Nanomedicine concepts in the general medical curriculum: initiating a discussion

References

• OslerWThe Evolution of Modern Medicine: A Series of Lectures Delivered at Yale University on the Silliman Foundation in April, 1913New HavenYale University Press1921
   Google Scholar
• BynumWFHardyAJacynaSLawrenceCTanseyEMThe Western Medical Tradition: 1800 to 2000New YorkCambridge University Press2006
   Google Scholar
• FlexnerAMedical Education in the United States and Canada: A Report to the Carnegie Foundation for the Advancement of TeachingBostonD. B. Updike, The Merrymount Press1910
   Google Scholar
• MurdayJSSiegelRWSteinJWrightJFTranslational nanomedicine: status assessment and opportunitiesNanomedicine2009525127319540359
   PubMed Web of Science ®Google Scholar
• MorrowKJJrBawaRWeiCRecent advances in basic and clinical nanomedicineMed Clin North Am20079180584317826104
   PubMed Web of Science ®Google Scholar
• RiehemannKSchneiderSWLugerTAGodinBFerrariMFuchsHNanomedicine – challenge and perspectivesAngew Chem Int Ed Engl20094887289719142939
   PubMed Web of Science ®Google Scholar
• PautlerMBrennerSNanomedicine: promises and challenges for the future of public healthInt J Nanomedicine2010580380921042425
   PubMed Web of Science ®Google Scholar
• WongKKLiuXLNanomedicine: a primer for surgeonsPediatr Surg Int20122894395122892910
   PubMedGoogle Scholar
• VenkatramanSHas nanomedicine lived up to its promise?Nanotechnology20142537250125148691
   PubMed Web of Science ®Google Scholar
• KimBYRutkaJTChanWCNanomedicineN Engl J Med20103632434244321158659
   PubMed Web of Science ®Google Scholar
• LiuYMiyoshiHNakamuraMNanomedicine for drug delivery and imaging: a promising avenue for cancer therapy and diagnosis using targeted functional nanoparticlesInt J Cancer20071202527253717390371
   PubMed Web of Science ®Google Scholar
• EtheridgeMLCampbellSAErdmanAGHaynesCLWolfSMMcCulloughJThe big picture on nanomedicine: the state of investigational and approved nanomedicine productsNanomedicine2013911422684017
   PubMed Web of Science ®Google Scholar
• DuncanRGasparRNanomedicine(s) under the microscopeMol Pharm201182101214121974749
   PubMed Web of Science ®Google Scholar
• SweeneyAESealSNanoscale Science and Engineering EducationLos AngelesAmerican Scientific Publishers2008
   Google Scholar
• European Science Foundation (ESF)Nanomedicine: An ESF–European Medical Research Councils (EMRC) Forward Look ReportStrasbourgESF2005 Available from: http://www.esf.org/fileadmin/Public_documents/Publications/Nanomedicine.pdfAccessed November 25, 2015
   Google Scholar
• WebsterTJNanomedicine: what’s in a definition?Int J Nanomedicine2006111511617722527
   PubMed Web of Science ®Google Scholar
• GreenAERosePGPegylated liposomal doxorubicin in ovarian cancerInt J Nanomedicine2006122923917717964
   PubMed Web of Science ®Google Scholar
• MieleESpinelliGPMieleETomaoFTomaoSAlbumin-bound formulation of paclitaxel (Abraxane ABI-007) in the treatment of breast cancerInt J Nanomedicine200949910519516888
   PubMed Web of Science ®Google Scholar
• SerdaREGodinBBlancoEChiappiniCFerrariMMulti-stage delivery nano-particle systems for therapeutic applicationsBiochim Biophys Acta2011181031732920493927
   PubMed Web of Science ®Google Scholar
• VentolaCLThe nanomedicine revolution: part 2: current and future clinical applicationsP T20123758259123115468
   PubMedGoogle Scholar
• BertrandNWuJXuXKamalyNFarokhzadOCCancer nanotechnology: the impact of passive and active targeting in the era of modern cancer biologyAdv Drug Deliv Rev20146622524270007
   PubMed Web of Science ®Google Scholar
• TasciottiELiuXBhavaneRMesoporous silicon particles as a multistage delivery system for imaging and therapeutic applicationsNat Nanotechnol2008315115718654487
   PubMed Web of Science ®Google Scholar
• BourzacKNanotechnology: carrying drugsNature2012491S58S6023320289
   PubMed Web of Science ®Google Scholar
• MartinezJOBrownBSQuattrocchiNEvangelopoulosMFerrariMTasciottiEMultifunctional to multistage delivery systems: the evolution of nanoparticles for biomedical applicationsChin Sci Bull2012573961397124587616
   PubMedGoogle Scholar
• AkhterSAhmadIAhmadMZNanomedicines as cancer therapeutics: current statusCurr Cancer Drug Targets20131336237823517593
   PubMed Web of Science ®Google Scholar
• WangRBillonePSMullettWMNanomedicine in action: an overview of cancer nanomedicine on the market and in clinical trialsJ Nanomater20132013629681
   Web of Science ®Google Scholar
• PillaiGNanomedicines for cancer therapy: an update of FDA approved and those under various stages of developmentSOJ Pharm Pharm Sci2014113
   Google Scholar
• RizzoLYTheekBStormGKiesslingFLammersTRecent progress in nanomedicine: therapeutic, diagnostic and theranostic applicationsCurr Opin Biotechnol2013241159116623578464
   PubMed Web of Science ®Google Scholar
• CondeJOlivaNArtziNImplantable hydrogel embedded dark-gold nanoswitch as a theranostic probe to sense and overcome cancer multi-drug resistanceProc Natl Acad Sci U S A2015112E1278E128725733851
   PubMed Web of Science ®Google Scholar
• MarkmanJLRekechenetskiyAHollerELjubimovaJYNanomedicine therapeutic approaches to overcome cancer drug resistanceAdv Drug Deliv Rev2013651866187924120656
   PubMed Web of Science ®Google Scholar
• NatarajanJVDarwitanABarathiVASustained drug release in nanomedicine: a long-acting nanocarrier-based formulation for glaucomaACS Nano2014841942924392729
   PubMed Web of Science ®Google Scholar
• RocoMCNational Nanotechnology Investment in the FY 2016 Budget [webpage on the Internet]WashingtonAmerican Association for the Advancement of Science2015 Available from: http://www.aaas.org/fy16budget/national-nanotechnology-investment-fy-2016-budgetAccessed October 30, 2015
   Google Scholar
• Estimates of Funding for Various Research, Condition, and Disease Categories (RCDC) [webpage on the Internet]WashingtonU.S. Department of Health & Human Services2015 [updated July 8, 2015]. Available from: http://report.nih.gov/categorical_spending.aspxAccessed October 30, 2015
   Google Scholar
• Clinically approved nanomedicines and nanoformulations [webpage on the Internet]LiverpoolBritish Society for Nanomedicine Available from: http://www.britishsocietynanomedicine.org/existing-nanomedicines.htmlAccessed November 3, 2015
   Google Scholar
• Verigene System [webpage on the Internet]NorthbrookNanosphere, Inc Available from: http://www.nanosphere.us/products/verigene-systemAccessed November 3, 2015
   Google Scholar
• WojewodaCMSerciaSNavasSEvaluation of the Verigene Gram-positive blood culture nucleic acid test for rapid detection of bacteria and resistance determinantsJ Clin Microbiol2013512072207623596240
   PubMed Web of Science ®Google Scholar
• BealSGCiurcaJSmithGEvaluation of the nanosphere Verigene gram-positive blood culture assay with the VersaTREK blood culture system and assessment of possible impact on selected patientsJ Clin Microbiol2013513988399224048531
   PubMed Web of Science ®Google Scholar
• DodémontMDe MendonçaRNonhoffCRoisinSDenisOPerformance of the Verigene Gram-negative blood culture assay for rapid detection of bacteria and resistance determinantsJ Clin Microbiol2014523085308724899026
   PubMed Web of Science ®Google Scholar
• HafnerALovrićJLakošGPPepićINanotherapeutics in the EU: an overview on the current state and future directionsInt J Nanomedicine201491005102324600222
   PubMed Web of Science ®Google Scholar
• FerrariMBrown Symposium XXXVI – Mauro Ferrari: “Nanomedicine and New Societal Horizons”YouTube2014 Available from: https://www.youtube.com/watch?v=4p2tnkMy1bsAccessed May 1, 2015
   Google Scholar
• MooreRNanomedicine: rethinking medical trainingMed Device Technol200819505253
   Google Scholar
• MooreRNanoscience and future trends in medical technologiesEuropean Medical Device Technology201015 Available from: http://www.emdt.co.uk/article/nanoscience-and-future-trends-medical-technologiesAccessed May 10, 2015
   Google Scholar
• MooreRUnlocking the potential of medical nanotechnologyEuropean Medical Device Technology201342 Available from: http://www.emdt.co.uk/article/unlocking-potential-medical-nanotechnologyAccessed May 10, 2015
   Google Scholar
• General Medical Council (GMC)Tomorrow’s Doctors: Outcomes and Standards for Undergraduate Medical EducationManchesterGMC2009
   Google Scholar
• AAMC-HHMI CommitteeScientific Foundations for Future PhysiciansWashingtonAAMC-HHMI Committee2009
   Google Scholar
• NormanGThe essential role of basic science in medical education: the perspective from psychologyClin Invest Med200023475110782317
   PubMed Web of Science ®Google Scholar
• DienstagJLRelevance and rigor in premedical educationN Engl J Med200835922122418635426
   PubMed Web of Science ®Google Scholar
• BrassEPBasic biomedical sciences and the future of medical education: implications for internal medicineJ Gen Intern Med2009241251125419882372
   PubMed Web of Science ®Google Scholar
• GrandeJPTraining of physicians for the twenty-first century: role of the basic sciencesMed Teach20093180280619811184
   PubMed Web of Science ®Google Scholar
• FinnertyEPChauvinSBonaminioGAndrewsMCarrollRGPangaroLNFlexner revisited: the role and value of the basic sciences in medical educationAcad Med20108534935520107367
   PubMed Web of Science ®Google Scholar
• LambertDRLurieSJLynessJMWardDSStandardizing and personalizing science in medical educationAcad Med20108535636220107368
   PubMed Web of Science ®Google Scholar
• FincherRMWallachPMRichardsonWSBasic science right, not basic science lite: medical education at a crossroadJ Gen Intern Med2009241255125819774422
   PubMed Web of Science ®Google Scholar
• MorelandBHHow much biochemistry should a good doctor know?Biochem Educ19962479
   Google Scholar
• CohenRDFeatures section: how much biochemistry should a medical student be taught? – The viewpoint of the General Medical CouncilBiochem Educ1996248082
   Google Scholar
• WoodEJHow much biochemistry should a good doctor know? A biochemist’s viewpointBiochem Educ1996248285
   Google Scholar
• DennickRHow much biochemistry should a good doctor know? An educationalist’s perspectiveBiochem Educ1996248588
   Google Scholar
• SaffranMHow much biochemistry should a good doctor know?Biochem Educ199725129133
   Google Scholar
• AbramsonSBJacobDRosenfeldMA 3-year M.D. – accelerating careers, diminishing debtN Engl J Med20133691085108724047055
   PubMed Web of Science ®Google Scholar
• GoldfarbSMorrisonGThe 3-year medical school – change or shortchange?N Engl J Med20133691087108924047056
   PubMed Web of Science ®Google Scholar
• BuzeaCPachecoIIRobbieKNanomaterials and nanoparticles: sources and toxicityBiointerphases20072MR17MR7120419892
   PubMed Web of Science ®Google Scholar
• BurgessRUnderstanding Nanomedicine: An Introductory TextbookSingaporePan Stanford Publishing Pte. Ltd2012
   Google Scholar
• WolfELNanophysics and Nanotechnology: An Introduction to Modern Concepts in NanoscienceWeinheimWiley-VCH2004
   Google Scholar
• WhitesidesGMNanoscience, nanotechnology, and chemistrySmall2005117217917193427
   PubMed Web of Science ®Google Scholar
• HobbieRKRothBJIntermediate Physics for Medicine and Biology4th edNew YorkSpringer Science + Business Media, LLC2007
   Google Scholar
• GrazúVMorosMSánchez-EspinelCNanocarriers as nanomedicines: design concepts and recent advancesde la FuenteJMGrazúVNanobiotechnology: Inorganic Nanoparticles vs Organic NanoparticlesOxfordElsevier2012337440
   Google Scholar
• MuQJiangGChenLChemical basis of interactions between engineered nanoparticles and biological systemsChem Rev20141147740778124927254
   PubMed Web of Science ®Google Scholar
• NelAEMädlerLVelegolDUnderstanding biophysicochemical interactions at the nano-bio interfaceNat Mater2009854355719525947
   PubMed Web of Science ®Google Scholar
• ZhangXQXuXBertrandNPridgenESwamiAFarokhzadOCInteractions of nanomaterials and biological systems: implications to personalized medicineAdv Drug Deliv Rev2012641363138422917779
   PubMed Web of Science ®Google Scholar
• SongGPetschauerJSMaddenAJZamboniWCNanoparticles and the mononuclear phagocyte system: pharmacokinetics and applications for inflammatory diseasesCurr Rheumatol Rev201410223425229496
   PubMedGoogle Scholar
• SanhaiWRSakamotoJHCanadyRFerrariMSeven challenges for nanomedicineNat Nanotechnol2008324224418654511
   PubMed Web of Science ®Google Scholar
• DuncanRVicentMJPolymer therapeutics-prospects for 21st century: the end of the beginningAdv Drug Deliv Rev201365607022981753
   PubMed Web of Science ®Google Scholar
• SalmasoSCalicetiPStealth properties to improve therapeutic efficacy of drug nanocarriersJ Drug Deliv2013201337425223533769
   PubMedGoogle Scholar
• KannanRMNanceEKannanSTomaliaDAEmerging concepts in dendrimer-based nanomedicine: from design principles to clinical applicationsJ Intern Med201427657961724995512
   PubMed Web of Science ®Google Scholar
• OberdörsterGSafety assessment for nanotechnology and nanomedicine: concepts of nanotoxicologyJ Intern Med20102678910520059646
   PubMed Web of Science ®Google Scholar
• PelazBCharronGPfeifferCInterfacing engineered nanoparticles with biological systems: anticipating adverse nano-bio interactionsSmall201391573158423112130
   PubMed Web of Science ®Google Scholar
• LammersTHenninkWEStormGTumour-targeted nanomedicines: principles and practiceBr J Cancer20089939239718648371
   PubMed Web of Science ®Google Scholar
• ChoiCHAlabiCAWebsterPDavisMEMechanism of active targeting in solid tumors with transferring-containing gold nanoparticlesProc Natl Acad Sci U S A20101071235124020080552
   PubMed Web of Science ®Google Scholar
• KatsogiannouMPengLCatapanoCVRocchiPActive-targeted nanotherapy strategies for prostate cancerCurr Cancer Drug Targets20111195496521861840
   PubMed Web of Science ®Google Scholar
• KhannaVKTargeted delivery of nanomedicinesISRN Pharmacol2012201257139422577576
   PubMedGoogle Scholar
• LuoDCarterKALovellJFNanomedical engineering: shaping future nanomedicinesWiley Interdiscip Rev Nanomed Nanobiotechnol2015716918825377691
   PubMedGoogle Scholar
• LemboDCavalliRNanoparticulate delivery systems for antiviral drugsAntivir Chem Chemother201021537021107015
   PubMedGoogle Scholar
• BhaskarSTianFStoegerTMultifunctional nanocarriers for diagnostics, drug delivery and targeted treatment across blood-brain barrier: perspectives on tracking and neuroimagingPart Fibre Toxicol20107320199661
   PubMed Web of Science ®Google Scholar
• KhanbabaieRJahanshahiMRevolutionary impact of nanodrug delivery on neuroscienceCurr Neuropharmacol20121037039223730260
   PubMed Web of Science ®Google Scholar
• MicheliMRBovaRMaginiAPolidoroMEmilianiCLipid-based nanocarriers for CNS-targeted drug deliveryRecent Pat CNS Drug Discov20127718622283231
   PubMedGoogle Scholar
• AlyautdinRKhalinINafeezaMIHaronMHKuznetsovDNanoscale drug delivery systems and the blood-brain barrierInt J Nanomedicine2014979581124550672
   PubMed Web of Science ®Google Scholar
• JainKKNanodiagnostics: application of nanotechnology in molecular diagnosticsExpert Rev Mol Diagn2003315316112647993
   PubMed Web of Science ®Google Scholar
• AzzazyHMMansourMMKazmierczakSCNanodiagnostics: a new frontier for clinical laboratory medicineClin Chem2006521238124616709623
   PubMed Web of Science ®Google Scholar
• BaptistaPVNanodiagnostics: leaving the research lab to enter the clinics?Diagnosis20141305309
   Google Scholar
• BoulaizHAlvarezPJRamirezANanomedicine: application areas and development prospectsInt J Mol Sci2011123303332121686186
   PubMed Web of Science ®Google Scholar
• WongIYBhatiaSNTonerMNanotechnology: emerging tools for biology and medicineGenes Dev2013272397240824240230
   PubMed Web of Science ®Google Scholar
• JainKKRole of nanodiagnostics in personalized cancer therapyClin Lab Med201232153122340841
   PubMed Web of Science ®Google Scholar
• TavallaieRDe AlmeidaSRGoodingJJToward biosensors for the detection of circulating microRNA as a cancer biomarker: an overview of the challenges and successesWiley Interdiscip Rev Nanomed Nanobiotechnol2015758059225529633
   PubMed Web of Science ®Google Scholar
• BrambillaDLe DroumaguetBNicolasJNanotechnologies for Alzheimer’s disease: diagnosis, therapy, and safety issuesNanomedicine2011752154021477665
   PubMed Web of Science ®Google Scholar
• DiSantoRMSubramanianVGuZRecent advances in nanotechnology for diabetes treatmentWiley Interdiscip Rev Nanomed Nanobiotechnol2015754856425641955
   PubMed Web of Science ®Google Scholar
• VeisehOTangBCWhiteheadKAAndersonDGLangerRManaging diabetes with nanomedicine: challenges and opportunitiesNat Rev Drug Discov201514455725430866
   PubMed Web of Science ®Google Scholar
• WangSInciFDe LiberoGSinghalADemirciUPoint-of-care assays for tuberculosis: role of nanotechnology/microfluidicsBiotechnol Adv20133143844923357365
   PubMed Web of Science ®Google Scholar
• Salieb-BeugelaarGBHunzikerPRTowards nano-diagnostics for rapid diagnosis of infectious diseases – current technological stateEur J Nanomed201461128
   Google Scholar
• Salieb-BeugelaarGBHunzikerPRTowards nano-diagnostics for bacterial infectionsEur J Nanomed201573750
   Google Scholar
• BawaRJohnsonSThe ethical dimensions of nanomedicineMed Clin North Am20079188188717826108
   PubMedGoogle Scholar
• SweeneyAESealSVaidyanathanPThe promises and perils of nanoscience and nanotechnology: exploring emerging social and ethical issuesBull Sci Technol Soc200323236245
   Google Scholar
• SweeneyAESocial and ethical dimensions of nanoscale science and engineering researchSci Eng Ethics20061243546416909148
   PubMed Web of Science ®Google Scholar
• AllhoffFThe coming era of nanomedicineAm J Bioeth2009931119998074
   PubMed Web of Science ®Google Scholar
• FoladoriGInvernizziNNanotechnology for the poor?PLoS Med20052e28016120016
   PubMedGoogle Scholar
• MaclurcanDNanotechnology and Global EqualitySingaporePan Stanford Publishing Pte. Ltd2012
   Google Scholar
• HallRMSunTFerrariMA portrait of nanomedicine and its bioethical implicationsJ Law Med Ethics20124076376923289679
   PubMedGoogle Scholar
• KhushfGSiegelRAWhat is unique about nanomedicine? The significance of the mesoscaleJ Law Med Ethics20124078079423289680
   PubMedGoogle Scholar
• DresserRBuilding an ethical foundation for first-in-human nanotrialsJ Law Med Ethics20124080280823289682
   PubMedGoogle Scholar
• HogleLFConcepts of risk in nanomedicine researchJ Law Med Ethics20124080982223289683
   PubMedGoogle Scholar
• KingNMNanomedicine first-in-human research: challenges for informed consentJ Law Med Ethics20124082383023289684
   PubMedGoogle Scholar
• KimmelmanJBeyond human subjects: risk, ethics, and clinical development of nanomedicinesJ Law Med Ethics20124084184723289686
   PubMedGoogle Scholar
• ResnikDBResponsible conduct in nanomedicine research: environmental concerns beyond the common ruleJ Law Med Ethics20124084885523289687
   PubMedGoogle Scholar
• KuikenTNanomedicine and ethics: is there anything new or unique?Wiley Interdiscip Rev Nanomed Nanobiotechnol2011311111820544800
   PubMed Web of Science ®Google Scholar
• BeauchampTLChildressJFPrinciples of Biomedical Ethics6th edNew YorkOxford University Press2009
   Google Scholar
• ResnikDBTinkleSSEthical issues in clinical trials involving nanomedicineContemp Clin Trials20072843344117166777
   PubMed Web of Science ®Google Scholar
• HopeTFulfordKWThe Oxford Practice Skills Project: teaching ethics, law and communication skills to clinical medical studentsJ Med Ethics1994202292347861428
   PubMed Web of Science ®Google Scholar
• LeBlancTWCommunication skills training in the twenty-first centuryAMA J Ethics20151714014325676227
   PubMedGoogle Scholar
• ArnoldRMForrowLWartmanSATenoJTeaching clinical medical ethics: a model programme for primary care residencyJ Med Ethics19881491963392724
   PubMed Web of Science ®Google Scholar
• EichnaLWMedical-school education, 1975–1979: a student’s perspectiveN Engl J Med19803037277347402270
   PubMed Web of Science ®Google Scholar
• MD/PhD in Medicine and Nanoscale Science or Engineering [webpage on the Internet]AlbanyColleges of Nanoscale Science + Engineering, SUNY Polytechnic Institute Available from: http://www.sunycnse.com/PioneeringAcademics/GraduatePrograms/Nanomedicine.aspxAccessed August 12, 2015
   Google Scholar
• MD-PhD program [webpage on the Internet]BryanTexas A&M Health Science Center Available from: https://medicine.tamhsc.edu/md-phd/index.htmlAccessed August 12, 2015
   Google Scholar
• Scholarly Concentrations Program [webpage on the Internet]HoustonThe University of Texas Health Science Center at Houston Available from: https://med.uth.edu/oep/medical-education/student-programs/scholarly-concentrations-program/Accessed August 12, 2015
   Google Scholar
• Areas of Concentration [webpage on the Internet]New YorkWeill Cornell Medical College Available from: http://weill.cornell.edu/education/curriculum/aoc.htmlAccessed August 12, 2015
   Google Scholar
• VélezJMVélezJJThe eminent need for an academic program in universities to teach nanomedicineInt J Nanomedicine201161733173821984868
   PubMed Web of Science ®Google Scholar
• WeatherallDScience and medical education: is it time to revisit Flexner?Med Educ201145445021155867
   PubMedGoogle Scholar
• SpencerALBrosenitschTLevineASKanterSLBack to the basic sciences: an innovative approach to teaching senior medical students how best to integrate basic science and clinical medicineAcad Med20088366266918580085
   PubMed Web of Science ®Google Scholar
• BrauerDGFergusonKJThe integrated curriculum in medical education: AMEE Guide No 96Med Teach20153731232225319403
   PubMed Web of Science ®Google Scholar
• LammersTAimeSHenninkWEStormGKiesslingFTheranostic nanomedicineAcc Chem Res2011441029103821545096
   PubMed Web of Science ®Google Scholar
• RajeevaBBMenzRZhengYTowards rational design of multifunctional theranostic nanoparticles: what barriers do we need to overcome?Nanomedicine (Lond)201491767177025325238
   PubMedGoogle Scholar
• Taking the MCAT^® Exam [webpage on the Internet]WashingtonAssociation of American Medical Colleges Available from: https://www.aamc.org/students/applying/mcat/about/Accessed August 24, 2015
   Google Scholar
• KiesSShultzMProposed changes to the United States Medical Licensing Examination: impact on curricula and librariesJ Med Libr Assoc201098121620098646
   PubMedGoogle Scholar
• HaistSThe changing United States Medical Licensing ExaminationSGIM Forum2013361911
   Google Scholar
• HaistSAKatsufrakisPJDillonGFThe evolution of the United States Medical Licensing Examination (USMLE): enhancing assessment of practice-related competenciesJAMA20133102245224624302081
   PubMed Web of Science ®Google Scholar
• BarbieriJSBasic science content in the USMLE Step 1JAMA20143111358135924691619
   PubMedGoogle Scholar
• What’s on the MCAT Exam? [webpage on the Internet]WashingtonAssociation of American Medical Colleges2015 Available from: https://students-residents.aamc.org/applying-medical-school/article/whats-mcat-exam/Accessed November 25, 2015
   Google Scholar
• United States Medical Licensing Examination (USMLE)Changes to USMLE^® 2015–2016USMLE2015 Available from: http://www.usmle.org/pdfs/Changes_to_USMLE_handout.pdfAccessed August 19, 2015
   Google Scholar
• United States Medical Licensing Examination (USMLE)USMLE Step 1: Content Description and General InformationFederation of State Medical Boards of the United States Inc. (FSMB), National Board of Medical Examiners® (NBME®)2015 Available from: http://www.usmle.org/pdfs/step-1/2015content_step1.pdfAccessed August 19, 2015
   Google Scholar
• United States Medical Licensing Examination (USMLE)USMLE Step 2: Clinical Knowledge (CK): Content Description and General InformationFederation of State Medical Boards of the United States Inc. (FSMB), National Board of Medical Examiners® (NBME®)2015 Available from: http://www.usmle.org/pdfs/step-2-ck/2015_Step2CK_Content.pdfAccessed August 19, 2015
   Google Scholar
• KanterSLThe future of academic medicine: what can Academic Medicine do about it?Acad Med20098440540619318761
   PubMedGoogle Scholar
• EisensteinMArtificial organs: Honey, I shrunk the lungsNature2015519S16S1825806493
   PubMedGoogle Scholar
• SchmidtHGNormanGRBoshuizenHPA cognitive perspective on medical expertise: theory and implicationAcad Med1990656116212261032
   PubMed Web of Science ®Google Scholar
• EvaKWWhat every teacher needs to know about clinical reasoningMed Educ2005399810615612906
   PubMed Web of Science ®Google Scholar
• BowenJLEducational strategies to promote clinical diagnostic reasoningN Engl J Med20063552217222517124019
   PubMed Web of Science ®Google Scholar
• CustersEJThirty years of illness scripts: theoretical origins and practical applicationsMed Teach20153745746225180878
   PubMed Web of Science ®Google Scholar
• CavazosLFRestructuring education and its impact on medical educationAcad Med1990652302332334503
   PubMedGoogle Scholar
• KanterSLToward a sound philosophy of premedical educationAcad Med20088342342418448893
   PubMedGoogle Scholar
• SweeneyAEVaidyanathanPSealSUndergraduate research and education in nanotechnologyThe International Journal of Engineering Education200622157170
   Web of Science ®Google Scholar
• BalserJRBaruchinAScience at the interstices: an evolution in the academyAcad Med20088382783118728436
   PubMedGoogle Scholar
• KuhnTSThe Structure of Scientific Revolutions2nd edChicagoUniversity of Chicago Press1970
   Google Scholar
• BaillieJThe structure of medical revolutionsCogito198822729
   Google Scholar