160
Views
0
CrossRef citations to date
0
Altmetric
ORIGINAL RESEARCH

Treatment of Vitamin K Deficiency in Hemodialysis Patients – A Pilot Study Comparing Menaquinone-7 Tablets and a Vitamin K Rich Diet

, , , ORCID Icon, , , , , & show all
Pages 267-276 | Received 11 Mar 2022, Accepted 29 Sep 2022, Published online: 17 Oct 2022

References

  • Go AS, Chertow GM, Fan D, Mcculloch CE, Hsu C-Y. Chronic kidney disease and the risks of death, cardiovascular events, and hospitalization. N Engl J Med. 2004;351(13):1296–1305. doi:10.1056/NEJMoa041031
  • Cranenburg ECM, Schurgers LJ, Uiterwijk HH, et al. Vitamin K intake and status are low in hemodialysis patients. Kidney Int. 2012;82(5):605–610. doi:10.1038/ki.2012.191
  • Cranenburg ECM, Koos R, Schurgers LJ, et al. Characterisation and potential diagnostic value of circulating matrix Gla protein (MGP) species. Thromb Haemost. 2010;104(4):811–822. doi:10.1160/TH09-11-0786
  • Fusaro M, D’Alessandro C, Noale M, et al. Low vitamin K1 intake in haemodialysis patients. Clin Nutr. 2017;36(2):601–607. doi:10.1016/j.clnu.2016.04.024
  • Caluwé R, Vandecasteele S, Van Vlem B, Vermeer C, De Vriese AS. Vitamin K2 supplementation in haemodialysis patients: a randomized dose-finding study. Nephrol Dial Transplant. 2014;29(7):1385–1390. doi:10.1093/ndt/gft464
  • Aoun M, Makki M, Azar H, Matta H, Chelala DN. High Dephosphorylated-Uncarboxylated MGP in Hemodialysis patients: risk factors and response to vitamin K2, A pre-post intervention clinical trial. BMC Nephrol. 2017;18(1). doi:10.1186/s12882-017-0609-3
  • Kaesler N, Magdeleyns E, Herfs M, et al. Impaired vitamin K recycling in uremia is rescued by vitamin K supplementation. Kidney Int. 2014;86(2):286–293. doi:10.1038/ki.2013.530
  • Geleijnse JM, Vermeer C, Grobbee DE, et al. Dietary intake of menaquinone is associated with a reduced risk of coronary heart disease: the Rotterdam Study. J Nutr. 2004;134(11):3100–3105. doi:10.1093/jn/134.11.3100
  • Apalset EM, Gjesdal CG, Eide GE, Tell GS. Intake of vitamin K1 and K2 and risk of Hip fractures: the Hordaland Health Study. Bone. 2011;49(5):990–995. doi:10.1016/j.bone.2011.07.035
  • Nakano T, Tsugawa N, Kuwabara A, Kamao M, Tanaka K, Okano T. High prevalence of hypovitaminosis D and K in patients with Hip fracture. Asia Pac J Clin Nutr. 2011;20(1):56–61.
  • Coombs GF. The Vitamins: Fundamental Aspects in Nutrition and Health. 4th ed. Cambridge, MA, USA: Academic Press; 2012:213–232.
  • Shearer MJ, Bach A, Kohlmeier M. Chemistry, nutritional sources, tissue distribution and metabolism of vitamin K with special reference to bone health. J Nutr. 1996;126(suppl_4):1181S–1186S. doi:10.1093/jn/126.suppl_4.1181S
  • Hirota Y, Tsugawa N, Nakagawa K, et al. Menadione (vitamin K3) is a catabolic product of oral phylloquinone (vitamin K1) in the intestine and a circulating precursor of tissue menaquinone-4 (vitamin K2) in rats. J Biol Chem. 2013;288(46):33071–33080. doi:10.1074/jbc.M113.477356
  • Vermeer C. γ -carboxyglutamate-containing proteins and the vitamin K-dependent carboxylase. Biochem J. 1990;266(3):625–636. doi:10.1042/bj2660625
  • Ducy P, Desbois C, Boyce B, et al. Increased bone formation in osteocalcin-deficient mice. Nature. 1996;382(6590):448–452. doi:10.1038/382448a0
  • Luo G, Ducy P, McKee MD, et al. Spontaneous calcification of arteries and cartilage in mice lacking matrix GLA protien. Nature. 1997;386(6620):78–81. doi:10.1038/386078a0
  • Gast GCM, de Roos NM, Sluijs I, et al. A high menaquinone intake reduces the incidence of coronary heart disease. Nutr Metabol Cardiovasc Dis. 2009;19(7):504–510. doi:10.1016/j.numecd.2008.10.004
  • Cozzolino M, Fusaro M, Ciceri P, Gasperoni L, Cianciolo G. The Role of Vitamin K in Vascular Calcification. Adv Chronic Kidney Dis. 2019;26:437–444. doi:10.1053/j.ackd.2019.10.005
  • Fusaro M, Crepaldi G, Maggi S, et al. Vitamin K, bone fractures, and vascular calcifications in chronic kidney disease: an important but poorly studied relationship. J Endocrinol Invest. 2011;34(4):317–323. doi:10.1007/BF03347093
  • Delanaye P, Krzesinski J-M, Warling X, et al. Dephosphorylated-uncarboxylated Matrix Gla protein concentration is predictive of vitamin K status and is correlated with vascular calcification in a cohort of hemodialysis patients. BMC Nephrology. 2014;15(1). doi:10.1186/1471-2369-15-145
  • Fusaro M, Noale M, Viola V, et al. Vitamin K, vertebral fractures, vascular calcifications, and mortality: vitamin K Italian (VIKI) Dialysis Study. J Bone Miner Res. 2012;27(11):2271–2278. doi:10.1002/jbmr.1677
  • Wikstrøm S, Lentz KA, Hansen D, et al. Causes of vitamin K deficiency in patients on haemodialysis. Nutrients. 2020;12(9):1–8. doi:10.3390/nu12092513
  • Beto JA, Bansal VK. Medical nutrition therapy in chronic kidney failure: integrating clinical practice guidelines. J Am Diet Assoc. 2004;104(3):404–409. doi:10.1016/j.jada.2003.12.028
  • Evenepoel P, Dejongh S, Verbeke K, Meijers B. The role of gut dysbiosis in the bone-vascular axis in chronic kidney disease. Toxins. 2020;12(5):285. doi:10.3390/toxins12050285
  • Jansz TT, Neradova A, Van Ballegooijen AJ, et al. The role of kidney transplantation and phosphate binder use in vitamin K status. PLoS One. 2018;13(8):e0203157. doi:10.1371/journal.pone.0203157
  • Levy-Schousboe K, Frimodt-Møller M, Hansen D, et al. Vitamin K supplementation and arterial calcification in dialysis: results of the double-blind, randomised, placebo-controlled RenaKvit trial. Clin Kidney J. 2021;14(9):2114–2123. doi:10.1093/ckj/sfab017
  • Jäpelt RB, Jakobsen J. Analysis of vitamin K1 in fruits and vegetables using accelerated solvent extraction and liquid chromatography tandem mass spectrometry with atmospheric pressure chemical ionization. Food Chem. 2016;192:402–408. doi:10.1016/j.foodchem.2015.06.111
  • Usermanual. IDS. InaKtif MGP (dp-ucMGP) Immunoassay. IDS-iSYS InaKtif MGP (dp-ucMGP); 2017 [ cited June 4, 2018]. Available from: https://www.idsplc.com/products/inaktif-mgp-dp-ucmgp-2/. Accessed September 30, 2022.
  • Westenfeld R, Krueger T, Schlieper G, et al. Effect of vitamin K 2 supplementation on functional vitamin K deficiency in hemodialysis patients: a randomized trial. Ame J Kidney Dis. 2012;59(2):186–195. doi:10.1053/j.ajkd.2011.10.041
  • Kurnatowska I, Grzelak P, Masajtis-Zagajewska A, et al. Plasma desphospho-uncarboxylated matrix gla protein as a marker of kidney damage and cardiovascular risk in advanced stage of chronic kidney disease. Kidney Blood Press Res. 2016;41:231–239. doi:10.1159/000443426
  • Tsukamoto Y, Ichise H, Kakuda H, Yamaguchi M. Intake of fermented soybean (natto) increases circulating vitamin K2 (menaquinone-7) and γ-carboxylated osteocalcin concentration in normal individuals. J Bone Miner Metab. 2000;18(4):216–222. doi:10.1007/s007740070023
  • Yamauchi M, Yamaguchi T, Nawata K, Takaoka S, Sugimoto T. Relationships between undercarboxylated osteocalcin and vitamin K intakes, bone turnover, and bone mineral density in healthy women. Clin Nutr. 2010;29(6):761–765. doi:10.1016/j.clnu.2010.02.010
  • Fusaro M, Gallieni M, Rizzo MA, et al. Vitamin K plasma levels determination in human health. Clin Chem Lab Med. 2017;55:789–799. doi:10.1515/cclm-2016-0783
  • Szulc P, Chapuy MC, Meunier PJ, Delmas PD. Serum undercarboxylated osteocalcin is a marker of the risk of Hip fracture in elderly women. J Clin Invest. 1993;91(4):1769–1774. doi:10.1172/JCI116387
  • Mizuiri S, Nishizawa Y, Yamashita K, et al. Relationship of matrix Gla protein and vitamin K with vascular calcification in hemodialysis patients. Ren Fail. 2019;41(1):770–777. doi:10.1080/0886022X.2019.1650065
  • Schurgers LJ, Shearer MJ, Soute BAM, et al. Novel effects of diets enriched with corn oil or with an olive oil/sunflower oil mixture on vitamin K metabolism and vitamin K-dependent proteins in young men Novel ef-fects of diets enriched with corn oil or with an olive oil/sunflower oil mixture on vitamin K metabolism and vitamin K-dependent proteins in young men Supplementary key words vitamin E • vegetable oils • gammacarboxy glutamate • blood coagulation • healthy volunteers. J Lipid Res. 2002;43(6):878–884.
  • Official JOurnal Of the internatiOnal SOciety Of nephrOlOgy KDIGO. Clinical practice guideline for the evaluation and management of chronic kidney disease. Kidney Int Suppl. 2012;2013(3):1–50.
  • Schurgers LJ, Teunissen KJF, Hamulyák K, Knapen MHJ, Vik H, Vermeer C. Vitamin K-containing dietary supplements: comparison of synthetic vitamin K1 and natto-derived menaquinone-7. Blood. 2007;109(8):3279–3283. doi:10.1182/blood-2006-08-040709
  • Kimura M, Itokawa Y. Cooking losses of minerals in foods and its nutritional significance. J Nutr Sci Vitaminol. 1990;36:S25–S33.
  • Cupisti A, Kovesdy CP, Kalantar-Zadeh K, Kalantar-Zadeh K. Dietary approach to recurrent or chronic hyperkalaemia in patients with decreased kidney function. Nutrients. 2018;10(3):261. doi:10.3390/nu10030261