033819783040
  • ChavanpatilMDKhdairAGerardBSurfactant-polymer nanoparticles overcome P-glycoprotein-mediated drug effluxMol Pharm20074573073817705442
  • BellocqNCPunSHJensenGSDavisMETransferrin-containing, cyclodextrin polymer-based particles for tumor-targeted gene deliveryBioconjug Chem20031461122113214624625
  • DuncanRPolymer conjugates as anticancer nanomedicinesNat Rev Cancer20066968870116900224
  • ZhangLGuFXChanJMWangAZLangerRSFarokhzadOCNanoparticles in medicine: therapeutic applications and developmentsClin Pharmacol Ther200883576176917957183
  • ThakorASGambhirSSNanooncology: the future of cancer diagnosis and therapyCA Cancer J Clin201363639541824114523
  • HeidelJDDavisMEClinical developments in nanotechnology for cancer therapyPharm Res201128218719920549313
  • WangAZLangerRFarokhzadOCNanoparticle delivery of cancer drugsAnnu Rev Med20126318519821888516
  • SannaVPalaNSechiMTargeted therapy using nanotechnology: focus on cancerInt J Nanomedicine2014946748324531078
  • DavisMEThe first targeted delivery of siRNA in humans via a self-assembling, cyclodextrin polymer-based nanoparticle: from concept to clinicMol Pharm20096365966819267452
  • HrkachJVon HoffDMukkaram AliMPreclinical development and clinical translation of a PSMA-targeted docetaxel nanoparticle with a differentiated pharmacological profileSci Transl Med20124128128ra39