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Original Research

Simvastatin enhances Rho/actin/cell rigidity pathway contributing to mesenchymal stem cells’ osteogenic differentiation

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Pages 5881-5894 | Published online: 21 Sep 2015

References

  • YelinEHFeltsWRA summary of the impact of musculoskeletal conditions in the United StatesArthritis Rheum19903357507552346529
  • CorsiniABellostaSBaettaRFumagalliRPaolettiRBerniniFNew insights into the pharmacodynamic and pharmacokinetic properties of statinsPharmacol Ther199984341342810665838
  • SchachterMChemical, pharmacokinetic and pharmacodynamic properties of statins: an updateFundam Clin Pharmacol200519111712515660968
  • MaedaTMatsunumaAKawaneTHoriuchiNSimvastatin promotes osteoblast differentiation and mineralization in MC3T3-E1 cellsBiochem Biophys Res Commun2001280387487711162604
  • SongCGuoZMaQSimvastatin induces osteoblastic differentiation and inhibits adipocytic differentiation in mouse bone marrow stromal cellsBiochem Biophys Res Commun2003308345846212914771
  • HwangRLeeEJKimMHCalcyclin, a Ca2+ ion-binding protein, contributes to the anabolic effects of simvastatin on boneJ Biol Chem200427920212392124714973129
  • BaekKHLeeWYOhKWThe effect of simvastatin on the proliferation and differentiation of human bone marrow stromal cellsJ Korean Med Sci200520343844415953866
  • SolomonDHFinkelsteinJSWangPSAvornJStatin lipid-lowering drugs and bone mineral densityPharmacoepidemiol Drug Saf200514421922615386702
  • MaritzFJConradieMMHulleyPAGopalRHoughSEffect of statins on bone mineral density and bone histomorphometry in rodentsArterioscler Thromb Vasc Biol200121101636164111597938
  • HoMLChenYHLiaoHJSimvastatin increases osteoblasts and osteogenic proteins in ovariectomized ratsEur J Clin Invest200939429630319292885
  • MundyGGarrettRHarrisSStimulation of bone formation in vitro and in rodents by statinsScience199928654461946194910583956
  • SkoglundBForslundCAspenbergPSimvastatin improves fracture healing in miceJ Bone Miner Res200217112004200812412808
  • TaiICFuYCWangCKChangJKHoMLLocal delivery of controlled-release simvastatin/PLGA/HAp microspheres enhances bone repairInt J Nanomedicine201383895390524143094
  • SteinDLeeYSchmidMJLocal simvastatin effects on mandibular bone growth and inflammationJ Periodontol200576111861187016274305
  • ThylinMRMcConnellJCSchmidMJEffects of simvastatin gels on murine calvarial boneJ Periodontol200273101141114812416771
  • NyanMSatoDOdaMBone formation with the combination of simvastatin and calcium sulfate in critical-sized rat calvarial defectJ Pharmacol Sci2007104438438617721043
  • DischerDEMooneyDJZandstraPWGrowth factors, matrices, and forces combine and control stem cellsScience200932459351673167719556500
  • McBeathRPironeDMNelsonCMBhadrirajuKChenCSCell shape, cytoskeletal tension, and RhoA regulate stem cell lineage commitmentDev Cell20046448349515068789
  • SunYChenCSFuJForcing stem cells to behave: a biophysical perspective of the cellular microenvironmentAnnu Rev Biophys20124151954222404680
  • ArnsdorfEJTummalaPKwonRYJacobsCRMechanically induced osteogenic differentiation – the role of RhoA, ROCKII and cytoskeletal dynamicsJ Cell Sci2009122pt 454655319174467
  • WoodsAWangGBeierFRhoA/ROCK signaling regulates Sox9 expression and actin organization during chondrogenesisJ Biol Chem200528012116261163415665004
  • WoodsABeierFRhoA/ROCK signaling regulates chondrogenesis in a context-dependent mannerJ Biol Chem200628119131341314016565087
  • TanSFangJYYangZNimniMEHanBThe synergetic effect of hydrogel stiffness and growth factor on osteogenic differentiationBiomaterials201435205294530624703716
  • ZouaniOFKaliskyJIbarboureEDurrieuMCEffect of BMP-2 from matrices of different stiffnesses for the modulation of stem cell fateBiomaterials20133492157216623290467
  • TakeuchiYSuzawaMKikuchiTNishidaEFujitaTMatsumotoTDifferentiation and transforming growth factor-beta receptor down-regulation by collagen-alpha2beta1 integrin interaction is mediated by focal adhesion kinase and its downstream signals in murine osteoblastic cellsJ Biol Chem19972724629309293169361011
  • TomaCDAshkarSGrayMLSchafferJLGerstenfeldLCSignal transduction of mechanical stimuli is dependent on microfilament integrity: identification of osteopontin as a mechanically induced gene in osteoblastsJ Bone Miner Res19971210162616369333123
  • FengTSzaboEDziakEOpasMCytoskeletal disassembly and cell rounding promotes adipogenesis from ES cellsStem Cell Rev201061748520148318
  • AdamsonPMarshallCJHallATilbrookPAPost-translational modifications of p21rho proteinsJ Biol Chem19922672820033200381400319
  • WongWWDimitroulakosJMindenMDPennLZHMG-CoA reductase inhibitors and the malignant cell: the statin family of drugs as triggers of tumor-specific apoptosisLeukemia200216450851911960327
  • LaufsULiaoJKTargeting Rho in cardiovascular diseaseCirc Res200087752652811009552
  • WooJTNakagawaHKrecicAMInhibitory effects of mevastatin and a geranylgeranyl transferase I inhibitor (GGTI-2166) on mononuclear osteoclast formation induced by receptor activator of NF kappa B ligand (RANKL) or tumor necrosis factor-alpha (TNF-alpha)Biochem Pharmacol2005691879515588717
  • TurnerSJZhuangSZhangTBossGRPilzRBEffects of lovastatin on Rho isoform expression, activity, and association with guanine nucleotide dissociation inhibitorsBiochem Pharmacol200875240541317920041
  • PorterKETurnerNAO’ReganDJBalmforthAJBallSGSimvastatin reduces human atrial myofibroblast proliferation independently of cholesterol lowering via inhibition of RhoACardiovasc Res200461474575514985071
  • VecchioneCBrandesRPWithdrawal of 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors elicits oxidative stress and induces endothelial dysfunction in miceCirc Res200291217317912142351
  • WangYHChiuWTWangYKDeregulation of AP-1 proteins in collagen gel-induced epithelial cell apoptosis mediated by low substratum rigidityJ Biol Chem2007282175276317085440
  • LiaoJKLaufsUPleiotropic effects of statinsAnnu Rev Pharmacol Toxicol2005458911815822172
  • GoldsteinJLBrownMSRegulation of the mevalonate pathwayNature199034362574254301967820
  • XiaZTanMMWongWWDimitroulakosJMindenMDPennLZBlocking protein geranylgeranylation is essential for lovastatin-induced apoptosis of human acute myeloid leukemia cellsLeukemia20011591398140711516100
  • ZhangFLCaseyPJProtein prenylation: molecular mechanisms and functional consequencesAnnu Rev Biochem1996652412698811180
  • CordleAKoenigsknecht-TalbooJWilkinsonBLimpertALandrethGMechanisms of statin-mediated inhibition of small G-protein functionJ Biol Chem200528040342023420916085653
  • BoureuxAVignalEFaureSFortPEvolution of the Rho family of ras-like GTPases in eukaryotesMol Biol Evol200724120321617035353
  • BusteloXRSauzeauVBerenjenoIMGTP-binding proteins of the Rho/Rac family: regulation, effectors and functions in vivoBioessays200729435637017373658
  • KanazawaIYamaguchiTYanoSYamauchiMSugimotoTActivation of AMP kinase and inhibition of Rho kinase induce the mineralization of osteoblastic MC3T3-E1 cells through endothelial NOS and BMP-2 expressionAm J Physiol Endocrinol Metab20092961E139E14619001547
  • HarmeyDStenbeckGNobesCDLaxAJGrigoriadisAERegulation of osteoblast differentiation by Pasteurella multocida toxin (PMT): a role for Rho GTPase in bone formationJ Bone Miner Res200419466167015005854
  • YoshikawaHYoshiokaKNakaseTItohKStimulation of ectopic bone formation in response to BMP-2 by Rho kinase inhibitor: a pilot studyClin Orthop Relat Res2009467123087309519609629
  • WangGWoodsASabariSPagnottaLStantonLABeierFRhoA/ROCK signaling suppresses hypertrophic chondrocyte differentiationJ Biol Chem200427913132051321414726536
  • HamamuraKSwarnkarGTanjungNRhoA-mediated signaling in mechanotransduction of osteoblastsConnect Tissue Res201253539840622420753
  • KhatiwalaCBKimPDPeytonSRPutnamAJECM compliance regulates osteogenesis by influencing MAPK signaling downstream of RhoA and ROCKJ Bone Miner Res200924588689819113908
  • McMurrayRJGadegaardNTsimbouriPMNanoscale surfaces for the long-term maintenance of mesenchymal stem cell phenotype and multipotencyNat Mater201110863764421765399
  • WangYKYuXCohenDMBone morphogenetic protein-2-induced signaling and osteogenesis is regulated by cell shape, RhoA/ROCK, and cytoskeletal tensionStem Cells Dev20122171176118621967638
  • Sarasa-RenedoATunc-CivelekVChiquetMRole of RhoA/ROCK-dependent actin contractility in the induction of tenascin-C by cyclic tensile strainExp Cell Res200631281361137016448650
  • EnglerAJSenSSweeneyHLDischerDEMatrix elasticity directs stem cell lineage specificationCell2006126467768916923388
  • TrappmannBGautrotJEConnellyJTExtracellular-matrix tethering regulates stem-cell fateNat Mater201211764264922635042
  • FuJWangYKYangMTMechanical regulation of cell function with geometrically modulated elastomeric substratesNat Methods20107973373620676108
  • ParkJSChuJSTsouADThe effect of matrix stiffness on the differentiation of mesenchymal stem cells in response to TGF-betaBiomaterials201132163921393021397942
  • ShihYRTsengKFLaiHYLinCHLeeOKMatrix stiffness regulation of integrin-mediated mechanotransduction during osteogenic differentiation of human mesenchymal stem cellsJ Bone Miner Res201126473073820939067
  • ArnsdorfEJTummalaPJacobsCRNon-canonical Wnt signaling and N-cadherin related beta-catenin signaling play a role in mechanically induced osteogenic cell fatePLoS One200944e538819401766