Molecular targets in arthritis and recent trends in nanotherapy

References

• LawrenceRCHelmickCGArnettFCEstimates of the prevalence of arthritis and selected musculoskeletal disorders in the United StatesArthritis Rheumatol199841778799
   Google Scholar
• CrossMSmithEHoyDThe global burden of rheumatoid arthritis: estimates from the Global Burden of Disease 2010 studyAnn Rheum Dis20147371316132224550173
   PubMed Web of Science ®Google Scholar
• van der HeijdeDTanakaYFleischmannRTofacitinib (CP-690,550) in patients with rheumatoid arthritis receiving methotrexate: twelve-month data from a twenty-four-month phase III randomized radiographic studyArthritis Rheum201365355957023348607
   PubMed Web of Science ®Google Scholar
• FleischmannRKremerJCushJPlacebo-controlled trial of tofacitinib monotherapy in rheumatoid arthritisNew Engl J Med2012367649550722873530
   PubMed Web of Science ®Google Scholar
• DowtyMEJessonMIGhoshSPreclinical to clinical translation of tofacitinib, a Janus kinase inhibitor, in rheumatoid arthritisJ Pharmacol Exp Ther2014348116517324218541
   PubMed Web of Science ®Google Scholar
• RieseRJKrishnaswamiSKremerJInhibition of JAK kinases in patients with rheumatoid arthritis: scientific rationale and clinical outcomesBest Pract Res Clin Rheumatol201024451352620732649
   PubMed Web of Science ®Google Scholar
• RajagopalanPRZhangZMcCourtLDwyerMBenkovicSJHammesGGInteraction of dihydrofolate reductase with methotrexate: ensemble and single-molecule kineticsProc Natl Acad Sci20029921134811348612359872
   PubMed Web of Science ®Google Scholar
• WesselsJHuizingaTGuchelaarH-JRecent insights in the pharmacological actions of methotrexate in the treatment of rheumatoid arthritisRheumatology200847324925518045808
   PubMed Web of Science ®Google Scholar
• BrodyMBöhmIBauerRMechanism of action of methotrexate: experimental evidence that methotrexate blocks the binding of interleukin 1β to the interleukin 1 receptor on target cellsClin Chem Lab Med19933110667674
   Google Scholar
• WeismanMHFurstDEParkGSRisk genotypes in folate-dependent enzymes and their association with methotrexate-related side effects in rheumatoid arthritisArthritis Rheum200654260761216447238
   PubMed Web of Science ®Google Scholar
• ToHYoshimatsuHTomonariMMethotrexate chronotherapy is effective against rheumatoid arthritisChronobiol Int201128326727421452922
   PubMed Web of Science ®Google Scholar
• CronsteinBNNaimeDOstadEThe antiinflammatory mechanism of methotrexate. Increased adenosine release at inflamed sites diminishes leukocyte accumulation in an in vivo model of inflammationJ Clin Invest199392626758254024
   PubMed Web of Science ®Google Scholar
• TekeogluIDoganAEdizLBudancamanakMDemirelAEffects of thymoquinone (volatile oil of black cumin) on rheumatoid arthritis in rat modelsPhytother Res200721989589717562570
   PubMed Web of Science ®Google Scholar
• EndaleMLeeWMKwakY-STorilin ameliorates type II collagen-induced arthritis in mouse model of rheumatoid arthritisInt Immunopharmacol201316223224223623942
   PubMed Web of Science ®Google Scholar
• BarichLLSchwarzJBarichDOral methotrexate in mice: a co-carcinogenic as well as an anti-tumor agent to methylcholanthrene-induced cutaneous tumorsJ Invest Dermatol1962396615620
   Web of Science ®Google Scholar
• DougadosMEmeryPLemmelEZerbiniCBrinSvan RielPWhen a DMARD fails, should patients switch to sulfasalazine or add sulfasalazine to continuing leflunomide?Ann Rheum Dis2005641445115271770
   PubMed Web of Science ®Google Scholar
• TeschnerSBurstVLeflunomide: a drug with a potential beyond rheumatologyImmunotherapy20102563765020874647
   PubMed Web of Science ®Google Scholar
• KaliaSDutzJPNew concepts in antimalarial use and mode of action in dermatologyDermatol Ther200720416017417970883
   PubMed Web of Science ®Google Scholar
• FoxRIMechanism of action of hydroxychloroquine as an antirheumatic drugSemin Arthritis Rheum1993232 Suppl 182918278823
   PubMed Web of Science ®Google Scholar
• YangLZhangJWangGThe effect of sodium hyaluronate treating knee osteoarthritis on synovial fluid interleukin-1β and clinical treatment mechanismPak J Pharm Sci201528140741025631505
   PubMed Web of Science ®Google Scholar
• BaiciALangAHörlerDKisslingRMerlinCCathepsin B in osteoarthritis: cytochemical and histochemical analysis of human femoral head cartilageAnn Rheum Dis19955442892977763107
   PubMed Web of Science ®Google Scholar
• BurragePSMixKSBrinckerhoffCEMatrix metalloproteinases: role in arthritisFront Biosci200611152954316146751
   PubMed Web of Science ®Google Scholar
• FengZLianKIdentification of genes and pathways associated with osteoarthritis by bioinformatics analysesEur Rev Med Pharmacol Sci201519573674425807424
   PubMed Web of Science ®Google Scholar
• OlivieroFScanuARamondaRIL-1β and IL-8 are scavenged by the hexadecylamide derivative of hyaluronic acid: a new mechanismJ Biomed Mater Res A201510.1002/jbm.a.35422
   Web of Science ®Google Scholar
• KikuchiJHashizumeMKanekoYYoshimotoKNishinaNTakeuchiTPeripheral blood CD4(+)CD25(+)CD127(low) regulatory T cells are significantly increased by tocilizumab treatment in patients with rheumatoid arthritis: increase in regulatory T cells correlates with clinical responseArthritis Res Ther20151711010.1186/s13075-015-0526-425604867
   PubMedGoogle Scholar
• HirotaKYoshitomiHHashimotoMPreferential recruitment of CCR6-expressing Th17 cells to inflamed joints via CCL20 in rheumatoid arthritis and its animal modelJ Exp Med2007204122803281218025126
   PubMed Web of Science ®Google Scholar
• PaulissenSMvan HamburgJPDankersWLubbertsEThe role and modulation of CCR6+ Th17 cell populations in rheumatoid arthritisCytokine2015S1043S466615576525828206
   PubMedGoogle Scholar
• ChenLLiDZhongJIL-17RA aptamer-mediated repression of IL-6 inhibits synovium inflammation in a murine model of osteoarthritisOsteoarthritis Cartilage201119671171821310253
   PubMed Web of Science ®Google Scholar
• ZiolkowskaMKocALuszczykiewiczGHigh levels of IL-17 in rheumatoid arthritis patients: IL-15 triggers in vitro IL-17 production via cyclosporin A-sensitive mechanismJ Immunol200016452832283810679127
   PubMed Web of Science ®Google Scholar
• FischerJAHueberAJWilsonSCombined inhibition of tumor necrosis factor α and interleukin-17 as a therapeutic opportunity in rheumatoid arthritis: development and characterization of a novel bispecific antibodyArthritis Rheumatol2015671516225303306
   PubMed Web of Science ®Google Scholar
• ThorntonSRaghuHJoneAMice deficient in urokinase-type plasminogen activator (uPA) or uPA receptor develop significantly diminished collagen-induced arthritisBlood201412421580580
   Web of Science ®Google Scholar
• RhodesADeakinASpaullJThe generation and characterization of antagonist RNA aptamers to human oncostatin MJ Biol Chem200027537285552856110882721
   PubMed Web of Science ®Google Scholar
• RousseauJ-CDelmasPDBiological markers in osteoarthritisNat Clin Pract Rheumatol20073634635617538566
   PubMedGoogle Scholar
• MizunoMFujisawaRKubokiYType I collagen-induced osteoblastic differentiation of bone-marrow cells mediated by collagen-α2β1 integrin interactionJ Cell Physiol2000184220721310867645
   PubMed Web of Science ®Google Scholar
• DodgeGRPooleARImmunohistochemical detection and immunochemical analysis of type II collagen degradation in human normal, rheumatoid, and osteoarthritic articular cartilages and in explants of bovine articular cartilage cultured with interleukin 1J Clin Invest19898326472783591
   PubMed Web of Science ®Google Scholar
• BillinghurstRCDahlbergLIonescuMEnhanced cleavage of type II collagen by collagenases in osteoarthritic articular cartilageJ Clin Invest199799715349119997
   PubMed Web of Science ®Google Scholar
• WangLEffects of RNAi-mediated inhibition of aggrecanase-1 and aggrecanase-2 on rat costochondral chondrocytes in vitro1Acta Pharmacol Sin200829101215122618817627
   PubMed Web of Science ®Google Scholar
• WangZHYangZQHeXJKamalBEXingZLentivirus-mediated knockdown of aggrecanase-1 and-2 promotes chondrocyte-engineered cartilage formation in vitroBiotechnol Bioeng2010107473073620632367
   PubMed Web of Science ®Google Scholar
• PlaceLWSekyiMKipperMJAggrecan-mimetic, glycosaminoglycan-containing nanoparticles for growth factor stabilization and deliveryBiomacromolecules201415268068924459987
   PubMed Web of Science ®Google Scholar
• TakayanagiHOdaHYamamotoSA new mechanism of bone destruction in rheumatoid arthritis: synovial fibroblasts induce osteoclastogenesisBiochem Biophys Res Commun199724022792869388467
   PubMed Web of Science ®Google Scholar
• GoughASambrookPDevlinJOsteoclastic activation is the principal mechanism leading to secondary osteoporosis in rheumatoid arthritisJ Rheumatol1998257128212899676757
   PubMed Web of Science ®Google Scholar
• DequekerJMaenautKVerwilghenJWesthovensROsteoporosis in rheumatoid arthritisClin Exp Rheumatol199413S21S268846540
   PubMedGoogle Scholar
• RobinsonDTashjian JrALevineLProstaglandin-stimulated bone resorption by rheumatoid synovia. A possible mechanism for bone destruction in rheumatoid arthritisJ Clin Invest197556511811184744
   PubMed Web of Science ®Google Scholar
• MonteKWilsonCShihFFIncreased number and function of FoxP3 regulatory T cells during experimental arthritisArthritis Rheum200858123730374119035490
   PubMedGoogle Scholar
• KomatsuNOkamotoKSawaSPathogenic conversion of Foxp3+ T cells into TH17 cells in autoimmune arthritisNat Med2014201626824362934
   PubMed Web of Science ®Google Scholar
• BanhamAHPulfordKTherapeutic targeting of FOXP3-positive regulatory T cells using a FOXP3 peptide vaccine WO2008081581Expert Opin Ther Pat20091971023102819456276
   PubMed Web of Science ®Google Scholar
• Gil-GuerreroLDotorJHuibregtseILIn vitro and in vivo down-regulation of regulatory T cell activity with a peptide inhibitor of TGF-β1J Immunol2008181112613518566377
   PubMed Web of Science ®Google Scholar
• CasaresNRudillaFArribillagaLA peptide inhibitor of FOXP3 impairs regulatory T cell activity and improves vaccine efficacy in miceJ Immunol201018595150515920870946
   PubMed Web of Science ®Google Scholar
• BeierUHWangLBhattiTRSirtuin-1 targeting promotes Foxp3+ T-regulatory cell function and prolongs allograft survivalMol Cell Biol20113151022102921199917
   PubMed Web of Science ®Google Scholar
• CastorCWThe microscopic structure of normal human synovial tissueArthritis Rheum19603214015113808324
   PubMedGoogle Scholar
• KienerHPBaghestanianMDominkusMExpression of the C5a receptor (CD88) on synovial mast cells in patients with rheumatoid arthritisArthritis Rheum19984122332459485081
   PubMedGoogle Scholar
• HueberAJAsquithDLMillerAMCutting edge: mast cells express IL-17A in rheumatoid arthritis synoviumJ Immunol201018473336334020200272
   PubMed Web of Science ®Google Scholar
• XuGNieHLiNRole of osteopontin in amplification and perpetuation of rheumatoid synovitisJ Clin Invest200511541060106715761492
   PubMed Web of Science ®Google Scholar
• YamamotoNSakaiFKonSEssential role of the cryptic epitope SLAYGLR within osteopontin in a murine model of rheumatoid arthritisJ Clin Invest2003112218118812865407
   PubMed Web of Science ®Google Scholar
• GravalleseEMOsteopontin: a bridge between bone and the immune systemJ Clin Invest2003112214714912865402
   PubMed Web of Science ®Google Scholar
• ChenJSinghKMukherjeeBBSodekJDevelopmental expression of osteopontin (OPN) mRNA in rat tissues: evidence for a role for OPN in bone formation and resorptionMatrix19931321131238492741
   PubMedGoogle Scholar
• LiawLBirkDEBallasCBWhitsittJSDavidsonJMHoganBAltered wound healing in mice lacking a functional osteopontin gene (spp1)J Clin Invest1998101714689525990
   PubMed Web of Science ®Google Scholar
• O’BrienERGarvinMRStewartDKOsteopontin is synthesized by macrophage, smooth muscle, and endothelial cells in primary and restenotic human coronary atherosclerotic plaquesArterioscl Thromb19941410164816567918316
   PubMedGoogle Scholar
• WessonJAJohnsonRJMazzaliMOsteopontin is a critical inhibitor of calcium oxalate crystal formation and retention in renal tubulesJ Am Soc Nephrol200314113914712506146
   PubMed Web of Science ®Google Scholar
• SennelsHSørensenSØstergaardMCirculating levels of osteopontin, osteoprotegerin, total soluble receptor activator of nuclear factor-kappa B ligand, and high-sensitivity C-reactive protein in patients with active rheumatoid arthritis randomized to etanercept alone or in combination with methotrexateScand J Rheumatol200837424124718612923
   PubMed Web of Science ®Google Scholar
• ChenGZhangXLiRRole of osteopontin in synovial Th17 differentiation in rheumatoid arthritisArthritis Rheum201062102900290820533542
   PubMed Web of Science ®Google Scholar
• KatagiriYUSleemanJFujiiHCD44 variants but not CD44s cooperate with β1-containing integrins to permit cells to bind to osteopontin independently of arginine-glycine-aspartic acid, thereby stimulating cell motility and chemotaxisCancer Res19995912192269892210
   PubMed Web of Science ®Google Scholar
• PetrowPKHummelKMSchedelJExpression of osteopontin messenger RNA and protein in rheumatoid arthritis: effects of osteopontin on the release of collagenase 1 from articular chondrocytes and synovial fibroblastsArthritis Rheum20004371597160510902765
   PubMedGoogle Scholar
• YumotoKIshijimaMRittlingSROsteopontin deficiency protects joints against destruction in anti-type II collagen antibody-induced arthritis in miceProc Natl Acad Sci U S A20029974556456111930008
   PubMed Web of Science ®Google Scholar
• ChengCGaoSLeiGAssociation of osteopontin with osteoarthritisRheumatol Int201434121627163124807695
   PubMed Web of Science ®Google Scholar
• XuMZhangLZhaoLPhosphorylation of osteopontin in osteoarthritis degenerative cartilage and its effect on matrix metalloprotease 13Rheumatol Int20133351313131923132541
   PubMed Web of Science ®Google Scholar
• IwadateHKobayashiHKannoTPlasma osteopontin is correlated with bone resorption markers in rheumatoid arthritis patientsInt J Rheum Dis2014171505624472267
   PubMed Web of Science ®Google Scholar
• GaoSLiKZengKTuMXuMLeiGElevated osteopontin level of synovial fluid and articular cartilage is associated with disease severity in knee osteoarthritis patientsOsteoarthritis Cartilage2010181828719747583
   PubMed Web of Science ®Google Scholar
• WiesenthalAHunterLWangSWickliffeJWilkersonMNanoparticles: small and mightyInt J Dermatol201150324725421342155
   PubMed Web of Science ®Google Scholar
• GallelliLGalassoOFalconeDThe effects of nonsteroidal anti-inflammatory drugs on clinical outcomes, synovial fluid cytokine concentration and signal transduction pathways in knee osteoarthritis. A randomized open label trialOsteoarthritis Cartilage20132191400140823973155
   PubMed Web of Science ®Google Scholar
• RadadKAl-ShraimMMoldzioRRauschW-DRecent advances in benefits and hazards of engineered nanoparticlesEnviron Toxicol Pharmacol201234366167222964156
   PubMed Web of Science ®Google Scholar
• CooperERNanoparticles: a personal experience for formulating poorly water soluble drugsJ Control Release2010141330030219822177
   PubMed Web of Science ®Google Scholar
• ZolnikBSGonzalez-FernandezASadriehNDobrovolskaiaMAMinireview: nanoparticles and the immune systemEndocrinology2010151245846520016026
   PubMed Web of Science ®Google Scholar
• SanvicensNMarcoMPMultifunctional nanoparticles–properties and prospects for their use in human medicineTrends Biotechnol200826842543318514941
   PubMed Web of Science ®Google Scholar
• SamarasingheRMKanwarRKKanwarJRThe effect of oral administration of iron saturated-bovine lactoferrin encapsulated chitosan-nanocarriers on osteoarthritisBiomaterials201435267522753424933511
   PubMed Web of Science ®Google Scholar
• SamarasingheRMKanwarRKKumarKKanwarJRAntiarthritic and chondroprotective activity of Lakshadi Guggul in novel alginate-enclosed chitosan calcium phosphate nanocarriersNanomedicine20149681983724401101
   PubMed Web of Science ®Google Scholar
• AroraRKuhadAKaurIChopraKCurcumin loaded solid lipid nanoparticles ameliorate adjuvant-induced arthritis in ratsEur J Pain201419794095210.1002/ejp.62025400173
   PubMed Web of Science ®Google Scholar
• BabazadaHYamashitaFHashidaMSuppression of experimental arthritis with self-assembling glycol-split heparin nanoparticles via inhibition of TLR4–NF-κB signalingJ Control Release201419429530025242730
   PubMed Web of Science ®Google Scholar
• HeoRParkJ-SJangHJHyaluronan nanoparticles bearing γ-secretase inhibitor: In vivo therapeutic effects on rheumatoid arthritisJ Control Release201419229530025109660
   PubMed Web of Science ®Google Scholar
• ZhangNWardwellPRBaderRAIn vitro efficacy of polysaccharide-based nanoparticles containing disease-modifying antirheumatic drugsPharm Res2014311–92326233424595497
   PubMed Web of Science ®Google Scholar
• DuanJDongJZhangTPolyethyleneimine-functionalized iron oxide nanoparticles for systemic siRNA delivery in experimental arthritisNanomedicine20149778980124392891
   PubMedGoogle Scholar
• NagaiNItoYTherapeutic effects of gel ointments containing tranilast nanoparticles on paw edema in adjuvant-induced arthritis ratsBiol Pharm Bull20143719610424389486
   PubMed Web of Science ®Google Scholar
• HowardKAPaludanSRBehlkeMABesenbacherFDeleuranBKjemsJChitosan/siRNA nanoparticle-mediated TNF-α knockdown in peritoneal macrophages for anti-inflammatory treatment in a murine arthritis modelMol Ther200817116216818827803
   PubMed Web of Science ®Google Scholar
• LeeSJLeeAHwangSRTNF-α Gene silencing using polymerized siRNA/thiolated glycol chitosan nanoparticles for rheumatoid arthritisMol Ther201322239740824145554
   PubMed Web of Science ®Google Scholar
• HwangJRodgersKOliverJCSchluepTα-Methylprednisolone conjugated cyclodextrin polymer-based nanoparticles for rheumatoid arthritis therapyInt J Nanomed200833359
   Web of Science ®Google Scholar
• LuH-DZhaoH-QWangKLvL-LNovel hyaluronic acid–chitosan nanoparticles as non-viral gene delivery vectors targeting osteoarthritisInt J Pharm2011420235836521911044
   PubMedGoogle Scholar
• LuHDaiYLvLZhaoHChitosan-graft-polyethylenimine/DNA nanoparticles as novel non-viral gene delivery vectors targeting osteoarthritisPLoS One201491e8470324392152
   PubMed Web of Science ®Google Scholar
• JainAMishraSKVuddandaPRSinghSKSinghRSinghSTargeting of diacerein loaded lipid nanoparticles to intra-articular cartilage using chondroitin sulfate as homing carrier for treatment of osteoarthritis in ratsNanomedicine20141051031104024512762
   PubMed Web of Science ®Google Scholar
• HanJGuoXLeiYDennisBSWuSWuCSynthesis and characterization of selenium–chondroitin sulfate nanoparticlesCarbohydr Polym201290112212624751019
   PubMed Web of Science ®Google Scholar
• BannwarthBSchaeverbekeTLabatLMarceSDemotes-MainardFDehaisJSide-effects during treatment of rheumatoid arthritis with methotrexateRev Rhum Ed Fr19946153373427812288
   PubMedGoogle Scholar
• GutkowskiKChwistAHartlebMLiver injury induced by high-dose methylprednisolone therapy: a case report and brief review of the literatureHepat Mon201111865622140391
   PubMed Web of Science ®Google Scholar
• MouraCCSegundoMAdas NevesJReisSSarmentoBCo-association of methotrexate and SPIONs into anti-CD64 antibody-conjugated PLGA nanoparticles for theranostic applicationInt J Nanomed20149149114922
   Google Scholar
• ZhouH-fYanHHuYFumagillin prodrug nanotherapy suppresses macrophage inflammatory response via endothelial nitric oxideACS Nano2014877305731724941020
   PubMed Web of Science ®Google Scholar
• ZhouH-fYanHSenpanASuppression of inflammation in a mouse model of rheumatoid arthritis using targeted lipase-labile fumagillin prodrug nanoparticlesBiomaterials201233338632864022922023
   PubMed Web of Science ®Google Scholar
• LeeHLeeM-YBhangSHHyaluronate–gold nanoparticle/tocilizumab complex for the treatment of rheumatoid arthritisACS Nano2014854790479824730974
   PubMed Web of Science ®Google Scholar
• LeeS-MKimHJHaY-JTargeted chemo-photothermal treatments of rheumatoid arthritis using gold half-shell multifunctional nanoparticlesACS Nano201271505723194301
   PubMed Web of Science ®Google Scholar
• ScheinmanRITrivediRVermillionSKompellaUBFunctionalized STAT1 siRNA nanoparticles regress rheumatoid arthritis in a mouse modelNanomedicine20116101669168222087799
   PubMed Web of Science ®Google Scholar
• HardingFASticklerMMRazoJDuBridgeRBThe immunogenicity of humanized and fully human antibodies: residual immunogenicity resides in the CDR regionsMAbs20102325626520400861
   PubMed Web of Science ®Google Scholar
• WangSBDengYQRenJXiaoBKChenZTaoZZLactoferrin administration into the nostril alleviates murine allergic rhinitis and its mechanismsScand J Immunol201378650751524111738
   PubMed Web of Science ®Google Scholar
• MachnickiMZimeckiMZagulskiTLactoferrin regulates the release of tumour necrosis factor alpha and interleukin 6 in vivoInt J Exp Pathol19937454334398217778
   PubMed Web of Science ®Google Scholar
• ValentiPCatizoneAPantanellaFLactoferrin decreases inflammatory response by cystic fibrosis bronchial cells invaded with Burkholderia cenocepacia iron-modulated biofilmInt J Immunopathol Pharmacol20102441057106822230411
   PubMed Web of Science ®Google Scholar
• SingerNGCaplanAIMesenchymal stem cells: mechanisms of inflammationAnnu Rev Pathol2011645747821073342
   PubMed Web of Science ®Google Scholar
• LinC-SXinZ-CDaiJLueTFCommonly used mesenchymal stem cell markers and tracking labels: Limitations and challengesHistol Histopathol2013289110923588700
   PubMed Web of Science ®Google Scholar
• KanwarJRMahidharaGRoyKFe-bLf nanoformulation targets survivin to kill colon cancer stem cells and maintains absorption of iron, calcium and zincNanomedicine2014101355525017148
   PubMed Web of Science ®Google Scholar
• TakayamaYMizumachiKInhibitory effect of lactoferrin on hypertrophic differentiation of ATDC5 mouse chondroprogenitor cellsBiometals201023347748420094900
   PubMed Web of Science ®Google Scholar
• TuYXueHFrancisWLactoferrin inhibits dexamethasone-induced chondrocyte impairment from osteoarthritic cartilage through up-regulation of extracellular signal-regulated kinase 1/2 and suppression of FASL, FAS, and Caspase 3Biochem Biophys Res Commun2013441124925524141118
   PubMed Web of Science ®Google Scholar
• CornishJCallonKENaotDLactoferrin is a potent regulator of bone cell activity and increases bone formation in vivoEndocrinology200414594366437415166119
   PubMed Web of Science ®Google Scholar
• HalversonPBMcCartyDJPatterns of radiographic abnormalities associated with basic calcium phosphate and calcium pyrophosphate dihydrate crystal deposition in the kneeAnn Rheum Dis19864576036053017246
   PubMed Web of Science ®Google Scholar
• MengZHudsonASchumacher JrHBakerJBakerDMonosodium urate, hydroxyapatite, and calcium pyrophosphate crystals induce tumor necrosis factor-alpha expression in a mononuclear cell lineJ Rheumatol19972412238523889415647
   PubMed Web of Science ®Google Scholar